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Mark Rolfe, PhD
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Journal Articles

Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen

Gang Lu, Christine Surka, Chin-Chun Lu, In Sock Jang, PhD, Kai Wang, PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 405.
https://doi.org/10.1182/blood-2019-125492
Published: 2019
Journal Articles

Activation of the Unfolded Protein Response with the First-in-Class P97 Inhibitor CB-5083 Induces Stable Disease Regression and Overcomes Ara-C Resistance in AML

Steffan T. Nawrocki, PhD, Yingchun Han, MD, Ronan LE Moigne, PhD, Valeria Visconte, PhD, Bartlomiej Przychodzen, MSc, Mark Rolfe, PhD, Stevan Djakovic, PhD, Daniel Anderson, David Wustrow, PhD, Han-Jie Zhou, Steve Wong, PhD, Anjali Advani, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Kevin R. Kelly, MD PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2015) 126 (23): 1350.
https://doi.org/10.1182/blood.V126.23.1350.1350
Published: 2015
Journal Articles

Inhibition of p97 with the First-in-Class Small Molecule CB-5083: A Novel Strategy for Acute Myeloid Leukemia Therapy

Rita Tohme, BS, Ronan Le Moigne, PhD, Bartlomiej P Przychodzen, Yingchun Han, MD, Mark Rolfe, PhD, Hetty E. Carraway, MD, Stevan Djakovic, PhD, Dan Anderson, PhD, David Wustrow, PhD, Han-Jie Zhou, PhD, Steve Wong, Kevin R. Kelly, MD, Yogen Saunthararajah, MD, Anjali S. Advani, MD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Steffan T. Nawrocki, PhD, Jennifer S. Carew, PhD
Journal: Blood
Blood (2014) 124 (21): 3766.
https://doi.org/10.1182/blood.V124.21.3766.3766
Published: 2014
Journal Articles

Pre-Clinical Activity of the Novel, First-in-Class p97 Inhibitor, CB-5083, in Multiple Myeloma

Blake T. Aftab, PhD, Daniel J Anderson, PhD, Ronan Le Moigne, PhD, Stevan Djakovic, PhD, Eugen Dhimolea, PhD, Megan Murnane, Emily King, Julie Rice, Steve Wong, Brajesh Kumar, PhD, Eduardo Valle, Mary-Kamala Menon, Szerenke Kiss von Soly, Jinhai Wang, PhD, Bing Yao, Ferdie Soriano, Martin Kampmann, PhD, Diego Alcost-Alvear, PhD, Marta Chesi, PhD, Leif Bergsagel, MD, F. Michael Yakes, PhD, Han-Jie Zhou, PhD, David Wustrow, PhD, Thomas G. Martin, MD, Jeffrey L. Wolf, Constantine S. Mitsiades, MD PhD, Mark Rolfe, PhD
Journal: Blood
Blood (2014) 124 (21): 4701.
https://doi.org/10.1182/blood.V124.21.4701.4701
Published: 2014