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Michelle I. Lin, PhD
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Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia

Michelle I Lin, PhD, Elizabeth J Paik, PhD, Bibhu P Mishra, PhD, Song Chou, PhD, Ying Zhang, PhD, Kaleigh Tomkinson, MS, Michael A Pettiglio, BS, Andrew Sanginario, BS, Amanda Woo, BS, Min Jin Lee, BS, Melanie Allen, MS, Thomas J Cradick, PhD, Tirtha Chakraborty, PhD, Matthew Porteus, MD PhD, Ciaran M Lee, PhD, Gang Bao, PhD, Annarita Miccio, PhD, Annalisa Lattanzi, PhD, Fulvio Mavilio, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 4708.
https://doi.org/10.1182/blood.V128.22.4708.4708
Published: 2016
Journal Articles

Crispr/Cas9- Mediated Genome Editing of Human CD34 + Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies

Bibhu Mishra, PhD, Song Chou, PhD, Michelle I Lin, PhD, Elizabeth J Paik, PhD, Ying Zhang, PhD, Ruibin Liang, MS, Kaleigh Tomkinson, MS, Michael Pettiglio, MS, Andrew Sanginario, BS, Melanie Allen, MS, Thomas Cradick, PhD, Matthias John, PhD, Tirtha Chakraborty, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 3623.
https://doi.org/10.1182/blood.V128.22.3623.3623
Published: 2016
Journal Articles

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

Michelle I Lin, PhD, Emily Price, Sonja Boatman, Eirini Trompouki, PhD, Sruthi Satishchandran, Charles W Carspecken, MD, Audrey Uong, Anthony DiBiase, Jon C. Aster, MD, PhD, Richard M. White, MD, PhD, Leonard I. Zon, M.D.
Journal: Blood
Blood (2013) 122 (21): 463.
https://doi.org/10.1182/blood.V122.21.463.463
Published: 2013
Journal Articles

Scl and Notch Act Downstream of Hedgehog Signaling to Promote Embryonic Hematopoiesis From Endothelial Cells

Peter G Kim, Colleen E Albacker, Il-ho Jang, PhD, Garrett C Heffner, PhD, Yoowon Lim, Teresa V. Bowman, PhD, Michelle I Lin, PhD, Leonard I. Zon, MD, Sabine Loewer, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1283.
https://doi.org/10.1182/blood.V118.21.1283.1283
Published: 2011
Journal Articles

Genetic Analyses in Zebrafish Reveal That Angiopoietin-Like Proteins 1 and 2 Are Required for HSC Development during Embryogenesis

Michelle I Lin, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2008) 112 (11): 729.
https://doi.org/10.1182/blood.V112.11.729.729
Published: 2008