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Journal Articles

Molecular Signature of Dormancy in CD34+CD38- Acute Myeloid Leukaemia Cells

Mazin Gh Al-Asadi, MD, Marcos Castellanos, PhD, Sean T May, Professor, Nigel H Russell, MD, Claire H Seedhouse, PhD, Monica Pallis, PhD

Blood (2016) 128 (22): 1660.

https://doi.org/10.1182/blood.V128.22.1660.1660

Published: 2016

Journal Articles

Comparison of Two Rapid Predictive Methods for Therapeutic Targeting in Acute Myeloid Leukaemia Cells

Martin Grundy, PhD, Jones Thomas, BSc, Liban Elmi, B MDSci, Michael Hall, B MDSci, Nigel H Russell, MD, Monica Pallis, PhD

Blood (2016) 128 (22): 1704.

https://doi.org/10.1182/blood.V128.22.1704.1704

Published: 2016

Journal Articles

Effectiveness of Transcriptional CDK Inhibitors in Targeting Non-Proliferating CD34+CD38- AML Cells,

Monica Pallis, PhD, Francis Burrows, PhD, Abigail Whittall, B Med Sci, Claire Seedhouse, PhD, Nicholas Boddy, B Med Sci, Nigel H. Russell, MD

Blood (2011) 118 (21): 3482.

https://doi.org/10.1182/blood.V118.21.3482.3482

Published: 2011

Journal Articles

Analysis of the Interaction of Induction Regimens with P-Glycoprotein Expression In Patients with Acute Myeloid Leukaemia: Results From the MRC AML15 Trial

Monica Pallis, PhD, Paul White, PhD, Robert Hills, MA, MSc, DPhil, Martin Grundy, BSc, Nigel H. Russell, MD, Alan Burnett

Blood (2010) 116 (21): 2724.

https://doi.org/10.1182/blood.V116.21.2724.2724

Published: 2010

Journal Articles

The Hypomethylating Agent 5-Azacytidine Can Target Leukaemic Stem and Progenitor Cells In Acute Myeloid Leukemia (AML) by Inducing DNA Damage and Stress Response Pathways

Mays Jawad, PhD, Ning Yu, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2010) 116 (21): 292.

https://doi.org/10.1182/blood.V116.21.292.292

Published: 2010

Journal Articles

RHPS4, An Anti-Telomere Agent, Specifically Targets the Subgroup of AML Cells with Loss or Gain of Parts of Chromosomes.

Monica Pallis, PhD, Simone Clarke, Martin Grundy, BSc, Jaineeta Richardson, Dotun Ojo, Susan Anderson, Nigel H. Russell, MD, Claire Seedhouse

Blood (2010) 116 (21): 1195.

https://doi.org/10.1182/blood.V116.21.1195.1195

Published: 2010

Journal Articles

An Immortalised Leukaemia Cell Line Models the Quiescence of Leukaemic Stem Cells and Shows Impaired Double Strand Break Repair Following Daunorubicin Treatment

Claire Seedhouse, Abigail Whittall, Karuna Tandon, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2010) 116 (21): 3989.

https://doi.org/10.1182/blood.V116.21.3989.3989

Published: 2010

Journal Articles

A Polymorphism In the 3'UTR Region of ABCB1 Is Associated with Increased Allele Activity with Corresponding Increases In P-Glycoprotein Expression and Function

Nada Bajuaifer, Martin Grundy, BSc, Robert Hills, MA, MSc, DPhil, Nigel H. Russell, MD, Monica Pallis, PhD, Claire Seedhouse

Blood (2010) 116 (21): 3990.

https://doi.org/10.1182/blood.V116.21.3990.3990

Published: 2010

Journal Articles

The Multi-Kinase Inhibitor TG02 targets CD34+CD38-CD123+ AML Cells

Monica Pallis, PhD, Francis Burrows, PhD, Nigel H. Russell, MD

Blood (2010) 116 (21): 1823.

https://doi.org/10.1182/blood.V116.21.1823.1823

Published: 2010

Journal Articles

DNA damage-induced Leukaemic Stem and Progenitor Cell Kill with Mylotarg and Tipifarnib/Zarnestra Drug Combination In Acute Myeloid Leukemia (AML)

Mays Jawad, PhD, Ning Yu, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2010) 116 (21): 1824.

https://doi.org/10.1182/blood.V116.21.1824.1824

Published: 2010

Journal Articles

Impaired S Phase Arrest in AML Cells with a FLT3-ITD Treated with Clofarabine Allows Prolonged Drug exposure to Reverse the Chemoresistant Phenotype.

Claire Seedhouse, PhD, Martin Grundy, BSc, Shili Shang, MD, MSc, John Ronan, CSci, FIBMS, Heather Pimblett, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2009) 114 (22): 1000.

https://doi.org/10.1182/blood.V114.22.1000.1000

Published: 2009

Journal Articles

Regulation of ABCB1 (p-glycoprotein) by the FOXO1 Transcription Factor in Acute Myeloid Leukemia.

Claire Seedhouse, PhD, Sophie Ahluwalia, BSc, Ken I Mills, Ph.D., FRCPath, Martin Grundy, BSc, Shili Shang, MD, MSc, Alan K. Burnett, MD, FRCP, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2009) 114 (22): 589.

https://doi.org/10.1182/blood.V114.22.589.589

Published: 2009

Journal Articles

The Telomerase Inhibitor RHPS4 Induces Telomere Shortening, DNA-Damage and Cell Death in AML Cells and Chemosensitises Cells to Daunorubicin.

Monica Pallis, PhD, Dotun Ojo, Jaineeta Richardson, MSc, John Ronan, CSci, FIBMS, Malcolm Stevens, PhD, FRS, Nigel H. Russell, MD, Claire Seedhouse, PhD

Blood (2009) 114 (22): 2760.

https://doi.org/10.1182/blood.V114.22.2760.2760

Published: 2009

Journal Articles

Azacytidine and Gemtuzumab Ozogamicin Co-Operate to Inhibit the Wnt Pathway and Increase Cytotoxicity in AML

Mays Jawad, BSc, PhD, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2008) 112 (11): 2991.

https://doi.org/10.1182/blood.V112.11.2991.2991

Published: 2008

Journal Articles

The Effect of ABC Transporters and FLT3 Status on the Activity of the Aurora Kinase B Inhibitor AZD1152 in AML Cells.

Martin Grundy, BSc, Shili Shang, MD, MSc, C. Seedhouse, PhD, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2008) 112 (11): 1627.

https://doi.org/10.1182/blood.V112.11.1627.1627

Published: 2008

Journal Articles

P-Glycoprotein Is Downregulated in KG1a Primitive Leukaemia Cells by LDL Cholesterol Deprivation and by HMG-CoA Reductase Inhibitors.

Laura Connelly-Smith, MBBCh, Joanne Pattinson, Martin Grundy, Shili Shang, Claire Seedhouse, PhD, Nigel Russell, MBChB, Monica Pallis, PhD

Blood (2007) 110 (11): 4192.

https://doi.org/10.1182/blood.V110.11.4192.4192

Published: 2007

Journal Articles

In Vitro Chemosensitivity of Leukaemic Stem and Progenitor Cells to Gemtuzumab Ozogamicin (Mylotarg) in AML.

Mays Jawad, PhD, Ullas Mony, MSC, Nigel H. Russell, MBChB, Monica Pallis, PhD

Blood (2007) 110 (11): 650.

https://doi.org/10.1182/blood.V110.11.650.650

Published: 2007

Journal Articles

A Role for DNA Double Strand Breaks in the Sensitivity of AML Cells to Clofarabine: Enhanced In Vitro Sensitivity in Primary AML Cells with FLT3 Mutations.

Monica Pallis, PhD, Martin Grundy, BSc, Claire Seedhouse, PhD, Heather Pimblett, B Med Sci, Nigel Russell, MD

Blood (2006) 108 (11): 2582.

https://doi.org/10.1182/blood.V108.11.2582.2582

Published: 2006

Journal Articles

Defined Bone Marrow Niche Components Mediate the In Vitro Resistance of Acute Myeloid Leukaemic Stem and Progenitor Cells (LSPC) to Cytosine Arabinoside.

Ullas Mony, Mays Jawad, PhD, Nigel H. Russell, MD, Monica Pallis, PhD

Blood (2006) 108 (11): 2543.

https://doi.org/10.1182/blood.V108.11.2543.2543

Published: 2006

Journal Articles

Increasing FLT3-ITD Length Increases Expression of bcl-xl in AML.

Claire H. Seedhouse, PhD, Monica Pallis, PhD, Martin Grundy, BSc, Nigel Russell, MD

Blood (2006) 108 (11): 1909.

https://doi.org/10.1182/blood.V108.11.1909.1909

Published: 2006

NARROW

Molecular Signature of Dormancy in CD34+CD38- Acute Myeloid Leukaemia Cells

Comparison of Two Rapid Predictive Methods for Therapeutic Targeting in Acute Myeloid Leukaemia Cells

Effectiveness of Transcriptional CDK Inhibitors in Targeting Non-Proliferating CD34+CD38- AML Cells,

Analysis of the Interaction of Induction Regimens with P-Glycoprotein Expression In Patients with Acute Myeloid Leukaemia: Results From the MRC AML15 Trial

The Hypomethylating Agent 5-Azacytidine Can Target Leukaemic Stem and Progenitor Cells In Acute Myeloid Leukemia (AML) by Inducing DNA Damage and Stress Response Pathways

RHPS4, An Anti-Telomere Agent, Specifically Targets the Subgroup of AML Cells with Loss or Gain of Parts of Chromosomes.

An Immortalised Leukaemia Cell Line Models the Quiescence of Leukaemic Stem Cells and Shows Impaired Double Strand Break Repair Following Daunorubicin Treatment

A Polymorphism In the 3'UTR Region of ABCB1 Is Associated with Increased Allele Activity with Corresponding Increases In P-Glycoprotein Expression and Function

The Multi-Kinase Inhibitor TG02 targets CD34+CD38-CD123+ AML Cells

DNA damage-induced Leukaemic Stem and Progenitor Cell Kill with Mylotarg and Tipifarnib/Zarnestra Drug Combination In Acute Myeloid Leukemia (AML)

Impaired S Phase Arrest in AML Cells with a FLT3-ITD Treated with Clofarabine Allows Prolonged Drug exposure to Reverse the Chemoresistant Phenotype.

Regulation of ABCB1 (p-glycoprotein) by the FOXO1 Transcription Factor in Acute Myeloid Leukemia.

The Telomerase Inhibitor RHPS4 Induces Telomere Shortening, DNA-Damage and Cell Death in AML Cells and Chemosensitises Cells to Daunorubicin.

Azacytidine and Gemtuzumab Ozogamicin Co-Operate to Inhibit the Wnt Pathway and Increase Cytotoxicity in AML

The Effect of ABC Transporters and FLT3 Status on the Activity of the Aurora Kinase B Inhibitor AZD1152 in AML Cells.

P-Glycoprotein Is Downregulated in KG1a Primitive Leukaemia Cells by LDL Cholesterol Deprivation and by HMG-CoA Reductase Inhibitors.

In Vitro Chemosensitivity of Leukaemic Stem and Progenitor Cells to Gemtuzumab Ozogamicin (Mylotarg) in AML.

A Role for DNA Double Strand Breaks in the Sensitivity of AML Cells to Clofarabine: Enhanced In Vitro Sensitivity in Primary AML Cells with FLT3 Mutations.

Defined Bone Marrow Niche Components Mediate the In Vitro Resistance of Acute Myeloid Leukaemic Stem and Progenitor Cells (LSPC) to Cytosine Arabinoside.

Increasing FLT3-ITD Length Increases Expression of bcl-xl in AML.

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American Society of Hematology

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American Society of Hematology

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