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Nathanael Gray, PhD
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Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 406.
https://doi.org/10.1182/blood-2019-123573
Published: 2019
Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2018-99-119941
Published: 2018
Journal Articles

Systematic Characterization of the "Resistome" of Tumor Cells Against Panels of Small Molecule Inhibitors — Application in the Context of Inhibitors of Transcriptional Cyclin-Dependent Kinases (tCDKs) and Implications for Future "Individualized" Clinical Applications

Ryosuke Shirasaki, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Tinghu Zhang, PhD, Megan Bariteau, Jeffrey Sorrell, BA, Nicholas P Kwiatkowski, PhD, Nathanael Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3343.
https://doi.org/10.1182/blood.V130.Suppl_1.3343.3343
Published: 2017
Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Paul Hengeveld, Johanna Bruggenthies, Eugen Dhimolea, PhD, Huihui Tang, PhD, Megan Bariteau, Andrew Aguirre, MD PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Brian Glassner, PhD, Christopher J. Ott, PhD, Dennis Buckley, Nicholas P Kwiatkowski, PhD, Jonathan D. Licht, MD, Nathanael Gray, PhD, Joshua Dempster, PhD, Richard WJ Groen, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1212.
https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212
Published: 2017
Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 719.
https://doi.org/10.1182/blood.V130.Suppl_1.719.719
Published: 2017
Journal Articles

A Unique N-Phenylbenzamide Inhibitor Targeting Non-Receptor Tyrosine Kinases Potently Suppresses AML Cell Growth In Vitro and In Vivo

Mark C Weir, PhD, Sherry Shu, PhD, Sabine Hellwig, PhD, Ravi Patel, Li Chen, PhD, Li Tan, PhD, Nathanael Gray, PhD, Thomas Smithgall, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3813.
https://doi.org/10.1182/blood.V130.Suppl_1.3813.3813
Published: 2017
Journal Articles

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

Sara Buhrlage, PhD, Ellen Weisberg, MD, Nathan Schauer, Jing Yang, PhD, Ilaria Lamberto, PhD, Laura Doherty, Atsushi Nonami, MDPhD, Amanda L. Christie, BS, David M. Weinstock, MD, Richard M. Stone, MD, Nathanael Gray, PhD, James D Griffin, MD
Journal: Blood
Blood (2016) 128 (22): 524.
https://doi.org/10.1182/blood.V128.22.524.524
Published: 2016
Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 436.
https://doi.org/10.1182/blood.V128.22.436.436
Published: 2016
Journal Articles

Targeting IRAK1/IRAK4 Signaling in Waldenstrom's Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Jie Chen, PhD, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, MFA, Jorge J Castillo, MD, Philip Cohen, Li Tan, PhD, Sara Buhrlage, PhD, Nathanael Gray, PhD, Steven P Treon, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4004.
https://doi.org/10.1182/blood.V126.23.4004.4004
Published: 2015
Journal Articles

Targeting Myddosome Self-Assembly in Waldenstrom's Macroglobulinemia

Xia Liu, MD, Zachary Hunter, PhD, Lian Xu, Jie Chen, PhD, Jiaji Chen, Nicholas Tsakmaklis, Christopher J Patterson, MFA, Jorge J Castillo, MD, Sara Buhrlage, PhD, Nathanael Gray, PhD, Steven P Treon, MD PhD, Guang Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 1563.
https://doi.org/10.1182/blood.V126.23.1563.1563
Published: 2015
Journal Articles

HCK Is a Highly Relevant Target of Ibrutinib in MYD88 Mutated Waldenstrom's Macroglobulinemia and Diffuse Large B-Cell Lymphoma

Guang Yang, PhD, Sara Buhrlage, PhD, Li Tan, PhD, Xia Liu, MD, Jie Chen, PhD, Zachary Hunter, PhD, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, MFA, Jorge J Castillo, MD, Wei Zhang, PhD, Nathanael Gray, PhD, Steven P Treon, MD PhD
Journal: Blood
Blood (2015) 126 (23): 705.
https://doi.org/10.1182/blood.V126.23.705.705
Published: 2015
Journal Articles

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia

Fiona Brown, PhD, Eric Still, Paolo Cifani, PhD, Scott Ficarro, PhD, Gayle Pouliot, MD PhD, Esther Drill, PhD, Mithat Gonen, PhD, Jie He, PhD, Sohail Balasubramanian, M.S., Shan Zhong, PhD, Dean Pavlick, Bahar Yilmazel, Andrei V. Krivtsov, PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD, Steven M. Kornblau, MD, Richard M. Stone, MD, Guido Marcucci, MD, John C. Byrd, MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2015) 126 (23): 88.
https://doi.org/10.1182/blood.V126.23.88.88
Published: 2015
Journal Articles

Transcription Regulation Targeting in Peripheral T Cell Lymphomas Induces Apoptosis and Sensitization to BCL2 Inhibitors

Pannee Praditsuktavorn, MD, Benet Pera, PhD, Nicholas Kwiatkowski, PhD, ShaoNing Yang, MS, Tinghu Zhang, PhD, Nathanael Gray, PhD, Leandro Cerchietti, MD
Journal: Blood
Blood (2014) 124 (21): 810.
https://doi.org/10.1182/blood.V124.21.810.810
Published: 2014
Journal Articles

Activity of Plk Inhibitor BI2536 on Myeloma Cells

Douglas W. McMillin, PhD, Joseph Negri, Jake Delmore, Melissa G. Ooi, MD, Jana Jakubikova, Renee Wright, Nathanael Gray, PhD, Andrew Kung, MD, PhD, Kenneth C. Anderson, MD, Constantine S. Mitsiades, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2764.
https://doi.org/10.1182/blood.V112.11.2764.2764
Published: 2008