Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 21

Sort by

Sort Order Select

Journal Articles

Optimized Induction of Mitochondrial Apoptosis By Combination Therapies with Venetoclax for Chemotherapy-Free Treatment of BCR-ABL + Acute Lymphoblastic Leukemia in Preclinical Models

Matthias Eder, MD, Hanna Kirchhoff, Karin Battmer, Katharina Wohlan, Melanie Ricke-Hoch, PhD, Sergej Erschow, Edward Law, PhD, Arnold Kloos, Michael Heuser, MD, Arnold Ganser, MD, Denise Hilfiker-Kleiner, PhD, Olaf Heidenreich, PhD, Michaela Scherr, PhD

Blood (2018) 132 (Supplement 1): 4025.

https://doi.org/10.1182/blood-2018-99-114463

Published: 2018

Journal Articles

Inhibition of ATR in Combination with Nucleoside Analogues Eradicates Acute Myeloid Leukaemia in an Orthotopic Murine Xenograft Model

Sarah E Fordham, PhD, Helen J Blair, PhD, Claire J Elstob, PhD, Deepali Pal, PhD, Nicola Curtin, PhD, Paul Milne, PhD, Matthew Collin, MD PhD, Graham H Jackson, MD MBBS, Helen J Marr, MD PhD, Olaf Heidenreich, PhD, Ruth Plummer, John Pollard, PhD, Tobias F. Menne, MD PhD FRCPath, Gail L Jones, MD BMBS, James M Allan, DPhil

Blood (2016) 128 (22): 4031.

https://doi.org/10.1182/blood.V128.22.4031.4031

Published: 2016

Journal Articles

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Lynsey McKenzie, PhD, Natalia Martinez-Soria, PhD, Julia Draper, DPhil, Sirintra Nakjang, PhD, Helen J Blair, PhD, Christian Wichmann, MD, Josef Vormoor, MD FRCPCH, Constanze Bonifer, PhD, Georges Lacaud, PhD, Olaf Heidenreich, PhD

Blood (2016) 128 (22): 835.

https://doi.org/10.1182/blood.V128.22.835.835

Published: 2016

Journal Articles

A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1

Paul Sinclair, PhD, Joanna Cheng, Prahlad Raninga, Rebecca Hanna, Shaun Hollern, Amir Enshaei, PhD, Helen Blair, PhD, Sirintra Nakjang, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Lars Buechler, Olaf Heidenreich, PhD, Christine Harrison, PhDFRCPath FMedSci

Blood (2015) 126 (23): 2449.

https://doi.org/10.1182/blood.V126.23.2449.2449

Published: 2015

Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD

Blood (2015) 126 (23): 2619.

https://doi.org/10.1182/blood.V126.23.2619.2619

Published: 2015

Journal Articles

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Alex Elder, PhD, Helen Blair, PhD, Katherine Dormon, Simon Bomken, PhD MBBS, Simon J Cockell, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD FRCPCH

Blood (2015) 126 (23): 844.

https://doi.org/10.1182/blood.V126.23.844.844

Published: 2015

Journal Articles

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Natalie Bell, PhD, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Chris Bacon, MBChB, PhD, Vikki Rand, PhD, Olaf Heidenreich, PhD, Simon Bomken, PhD MBBS

Blood (2014) 124 (21): 5501.

https://doi.org/10.1182/blood.V124.21.5501.5501

Published: 2014

Journal Articles

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Frida Ponthan, PhD, Simon Bomken, PhD MBBS, Deepali Pal, PhD, Alex Elder, PhD, Hesta McNeill, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD

Blood (2014) 124 (21): 2390.

https://doi.org/10.1182/blood.V124.21.2390.2390

Published: 2014

Journal Articles

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML Regulating Differentiation Block and Self-Renewal

Anetta Ptasinska, PhD, Salam Assi, PhD, Natalia Martinez-Soria, PhD, Maria Rosaria Imperato, PhD, Jason Piper, PhD, Pierre Cauchy, PhD, Anna Pickin, Sally James, PhD, Maarten Hoogenkamp, PhD, Daniel G Tenen, MD, Sascha Ott, PhD, David R Westhead, PhD, Peter N Cockerill, PhD, Olaf Heidenreich, PhD, Constanze Bonifer, PhD

Blood (2014) 124 (21): 1061.

https://doi.org/10.1182/blood.V124.21.1061.1061

Published: 2014

Journal Articles

Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Matthias Eder, MD, Alex Elder, David Barzan, Karin Battmer, Simon Bomken, Melanie Ricke-Hoch, Anke Schröder, Letizia Venturini, Heike Pfeiffer, Helen J Blair, PhD, Josef Vormoor, MD, Oliver G. Ottmann, MD, Arnold Ganser, Andreas Pich, Denise Hilfiker-Kleiner, Olaf Heidenreich, PhD, Michaela Scherr

Blood (2013) 122 (21): 835.

https://doi.org/10.1182/blood.V122.21.835.835

Published: 2013

Journal Articles

Clonal Progression Including Evolution Of An iAMP21 Chromosome In Xenograft Models Of BCP-ALL

Paul B Sinclair, PhD, Lars Buechler, PhD, Joanna Cheng, MSc, Jake Clayton, MRes, Claire Schwab, BSc, Lisa Jones, BSc, Helen Blair, PhD, Lisa J Russell, PhD, Bryan D Young, BSc, PhD, Olaf Heidenreich, PhD, Christine J Harrison, PhD

Blood (2013) 122 (21): 2485.

https://doi.org/10.1182/blood.V122.21.2485.2485

Published: 2013

Journal Articles

The Genomic Landscape Of Lineage Switch Acute Leukemia

Blood (2013) 122 (21): 2552.

https://doi.org/10.1182/blood.V122.21.2552.2552

Published: 2013

Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Blood (2013) 122 (21): 3866.

https://doi.org/10.1182/blood.V122.21.3866.3866

Published: 2013

Journal Articles

AML1/ETO Confers a Mutator Phenotype In Acute Myeloid Leukemia Associated with Downregulation of the Base-Excision-Repair Gene OGG1 ,

Victoria J Forster, Andrea Beyerle, PhD, Olaf Heidenreich, PhD, James M Allan, DPhil

Blood (2011) 118 (21): 3441.

https://doi.org/10.1182/blood.V118.21.3441.3441

Published: 2011

Journal Articles

Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1,

Christina Halsey, MD, PhD, Mark TS Williams, PhD, Yasar Yousafzai, MD, Klaus Rehe, MD, Olaf Heidenreich, PhD, Josef Vormoor, MD, Brenda Gibson, Gerard Graham, PhD

Blood (2011) 118 (21): 3449.

https://doi.org/10.1182/blood.V118.21.3449.3449

Published: 2011

Journal Articles

Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance,

Simon Bomken, MBBS, Lars Buechler, PhD, Klaus Rehe, MD, Frida Ponthan, PhD, Helen Blair, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD

Blood (2011) 118 (21): 4000.

https://doi.org/10.1182/blood.V118.21.4000.4000

Published: 2011

Journal Articles

The Angiogenic Factor Angiopoietin-1 Is Regulated by the Acute Myeloid Leukemia Fusion Protein AML1/ETO

Victoria J Forster, Patricia Garrido Castro, Dipl.-Biochem., Amy K Bradburn, James M Allan, DPhil, Olaf Heidenreich, PhD

Blood (2011) 118 (21): 2426.

https://doi.org/10.1182/blood.V118.21.2426.2426

Published: 2011

Journal Articles

Significance of Fusion Genes for Maintenance of Leukaemia

Frida Ponthan, PhD, Hesta McNeill, Lars Buechler, PhD, Vasily Grinev, PhD, Josef Vormoor, MD, FRCPCH, Olaf Heidenreich, PhD

Blood (2011) 118 (21): 2455.

https://doi.org/10.1182/blood.V118.21.2455.2455

Published: 2011

Journal Articles

ANGIOPOIETIN1 - a Novel Factor Implicated In MLL-Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene-Dependent Manner

Patricia Garrido Castro, Dipl.-Biochem., Simon Bomken, MD, Lidija Seslija, Ronald Stam, PhD, Elda S Latif, Michael A Batey, MPhil, Hesta McNeill, Rob Pieters, MD, PhD, Josef Vormoor, MD, Prof., Johann Greil, MD, Olaf Heidenreich, PhD

Blood (2010) 116 (21): 66.

https://doi.org/10.1182/blood.V116.21.66.66

Published: 2010

Journal Articles

Epigenetic Repression of the Adaptor Molecule LAT2 by the Leukemic Fusion Protein AML1/ETO.

Jesus Duque-Afonso, MD, Tobias Berg, MD, Olaf Heidenreich, PhD, Michael Luebbert, MD PhD

Blood (2007) 110 (11): 987.

https://doi.org/10.1182/blood.V110.11.987.987

Published: 2007

NARROW

Optimized Induction of Mitochondrial Apoptosis By Combination Therapies with Venetoclax for Chemotherapy-Free Treatment of BCR-ABL + Acute Lymphoblastic Leukemia in Preclinical Models

Inhibition of ATR in Combination with Nucleoside Analogues Eradicates Acute Myeloid Leukaemia in an Orthotopic Murine Xenograft Model

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML Regulating Differentiation Block and Self-Renewal

Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Clonal Progression Including Evolution Of An iAMP21 Chromosome In Xenograft Models Of BCP-ALL

The Genomic Landscape Of Lineage Switch Acute Leukemia

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

AML1/ETO Confers a Mutator Phenotype In Acute Myeloid Leukemia Associated with Downregulation of the Base-Excision-Repair Gene OGG1 ,

Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1,

Lentiviral Transduction of Patient Derived Leukaemic Blasts Allowing In Vivo Bioluminescent Monitoring in An NSG Model of Leukaemia Stem Cell Maintenance,

The Angiogenic Factor Angiopoietin-1 Is Regulated by the Acute Myeloid Leukemia Fusion Protein AML1/ETO

Significance of Fusion Genes for Maintenance of Leukaemia

ANGIOPOIETIN1 - a Novel Factor Implicated In MLL-Rearranged Acute Lymphoblastic Leukemia and Regulated In a Fusion Gene-Dependent Manner

Epigenetic Repression of the Adaptor Molecule LAT2 by the Leukemic Fusion Protein AML1/ETO.

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only