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Journal Articles

The 3-OH Derivative of the Polychlorinated Biphenyl (PCB)-28 Inhibits Telomerase Expression and Accelerates Telomere Shortening in Vitro : A Rationale for the Significantly Shortened Telomere Length Found in Peripheral Blood Lymphocytes of Workers Exposed to High Doses of Lower Chlorinated PCBs

Patrick Ziegler, PhD, Thomas Schettgen, PhD, Stefan Wilop, MD, Natalia Soares Quintete, PhD, Susanne Ziegler, PhD, Fabian Beier, MD, Monica S.V. Ferreira, PhD, Peter Uciechowski, PhD, Lothar Rink, PhD, Thomas Kraus, MD, Tim H. Brümmendorf, MD

Blood (2014) 124 (21): 4139.

https://doi.org/10.1182/blood.V124.21.4139.4139

Published: 2014

Journal Articles

Evidence for Premature Aging of (Clonal but also) Non-Clonal Hematopoietic Stem Cells in Patients with Acute Myeloid Leukemia (AML)

Martina Crysandt, MD, Monica S.V. Ferreira, PhD, Patrick Ziegler, PhD, Sebastian Hummel, Julian Kaufmann, Stefan Wilop, MD, Edgar Jost, MD, Wolfgang Wagner, MD PhD, Tim H. Brummendorf, MD PhD, Fabian Beier, MD

Blood (2014) 124 (21): 1048.

https://doi.org/10.1182/blood.V124.21.1048.1048

Published: 2014

Journal Articles

Angptl-4 Is Upregulated Under Inflammatory Conditions In The BM Of Mice, Expands Myeloid Progenitors and Accelerates Reconstitution Of Platelets After Myelosuppressive Therapy

Anne Schumacher, Till Braunschweig, MD, Bernd Denecke, PhD, Tim H. Brümmendorf, MD, Patrick Ziegler, PhD

Blood (2013) 122 (21): 3677.

https://doi.org/10.1182/blood.V122.21.3677.3677

Published: 2013

Journal Articles

Telomere Length Of Granulocytes Significantly Increases During The First Six Months Of Lenalidomide Treatment In Patients With Isolated 5q- Syndrome

Fabian Beier, MD, Ulrich Germing, MD, Guntram Büsche, MD, Patrick Ziegler, PhD, Stefan Wilop, MD, Lucia Vankann, Norbert Gattermann, MD, Uwe Platzbecker, MD, PhD, Aristoteles Giagounidis, MD, PhD, Katharina S. Götze, MD, Wolf-Karsten Hofmann, Detlef Haase, MD, PhD, Hans Kreipe, MD, Jens Panse, MD, Tim H. Brümmendorf, MD

Blood (2013) 122 (21): 2781.

https://doi.org/10.1182/blood.V122.21.2781.2781

Published: 2013

Journal Articles

Telomere Shortening At Diagnosis Of Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Is Significantly More Pronounced In Patients With Less-Than-Optimal Versus Optimal Molecular Response (ELN criteria) After 12 Months Of Treatment With Nilotinib

Katrin Wenn, Lena Tomala, Fabian Beier, MD, Stefan Wilop, MD, Lucia Vankann, Christian Hasenbank, Oliver Frank, Claudia Walasek, Andreas Hochhaus, MD, Frank Giles, MD MB, Steffen Koschmieder, Patrick Ziegler, PhD, Tim H. Brümmendorf, MD

Blood (2013) 122 (21): 1471.

https://doi.org/10.1182/blood.V122.21.1471.1471

Published: 2013

Journal Articles

Enterocytes Of Patients With Uncontrolled Acute Graft Versus Host Disease Of The Gut Undergo Massive Telomere Shortening Compared To Unaffected Controls

Sebastian Hummel, Daniel Heudobler, MD, Elisabeth Huber, MD, Monica S Ventura Ferreira, PhD, Dirk Fahrenkamp, Karin Schmid, MD, Felix Gremse, PhD, Gerhard Müller-Newen, PhD, Patrick Ziegler, PhD, Edgar Jost, MD, Tim H. Brümmendorf, MD, Ernst Holler, MD, PhD, Fabian Beier, MD

Blood (2013) 122 (21): 4467.

https://doi.org/10.1182/blood.V122.21.4467.4467

Published: 2013

Journal Articles

Sustained Alterations In Bone Marrow Stromal Cells From Patients With Myeloproliferative Neoplasms (MPN) Contribute To Remodelling Of The Bone Marrow Microenvironment Prior To The Manifestation Of Myelofibrosis

Rebekka K. Schneider, MD, Isabelle Leisten, Susanne Ziegler, PhD, Anne Schumacher, Björn Rath, MD, Dirk Fahrenkamp, Gerhard Mueller-Newen, PhD, Martina Crysandt, MD, Stefan Wilop, MD, Edgar Jost, MD, Ruth Knuechel, MD, Tim H. Bruemmendorf, MD, Patrick Ziegler, PhD

Blood (2013) 122 (21): 4102.

https://doi.org/10.1182/blood.V122.21.4102.4102

Published: 2013

Journal Articles

Age-Associated DNA Methylation Signature Reveals Premature Aging In Patients With Aplastic Anemia and Dyskeratosis Congenita Which Correlates With Telomere Shortening

Fabian Beier, MD, Carola I. Weidner, Qiong Lin, Patrick Ziegler, PhD, Martin Zenke, Tim H. Brümmendorf, MD, Wolfgang Wagner, MD, PhD

Blood (2013) 122 (21): 1223.

https://doi.org/10.1182/blood.V122.21.1223.1223

Published: 2013

Journal Articles

Comparative Analysis of Hematopoiesis Supporting Capacity and Matrix Remodeling of Bone Marrow Stromal Cells Isolated From Patients with Myeloproliferative Neoplasms.

Rebekka K Schneider, MD, Isabelle Leisten, Susanne Ziegler, PhD, Anne Schumacher, Dirk Fahrenkamp, Gerhard Mueller-Newen, PhD, Martina Crysandt, MD, Edgar Jost, MD, Ruth Knuechel, MD, Tim H Brümmendorf, Patrick Ziegler, PhD

Blood (2012) 120 (21): 2864.

https://doi.org/10.1182/blood.V120.21.2864.2864

Published: 2012

Journal Articles

Telomere Elongation In Vivo and Clinical Response Upon Androgen Treatment in a Patient with Aplastic Anemia and a Heterozygous hTERT Gene Mutation,

Tim H Brümmendorf, Patrick Ziegler, PhD, Jamil Akkad, MD, Ute Brassat, PhD, Lucia Vankann, Jens Panse, MD, Stefan Wilop, MD, Stefan Balabanov, MD, PhD, Klaus Schwarz, MD, Uwe M. Martens, MD, PhD, Hubert Schrezenmeier, MD

Blood (2011) 118 (21): 3427.

https://doi.org/10.1182/blood.V118.21.3427.3427

Published: 2011

Journal Articles

MSCs From Patients with Myelofibrosis Display a Fibrotic Phenotype

Rebekka K Schneider, MD, Isabelle Leisten, Susanne Ziegler, PhD, Anne Schumacher, Tim H Brümmendorf, Edgar Jost, MD, Patrick Ziegler, PhD

Blood (2011) 118 (21): 5160.

https://doi.org/10.1182/blood.V118.21.5160.5160

Published: 2011

Journal Articles

Non-Hematopoietic Stromal Cells Sense Toll-Like Receptor 4 Agonists and Consequently Enhance Myelopoiesis.

Steffen Boettcher, Patrick Ziegler, PhD, Michael A Schmid, PhD, Guido Garavaglia, MD, Hitoshi Takizawa, PhD, Markus G Manz, MD

Blood (2010) 116 (21): 2583.

https://doi.org/10.1182/blood.V116.21.2583.2583

Published: 2010

Journal Articles

TLR4-Agonist Stimulated Human Multipotent Mesenchymal Stromal Cells Enhance Both Hematopoietic Progenitors and Myeloid Differentiation

Patrick Ziegler, PhD, Steffen Boettcher, Guido Garavaglia, MD, Markus G. Manz, MD

Blood (2008) 112 (11): 1366.

https://doi.org/10.1182/blood.V112.11.1366.1366

Published: 2008

Journal Articles

Engraftment of Human Mesenchymal Stem Cells upon Transplantation into Newborn Rag2−/−gc−/− Mice.

Patrick Ziegler, PhD, Steffen Boettcher, Hildegard Keppeler, Bettina Kirchner, Markus G. Manz, MD

Blood (2006) 108 (11): 1652.

https://doi.org/10.1182/blood.V108.11.1652.1652

Published: 2006

Journal Articles

Combination of Imatinib and Hypusination Inhibitors Represents a Novel Therapeutic Strategy in Bcr-Abl Positive Leukemias.

Stefan Balabanov, MD, PhD, Artur Gontarewicz, MD, Patrick Ziegler, PhD, Ulrike Hartmann, PhD, Mhairi Copland, MD, Ute Brassat, Ilona Hauber, PhD, Lothar Kanz, MD, Carsten Bokemeyer, MD, Alfred Nordheim, PhD, Joachim Hauber, PhD, Tessa L. Holyoake, MD, Tim H. Brummendorf, MD

Blood (2006) 108 (11): 1379.

https://doi.org/10.1182/blood.V108.11.1379.1379

Published: 2006

Journal Articles

Inhibition of Hypusination of Eukaryotic Initiation Factor 5a (eIF-5A) as a Novel a Synergistic Treatment Strategy in Imatinib-Treated BCR-ABL Positive Leukemias Identified by a Global Proteomics Approach.

Stefan Balabanov, MD, PhD, Patrick Ziegler, PhD, Ulricke Hartmann, Winfried Kammer, PhD, Mhairi Copland, MD, Martin Priemer, Thomas Wilhelm, Carsten Bokemeyer, MD, Lothar Kanz, MD, Tessa Holyoake, MD, Alfred Nordheim, PhD, Tim Bruemmendorf, MD

Blood (2005) 106 (11): 1997.

https://doi.org/10.1182/blood.V106.11.1997.1997

Published: 2005

Journal Articles

Identification of BCR-ABL Dependent Gene Regulation by Using a Phosphoproteomics Approach.

Patrick Ziegler, PhD, Stefan Balabanov, MD PhD, Ulrike Hartmann, Winfried Kammer Kammer, PhD, Alfred Nordheim, PhD, Tim H. Brummendorf, MD

Blood (2004) 104 (11): 2944.

https://doi.org/10.1182/blood.V104.11.2944.2944

Published: 2004

Journal Articles

Identification of Hypusination Inhibitors as a Novel Therapuetical Option in BCR-ABL Positive Leukemias Using a Proteomics Approach.

Stefan Balabanov, MD PhD, Ulrike Hartmann, Winfried Kammer, PhD, Patrick Ziegler, PhD, Martin Priemer, Gerold Schwarz, Lothar Kanz, MD, Alfred Nordheim, PhD, Tim H. Brummendorf, MD

Blood (2004) 104 (11): 2957.

https://doi.org/10.1182/blood.V104.11.2957.2957

Published: 2004

NARROW

The 3-OH Derivative of the Polychlorinated Biphenyl (PCB)-28 Inhibits Telomerase Expression and Accelerates Telomere Shortening in Vitro : A Rationale for the Significantly Shortened Telomere Length Found in Peripheral Blood Lymphocytes of Workers Exposed to High Doses of Lower Chlorinated PCBs

Evidence for Premature Aging of (Clonal but also) Non-Clonal Hematopoietic Stem Cells in Patients with Acute Myeloid Leukemia (AML)

Angptl-4 Is Upregulated Under Inflammatory Conditions In The BM Of Mice, Expands Myeloid Progenitors and Accelerates Reconstitution Of Platelets After Myelosuppressive Therapy

Genetic Characterization Of Aplastic Anemia Patients By Targeted Sequencing

Telomere Length Of Granulocytes Significantly Increases During The First Six Months Of Lenalidomide Treatment In Patients With Isolated 5q- Syndrome

Telomere Shortening At Diagnosis Of Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Is Significantly More Pronounced In Patients With Less-Than-Optimal Versus Optimal Molecular Response (ELN criteria) After 12 Months Of Treatment With Nilotinib

Enterocytes Of Patients With Uncontrolled Acute Graft Versus Host Disease Of The Gut Undergo Massive Telomere Shortening Compared To Unaffected Controls

Sustained Alterations In Bone Marrow Stromal Cells From Patients With Myeloproliferative Neoplasms (MPN) Contribute To Remodelling Of The Bone Marrow Microenvironment Prior To The Manifestation Of Myelofibrosis

Age-Associated DNA Methylation Signature Reveals Premature Aging In Patients With Aplastic Anemia and Dyskeratosis Congenita Which Correlates With Telomere Shortening

Comparative Analysis of Hematopoiesis Supporting Capacity and Matrix Remodeling of Bone Marrow Stromal Cells Isolated From Patients with Myeloproliferative Neoplasms.

Telomere Elongation In Vivo and Clinical Response Upon Androgen Treatment in a Patient with Aplastic Anemia and a Heterozygous hTERT Gene Mutation,

MSCs From Patients with Myelofibrosis Display a Fibrotic Phenotype

Non-Hematopoietic Stromal Cells Sense Toll-Like Receptor 4 Agonists and Consequently Enhance Myelopoiesis.

TLR4-Agonist Stimulated Human Multipotent Mesenchymal Stromal Cells Enhance Both Hematopoietic Progenitors and Myeloid Differentiation

Engraftment of Human Mesenchymal Stem Cells upon Transplantation into Newborn Rag2−/−gc−/− Mice.

Combination of Imatinib and Hypusination Inhibitors Represents a Novel Therapeutic Strategy in Bcr-Abl Positive Leukemias.

Inhibition of Hypusination of Eukaryotic Initiation Factor 5a (eIF-5A) as a Novel a Synergistic Treatment Strategy in Imatinib-Treated BCR-ABL Positive Leukemias Identified by a Global Proteomics Approach.

Identification of BCR-ABL Dependent Gene Regulation by Using a Phosphoproteomics Approach.

Identification of Hypusination Inhibitors as a Novel Therapuetical Option in BCR-ABL Positive Leukemias Using a Proteomics Approach.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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