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Journal Articles

Disruption of the Normal Hematopoietic Hierarchy Leading to Stem Cell Exhaustion in an Animal Model of Myelodysplastic Syndrome

Yang Jo Chung, PhD, Peter D. Aplan, MD

Blood (2019) 134 (Supplement_1): 1698.

https://doi.org/10.1182/blood-2019-128707

Published: 2019

Journal Articles

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

Vijay Negi, PhD, Liat Goldberg, PhD, Yang Jo Chung, PhD, Masahiro Onozawa, MD, Peter D. Aplan, MD

Blood (2019) 134 (Supplement_1): 1346.

https://doi.org/10.1182/blood-2019-128675

Published: 2019

Journal Articles

A Novel DNA Methyltransferase Inhibitor Is Effective in an In Vivo Model of Myelodysplastic Syndrome

Ghanwa Khawaja, BS, Yang Jo Chung, PhD, Eunsil Park, MD, Micheal Difilippantonio, PhD, James H. Doroshow, MD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1804.

https://doi.org/10.1182/blood-2018-99-119265

Published: 2018

Journal Articles

Engineered Bcor Mutations Lead to Acute Lymphoblastic Leukemia of Progenitor B-1 Lymphocyte Origin in a Sensitized Background

Mianmian Yin, PhD, Yang Jo Chung, PhD, R. Coleman Lindsley, MD, PhD, Yeulin Zhu, PhD, Robert L. Walker, PhD, Benjamin L. Ebert, MDPhD, Paul S. Meltzer, MD PhD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1331.

https://doi.org/10.1182/blood-2018-99-115388

Published: 2018

Journal Articles

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

Mianmian Yin, PhD, Timour Baslan, PhD, Amy Freeland, PhD, Toshihiro Matsukawa, PhD, Steven C. Pruitt, PhD, Peter D. Aplan, MD

Blood (2018) 132 (Supplement 1): 1332.

https://doi.org/10.1182/blood-2018-99-115176

Published: 2018

Journal Articles

Activation of SIRT1 Deacetylase As a Therapeutic Approach for Myelodysplastic Syndromes By Restoring TET2 Function

Blood (2017) 130 (Supplement 1): 2497.

https://doi.org/10.1182/blood.V130.Suppl_1.2497.2497

Published: 2017

Journal Articles

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Bonnie W Lau, MD PhD, Kyounghee Huh, MS, Rafael Madero-Marroquin, MD, Federico De Marchi, MD, Yiting Lim, PhD, Francisco Lobo, PhD, Luigi Marchionni, PhD, Peter D. Aplan, MD, William Matsui, MD, Lukasz P. Gondek, MD PhD

Blood (2017) 130 (Supplement 1): 1676.

https://doi.org/10.1182/blood.V130.Suppl_1.1676.1676

Published: 2017

Journal Articles

Thymic Precursor Cells Generate Acute Myeloid Leukemia in NUP98-PHF23/NUP98-HOXD13 Double Transgenic Mice

Subhadip Kundu, PhD, Eun Sil Park, MD, Yang Jo Chung, PhD, Trevor Stephen Barlowe, BA, Peter D. Aplan, MD

Blood (2016) 128 (22): 2883.

https://doi.org/10.1182/blood.V128.22.2883.2883

Published: 2016

Journal Articles

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Stacy Cooper, MD, Hong Guo, MD PhD, Justin Thomas, Jay L. Hess, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Alan D. Friedman, MD

Blood (2016) 128 (22): 2691.

https://doi.org/10.1182/blood.V128.22.2691.2691

Published: 2016

Journal Articles

Mouse Modeling of GATA2 Related MDS/AML

Lisa J. McReynolds, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Li Ding, MD, Kirby D. Johnson, Emery H Bresnick, PhD, Steven M. Holland, MD

Blood (2015) 126 (23): 2855.

https://doi.org/10.1182/blood.V126.23.2855.2855

Published: 2015

Journal Articles

Mixed Lineage Leukemia Rearrangements ( MLL- R ) Are Determinants of High Risk Disease in Homeobox A (HOXA)- deregulated T-Lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

Blood (2015) 126 (23): 694.

https://doi.org/10.1182/blood.V126.23.694.694

Published: 2015

Journal Articles

Co-Expression of NUP98-HOXD13 and Mutant IDH2 Triggers an Early T-Cell Precursor-like Leukemia in Mice

Liat Goldberg, PhD, Rachel M Pierce, Masahiro Onozawa, MD PhD, Robert L Walker, Yeulin J Zhu, Paul S Meltzer, MD PhD, Peter D. Aplan, MD

Blood (2015) 126 (23): 904.

https://doi.org/10.1182/blood.V126.23.904.904

Published: 2015

Journal Articles

FLT3 Inhibition and Retinoid Signaling Overcome Stromal Protection to Target FLT3/ITD-Expressing Leukemia Stem Cells in the Bone Marrow Microenvironment

Hayley S Ma, PhD, Megan E McCray, BA, Courtney M Shirley, PhD, Amy S. Duffield, MD PhD, J Kyle Bruner, Li Li, PhD, Bao Nguyen, M.S., Sarah Greenblatt, PhD, Eric Jung, BS, Peter D. Aplan, MD, Richard J Jones, MD, Donald Small, MD PhD, Gabriel Ghiaur, MD PhD

Blood (2015) 126 (23): 790.

https://doi.org/10.1182/blood.V126.23.790.790

Published: 2015

Journal Articles

Plasticity of Stromal and Hematopoietic Bone Marrow Cells in a Murine Model of Myelodysplastic Syndrome

Yang Jo Chung, PhD, Suntae Kim, Ph. D, Zhenhua Zhang, MD, Peter D. Aplan, MD

Blood (2015) 126 (23): 2844.

https://doi.org/10.1182/blood.V126.23.2844.2844

Published: 2015

Journal Articles

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Lukasz P Gondek, MD PhD, Yiting Lim, PhD, Hideki Makishima, MD PhD, Qiuju Wang, MA, Jaroslaw P. Maciejewski, MD PhD FACP, Peter D Aplan, MD, Amy E. DeZern, MD MHS, William Matsui, MD

Blood (2014) 124 (21): 528.

https://doi.org/10.1182/blood.V124.21.528.528

Published: 2014

Journal Articles

Spontaneous Mutations of Bcor and Jak1/2 genes Lead to an Aggressive Leukemia of B-1 Progenitor B Cells

Sheryl M Gough, PhD BSc, Liat Goldberg, PhD, Marbin Pineda, MS, Robert L Walker, BSc, Yuelin J Zhu, MD MSc, Sven Bilke, PhD, Paul S Meltzer, MD PhD, Peter D Aplan, MD

Blood (2014) 124 (21): 3573.

https://doi.org/10.1182/blood.V124.21.3573.3573

Published: 2014

Journal Articles

Repair Of DNA Double Strand Breaks By Insertion Of Nucleotide Sequences Derived From Distant Regions Of The Genome

Masahiro Onozawa, MD, PhD., Zhenhua Zhang, Yoo Jung Kim, Liat Goldberg, PhD, Tamas Varga, PhD, Leif Bergsagel, M.D., Michael Kuehl, MD, Peter D Aplan, MD

Blood (2013) 122 (21): 1243.

https://doi.org/10.1182/blood.V122.21.1243.1243

Published: 2013

Journal Articles

Leukemia Driven By a NUP98-Phd Domain Fusion Is Highly Sensitive To Disruption Of H3K4me3-Phd Domain Binding By a Small Molecule Inhibitor

Sheryl M Gough, PhD, Fan Lee, BS, Robert L Walker, BSc, Fan Yang, PhD, Yuelin Zhu, MD, Marbin Pineda, MS, Masahiro Onozawa, MD, PhD., Yang Jo Chung, PhD, Sven Bilke, PhD, Elise K Wagner, PhD, John M Denu, PhD, Yi Ning, MD, PhD, Paul S Meltzer, MD, PhD, Peter D Aplan, MD

Blood (2013) 122 (21): 3759.

https://doi.org/10.1182/blood.V122.21.3759.3759

Published: 2013

Journal Articles

The T Cell Receptor As An Oncogene: Thymic Expression Of Self-Reactive T Cell Receptors Targeting Survivin Induces T-Cell Lymphoblastic Leukmia

Yongzhi Cui, MD, PhD., Masahiro Onozawa, MD, PhD., Leigh Samsel, MS, Haven Garber, M.D., Hua Zhang, Haiying Qin, MS, Terry J Fry, MD, J. Philip McCoy, PhD, Xiaolin Wu, Ph.D., Peter D Aplan, MD, Crystal L Mackall, MD

Blood (2013) 122 (21): 167.

https://doi.org/10.1182/blood.V122.21.167.167

Published: 2013

Journal Articles

Syngeneic and Allogeneic Hematopoietic Stem Cell Transplantation In Mice With Myelodysplastic Syndrome

Yang Jo Chung, PhD, Terry J Fry, MD, Peter D Aplan, MD

Blood (2013) 122 (21): 1515.

https://doi.org/10.1182/blood.V122.21.1515.1515

Published: 2013

NARROW

Disruption of the Normal Hematopoietic Hierarchy Leading to Stem Cell Exhaustion in an Animal Model of Myelodysplastic Syndrome

Idh2R140Q Cooperates with NHD13 to Induce Immature T Cell Leukemia By Targeting Early T Cell Progenitors or DN2 Thymocytes

A Novel DNA Methyltransferase Inhibitor Is Effective in an In Vivo Model of Myelodysplastic Syndrome

Engineered Bcor Mutations Lead to Acute Lymphoblastic Leukemia of Progenitor B-1 Lymphocyte Origin in a Sensitized Background

Mice with a Unique Mutator Phenotype Allow Detection of Lymphoid Leukemia Tumor Suppressor Genes

Activation of SIRT1 Deacetylase As a Therapeutic Approach for Myelodysplastic Syndromes By Restoring TET2 Function

Aberrant Hedgehog Signaling in Myelodysplastic Syndrome Accelerates Leukemic Transformation Via Smoothened-Dependent and Smoothened-Independent Gli1 Activation

Thymic Precursor Cells Generate Acute Myeloid Leukemia in NUP98-PHF23/NUP98-HOXD13 Double Transgenic Mice

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Mouse Modeling of GATA2 Related MDS/AML

Mixed Lineage Leukemia Rearrangements ( MLL- R ) Are Determinants of High Risk Disease in Homeobox A (HOXA)- deregulated T-Lineage Acute Lymphoblastic Leukemia: A Children's Oncology Group Study

Co-Expression of NUP98-HOXD13 and Mutant IDH2 Triggers an Early T-Cell Precursor-like Leukemia in Mice

FLT3 Inhibition and Retinoid Signaling Overcome Stromal Protection to Target FLT3/ITD-Expressing Leukemia Stem Cells in the Bone Marrow Microenvironment

Plasticity of Stromal and Hematopoietic Bone Marrow Cells in a Murine Model of Myelodysplastic Syndrome

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo

Spontaneous Mutations of Bcor and Jak1/2 genes Lead to an Aggressive Leukemia of B-1 Progenitor B Cells

Repair Of DNA Double Strand Breaks By Insertion Of Nucleotide Sequences Derived From Distant Regions Of The Genome

Leukemia Driven By a NUP98-Phd Domain Fusion Is Highly Sensitive To Disruption Of H3K4me3-Phd Domain Binding By a Small Molecule Inhibitor

The T Cell Receptor As An Oncogene: Thymic Expression Of Self-Reactive T Cell Receptors Targeting Survivin Induces T-Cell Lymphoblastic Leukmia

Syngeneic and Allogeneic Hematopoietic Stem Cell Transplantation In Mice With Myelodysplastic Syndrome

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American Society of Hematology

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ASH Publications

American Society of Hematology

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