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Journal Articles

Precision Medicine Test Is Similar but Faster Than Conventional Cytogenetics Predicting Response in AML Patients and Provides Alternative Treatments

Joan Ballesteros, PhD, David Martínez-Cuadron, MD, Joaquin Martinez Lopez, MD PhD, Juan Miguel Miguel Bergua Burgues, Mar Tormo, MD PhD, Josefina Serrano, MD, Ataulfo González, MD, Jaime Perez De Oteyza, MDPhD, Susana Vives, MD, Maria-Belen Vidriales, MD, Pilar Herrera, MD, Juan Antonio Vera, MD, Aurelio Lopez Martinez, MD, Adolfo de la Fuente, MD, Lourdes Amador Barciela, MD, Jose Angel Hernandez-Rivas, MD, Maria Angeles Fernandez Fernandez, MD, Carlos Cervero, MD, Daniel Morillo, MD, Pilar Hernandez, PhD, Daniel Primo, PhD, Julian Gorrochategui, Jose Luis Rojas, Iñaki Troconiz, PhD, Jesús Villoria, Miguel Sanz, Pau Montesinos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1493.
https://doi.org/10.1182/blood-2018-99-115849
Published: 2018
Journal Articles

Bispecific Antibodies on Hematological Malignancies: A Novel Mechanism of Action That May Contribute to Therapeutic Efficacy

Daniel Primo, PhD, Pilar Hernandez, Javier de la Serna, MD, Josep-Maria Ribera, MD, Susana Vives, MD, Juan Bergua, MD, Jaime Perez de Oteyza, MD, Josefina Serrano, MD, Julian Gorrochategui, Vicente María Luisa, David Martínez-Cuadron, MD, Pau Montesinos, MD PhD, Joaquin Martinez Lopez, MD PhD, Joan Ballesteros, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2289.
https://doi.org/10.1182/blood.V130.Suppl_1.2289.2289
Published: 2017
Journal Articles

High Correlation Clinical Responses to 1 st Line Acute Myeloid Leukemia Treatment with an Ex Vivo Native Environment Precision Medicine Test

Pau Montesinos, MD, Joan Ballesteros, David Martínez-Cuadrón, Joaquín Martínez-López, Josefina Serrano, Jaime Perez de Oteyza, Pascual Fernández, Gabriela Rodriguez-Macías, Mª Belén Vidriales, Pilar Herrera, MD PhD, Mar Tormo, MD PhD, Juan Bergua, Raimundo García, MD, Susana Vives, Mª Ángeles Fernández, Esperanza Lavilla, MD, Santiago Jimenez, Jose Antonio Pérez-Simón, Adriana Simiele, Ataulfo González, Bernardo J. González, Carmen Burgaleta, Juan Antonio López, Concepción Bethancourt, Guiomar Bautista, Arancha Alonso, Mercedes Colorado, Jordi Sierra, Begoña Navas, José Angel Hernández-Rivas, Juan Antonio Vera, Mª Lourdes Amador, Raúl Cordoba, MD, Adolfo de la Fuente, Fernando Ramos, MD PhD MPH, Carlos Javier Cerveró, Consolación Rayón, Olga Salamero, Edelmira Martí, Aurelio López, Teresa Olavé, Marta Gaspar, Julian Gorrochategui, José Luis Rojas, Cristina Gomez, Pilar Hernández, Alicia Robles, Ignacio Ortega, Jesús Villoria, Federico Moscardó, Iñaki Troconiz, Miguel A. Sanz, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4837.
https://doi.org/10.1182/blood.V126.23.4837.4837
Published: 2015
Journal Articles

Development of a High-Throughput Screening Assay with Nurse-like Cell-Based Microenviroment in Chronic Lymphoid Leukemia Cells.

Daniel Primo, PhD, Javier De la Serna, MD PhD, Joaquin Martinez, MD, Marcos González, MD, Javier Lopez, Abelardo Bárez, Macarena Ortiz, MD, Javier Loscertales, MD, Julian Vidán, MD, Alicia Rodriguez, MD, Marta Polo, MD, Sandra Irhaeta, MD, Jose Maria Alonso, MD, Jose Antonio Queizan, MD, Jose Angel Hernandez Rivas, MD, María Jesus Peñarrubia, MD, Julian Gorrochategui, Ana Belen Espinosa, PhD, Elena Arroyo, Melanie Oates, PhD, Andrew R Pettit, FRCP, PhD, Joan Ballesteros, PhD, Pilar Hernandez, PhD
Journal: Blood
Blood (2014) 124 (21): 3639.
https://doi.org/10.1182/blood.V124.21.3639.3639
Published: 2014
Journal Articles

Novel Assay for Ex Vivo Evaluation of Antiproliferative Effect of Hypomethylating Agents 5-Azacytidine and Decitabine in AML Patient Samples

Pilar Hernandez, PhD, Pau Montesinos, MD, Josefina Serrano, MD, Pilar Herrera, MD, Juan Pedro Bergua, MD, Mercedes Colorado, MD, Bernando J Gonzalez, MD, Cristina Gomez, Alicia Robles, Julian Gorrochategui, Jesus Sanchez, Joan Ballesteros, PhD, Federico Moscardo, MD, David Martinez, MD, Miguel Angel Sanz, MD, Jaime Pérez de Oteyza, MD, Joaquin Martinez, MD
Journal: Blood
Blood (2014) 124 (21): 5311.
https://doi.org/10.1182/blood.V124.21.5311.5311
Published: 2014
Journal Articles

Ruxolitinib in Combination with Nilotinib and Prednisolone, a New Synergistic Approach to Treat Myelofibrosis

Alicia Arenas, Pilar Hernandez-Campo, PhD, Julian Gorrochategui, Daniel Primo, PhD, Rosa M. Ayala, MD PhD, Blanca Ferrer-Lores, MD, Joan Ballesteros, PhD, Joaquin Martinez-Lopez, MD PhD
Journal: Blood
Blood (2014) 124 (21): 903.
https://doi.org/10.1182/blood.V124.21.903.903
Published: 2014
Journal Articles

Novel Ex Vivo Assay Measures Drug-Induced Depletion of Hematopoietic Progenitors As an Estimate of Hematotoxicity

Daniel Primo, PhD, Joan Ballesteros, PhD, Antonio Jimenez, MD, Ataulfo Gonzalez, MD, Miguel Hernandez, MD, Raul Cordoba, MD, Yolanda González, MD, Hernan Jose Moreno, MD, Alicia Bailen, MD, Jesus Martin, MD, Anabelle Chinea, MD, Asuncion Etxeveste, MD, Jose Mariano Hernandez, MD, Albert Oriol, MD, Jaime Perez de Oteiza, MD, Luis Palomera, Cristina Encinas, MD, Felipe Prosper, MD, Rebeca Iglesias, MD, Laura Rosiñol, MD PhD, Alicia Robles, Julian Gorrochategui, Veronica Garcia, Pilar Hernandez, PhD, Enrique Ocio, MD, Joaquin Martinez, MD
Journal: Blood
Blood (2014) 124 (21): 5785.
https://doi.org/10.1182/blood.V124.21.5785.5785
Published: 2014
Journal Articles

High Throughput Screening, With a Flow Cytometry Automated Platform (Ex vivo Biotech), To Identify Potential Combination Partners, For The JAK 2 Inhibitor Ruxolitinib

Alicia Arenas, Pilar Hernandez-Campo, Daniel Primo, Santiago Barrio, PhD, Rosa M. Ayala, MD, PhD, Joan Ballesteros, Joaquín Martínez-López, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2534.
https://doi.org/10.1182/blood.V122.21.2534.2534
Published: 2013
Journal Articles

Pharmacological Profile Of Cytarabine and Idarubicin In Patient Samples (ex vivo) With Newly Diagnosed Acute Myeloid Leukemia Identifies Responders Vs Non Responders

Pau Montesinos, David Martinez, Joaquin Martínez, Raimundo Garcia, Jaime Pérez de Oteyza, Pascual Fernandez, Josefina Serrano, Angeles Fernandez, Pilar Herrera, Arancha Alonso, Ataulfo Gonzalez, Concepcion Bethancourt, Esperanza Lavilla, Juan Antonio Vera, Begoña Navas, Gabriela Rodriguez, Juan Antonio Lopez, Santiago Jimenez, Adriana Simiele, Bernardo Gonzalez, Jose Angel Hernandez, Raul Cordoba, Consolación Rayón, Carmen Burgaleta, Jordi Sierra, Iñaki Troconiz, Ignacio Ortega, Andrew G. Bosanquet, Daniel Primo, Pilar Hernandez-Campo, Julian Gorrochategui, Jose L. Rojas, Teresa A. Bennett, Belen Liebana, Rocio Lopez, Joan Ballesteros, Federico Moscardo, Miguel Sanz
Journal: Blood
Blood (2013) 122 (21): 3923.
https://doi.org/10.1182/blood.V122.21.3923.3923
Published: 2013
Journal Articles

Personalizing Therapies With Ex Vivo Pharmacological Responses May Uncover The Differences Between IDA-DNR-MIT Among European AML Protocols

Pau Montesinos, David Martinez, Raimundo Garcia Boyero, Jaime Pérez de Oteyza, Pascual Fernandez, Josefina Serrano, Angeles Fernandez, Pilar Herrera, Arancha Alonso, Ataulfo Gonzalez, Concepcion Bethancourt, Esperanza Lavilla, Juan Antonio Vera, Begoña Navas, Gabriela Rodriguez, Juan Antonio Lopez, Santiago Jimenez Bravo de Laguna, Adriana Simiele, Bernardo Gonzalez, Jose Angel Hernandez Rivas, Raul Cordoba, Consolación Rayón, Carmen Burgaleta, Jordi Sierra, Iñaki Troconiz, Ignacio Ortega, Andrew G. Bosanquet, Daniel Primo, Pilar Hernandez-Campo, Julian Gorrochategui, Jose L. Rojas, Teresa A. Bennett, Belen Liebana, Rocio Lopez, Joan Ballesteros, Federico Moscardo, Miguel Sanz, Joaquín Martínez
Journal: Blood
Blood (2013) 122 (21): 1294.
https://doi.org/10.1182/blood.V122.21.1294.1294
Published: 2013
Journal Articles

Population Pharmacological Profiles Of AML Treatments In Patient Samples By Automated Flow Cytometry; A Bridge To Individualized Medicine

Joan Ballesteros, Pau Montesinos, Federico Moscardo, David Martinez, Miguel Angel Sanz, Joaquin Martinez Lopez, Raimundo Garcia Boyero, Jaime Pérez de Oteyza, Pascual Fernandez, Josefina Serrano, Angeles Fernandez, Pilar Herrera, Arancha Alonso, Ataulfo Gonzalez, Concepcion Bethancourt, Esperanza Lavilla, Juan Antonio Vera, Begoña Navas, Gabriela Rodriguez, Juan Antonio Lopez, Santiago Jimenez Bravo de Laguna, Adriana Simiele, Bernardo Gonzalez, Jose Angel Hernandez Rivas, Raul Cordoba, Consolación Rayón, Carmen Burgaleta, Jordi Sierra, Daniel Primo, Pilar Hernandez-Campo, Julian Gorrochategui, Jose L. Rojas, Belen Liebana, Rocio Lopez, Troconiz Iñaki, Ignacio Ortega, Teresa A. Bennett
Journal: Blood
Blood (2013) 122 (21): 1347.
https://doi.org/10.1182/blood.V122.21.1347.1347
Published: 2013
Journal Articles

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

Luis I. Sánchez-Abarca, Silvia Gutierrez-Cosio, Carlos Santamaría, Teresa Caballero-Velazquez, Belen Blanco, Carmen Herrero-Sánchez, Juan L. García, Soraya Carrancio, Pilar Hernández-Campo, Francisco J. González, Teresa Flores, Laura Ciudad, Esteban Ballestar, Consuelo del Cañizo, Jesus F. San Miguel, Jose A. Pérez-Simon
Journal: Blood
Blood (2010) 115 (1): 107–121.
https://doi.org/10.1182/blood-2009-03-210393
Published: 2010
Includes: Supplemental data
Journal Articles

Both Expanded and Uncultured Mesenchymal Stem Cells from MDS Patients Are Genomically Abnormal, Showing a Specific Genetic Profile for the 5q- Syndrome.

Olga López Villar, MD, Juan LuíS. García, PhD, Fermín. M Sánchez Guijo, MD, PhD, Cristina Robledo, Pilar Hernandez Campo, PhD, Maria Diez Campelo, MD, PhD, Sandra Muntion, Jose Antonio Pérez Simón, MD, PhD, J.F. San Miguel, MD, PhD, MaríA. Consuelo Del Cañizo, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1650.
https://doi.org/10.1182/blood.V112.11.1650.1650
Published: 2008