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Pin Lu, PhD
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Journal Articles

Inhibition of B-Cell Receptor Signaling Disrupts Cell Adhesion in Mantle Cell Lymphoma Via RAC2

Weige Wang, MD, Franzen Carrie, Hui Guo, PhD, Jimmy Lee, MD, Yan Li, Madina Sukhanova, PhD, Dong Sheng, MD, Girish Venkataraman, MD MBBS, Ming Mei, Pin Lu, PhD, Anhui Gao, Chunmei Xia, Li Jia, Liang Zhang, MD PhD, Michael Wang, MD, Jorge Andrade, Zhou Xiaoyan, Y. Lynn Lynn Wang, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2018-99-118598
Published: 2018
Journal Articles

XPO1 Inhibitor Selinexor Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma Via Nuclear Retention of IκB

Y. Lynn Wang, MD PhD, Mei Ming, PhD, Bingqing Xie, Madina Sukhanova, Weige Wang, MD, Sabah Kadri, PhD, Shruti Sharma, Jimmy Lee, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Natalia Maltsev, Pin Lu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3837.
https://doi.org/10.1182/blood.V130.Suppl_1.3837.3837
Published: 2017
Journal Articles

Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B Cell Malignancies: Results from a Phase I Dose Escalation Study

Gregory P. Coffey, PhD, Jiajia Feng, MD, Andreas Betz, PhD, Anjali Pandey, PhD, Matt Birrell, B.S., Janet M. Leeds, PhD, Kenneth Der, PhD, Sabah Kadri, PhD, Pin Lu, PhD, Jeremy Segal, PhD, Lynn Wang, MD PhD, Glenn Michelson, MD, John T Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2782.
https://doi.org/10.1182/blood.V130.Suppl_1.2782.2782
Published: 2017
Journal Articles

RAC2 Links B-Cell Receptor Signaling and Cell Adhesion in Mantle Cell Lymphoma

Weige Wang, Franzen Carrie, Madina Sukhanova, Venkataraman Girish, Ming Mei, Guo Ailin, Pin Lu, PhD, Dong Sheng, MD, Gao Anhui, Xia Chunmei, Li Jia, Zhou Xiaoyan, Y Lynn Wang
Journal: Blood
Blood (2017) 130 (Supplement 1): 2752.
https://doi.org/10.1182/blood.V130.Suppl_1.2752.2752
Published: 2017
Journal Articles

Clonal Evolution Pattern of Leukemia Progression and Richter Transformation in Ibrutinib-Relapsed CLL Patients

Sabah Kadri, PhD, Jimmy Lee, MD, Carrie Fitzpatrick, PhD DABMG, Natalie Galanina, MD, Madina Sukhanova, PhD, Girish Venkataraman, MD MBBS, Shruti Sharma, PhD, Bradley Long, Megan Theissen, Mei Ming, PhD, Yuri Kobzev, Kang Wenjun, Ailin Guo, PhD MD, Weige V Wang, MD, Nifang Niu, PhD, Howie Lawrence Weiner, Michael J. Thirman, MD, Sonali M. Smith, MD, Jeremy P. Segal, MD PhD, Pin Lu, PhD, Y. Lynn Wang, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3961.
https://doi.org/10.1182/blood.V128.22.3961.3961
Published: 2016
Journal Articles

Genetic or CD40L-Mediated Loss of Iκbα Is Associated with Resistance to the Dual SYK/JAK Inhibitor Cerdulatinib in DLBCL Cell Lines

Greg P Coffey, PhD, Jiajia Feng, MD, Sabah Kadri, PhD, Y. Lynn Wang, MD PhD, Pin Lu, PhD, Shruti Sharma, PhD, Jeremy Segal, PhD, Glenn Michelson, MD, Anjali Pandey, PhD, John T. Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2016) 128 (22): 2768.
https://doi.org/10.1182/blood.V128.22.2768.2768
Published: 2016
Journal Articles

Dual SYK/JAK Inhibition Overcomes Ibrutinib Resistance in Chronic Lymphocytic Leukemia

Yue Lynn Wang, MD PhD, Pin Lu, PhD, Greg P Coffey, PhD, Anjali Pandey, PhD, Ailin Guo, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5377.
https://doi.org/10.1182/blood.V128.22.5377.5377
Published: 2016
Journal Articles

HSP90 Stabilizes B-Cell Receptor Kinases in a Multi-Client Interactome: PU-H71 Induces CLL Apoptosis in a Cytoprotective Microenvironment

Yue Lynn Wang, MD PhD, Pin Lu, PhD, Jimmy Lee, MD, Chao Jie Zhen, BS, Gabriela Chiosis, PhD, Ailin Guo, Ph DMD
Journal: Blood
Blood (2016) 128 (22): 5105.
https://doi.org/10.1182/blood.V128.22.5105.5105
Published: 2016
Journal Articles

Higher BTK-Dependent Cell Proliferation in Unmutated Chronic Lymphocytic Leukemia Confers Increased Sensitivity to Ibrutinib

Ailin Guo, PhDMD, Pin Lu, PhD, Natalie Galanina, MD, Chadi Nabhan, MD, Sonali M. Smith, MD, Morton Coleman, MD, Yue Lynn Wang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5296.
https://doi.org/10.1182/blood.V126.23.5296.5296
Published: 2015
Journal Articles

An Accurate and Sensitive RT-qPCR Method That Reliably Detects BCR-ABL1 Beyond MR4.5

Nadia A. McDonald, B.Sc., MS, Brett E. Close, PhD, Pin Lu, PhD, Jeremy P. Segal, MD PhD, Yue Lynn Wang, MD PhD, Larissa V. Furtado, MD
Journal: Blood
Blood (2015) 126 (23): 5159.
https://doi.org/10.1182/blood.V126.23.5159.5159
Published: 2015
Journal Articles

An HSP90 Inhibitor, PU-H71, Antagonizes Stroma-Induced Pro-Survival Effects in CLL through Its Inhibition of Multi-Component B-Cell Receptor Signaling Pathway

Ailin Guo, PhDMD, Pin Lu, PhD, Chaojie Zhen, PhD, Gabriela Chiosis, PhD, Yue Lynn Wang, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5289.
https://doi.org/10.1182/blood.V126.23.5289.5289
Published: 2015