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Journal Articles

A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance

Ze Tian, Ph.D, Padraig D'Arcy, Ph.D, Xin Wang, Ph.D, Arghya Ray, Yu-Tzu Tai, PhD, Yiguo Hu, PhD, Ruben Carrasco, MD, PhD, Deepika Das, Ph.D, Paul Richardson, MD, Stig Linder, MD, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 1923.

https://doi.org/10.1182/blood.V122.21.1923.1923

Published: 2013

Journal Articles

Mitochondrial Apoptotic Priming Measured by BH3 Profiling Regulates Clinical Response to Chemotherapy in Myeloma and Acute Lymphoblastic Leukemia and Explains Therapeutic Index

Triona Ni Chonghaile, PhD, Kristopher Sarosiek, PhD, Jeremy Ryan, Vicki Del Gaizo Moore, PhD, Yu-Tzu Tai, PhD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Richard M. Stone, MD, Daniel J DeAngelo, MD, PhD, Constantine S. Mitsiades, MD, PhD, Stephen E. Sallan, MD, Michelle Hirsch, MD PhD, Lewis B. Silverman, MD, Ruben Carrasco, MD, PhD, Anthony G. Letai, MD, PhD

Blood (2011) 118 (21): 1442.

https://doi.org/10.1182/blood.V118.21.1442.1442

Published: 2011

Journal Articles

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Blood (2011) 118 (21): 883.

https://doi.org/10.1182/blood.V118.21.883.883

Published: 2011

Journal Articles

Deregulation of TNFRSF18 (GITR) Through Promoter CpG Island Methylation Induces Tumor Proliferation in Multiple Myeloma

Yang Liu, PhD, Yong Zhang, PhD, Phong Quang, BS, Hai T Ngo, BS, Feda Azab, BPharm, Abdel Kareem Azab, PhD, BSPharm, Brittany Morgan, Patricia Maiso, PhD, Michaela Reagan, PhD, Christopher P. Rombaoa, Antonio Sacco, BS, Aldo M Roccaro, MD, PhD, Ruben Carrasco, MD, PhD, Irene M. Ghobrial, MD

Blood (2011) 118 (21): 2424.

https://doi.org/10.1182/blood.V118.21.2424.2424

Published: 2011

Journal Articles

Novel Myeloma-Specific Multiple Peptides Able to Generate Cytotoxic T Lymphocytes: Potential Therapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders,

Jooeun Bae, Ph.D., Ruben Carrasco, MD, PhD, Ann-Hwee Lee, Ph.D., Rao Prabhala, Ph.D., Yu-Tzu Tai, PhD, Weihua Song, MD, Kenneth C Anderson, MD, Nikhil C. Munshi, MD

Blood (2011) 118 (21): 3990.

https://doi.org/10.1182/blood.V118.21.3990.3990

Published: 2011

Journal Articles

Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Jian-Jun Zhao, M.D., Ph.D., Zhangbo Chu, M.D., Jianhong Lin, PhD, Yu-Tzu Tai, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Ruben Carrasco, MD, PhD

Blood (2011) 118 (21): 1419.

https://doi.org/10.1182/blood.V118.21.1419.1419

Published: 2011

Journal Articles

Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway.

Jian-Jun Zhao, M.D., Ph.D., Jianhong Lin, M.D., Zhangbo Chu, M.D., Qi Wang, Ph.D., Kohichi Takada, M.D., Ph.D., Mala Mani, Ph.D., Bryan Ciccarelli, Teru Hideshima, M.D., Ph.D., Tai Yu-Tzu, Ph.D., Jianguo Tao, MD, PhD, Steven P. Treon, MD, PhD, Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D., Ruben Carrasco, MD, PhD

Blood (2010) 116 (21): 1569.

https://doi.org/10.1182/blood.V116.21.1569.1569

Published: 2010

Journal Articles

Selectin Inhibition Disrupts Multiple Myeloma Cells Interaction with the Bone Marrow Microenvironment and Sensitizes Them to Therapy

Abdel Kareem A. Azab, PhD, BSPharm, Phong Quang, Feda Azab, John Magnani, John Patton, Theodore Smith, Arun Sarkar, Patricia Maiso, Hai T Ngo, Aldo M. Roccaro, MD, PhD, Antonio Sacco, Yang Liu, PhD, Yong Zhang, PhD, Brittany Morgan, Kenneth C. Anderson, Andrew L. Kung, MD, PhD, Ruben Carrasco, MD, PhD, Irene M. Ghobrial, MD

Blood (2010) 116 (21): 453.

https://doi.org/10.1182/blood.V116.21.453.453

Published: 2010

Journal Articles

Preclinical Validation of a Clinical Grade Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00 for the Treatment of Multiple Myeloma.

Blood (2007) 110 (11): 256.

https://doi.org/10.1182/blood.V110.11.256.256

Published: 2007

Journal Articles

Delineation of Canonical and Non-Canonical NF-κB Pathways in Multiple Myeloma: Therapeutic Implications.

Teru Hideshima, MD, PhD, Noopur Raje, MD, Ruben Carrasco, MD, PhD, Hiroshi Ikeda, MD, PhD, Yutaka Okawa, MD, PhD, Tanyel Kiziltepe, PhD, Sonia Valet, MD, Samantha Pozzi, MD, Dharminder Chauhan, PhD, Constantine Mitsiades, MD, PhD, Klaus Podar, MD, PhD, Yu-Tzu Tai, PhD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD

Blood (2007) 110 (11): 670.

https://doi.org/10.1182/blood.V110.11.670.670

Published: 2007

Journal Articles

Novel Murine Model To Study Modulation of Genes and Molecular Pathways Induced Following In Vivo Interaction between Multiple Myeloma Cells and Human BM Milieu.

Paola Neri, MD, Pierfrancesco Tassone, MD, Masood Shammas, PhD, Mariateresa Fulciniti, PhD, Yu-Tzu Tai, PhD, Simona Blotta, MD, Rao Prabhala, PhD, Mariateresa Di Martino, PhD, Laurence Catley, MD, Pierosandro Tagliaferri, MD, Salvatore Venuta, MD, Ruben Carrasco, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2006) 108 (11): 3409.

https://doi.org/10.1182/blood.V108.11.3409.3409

Published: 2006

Journal Articles

Molecular Mechanisms Regulating Resistance to the Akt Inhibitor Perifosine in Waldenstrom’s Macroglobulinemia, the Role of the ERK and PKC Pathways.

Xavier Leleu, MD, Hai Ngo, Xiaoying Jia, Anne-Sophie Moreau, MD, Evdoxia Hatjiharisi, MD, Ruben Carrasco, MD, Garrett O’Sullivan, Judith Runnels, PhD, Yu-Tsu Tai, PhD, Steven Treon, MD, Teru Hideshima, MD, Kenneth Anderson, MD, Irene Ghobrial, MD

Blood (2006) 108 (11): 2416.

https://doi.org/10.1182/blood.V108.11.2416.2416

Published: 2006

Journal Articles

Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis.

Ruben Carrasco, MD., PHD., Giovanni Tonon, MD., PHD., Cameron Brennan, MD, Alexei Protopopov, PHD, Raktim Sinha, BS, Bin Feng, PHD, Christopher Leo, PHD, Yunyu Zhang, MD, Jean Zhang, MS, Fenghuang Zhan, PHD, Marina Protopopova, PHD, Constantine Mitsiades, MD., Nikhil Munshi, MD, Lynda Chin, MD, Peter Bergsagel, MD, Michael Kuehl, MD, John Shaughnessy, MD, Kenneth Anderson, MD, Ronald DePinho, MD

Blood (2004) 104 (11): 785.

https://doi.org/10.1182/blood.V104.11.785.785

Published: 2004

NARROW

A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance

Mitochondrial Apoptotic Priming Measured by BH3 Profiling Regulates Clinical Response to Chemotherapy in Myeloma and Acute Lymphoblastic Leukemia and Explains Therapeutic Index

Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenström Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment

Deregulation of TNFRSF18 (GITR) Through Promoter CpG Island Methylation Induces Tumor Proliferation in Multiple Myeloma

Novel Myeloma-Specific Multiple Peptides Able to Generate Cytotoxic T Lymphocytes: Potential Therapeutic Application in Multiple Myeloma and Other Plasma Cell Disorders,

Mir-222-221 Induce Dexamethasone Resistance by Targeting BBC3/PUMA in Human Multiple Myeloma

Bone Marrow Niche Down-Regulates Mir-30 In Multiple Myeloma Cells to Promote Cancer Progression and Cancer Initiation by Targeting BCL9/Wnt Pathway.

Selectin Inhibition Disrupts Multiple Myeloma Cells Interaction with the Bone Marrow Microenvironment and Sensitizes Them to Therapy

Preclinical Validation of a Clinical Grade Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00 for the Treatment of Multiple Myeloma.

Delineation of Canonical and Non-Canonical NF-κB Pathways in Multiple Myeloma: Therapeutic Implications.

Novel Murine Model To Study Modulation of Genes and Molecular Pathways Induced Following In Vivo Interaction between Multiple Myeloma Cells and Human BM Milieu.

Molecular Mechanisms Regulating Resistance to the Akt Inhibitor Perifosine in Waldenstrom’s Macroglobulinemia, the Role of the ERK and PKC Pathways.

Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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