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Journal Articles

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Erin Guest, MD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Midhat S. Farooqi, MD PhD, Emily Farrow, PhD CGC, Margaret Gibson, Neil Miller, Karina Shah, Tomi Pastinen, MD PhD, Patrick A. Brown, MD

Blood (2019) 134 (Supplement_1): 2756.

https://doi.org/10.1182/blood-2019-131999

Published: 2019

Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD

Blood (2018) 132 (Supplement 1): 918.

https://doi.org/10.1182/blood-2018-99-119206

Published: 2018

Journal Articles

Genomic Analysis and Pathway Characterization of Genes with Somatic Variants in Infant Acute Lymphoblastic Leukemia

Jillian Fry, Midhat S. Farooqi, MD PhD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Emily Farrow, PhD CGC, Shannon Kelley, MS, Margaret Gibson, Neil Miller, Jeffrey Johnston, Patrick Brown, MD, Erin Guest, MD

Blood (2017) 130 (Supplement 1): 3970.

https://doi.org/10.1182/blood.V130.Suppl_1.3970.3970

Published: 2017

Journal Articles

Landscape of Somatic Mutations and Gene Expression Changes in Relapsed Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Rumen Kostadinov, PhD, Midhat Farooqi, MD PhD, Byunggil Yoo, MS, Emily Farrow, PhD CGC, Shannon Kelley, Margaret Gibson, Neil Miller, Erin M. Guest, MD, Patrick Brown, MD

Blood (2016) 128 (22): 1735.

https://doi.org/10.1182/blood.V128.22.1735.1735

Published: 2016

Journal Articles

Proteomic/Transcriptomic Signatures of Infant MLL-r Rearranged B-ALL at Diagnosis and Relapse Reveal Lineage Plasticity and Diagnostic Heterogeneity

Jevon Cutler, Raiha Tahir, Rumen Kostadinov, PhD, Raja Sekhar, PhD, Tai-Chung Huang, MD PhD, Akhilesh Pandey, MD PhD, Patrick Brown, MD, Mohammad Heydarian, PhD, Karen Reddy, PhD

Blood (2016) 128 (22): 2697.

https://doi.org/10.1182/blood.V128.22.2697.2697

Published: 2016

Journal Articles

Identifying Subclonal Epigenetic Changes Driving Chemoresistance in Infant MLL-r Acute Lymphoblastic Leukemias

Rumen Kostadinov, PhD, Robert Scharpf, PhD, Patrick Brown, MD

Blood (2015) 126 (23): 809.

https://doi.org/10.1182/blood.V126.23.809.809

Published: 2015

Journal Articles

Lymphoproliferative Disease Risk in Patients with Autoimmune Disease: Clustering of Primary CNS Lymphoma with Drug Regimen and Disease Process

Genevieve Marie Crane, MD PhD, Helen Powell, PhD, Rumen Kostadinov, PhD, Peter C. Burger, MD, Richard F. Ambinder, MD PhD, Lode J. Swinnen, MBChB, Michael J. Borowitz, MD PhD, Amy S. Duffield, MD PhD

Blood (2015) 126 (23): 1490.

https://doi.org/10.1182/blood.V126.23.1490.1490

Published: 2015

Journal Articles

A Rise in CNS Lymphoproliferative Disease Incidence Reveals a Protective Role of Calcineurin Inhibitors

Genevieve M. Crane, MD PhD, Helen Powell, PhD, Rumen Kostadinov, PhD, Richard F. Ambinder, MD PhD, Lode J. Swinnen, Michael Borowitz, MD PhD, Amy S. Duffield, MD PhD

Blood (2014) 124 (21): 3020.

https://doi.org/10.1182/blood.V124.21.3020.3020

Published: 2014

Journal Articles

Identifying Methylation Changes Driving Evolution of Relapse in MLL-Rearranged Acute Lymphoblastic Leukemias

Rumen Kostadinov, PhD, Robert Scharpf, PhD, Sarven Sabunciyan, PhD, Daniel Magoon, Rafael Irizarry, PhD, Patrick Brown, MD

Blood (2014) 124 (21): 3797.

https://doi.org/10.1182/blood.V124.21.3797.3797

Published: 2014

Journal Articles

Lineage, Fusion Partner and Age Differences in the Methylome of MLL-r Leukemias

Eric S Schafer, MD, Rumen Kostadinov, PhD, Peter Murakami, MSc, Sandeep S. Negi, PhD, Maria E Figueroa, MD, Ari Melnick, MD, Patrick Brown, MD

Blood (2012) 120 (21): 3506.

https://doi.org/10.1182/blood.V120.21.3506.3506

Published: 2012

NARROW

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Genomic Analysis and Pathway Characterization of Genes with Somatic Variants in Infant Acute Lymphoblastic Leukemia

Landscape of Somatic Mutations and Gene Expression Changes in Relapsed Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Proteomic/Transcriptomic Signatures of Infant MLL-r Rearranged B-ALL at Diagnosis and Relapse Reveal Lineage Plasticity and Diagnostic Heterogeneity

Identifying Subclonal Epigenetic Changes Driving Chemoresistance in Infant MLL-r Acute Lymphoblastic Leukemias

Lymphoproliferative Disease Risk in Patients with Autoimmune Disease: Clustering of Primary CNS Lymphoma with Drug Regimen and Disease Process

A Rise in CNS Lymphoproliferative Disease Incidence Reveals a Protective Role of Calcineurin Inhibitors

Identifying Methylation Changes Driving Evolution of Relapse in MLL-Rearranged Acute Lymphoblastic Leukemias

Lineage, Fusion Partner and Age Differences in the Methylome of MLL-r Leukemias

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American Society of Hematology

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ASH Publications

American Society of Hematology

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