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Journal Articles

Regulation of Hematopoietic Stem Cell Mitochondrial Metabolism

Saghi Ghaffari, MD PhD

Blood (2016) 128 (22): SCI-33.

https://doi.org/10.1182/blood.V128.22.SCI-33.SCI-33

Published: 2016

Journal Articles

Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice

Raymond Liang, B.S., Genís Campreciós, PhD, Carolina L. Bigarella, PhD, Saghi Ghaffari, MD PhD

Blood (2015) 126 (23): 756.

https://doi.org/10.1182/blood.V126.23.756.756

Published: 2015

Journal Articles

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

Raymond Liang, Genís Campreciós, PhD, Yan Kou, Ms, Kathleen E McGrath, PhD, Roberta Novak, Seana C Catherman, B.S., Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Emery H Bresnick, PhD, Dmitri Papatsenko, PhD, Avi Ma'ayan, Velia M. Fowler, PhD, James Palis, MD, Saghi Ghaffari, MD PhD

Blood (2014) 124 (21): 445.

https://doi.org/10.1182/blood.V124.21.445.445

Published: 2014

Journal Articles

The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation

Skye C McIver, PhD, Yoon-A Kang, PhD, Andrew W DeVilbiss, BS, Chelsea A O'Driscoll, BS, David T. Yang, MD, Saghi Ghaffari, MD PhD, Emery H Bresnick, PhD

Blood (2014) 124 (21): 2659.

https://doi.org/10.1182/blood.V124.21.2659.2659

Published: 2014

Journal Articles

Loss Of p53 Rescues The Defective Function Of Foxo3 -/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Rebeca Dieguez-Gonzalez, PhD, Raymond Liang, Brigitte Izac, MSc, Dmitri Papatsenko, PhD, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 4199.

https://doi.org/10.1182/blood.V122.21.4199.4199

Published: 2013

Journal Articles

RNA Sequencing Of Adult Bone Marrow Erythroid Populations Reveals Significant Transcriptional Deregulation In Foxo3 -/- Mutant Cells

Genís Campreciós, PhD, Xin Zhang, MD, PhD, Yan Kou, Ms, Avi Ma'ayan, PhD, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 3416.

https://doi.org/10.1182/blood.V122.21.3416.3416

Published: 2013

Journal Articles

Steady State Differences In Metabolic Properties Of Bone Marrow Versus Spleen Erythroid Cells

Genís Campreciós, PhD, Jeffrey Barminko, PhD, Jeffrey Bernitz, BS, Saghi Ghaffari, MD, PhD

Blood (2013) 122 (21): 943.

https://doi.org/10.1182/blood.V122.21.943.943

Published: 2013

Journal Articles

SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.

Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Valentina d'Escamard, MSc, Brigitte Izac, MSc, David Sinclair, PhD, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 2315.

https://doi.org/10.1182/blood.V120.21.2315.2315

Published: 2012

Journal Articles

Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 2295.

https://doi.org/10.1182/blood.V120.21.2295.2295

Published: 2012

Journal Articles

Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Raymond Liang, Yasaman Azodi, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 1198.

https://doi.org/10.1182/blood.V120.21.1198.1198

Published: 2012

Journal Articles

Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice

Sara Santos Franco, PhD student, Luigia De Falco, PhD, Saghi Ghaffari, MD, PhD, Carlo Brugnara, M.D., David Sinclair, PhD, Achille Iolascon, MD, PhD, Mohandas Narla, DSc, Mariarita Bertoldi, PhD, Christophe Lebouf, PhD, Anne Janin, MD, PhD, Angela Siciliano, Mrs, Pauline Rimmele, PhD, Maria Domenica Cappellini, MD, Shady Michan, PhD, Elisa Zoratti, PhD, Lucia De Franceschi, MD

Blood (2012) 120 (21): 3191.

https://doi.org/10.1182/blood.V120.21.3191.3191

Published: 2012

Journal Articles

Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function

Pauline Rimmele, PhD, Valentina d'Escamard, MSc, Kocabas Fatih, Ph.D, Chengcheng Zhang, Ph.D, Hesham A. Sadek, M.D., Ph.D, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 856.

https://doi.org/10.1182/blood.V120.21.856.856

Published: 2012

Journal Articles

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Pedro Ramos, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Laura Breda, Ph.D, Bart J Crielaard, PhD, Ritama Gupta, Undergraduate student, Ella Guy, Maria F Mariongiu, PhD, Ross L. Levine, Omar Abdel-Wahab, PhD, Benjamin L. Ebert, Nico van Rooijen, PhD, Saghi Ghaffari, MD, PhD, Robert W Grady, PhD, Patricia Giardina, MD, Stefano Rivella, PhD

Blood (2012) 120 (21): 81.

https://doi.org/10.1182/blood.V120.21.81.81

Published: 2012

Journal Articles

Linking Organelle Remodeling with the Erythroid Cell Genetic Network

Yoon-A Kang, Jonathan N Ouellette, Genís Campreciós, PhD, Saghi Ghaffari, MD, PhD, Emery H Bresnick, PhD

Blood (2012) 120 (21): 367.

https://doi.org/10.1182/blood.V120.21.367.367

Published: 2012

Journal Articles

Metabolic Pathways Control Normal and Beta-Thalassemic Erythroid Cell Maturation

Geníis Camprecióos, PhD, Xin Zhang, MD, PhD, Valentina D'Escamard, MSc, Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Brigitte Izac, MSc, Carlo Brugnara, M.D., Emery H Bresnick, PhD, Stefano Rivella, PhD, Saghi Ghaffari, MD, PhD

Blood (2012) 120 (21): 369.

https://doi.org/10.1182/blood.V120.21.369.369

Published: 2012

Journal Articles

Regulation of Erythroid Cell Maturation Is Mediated by a Foxo3-mTOR Cross Talk: Outcome for Beta-Thalassemic Erythropoiesis

Xin Zhang, MD, PhD, Valentina D'Escamard, MSc, Pauline Rimmele, PhD, Saghi Ghaffari, MD, PhD

Blood (2011) 118 (21): 176.

https://doi.org/10.1182/blood.V118.21.176.176

Published: 2011

Journal Articles

The microRNA144/451 Locus Enhances Nuclear FOXO3a Activity to Protect Erythroid Cells against Oxidant Stress

Camila O. dos Santos, Ph.D., Duonan Yu, PhD, Julio Amigo, Ph.D., Eugene Kandros, Eric R Valentine, Suresh Shelat, MD, Louis C Dore, Yu Yao, Janine D’ Souza, Saghi Ghaffari, MD, PhD, Barry H. Paw, M.D., Ph.D., Jordan S Orange, MD, PhD, Mitchell J. Weiss, M.D., Ph.D.

Blood (2008) 112 (11): 277.

https://doi.org/10.1182/blood.V112.11.277.277

Published: 2008

Journal Articles

Role of mTOR Signaling in Erythropoiesis

Sathish Kumar Mungamuri, Saghi Ghaffari, MD, PhD

Blood (2008) 112 (11): 3870.

https://doi.org/10.1182/blood.V112.11.3870.3870

Published: 2008

Journal Articles

Oxidative Stress-Mediated Activation of AKT/mTOR Signaling Pathway Leads to Myeloproliferative Syndrome in FoxO3 Null Mice: A Role for Lnk Adaptor Protein

Safak Yalcin, Sathish Kumar Mungamuri, Dragan Marinkovic, Xin Zhang, Wei Tong, PhD, Dana Cullen, Saghi Ghaffari, MD, PhD

Blood (2008) 112 (11): 509.

https://doi.org/10.1182/blood.V112.11.509.509

Published: 2008

Journal Articles

Foxo3 Transcription Factor Regulates Oxidative Stress in In Vivo Erythropoiesis.

Dragan Marinkovic, PhD, Xin Zhang, Ph.D., Carlo Brugnara, M.D., Saghi Ghaffari, MD, PhD

Blood (2006) 108 (11): 468.

https://doi.org/10.1182/blood.V108.11.468.468

Published: 2006

NARROW

Regulation of Hematopoietic Stem Cell Mitochondrial Metabolism

Loss of Foxo3 Reduces Erythroblast Apoptosis and Enhances RBC Production in Beta-Thalassemic Mice

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation

Loss Of p53 Rescues The Defective Function Of Foxo3 -/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy

RNA Sequencing Of Adult Bone Marrow Erythroid Populations Reveals Significant Transcriptional Deregulation In Foxo3 -/- Mutant Cells

Steady State Differences In Metabolic Properties Of Bone Marrow Versus Spleen Erythroid Cells

SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.

Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.

Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells

Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice

Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Linking Organelle Remodeling with the Erythroid Cell Genetic Network

Metabolic Pathways Control Normal and Beta-Thalassemic Erythroid Cell Maturation

Regulation of Erythroid Cell Maturation Is Mediated by a Foxo3-mTOR Cross Talk: Outcome for Beta-Thalassemic Erythropoiesis

The microRNA144/451 Locus Enhances Nuclear FOXO3a Activity to Protect Erythroid Cells against Oxidant Stress

Role of mTOR Signaling in Erythropoiesis

Oxidative Stress-Mediated Activation of AKT/mTOR Signaling Pathway Leads to Myeloproliferative Syndrome in FoxO3 Null Mice: A Role for Lnk Adaptor Protein

Foxo3 Transcription Factor Regulates Oxidative Stress in In Vivo Erythropoiesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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