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Journal Articles

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Lediana I Miguel, B.Sc., Camila B. Almeida, M.Sc., Carla F Franco-Penteado, Ph.D, Marcos André C Bezerra, Ph.D., Fabiola Traina, M.D., Ph.D., Venina M Dominical, B.Sc., Aderson S Araujo, M.D., Ph.D., Sara T.O. Saad, M.D, Ph.D., Fernando F. Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 1520.

https://doi.org/10.1182/blood.V114.22.1520.1520

Published: 2009

Journal Articles

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

Karin Spat Barcellos, PhD, in, Molecular, Biology, Sheila Maria Winnischofer, PhD, Mariana Lazarini, Master, Degree, Doctorate, Stude, Adriana Silva Santos Duarte, PhD, Carolina Louzao Bigarella, PhD, Fabiola Traina, MD, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1778.

https://doi.org/10.1182/blood.V114.22.1778.1778

Published: 2009

Journal Articles

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Fabiola Traina, MD, PhD, João Agostinho Machado Neto, BSci, Arthur Antolini, Flavio Araújo Borges, Junior, Mariana Lazarini, Master, Degree, Doctorate, Stude, Patricia M.B. Favaro, PhD, Leticia Fröhlich -Archangelo, PhD, Paulo C.A. Pernanbuco Filho, Adriana Silva Santos Duarte, PhD, Fernando Ferreira Costa, Ph.D., M.D., Sara T.O Saad, M.D., Ph.D.

Blood (2009) 114 (22): 1779.

https://doi.org/10.1182/blood.V114.22.1779.1779

Published: 2009

Journal Articles

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Renata Proença-Ferreira, M.Sc., Tania F.G.S. Machado, Fabiola Traina, M.D., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D., Nicola Conran, Ph.D.

Blood (2009) 114 (22): 2565.

https://doi.org/10.1182/blood.V114.22.2565.2565

Published: 2009

Journal Articles

Effect of High Levels of Growth Differentiation Factor 15 (GDF15) On Hepcidin Expression in Monocytes of β-Thalassemia Intermedia Patients.

Kleber Yotsumoto Fertrin, MD, Carolina Lanaro, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Dulcinéia M Albuquerque, B.Sc., M.Sc.,Ph.D, Mariana R. B. Mello, B.Sc., M.Sc, Marcos André C Bezerra, Ph.D., Betania Lucena Borges Tavares Domingues, B.Sc, Sara T.O Saad, M.D., Ph.D., Aderson S Araujo, M.D., Ph.D., Fernando Ferreira Costa, Ph.D., M.D.

Blood (2009) 114 (22): 4061.

https://doi.org/10.1182/blood.V114.22.4061.4061

Published: 2009

Journal Articles

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

Renata P. Ferreira, B.Sc., Carla F. Franco-Penteado, Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, Ph.D.

Blood (2008) 112 (11): 2472.

https://doi.org/10.1182/blood.V112.11.2472.2472

Published: 2008

Journal Articles

The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro , Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.

Andreia A. Canalli, MSc, Renata F. Proenca, B.Sc., Sara T.O. Saad, M.D., Ph.D., Nicola Conran, Ph.D., Fernando F. Costa, M.D., Ph.D.

Blood (2007) 110 (11): 2264.

https://doi.org/10.1182/blood.V110.11.2264.2264

Published: 2007

Journal Articles

AHSP Knockdown in Human Erythroleukemia Cell Line and Human Hematopoietic Stem Cells Results in Alpha Hemoglobin Chain Precipitation, Decreased Hemoglobin Levels and Increased Cell Death.

Flavia O. Pinho, M.Sc., Dulcineia M. Albuquerque, Ph.D., Sara T.O Saad, M.D., Ph.D., Fernando F. Costa, MD, PhD

Blood (2007) 110 (11): 1778.

https://doi.org/10.1182/blood.V110.11.1778.1778

Published: 2007

Journal Articles

A Constitutive Increase in Gamma Globin Gene Production during the Erythroid Differentiation of CD34 + Cells from Sickle Cell Disease Patients and Alterations in Cyclic Nucleotide Levels during This Differentiation.

Carolina Lanaro, Ph.D., Adriana S.S Duarte, M.Sc., Dulcineia M. Albuquerque, Ph.D., Nicola Conran, Ph.D., Sara T.O Saad, M.D., Ph.D., Fernando F. Costa, MD, PhD

Blood (2007) 110 (11): 3790.

https://doi.org/10.1182/blood.V110.11.3790.3790

Published: 2007

Journal Articles

Increased Expression of the cGMP-Specific Phophodiesterase, PDE9A, in Sickle Cell Disease (SCD) Reticulocytes and Neutrophils, and Induction of Erythroid γ Globin Expression and Reduction of SCD Neutrophil Adhesion Following PDE9A Inhibition.

Camila B. Almeida, M.Sc., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, PhD

Blood (2007) 110 (11): 3397.

https://doi.org/10.1182/blood.V110.11.3397.3397

Published: 2007

Journal Articles

Increased Levels and Activities of Matrix Metalloproteinases in Sickle Cell Disease.

Carla F. Franco-Penteado, BSc, MSc, PhD, Stephen Hyslop, B.Sc., Ph.D., Nicola Conran, B.Sc., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, Md., Ph.D.

Blood (2006) 108 (11): 1220.

https://doi.org/10.1182/blood.V108.11.1220.1220

Published: 2006

Journal Articles

Hydroxyurea Reverses Increased Adhesive Properties of Neutrophils in Sickle Cell Disease.

Andreia A. Canalli, BSc, MSc, Nicola Conran, B.Sc., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D.

Blood (2006) 108 (11): 1231.

https://doi.org/10.1182/blood.V108.11.1231.1231

Published: 2006

Journal Articles

cAMP-PKA Signaling Plays an Important Role in Augmented Neutrophil Adhesion and Chemotaxis in Sickle Cell Disease.

Carla Franco-Penteado, BS, MSc, PhD, Andreia A. Canalli, B.Sc., M.Sc., Renata P. Ferreira, Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D., Nicola Conran, B.Sc., Ph.D.

Blood (2006) 108 (11): 1232.

https://doi.org/10.1182/blood.V108.11.1232.1232

Published: 2006

Journal Articles

Anti-Inflammatory Effect of Hydroxyurea Therapy in Sickle Cell Disease.

Carolina Lanaro, BSc, Carla F. Franco-Penteado, B.Sc., M.Sc., Ph.D., Nicola Conran, B.Sc., Ph.D., Sara T.O. Saad, M.D., Ph.D., Fernando F. Costa, M.D., Ph.D.

Blood (2006) 108 (11): 3806.

https://doi.org/10.1182/blood.V108.11.3806.3806

Published: 2006

NARROW

Inhibition of Phosphodiesterase 9A (PDE9A) Significantly Reduces Cytokine-Stimulated Adhesion of Neutrophils From Sickle Cell Disease Individuals, in Vitro , but Not Red Cell Adhesion.

Alpha-Catenin, ARHGAP21 and β-Catenin Are Abnormally Expressed in Bone Marrow Cells From Patients with Myelodysplatic Syndromes and Are a Possible Target for Decitabine Treatment.

IRS1 and SHP2 Signaling in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Hydroxyurea Therapy Is Associated with Decreased Platelet Aggregation Responses and Activation in Sickle Cell Disease.

Effect of High Levels of Growth Differentiation Factor 15 (GDF15) On Hepcidin Expression in Monocytes of β-Thalassemia Intermedia Patients.

Platelets from Sickle Cell Disease Individuals Demonstrate Increased Adhesive Properties That Are Reversed by Hydroxyurea Therapy in Association with Alterations in Intraplatelet cAMP and α IIb α 3 Integrin Activation

The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro , Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.

AHSP Knockdown in Human Erythroleukemia Cell Line and Human Hematopoietic Stem Cells Results in Alpha Hemoglobin Chain Precipitation, Decreased Hemoglobin Levels and Increased Cell Death.

A Constitutive Increase in Gamma Globin Gene Production during the Erythroid Differentiation of CD34 + Cells from Sickle Cell Disease Patients and Alterations in Cyclic Nucleotide Levels during This Differentiation.

Increased Expression of the cGMP-Specific Phophodiesterase, PDE9A, in Sickle Cell Disease (SCD) Reticulocytes and Neutrophils, and Induction of Erythroid γ Globin Expression and Reduction of SCD Neutrophil Adhesion Following PDE9A Inhibition.

Increased Levels and Activities of Matrix Metalloproteinases in Sickle Cell Disease.

Hydroxyurea Reverses Increased Adhesive Properties of Neutrophils in Sickle Cell Disease.

cAMP-PKA Signaling Plays an Important Role in Augmented Neutrophil Adhesion and Chemotaxis in Sickle Cell Disease.

Anti-Inflammatory Effect of Hydroxyurea Therapy in Sickle Cell Disease.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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