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Journal Articles

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Andrew E. Place, MDPhD, Seth E. Karol, MD, Christopher J. Forlenza, MD, Marion Gambart, MD, Todd M. Cooper, DO, Christopher Fraser, MBBS, Gunnar Cario, MD PhD, Maureen M O'Brien, MD, Nicolas U. Gerber, MD, Phillip Barnette, MD, Dirk Reinhardt, MDPhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Mignon L. Loh, MD

Blood (2020) 136 (Supplement 1): 37–38.

https://doi.org/10.1182/blood-2020-137376

Published: 2020

Journal Articles

Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access

Katherine Tarlock, MD, Soheil Meshinchi, MDPhD, Jeffrey E. Rubnitz, MD, Seth E. Karol, MD, Barbara Spitzer, MD, Amit J. Sabnis, MD, Asif Pathan, PhD RPh, Boo Messahel, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-140399

Published: 2020

Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-136999

Published: 2020

Journal Articles

Proposed Scheme for Dosing Venetoclax in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships

Mohamed A Badawi, PhD, Sathej Gopalakrishnan, PhD, Benjamin Engelhardt, PhD, Tammy L. Palenski, PhD, Su Young Kim, Seth E. Karol, MD, Jeffrey E. Rubnitz, MD, Rajeev Menon, PhD, Ahmed Hamed Salem, PhD FCP

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-139593

Published: 2020

Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-138528

Published: 2020

Journal Articles

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Seth E Karol, MD, Thomas Alexander, MDMPH, Amit Budraja, PhD, Stanley Pounds, PhD, Kristin E Canavera, PhD, Lei Wang, MS, Joshua Wolf, MBBS, PhD, Jeffery M. Klco, MD PhD, Ahmed Hamed Salem, PhD FCP, Tammy Palenski, PhD, Norman J. Lacayo, MD, Ching-Hon Pui, MD, Joseph T. Opferman, PhD, Jeffrey Rubnitz, MD PhD

Blood (2019) 134 (Supplement_1): 178.

https://doi.org/10.1182/blood-2019-127716

Published: 2019

Journal Articles

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Seth E Karol, MD, Todd M Cooper, DO, Henrique Bittencourt, Lia Gore, MD, Maureen M O'Brien, MD, Christopher Fraser, MD, Marion Gambart, MD, Gunnar Cario, MD PhD, Christian Michel Zwaan, MD PhD, Jean-Pierre Bourquin, MD PhD, Mignon L. Loh, MD, Hubert Caron, MD PhD, Betty Prine, Ahmed Hamed Salem, PhD FCP, Kristina Unnebrink, Bo Tong, PhD, Tammy Palenski, PhD, Andrew E. Place, MD PhD

Blood (2019) 134 (Supplement_1): 2649.

https://doi.org/10.1182/blood-2019-129805

Published: 2019

Journal Articles

Zoledronic Acid Reduces Osteonecrosis and Anti-Leukemic Efficacy in Murine Models of Acute Lymphoblastic Leukemia Therapy

Laura Janke, DVM, PhD, Jieun Kim, PhD, David Jenkins, BS, Monique A Payton, BS, Mary V Relling, PharmD, Seth E Karol, MD

Blood (2018) 132 (Supplement 1): 4029.

https://doi.org/10.1182/blood-2018-99-112941

Published: 2018

Journal Articles

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy

Blood (2018) 132 (Supplement 1): 2697.

https://doi.org/10.1182/blood-2018-99-110141

Published: 2018

Journal Articles

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Emily R Finch, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Nancy M Kornegay, John C Panetta, PhD, Kristine R Crews, PharmD, Alejandro R Molinelli, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Laura B. Ramsey, PhD, Seth E Karol, MD, Hiroto Inaba, MD, John T. Sandlund, MD, Monika Metzger, MD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Mary V Relling, PharmD

Blood (2018) 132 (Supplement 1): 2665.

https://doi.org/10.1182/blood-2018-99-117093

Published: 2018

Journal Articles

Genetic Risk Factors for the Development of Osteonecrosis in Children Under Age 10 Treated for Acute Lymphoblastic Leukemia

Blood (2015) 126 (23): 250.

https://doi.org/10.1182/blood.V126.23.250.250

Published: 2015

Journal Articles

Genome-Wide Association Study Identifies PNPLA3 I148M Variant Associated with Elevated Transaminase Levels after Induction Therapy in Pediatric ALL Patients

Christian A. Fernandez, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Chengcheng Liu, B.S, Laura B. Ramsey, PhD, Seth E. Karol, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Sima Jeha, MD, Mary V. Relling, PharmD

Blood (2015) 126 (23): 3714.

https://doi.org/10.1182/blood.V126.23.3714.3714

Published: 2015

Journal Articles

Tolerability of 6-Mercaptopurine (6MP) in Patients with Thiopurine Methyltransferase ( TPMT ) Heterozygosity in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia (ALL)

Chengcheng Liu, Deqing Pei, MS, Cheng Cheng, PhD, Jun J. Yang, PhD, Kristine Crews, PharmD, Wenjian Yang, PhD, Seth E. Karol, MD, Sima Jeha, MD, John T. Sandlund, MD, Raul C Ribeiro, MD, Jeffrey E Rubnitz, MD PhD, Monika L. Metzger, MD MS, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD

Blood (2014) 124 (21): 3722.

https://doi.org/10.1182/blood.V124.21.3722.3722

Published: 2014

Journal Articles

Genetic Variation in NFATC2 Is Associated with a Higher Risk of Asparaginase Allergy

Blood (2014) 124 (21): 63.

https://doi.org/10.1182/blood.V124.21.63.63

Published: 2014

Journal Articles

A Murine Model of Asparaginase Allergy

Christian A. Fernandez, PhD, Colton Smith, PhD, Seth E. Karol, MD, Laura B. Ramsey, PhD, Chengcheng Liu, Ching-Hon Pui, MD, Sima Jeha, MD, William E. Evans, PharmD, Fred D. Finkelman, PhD, Mary V. Relling, PharmD

Blood (2014) 124 (21): 2295.

https://doi.org/10.1182/blood.V124.21.2295.2295

Published: 2014

Journal Articles

Prognostic Factors For Children With Acute Myeloid Leukemia Who Achieve Minimal Residual Disease-Negative Status After Induction Therapy

Seth E Karol, MD, Elaine Coustan-Smith, MS, Xueyuan Cao, PhD, Sheila A Shurtleff, PhD, Susana C Raimondi, PhD, John K Choi, MD, PhD, Raul C Ribeiro, MD, Gary V Dahl, MD, W Paul Bowman, MD, Jeffrey W Taub, MD, Barbara Degar, MD, Wing Leung, MD, PhD, James R Downing, MD, Ching-Hon Pui, MD, Jeffrey E Rubnitz, MD, PhD, Dario Campana, MD, PhD, Hiroto Inaba, MD, PhD

Blood (2013) 122 (21): 490.

https://doi.org/10.1182/blood.V122.21.490.490

Published: 2013

NARROW

Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia Harboring Heterogeneous Genomic Profiles Respond to Venetoclax in Combination with Chemotherapy

Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Proposed Scheme for Dosing Venetoclax in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Venetoclax in Combination with High-Dose Chemotherapy Is Active and Well-Tolerated in Children with Relapsed or Refractory Acute Myeloid Leukemia

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Zoledronic Acid Reduces Osteonecrosis and Anti-Leukemic Efficacy in Murine Models of Acute Lymphoblastic Leukemia Therapy

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Genetic Risk Factors for the Development of Osteonecrosis in Children Under Age 10 Treated for Acute Lymphoblastic Leukemia

Genome-Wide Association Study Identifies PNPLA3 I148M Variant Associated with Elevated Transaminase Levels after Induction Therapy in Pediatric ALL Patients

Tolerability of 6-Mercaptopurine (6MP) in Patients with Thiopurine Methyltransferase ( TPMT ) Heterozygosity in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia (ALL)

Genetic Variation in NFATC2 Is Associated with a Higher Risk of Asparaginase Allergy

A Murine Model of Asparaginase Allergy

Prognostic Factors For Children With Acute Myeloid Leukemia Who Achieve Minimal Residual Disease-Negative Status After Induction Therapy

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American Society of Hematology

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American Society of Hematology

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