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Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Functions As MMP-13 Receptor on Osteoclasts and Mediates MMP-13 Induced Osteoclast Activation in Multiple Myeloma

Jing Fu, PhD, Shirong Li, PhD, Chen Yang, Lewis M Brown, PhD, Stephen J Weiss, MD PhD, Charles G Drake, MD PhD, Markus Y. Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2019) 134 (Supplement_1): 3072.

https://doi.org/10.1182/blood-2019-129177

Published: 2019

Journal Articles

Gck Kinase Activity Is Critical for RAS Mutated Myeloma - a Potential Treatment Approach for Targeting Specific Mutations

Shirong Li, PhD, Jing Fu, PhD, Xiaoming Xu, PhD, Shixian Deng, PhD, Markus Y Mapara, MD PhD, Christophe Marcireau, Suzanne Lentzsch, MD PhD

Blood (2019) 134 (Supplement_1): 1813.

https://doi.org/10.1182/blood-2019-129531

Published: 2019

Journal Articles

Silencing c-Myc Translation As a Therapeutic Strategy through Targeting PI3K Delta and CK1 Epsilon in Hematological Malignancies

Changchun Deng, MD PhD, Mark Lipstein, Luigi Scotto, PhD, Xavier O Jirau Serrano, B.S., Michael Mangone, PhD, Shirong Li, PhD, Jeremie Vendome, PhD, Yun Hao, Xiaoming Xu, Xiaoping Liu, MD PhD, Ipsita Pal, PhD, Shi-Xian Deng, PhD, Nicholas P. Tatonetti, PhD, Suzanne Lentzsch, MD PhD, Barry Honig, PhD, Donald Landry, MD PhD, Owen A. O'Connor, MD PhD

Blood (2016) 128 (22): 291.

https://doi.org/10.1182/blood.V128.22.291.291

Published: 2016

Journal Articles

Interferon Gamma (IFNγ)/STAT1 Signaling in Host Antigen Present Cells Suppresses MHC Class II-Dependent Presentation of Self-Antigens and Development of Graft Versus Host Disease (GVHD)

Caisheng Lu, MD PhD, Huihui Ma, MD, PhD, Liangsong Song, MD, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD PhD, Markus Y Mapara, MD PhD

Blood (2016) 128 (22): 2147.

https://doi.org/10.1182/blood.V128.22.2147.2147

Published: 2016

Journal Articles

SYK-Inhibitor Bay 61-3606 Induces Cell Cycle Arrest and Apoptosis in Multiple Myeloma Cells Independent of SYK Inhibitory Effects but Via Degradation of IKZF1/3

Shirong Li, PhD, Jing Fu, PhD, Jing Wu, MD PhD, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2016) 128 (22): 4477.

https://doi.org/10.1182/blood.V128.22.4477.4477

Published: 2016

Journal Articles

IKZF1 Mutation Mediate Resistance to IMiDs in Human Hematopoietic Stem Cells

Shirong Li, PhD, Jing Fu, PhD, Jing Wu, MD PhD, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2015) 126 (23): 3003.

https://doi.org/10.1182/blood.V126.23.3003.3003

Published: 2015

Journal Articles

Mechanism Study of Matrix Metalloproteinase 13 Effects on Osteoclast Activation and Lytic Bone Lesions in Multiple Myeloma

Jing Fu, PhD, Shirong Li, PhD, G. David Roodman, MD PhD, Markus Mapara, MD PhD, Stephen J. Weiss, MD, Suzanne Lentzsch, MD PhD

Blood (2015) 126 (23): 3009.

https://doi.org/10.1182/blood.V126.23.3009.3009

Published: 2015

Journal Articles

Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas

Changchun Deng, MD PhD, Mark Lipstein, Luigi Scotto, PhD, Yun Hao, Nicholas P. Tatonetti, PhD, Michael Mangone, PhD, Shirong Li, PhD, Suzanne Lentzsch, Ronald B. Realubit, PhD, Charles Karan, Jr., PhD, Owen A. O'Connor, MD PhD

Blood (2015) 126 (23): 593.

https://doi.org/10.1182/blood.V126.23.593.593

Published: 2015

Journal Articles

Pomalidomide Induces Mir-125b with Subsequent Downregulation of P53 in CD34 + cells Conferring Decreased Apoptosis: A Potential Mechanism of Secondary Primary Malignancies

Yijie Zheng, PhD, Shirong Li, PhD, Jing Fu, PhD, Markus Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2014) 124 (21): 3437.

https://doi.org/10.1182/blood.V124.21.3437.3437

Published: 2014

Journal Articles

IMiD® Compounds Affect the Hematopoiesis Via CRBN Dependent Degradation of IKZF1 Protein in CD34 + Cells

Shirong Li, PhD, Jing Fu, PhD, Markus Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2014) 124 (21): 418.

https://doi.org/10.1182/blood.V124.21.418.418

Published: 2014

Journal Articles

IFN-γ/STAT1-Dependent Regulation Of Antigen Presenting Cell (APC) Function: Role In Graft-Versus-Host Disease (GVHD)

Caisheng Lu, PHD, Huihui Ma, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD, PhD, Markus Mapara, MD, PhD

Blood (2013) 122 (21): 3252.

https://doi.org/10.1182/blood.V122.21.3252.3252

Published: 2013

Journal Articles

Inducible Silencing Of eIF4E Using a Tet-On System Results In Myeloma Growth In Vivo That Correlates With eIF4E Expression

Shirong Li, PHD, Jing Fu, Ph D, Jordan M. Schecter, MD, Caisheng Lu, PHD, Markus Y. Mapara, MD PhD, Suzanne Lentzsch, MD, PhD

Blood (2013) 122 (21): 3164.

https://doi.org/10.1182/blood.V122.21.3164.3164

Published: 2013

Journal Articles

Knockdown Of Matrix Metalloproteinase 13 (MMP13) In 5TGM1 Multiple Myeloma Cells Inhibits Development Of Lytic Bone Lesions In Vivo

Jing Fu, PhD, Shirong Li, PHD, Huihui Ma, PhD, G. David Roodman, M.D., Ph.D., Markus Y. Mapara, MD PhD, Stephen J Weiss, MD, Suzanne Lentzsch, MD, PhD

Blood (2013) 122 (21): 879.

https://doi.org/10.1182/blood.V122.21.879.879

Published: 2013

Journal Articles

Overexpression of Eukaryotic Initiation Factor 4E Induces Critical Transcription Factors Such As c-Myc in Multiple Myeloma Resulting in Enhanced Clonogenic Tumor Growth in Vitro and in Vivo .

Shirong Li, PhD, Jing Fu, Ph D, Jordan M. Schecter, MD, BS, Caisheng Lu, PhD, Markus Mapara, MD PhD, Suzanne Lentzsch, MD, PhD

Blood (2012) 120 (21): 2908.

https://doi.org/10.1182/blood.V120.21.2908.2908

Published: 2012

Journal Articles

Matrix Metalloproteinase 13 (MMP13) Upregulation Is Essential for Multiple Myeloma Related Bone Lytic Lesion

Jing Fu, Ph D, Shirong Li, PhD, Rentian Feng, PhD, Huihui Ma, PhD, Farideh Sabeh, PhD, G David Roodman, MD, PhD, Markus Mapara, MD PhD, Stephen J Weiss, MD, Suzanne Lentzsch, MD, PhD

Blood (2012) 120 (21): 4025.

https://doi.org/10.1182/blood.V120.21.4025.4025

Published: 2012

Journal Articles

Absence of STAT1 Signaling in Host Hematopoietic Cells Leads to Enhanced Gvhd Induction and Involves Increased Expression of MHC Class II and Reduced PD-L1 Expression on Dendritic Cells,

Caisheng Lu, PhD, Huihui Ma, M.D., Ph.D., Ailing Liu, PhD, MeiHua Jin, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD, PhD, Markus Y. Mapara, MD, PhD

Blood (2011) 118 (21): 4026.

https://doi.org/10.1182/blood.V118.21.4026.4026

Published: 2011

Journal Articles

Targeting STAT1 Separates Graft-Versus-Host Disease (GVHD) and Graft-Versus-Leukemia (GVL) Effects in Mice

Caisheng Lu, PhD, Huihui Ma, PhD, MeiHua Jin, PhD, Ailing Liu, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD, PhD, Markus Y. Mapara, MD, PhD

Blood (2011) 118 (21): 2973.

https://doi.org/10.1182/blood.V118.21.2973.2973

Published: 2011

Journal Articles

The Translation Initiation Factor eIF4E Is Overexpressed in Multiple Myeloma and Is Critical for Myeloma Cell Proliferation and Survival

Shirong Li, PhD, MeiHua Jin, PhD, Ailing Liu, PhD, Markus Y. Mapara, MD, PhD, Suzanne Lentzsch, MD, PhD

Blood (2011) 118 (21): 1853.

https://doi.org/10.1182/blood.V118.21.1853.1853

Published: 2011

Journal Articles

IMiD® Immunomodulatory Drugs Lenalidomide and Pomalidomide Inhibit the Maturation of Megakaryocytes by Suppressing the Expression of GATA1

Ailing Liu, PhD, Vera Donnenberg, PhD, Shirong Li, PhD, Susanne M. Gollin, PhD, Huihui Ma, PhD, Caisheng Lu, PhD, Meihua Jin, PhD, Donna B Stolz, PhD, Markus Y. Mapara, MD, PhD, Sara A. Monaghan, MD, Suzanne Lentzsch, MD, PhD

Blood (2011) 118 (21): 1840.

https://doi.org/10.1182/blood.V118.21.1840.1840

Published: 2011

Journal Articles

C/EBPb Is a Critical Mediator of Resistance to IMiD® Immunomodulatory Compounds and Affected by IMiD Compounds Via Control of Protein Translation

Shirong Li, PhD, Rekha Pal, PhD, Sara Monaghan, MD, Peter Schafer, PhD, Hongjiao Ouyang, DDS, PhD, Markus Y Mapara, MD, PhD, Suzanne Lentzsch, MD, PhD

Blood (2010) 116 (21): 135.

https://doi.org/10.1182/blood.V116.21.135.135

Published: 2010

NARROW

Checkpoint Inhibitor PD-1H/VISTA Functions As MMP-13 Receptor on Osteoclasts and Mediates MMP-13 Induced Osteoclast Activation in Multiple Myeloma

Gck Kinase Activity Is Critical for RAS Mutated Myeloma - a Potential Treatment Approach for Targeting Specific Mutations

Silencing c-Myc Translation As a Therapeutic Strategy through Targeting PI3K Delta and CK1 Epsilon in Hematological Malignancies

Interferon Gamma (IFNγ)/STAT1 Signaling in Host Antigen Present Cells Suppresses MHC Class II-Dependent Presentation of Self-Antigens and Development of Graft Versus Host Disease (GVHD)

SYK-Inhibitor Bay 61-3606 Induces Cell Cycle Arrest and Apoptosis in Multiple Myeloma Cells Independent of SYK Inhibitory Effects but Via Degradation of IKZF1/3

IKZF1 Mutation Mediate Resistance to IMiDs in Human Hematopoietic Stem Cells

Mechanism Study of Matrix Metalloproteinase 13 Effects on Osteoclast Activation and Lytic Bone Lesions in Multiple Myeloma

Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas

Pomalidomide Induces Mir-125b with Subsequent Downregulation of P53 in CD34 + cells Conferring Decreased Apoptosis: A Potential Mechanism of Secondary Primary Malignancies

IMiD® Compounds Affect the Hematopoiesis Via CRBN Dependent Degradation of IKZF1 Protein in CD34 + Cells

IFN-γ/STAT1-Dependent Regulation Of Antigen Presenting Cell (APC) Function: Role In Graft-Versus-Host Disease (GVHD)

Inducible Silencing Of eIF4E Using a Tet-On System Results In Myeloma Growth In Vivo That Correlates With eIF4E Expression

Knockdown Of Matrix Metalloproteinase 13 (MMP13) In 5TGM1 Multiple Myeloma Cells Inhibits Development Of Lytic Bone Lesions In Vivo

Overexpression of Eukaryotic Initiation Factor 4E Induces Critical Transcription Factors Such As c-Myc in Multiple Myeloma Resulting in Enhanced Clonogenic Tumor Growth in Vitro and in Vivo .

Matrix Metalloproteinase 13 (MMP13) Upregulation Is Essential for Multiple Myeloma Related Bone Lytic Lesion

Absence of STAT1 Signaling in Host Hematopoietic Cells Leads to Enhanced Gvhd Induction and Involves Increased Expression of MHC Class II and Reduced PD-L1 Expression on Dendritic Cells,

Targeting STAT1 Separates Graft-Versus-Host Disease (GVHD) and Graft-Versus-Leukemia (GVL) Effects in Mice

The Translation Initiation Factor eIF4E Is Overexpressed in Multiple Myeloma and Is Critical for Myeloma Cell Proliferation and Survival

IMiD® Immunomodulatory Drugs Lenalidomide and Pomalidomide Inhibit the Maturation of Megakaryocytes by Suppressing the Expression of GATA1

C/EBPb Is a Critical Mediator of Resistance to IMiD® Immunomodulatory Compounds and Affected by IMiD Compounds Via Control of Protein Translation

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American Society of Hematology

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American Society of Hematology

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