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Journal Articles

The PDI-ATF6-axis as a novel treatment target in CSF3R driven chronic neutrophilic leukemia (CNL)

Blood (2025) 146 (Supplement 1): 1453.

https://doi.org/10.1182/blood-2025-1453

Published: 2025

Journal Articles

Therapeutic targeting of focal adhesion kinase (FAK) modulates oncogenic and immune pathways in myeloid progenitor cells expressing oncogenic Janus kinase 2-V617F.

Subbaiah Chary Nimmagadda, Yifan Zhi, Matti Lawrenz, Elena Afanaseva, Sivahari P. Gorantla, Pradeep Kumar Patnana, Jan Vorwerk, Marah Hussein, Helal Ahmed, Nikolas Von Bubnoff, Cyrus Khandanpour

Blood (2025) 146 (Supplement 1): 3757.

https://doi.org/10.1182/blood-2025-3757

Published: 2025

Journal Articles

CSF3R T618I Is Stabilized By Calnexin and Induces Unfolded Protein Response (UPR) and ER-Phagy: A Pro-Survival Pathway for Oncogenic Misfolded CSF3R Proteins in Chronic Neutrophilic Leukemia (CNL)

Alessandra Hartke, Julia Klotz, Axel Künstner, Anke Fähnrich, Hauke Busch, Timo Gemoll, Jasmin Osius, Steffen Koschmieder, Tim H. H. Brummendorf, Heike L. Pahl, Florian H. Heidel, Konstanze Döhner, Martin Griesshammer, Andreas Reiter, Justus Duyster, Nikolas C. C. von Bubnoff, Sivahari P. Gorantla

Blood (2024) 144 (Supplement 1): 1348.

https://doi.org/10.1182/blood-2024-202513

Published: 2024

Journal Articles

Ruxolitinib Mediated Paradox JAK2 Hyperphosphorylation Is Due To The Protection Of Activation Loop Phosphotyrosines From Phosphatases

Sivahari P. Gorantla, Ph.D, Kolluri Suresh Babu, M.sc, Anna Lena Illert, M.D, Nikolas von Bubnoff, Christian Peschel, Justus Duyster

Blood (2013) 122 (21): 2847.

https://doi.org/10.1182/blood.V122.21.2847.2847

Published: 2013

Journal Articles

FLT3-ITD Interacts with and Phosphorylates IL-3β, and JAK1/2 Dependent IL-3β Activation Bypasses FLT3-ITD in FLT3 Kinase Independent Inhibitor Resistance in Vitro: Evidence for the Significance of IL-3β for FLT3-ITD Dependent Oncogeneic Signaling in AML.

Christoph Rummelt, Sivahari P. Gorantla, Michael Sigl, Jana Saenger, Katharina Götze, Christian Peschel, MD, Justus Duyster, Nikolas von Bubnoff

Blood (2012) 120 (21): 2423.

https://doi.org/10.1182/blood.V120.21.2423.2423

Published: 2012

Journal Articles

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Sivahari P. Gorantla, Tobias N. Dechow, Rebekka Grundler, Anna Lena Illert, Christian Meyer zum Büschenfelde, Marcus Kremer, Christian Peschel, Justus Duyster

Blood (2010) 116 (22): 4600–4611.

https://doi.org/10.1182/blood-2009-07-236133

Published: 2010

Includes: Supplemental data

Journal Articles

Sorafenib and Nilotinib Are Candidates to Overcome Imatinib Resistance in Myeloproliferation with FIP1L1-PDGFRA.

Nikolas von Bubnoff, MD, Sivahari P Gorantla, MSc, Richard A. Engh, PhD, Taiana de Oliveira, PhD, Silvia Thoene, MSc, Espen Åberg, PhD, Christian Peschel, MD, Justus Duyster, MD

Blood (2009) 114 (22): 2912.

https://doi.org/10.1182/blood.V114.22.2912.2912

Published: 2009

Journal Articles

Identification of a Novel Mode of Kinase Inhibitor Resistance: An F604S Exchange in FIP1L1-PDGFRA Modulates FIP1L1-PDGFRA Protein Stability in a SRC-Dependent Manner

Sivahari P. Gorantla, Nikolas von Bubnoff, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2008) 112 (11): 2792.

https://doi.org/10.1182/blood.V112.11.2792.2792

Published: 2008

Journal Articles

Molecular Mechanisms of JAK2V617F Oncogenic Activation: The JAK2- V617F Mutant Utilizes the SH2 Domain for Constitutive Kinase Activity in the Presence of Unstimulated Heterodimeric Cytokine Receptor.

Sivahari P Gorantla, M.Sc., Tobias Dechow, M.D., Rebekka Grundler, Ph.D, Christian Peschel, MD, Justus Duyster

Blood (2008) 112 (11): 175.

https://doi.org/10.1182/blood.V112.11.175.175

Published: 2008

Journal Articles

Role of SH2 Domain in JAK2-V617F Mediated Transformation.

Sivahari P. Gorantla, MSc, Tobias Dechow, M.D, Christian Peschel, M.D, Justus Duyster, M.D

Blood (2006) 108 (11): 3608.

https://doi.org/10.1182/blood.V108.11.3608.3608

Published: 2006

Journal Articles

Generation of Specific Resistance Profiles in FLT3-ITD and FIP1L1-PDGFRalpha towards Specifically Acting Tyrosine Kinase Inhibitors.

Nikolas von Bubnoff, MD, Silvia Thoene, Sivahari P. Gorantla, Jana Saenger, Christian Peschel, MD, Justus Duyster, MD

Blood (2006) 108 (11): 1376.

https://doi.org/10.1182/blood.V108.11.1376.1376

Published: 2006

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The PDI-ATF6-axis as a novel treatment target in CSF3R driven chronic neutrophilic leukemia (CNL)

Therapeutic targeting of focal adhesion kinase (FAK) modulates oncogenic and immune pathways in myeloid progenitor cells expressing oncogenic Janus kinase 2-V617F.

CSF3R T618I Is Stabilized By Calnexin and Induces Unfolded Protein Response (UPR) and ER-Phagy: A Pro-Survival Pathway for Oncogenic Misfolded CSF3R Proteins in Chronic Neutrophilic Leukemia (CNL)

Ruxolitinib Mediated Paradox JAK2 Hyperphosphorylation Is Due To The Protection Of Activation Loop Phosphotyrosines From Phosphatases

FLT3-ITD Interacts with and Phosphorylates IL-3β, and JAK1/2 Dependent IL-3β Activation Bypasses FLT3-ITD in FLT3 Kinase Independent Inhibitor Resistance in Vitro: Evidence for the Significance of IL-3β for FLT3-ITD Dependent Oncogeneic Signaling in AML.

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Sorafenib and Nilotinib Are Candidates to Overcome Imatinib Resistance in Myeloproliferation with FIP1L1-PDGFRA.

Identification of a Novel Mode of Kinase Inhibitor Resistance: An F604S Exchange in FIP1L1-PDGFRA Modulates FIP1L1-PDGFRA Protein Stability in a SRC-Dependent Manner

Molecular Mechanisms of JAK2V617F Oncogenic Activation: The JAK2- V617F Mutant Utilizes the SH2 Domain for Constitutive Kinase Activity in the Presence of Unstimulated Heterodimeric Cytokine Receptor.

Role of SH2 Domain in JAK2-V617F Mediated Transformation.

Generation of Specific Resistance Profiles in FLT3-ITD and FIP1L1-PDGFRalpha towards Specifically Acting Tyrosine Kinase Inhibitors.

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