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Sruti Shiva, PhD
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Journal Articles

Xanthine Oxidase Has a Protective Role during Heme Crisis By Binding and Degrading Heme

Heidi M Schmidt, Scott Hahn, MS, Gowtham K Annarapu, PhD, Mara Carreño, Francisco Schopfer, Sruti Shiva, PhD, Dario A. Vitturi, PhD, Eric Kelley, PhD, Adam C Straub, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12.
https://doi.org/10.1182/blood-2020-137185
Published: 2020
Journal Articles

Heme Induced Platelet Mitochondrial Oxidant Production Regulates Thrombospondin-1 Release from Platelets

Gowtham K Annarapu, PhD, Deirdre Nolfi-Donegan, MD, Anuradha Bharara Singh, PhD, Michael Reynolds, Sruti Shiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30.
https://doi.org/10.1182/blood-2020-142640
Published: 2020
Journal Articles

HMGB1-Mediated Platelet Activation Is Independent of Platelet Mitochondrial Reactive Oxygen Species Generation

Deirdre Nolfi-Donegan, MD, Gowtham K Annarapu, PhD, Cheryl A Hillery, MD, Sruti Shiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-141160
Published: 2020
Journal Articles

The Mitochondrion: A Link Between Hemolysis and Platelet Activation

Sruti Shiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-39.
https://doi.org/10.1182/blood-2019-121112
Published: 2019
Journal Articles

Parenteral L-Arginine Improves Mitochondrial Function in Children with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Episodes

Sruti Shiva, PhD, Lou Ann Brown, PhD, Y Wang, Carlton Dampier, MD, Amanda Watt, Vinita Tripathi, Amina Bhutta, MD, Polly Kumari, MD, Janet Figueroa, MPH, April Zmitrovich, MSW, MPH, Claudia R. Morris, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 508.
https://doi.org/10.1182/blood-2018-99-112666
Published: 2018
Journal Articles

HMGB1 As a Novel Platelet Agonist That Acts Synergistically with ADP to Activate Platelets in Sickle Cell Disease

Deirdre Nolfi-Donegan, MD, Sruti Shiva, PhD, Cheryl A Hillery, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1073.
https://doi.org/10.1182/blood-2018-99-110269
Published: 2018
Journal Articles

Role of Iron-Responsive Mitochondrial Metabolism and ROS in Anemia

Chanté L Richardson, MS, PhD, Valerie M Schrott, MS, Claudette M St. Croix, PhD, Yinna Wang, MD PhD, Catherine G Corey, BS, Sruti Shiva, PhD, Grant C Bullock, MD PhD
Journal: Blood
Blood (2014) 124 (21): 216.
https://doi.org/10.1182/blood.V124.21.216.216
Published: 2014
Journal Articles

Mitochondrial Uncoupling Protein 2 Is Present in Human Platelets and Regulates Platelet Activation

Sruti Shiva, PhD, Enrico M Novelli, MD MS, Grant C Bullock, MD PhD, Elizabeth Kenny, Gabrielle Hill, Catherine G Corey, BS
Journal: Blood
Blood (2014) 124 (21): 4147.
https://doi.org/10.1182/blood.V124.21.4147.4147
Published: 2014
Journal Articles

Citrate Synthase Activity Is Increased In Children With Sickle Cell Disease (SCD) On Hydroxyurea (HU) Therapy

Claudia R. Morris, MD, Cornelia Latronica, MD, Frans A Kuypers, PhD, Howard Rosenfeld, MD, Sandra K Larkin, MS, Stephanie Doniger, MD, Elliott Vichinsky, MD, Sruti Shiva, PhD
Journal: Blood
Blood (2013) 122 (21): 4690.
https://doi.org/10.1182/blood.V122.21.4690.4690
Published: 2013
Journal Articles

Nitrite Oxidase Activities of Cytochrome P450 and Mitochondria

Erin Curtis, Lewis L Hsu, MD, PhD, Yuen Yi Hon, PharmD, Lisa Geary, PhD, Audrey C Noguchi, Sruti Shiva, PhD
Journal: Blood
Blood (2011) 118 (21): 5310.
https://doi.org/10.1182/blood.V118.21.5310.5310
Published: 2011
Journal Articles

Sickle Cell Mice with Hypoxia-Reoxygenation Have Oxidative and Inflammatory Liver Injury - toward a New Experimental Model for Vaso- Occlusive Injury

Lewis L. Hsu, MD, PhD, Sruti Shiva, PhD, Caroline Mendelsohn, Michael R Hsu, Audrey C Noguchi, Laurel Mendelsohn, Mark Gladwin, MD
Journal: Blood
Blood (2008) 112 (11): 121.
https://doi.org/10.1182/blood.V112.11.121.121
Published: 2008
Journal Articles

Depletion and Restoration of the Intravascular Nitrite (NO2-) Reserve Modulate Susceptibility to Liver Vaso-Occlusive Infarction in Sickle Cell Transgenic Mice.

Lewis L. Hsu, MD, PhD, Sruti Shiva, PhD, Audrey Noguchi, Erin Curtis, Peter MacArthur, Nicolaas J.H. Raat, PhD, Bhalchandra A. Diwan, PhD, Alan N. Schechter, MD, Constance Tom Noguchi, PhD, Mark T. Gladwin, MD
Journal: Blood
Blood (2007) 110 (11): 841.
https://doi.org/10.1182/blood.V110.11.841.841
Published: 2007
Journal Articles

Myoglobin Is a Nitrite Reductase That Generates NO and Regulates Mitochondrial Respiration.

Sruti Shiva, PhD, Zhi Huang, PhD, Peter H. MacArthur, BS, Lorna A. Ringwood, BS, Mark T. Gladwin, MD
Journal: Blood
Blood (2006) 108 (11): 1561.
https://doi.org/10.1182/blood.V108.11.1561.1561
Published: 2006
Journal Articles

Reduction of Nitrite to Nitric Oxide by Myoglobin Modulates Mitochondrial Respiration during Ischemia and Limits Reperfusion Injury.

Sruti Shiva, PhD, Zhi Huang, PhD, Lorna A. Ringwood, BS, David J. Lefer, PhD, Mark T. Gladwin, MD
Journal: Blood
Blood (2005) 106 (11): 1673.
https://doi.org/10.1182/blood.V106.11.1673.1673
Published: 2005