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Journal Articles

Treatment of Myelofibrosis Using I.V. Treosulfan and Autologous Peripheral Blood Progenitor Cell Transplantation Is Feasible and Results in Hematologic Responses – Long-Term Follow-up and Final Analysis of a One-Armed Clinical Study and of Individual Cases

Eike C. Buss, MD, Julian Topaly, MD, Hans H. Kreipe, MD, Stefan Fruehauf, MD, Anthony D. Ho, MD

Blood (2011) 118 (21): 4514.

https://doi.org/10.1182/blood.V118.21.4514.4514

Published: 2011

Journal Articles

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

Leopold Sellner, MD, Marlon R Veldwijk, PhD, Jürgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2009) 114 (22): 4506.

https://doi.org/10.1182/blood.V114.22.4506.4506

Published: 2009

Journal Articles

Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma

John F. DiPersio, Edward A. Stadtmauer, Auayporn Nademanee, Ivana N. M. Micallef, Patrick J. Stiff, Jonathan L. Kaufman, Richard T. Maziarz, Chitra Hosing, Stefan Früehauf, Mitchell Horwitz, Dennis Cooper, Gary Bridger, Gary Calandra, for the 3102 Investigators

Blood (2009) 113 (23): 5720–5726.

https://doi.org/10.1182/blood-2008-08-174946

Published: 2009

Journal Articles

Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc −/− stem cells

Yue Si, Anna C. Pulliam, Yvonne Linka, Samantha Ciccone, Cordula Leurs, Jin Yuan, Olaf Eckermann, Stefan Fruehauf, Sean Mooney, Helmut Hanenberg, D. Wade Clapp

Blood (2008) 112 (12): 4458–4465.

https://doi.org/10.1182/blood-2007-07-102947

Published: 2008

Journal Articles

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Nadja Grund, Patrick Maier, Uwe Appelt, Heike Allgayer, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf, MD, Stefanie Laufs

Blood (2008) 112 (11): 4622.

https://doi.org/10.1182/blood.V112.11.4622.4622

Published: 2008

Journal Articles

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

Leopold Sellner, Marlon Veldwijk, PhD, Marius Stiefelhagen, Jurgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2008) 112 (11): 4627.

https://doi.org/10.1182/blood.V112.11.4627.4627

Published: 2008

Journal Articles

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Eike C. Buss, MD, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, MSc, Orit Kollet, PhD, Ayelet Dar, PhD, Melania Tesio, PhD, Stefan Fruehauf, MD, Marc Hotfilder, PhD, Anthony D. Ho, MD, Leonard D. Shultz, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 1920.

https://doi.org/10.1182/blood.V112.11.1920.1920

Published: 2008

Journal Articles

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Jens U. Appelt, Frank A. Giordano, Marcel Zimmermann, Stephan Weinhard, Ph.D., Nadja Grund, Agnes Hotz-Wagenblatt, Ph.D., W. Jens Zeller, M.D., Heike Allgayer, M.D., Ph.D., Stefan Fruehauf, MD, Stephanie Laufs, Ph.D.

Blood (2007) 110 (11): 3738.

https://doi.org/10.1182/blood.V110.11.3738.3738

Published: 2007

Journal Articles

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Marlon R. Veldwijk, Ph.D., Leopold Sellner, Marius Stiefelhagen, Jürgen A. Kleinschmidt, Ph.D., Stephanie Laufs, Ph.D., Julian Topaly, M.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5144.

https://doi.org/10.1182/blood.V110.11.5144.5144

Published: 2007

Journal Articles

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Isabel Spier, Patrick Maier, Ph.D., Stephanie Laufs, Ph.D., Marlon R. Veldwijk, Ph.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5146.

https://doi.org/10.1182/blood.V110.11.5146.5146

Published: 2007

Journal Articles

Lentiviral MDR1 Gene Transfer Confers Radioprotection to Human CD34(+) Haematopoietic Progenitor Cells.

Patrick Maier, Carsten Herskind, Fleckenstein Katharina, Stephanie Laufs, Jens W. Zeller, Frederik Wenz, Stefan Fruehauf

Blood (2006) 108 (11): 5470.

https://doi.org/10.1182/blood.V108.11.5470.5470

Published: 2006

Journal Articles

Steady State Mobilization of Autologous Blood Stem Cells Using G-CSF and AMD3100 in Patients with Multiple Myeloma (MM).

Gerhard Ehninger, Stefan Fruehauf, Kai Hubel, Uwe Platzbecker, Karin Badel, Gary Calandra

Blood (2006) 108 (11): 5219.

https://doi.org/10.1182/blood.V108.11.5219.5219

Published: 2006

Journal Articles

Multiple Displacement Amplification Enables Large Scale Clonal Analysis after Retroviral Gene Therapy.

Stephanie Bleier, Patrick Maier, Frederik Wenz, W. Jens Zeller, Stephanie Laufs, Stefan Fruehauf

Blood (2006) 108 (11): 5469.

https://doi.org/10.1182/blood.V108.11.5469.5469

Published: 2006

Journal Articles

Synergistic Activity of Nilotinib and Established Chemotherapeutic Agents in Imatinib-Sensitive and -Resistant BCR-ABL -Positive Leukemia Cells.

Aleksandar Radujkovic, Julian Topaly, Anthony D. Ho, W.J. Zeller, Stefan Fruehauf

Blood (2006) 108 (11): 4778.

https://doi.org/10.1182/blood.V108.11.4778.4778

Published: 2006

Journal Articles

AMD3100 Inhibits Chemotaxis towards SDF-1 and CXCR4-Mediated Stroma-Contact in a Dose-Dependent Manner, Resulting in Increased Susceptibility to Imatinib.

Falk M. Dillmann, Marlon R. Veldwijk, Gary Calandra, Werner J. Zeller, Anthony D. Ho, Stefan Fruehauf

Blood (2006) 108 (11): 4799.

https://doi.org/10.1182/blood.V108.11.4799.4799

Published: 2006

Journal Articles

Generation of Highly Efficient Recombinant Adeno-Associated Virus (rAAV) Vectors Targeted to Chronic Myelogenous Leukemia (CML) - and CD34+ Progenitor Cells Obtained by the „AAV Random Peptide Library“ Method.

Leopold Sellner, Marlon Veldwijk, Marius Stiefelhagen, Juergen A. Kleinschmidt, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf

Blood (2006) 108 (11): 2203.

https://doi.org/10.1182/blood.V108.11.2203.2203

Published: 2006

Journal Articles

Combination Treatment with Imatinib and Mitoxantrone/Etoposide Is a Suitable Preparative Regimen before Allogeneic Transplantation in Patients with Myeloid Blast Crisis of Chronic Myeloid Leukemia.

Stefan Fruehauf, MD, Julian Topaly, MD, Eike C. Buss, MD, Tanja Lahaye, MD, Oliver G. Ottmann, MD, Thomas Fischer, MD, Bertold Emmerich, MD, Ulrike Haus, Rudiger Hehlmann, MD, Anthony D. Ho, MD, Andreas Hochhaus, MD

Blood (2005) 106 (11): 1105.

https://doi.org/10.1182/blood.V106.11.1105.1105

Published: 2005

Journal Articles

A ComParison of Retroviral Integration Sites in Donor T-Lymphocytes In Vivo and In Vitro.

Frank A. Giordano, Stephanie Laufs, Boris Fehse, K. Zsuzsanna Nagy, Agnes Hotz-Wagenblatt, Daniel Lauterborn, Kurt Fellenberg, Klaus Kuehlcke, Sonja Naundorf, Axel R. Zander, W. Jens Zeller, Stefan Fruehauf

Blood (2005) 106 (11): 1403.

https://doi.org/10.1182/blood.V106.11.1403.1403

Published: 2005

Journal Articles

The CXCR4-Antagonist AMD3100 Augments the Number of Mobilized Peripheral Blood Progenitor Cells (PBPC) When Added to a G-CSF Standard Mobilization Regime and AMD3100-Mobilized PBPC Result in Rapid Hematopoietic Reconstitution after Autologous Transplantation.

Stefan Fruehauf, MD, Timon Seeger, Julian Topaly, MD, Doris Herrmann, PhD, Falk Dillmann, Per Humpert, MD, Gary Calandra, MD, PhD, Stephanie Laufs, PhD, Hartmut Goldschmidt, MD, Anthony D. Ho, MD

Blood (2005) 106 (11): 1961.

https://doi.org/10.1182/blood.V106.11.1961.1961

Published: 2005

Journal Articles

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

Farastuk Bozorgmehr, Stephanie Laufs, PhD, Eike C. Buss, MD, Katalina Z. Nagy, Stephanie E. Sellers, PhD, W. Jens Zeller, MD, Cynthia E. Dunbar, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 2198.

https://doi.org/10.1182/blood.V106.11.2198.2198

Published: 2005

NARROW

Treatment of Myelofibrosis Using I.V. Treosulfan and Autologous Peripheral Blood Progenitor Cell Transplantation Is Feasible and Results in Hematologic Responses – Long-Term Follow-up and Final Analysis of a One-Armed Clinical Study and of Individual Cases

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma

Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc −/− stem cells

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Lentiviral MDR1 Gene Transfer Confers Radioprotection to Human CD34(+) Haematopoietic Progenitor Cells.

Steady State Mobilization of Autologous Blood Stem Cells Using G-CSF and AMD3100 in Patients with Multiple Myeloma (MM).

Multiple Displacement Amplification Enables Large Scale Clonal Analysis after Retroviral Gene Therapy.

Synergistic Activity of Nilotinib and Established Chemotherapeutic Agents in Imatinib-Sensitive and -Resistant BCR-ABL -Positive Leukemia Cells.

AMD3100 Inhibits Chemotaxis towards SDF-1 and CXCR4-Mediated Stroma-Contact in a Dose-Dependent Manner, Resulting in Increased Susceptibility to Imatinib.

Generation of Highly Efficient Recombinant Adeno-Associated Virus (rAAV) Vectors Targeted to Chronic Myelogenous Leukemia (CML) - and CD34+ Progenitor Cells Obtained by the „AAV Random Peptide Library“ Method.

Combination Treatment with Imatinib and Mitoxantrone/Etoposide Is a Suitable Preparative Regimen before Allogeneic Transplantation in Patients with Myeloid Blast Crisis of Chronic Myeloid Leukemia.

A ComParison of Retroviral Integration Sites in Donor T-Lymphocytes In Vivo and In Vitro.

The CXCR4-Antagonist AMD3100 Augments the Number of Mobilized Peripheral Blood Progenitor Cells (PBPC) When Added to a G-CSF Standard Mobilization Regime and AMD3100-Mobilized PBPC Result in Rapid Hematopoietic Reconstitution after Autologous Transplantation.

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

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American Society of Hematology

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American Society of Hematology

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