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Journal Articles

Hypersialylation Protects Multiple Myeloma Cells from NK Cell-Mediated Immunosurveillance and This Can be Overcome By Targeted Desialylation Using a Sialyltransferase Inhibitor

John Daly, MSc, Subhashis Sarkar, PhD, Alessandro Natoni, PhD, Robert Henderson, MB BCh, Dawn Swan, Mattias Carlsten, MD PhD, Michael E O'Dwyer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 138.
https://doi.org/10.1182/blood-2019-126613
Published: 2019
Journal Articles

Targeting CD38 high Acute Myeloid Leukaemia with "Affinity Optimized" Chimeric Antigen Receptor and Membrane Bound TRAIL Expressing Natural Killer Cells

Emma Nolan, BSc, Arwen Stikvoort, PhD, Mark Gurney, MD, Nutsa Burduli, BSc, Lucy Kirkham-McCarthy, MSc, John Daly, MSc, Niels W. C. J. Van De Donk, Tuna Mutis, MD PhD, Subhashis Sarkar, PhD, Michael E O'Dwyer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5536.
https://doi.org/10.1182/blood-2019-128605
Published: 2019
Journal Articles

CD38 Specific Chimeric Antigen Receptor KHYG-1 Natural Killer Cells: A Potential "Off the Shelf" Therapy for Multiple Myeloma

Arwen Stikvoort, PhD, Subhashis Sarkar, PhD, Renée Poels, BSc, Niels WCJ van de Donk, MD PhD, Sonja Zweegman, MD PhD, Michael E O'Dwyer, MD, Tuna Mutis, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2018-99-116403
Published: 2018
Journal Articles

CD38 low Natural Killer Cells Transiently Expressing CD16 F158V m-RNA Potentiates the Therapeutic Activity of Daratumumab Against Multiple Myeloma with Minimal Effector NK Cell Fratricide

Subhashis Sarkar, PhD, Sachin Chauhan, MSc, Arwen Stikvoort, PhD, Alessandro Natoni, PhD, John Daly, MSc, Robert Henderson, MB BCh, Tuna Mutis, PhD, Michael E O'Dwyer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3199.
https://doi.org/10.1182/blood-2018-99-118926
Published: 2018
Journal Articles

In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment

Ryosuke Shirasaki, MD, Csikos Tamas, PhD, Geoffrey Matthews, PhD, Ricardo De Matos Simoes, PhD, Subhashis Sarkar, PhD, Olga Dashevsky, PhD, Hu Yiguo, PhD, Jeffrey Sorrell, BA, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Megan Bariteau, Brian Glassner, PhD, Aedin Culhane, PhD, Richard WJ Groen, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4414.
https://doi.org/10.1182/blood.V130.Suppl_1.4414.4414
Published: 2017
Journal Articles

Targeting Siglec-7: A Novel Immunotherapeutic Approach to Potentiate the Cytotoxic Functions of Natural Killer Cells Against Multiple Myeloma

John Daly, MSc, Tony Duggan, BSc, Jinsong Hu, PhD, Alessandro Natoni, PhD, Subhashis Sarkar, PhD, Lucy Kirkham-McCarthy, MSc, Cian McEllistrim, MD, Janusz Krawczyk, MD, Michael O'Dwyer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1799.
https://doi.org/10.1182/blood.V130.Suppl_1.1799.1799
Published: 2017
Journal Articles

Constitutive Vs. Stroma-Induced Kinase Dependencies in Myeloma Cells: Functional Mapping Using Small Molecule Inhibitors As Chemical Probes

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, MDPhD, Pallavi P. Awate, Subhashis Sarkar, PhD, Geoffrey M. Matthews, PhD, Megan Murnane, Megan A. Bariteau, BSc, Blake T. Aftab, PhD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3709.
https://doi.org/10.1182/blood.V126.23.3709.3709
Published: 2015
Journal Articles

Functional Mapping of Multiple Myeloma Kinome Using a Small Molecule Inhibitor Library

Eugen Dhimolea, PhD, Emily King, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Megan Murnane, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3642.
https://doi.org/10.1182/blood.V124.21.3642.3642
Published: 2014
Journal Articles

Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications

Eugen Dhimolea, PhD, Emily King, Efstathios Kastritis, MD, Douglas W. McMillin, PhD, Jake E. Delmore, B.Sc., Joseph M. Negri, B.Sc., Hannah M. Jacobs, B.Sc., Catriona A. Hayes, MD, Michal Sheffer, PhD, Yiguo Hu, PhD, Subhashis Sarkar, PhD, Richard W.J. Groen, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 276.
https://doi.org/10.1182/blood.V124.21.276.276
Published: 2014
Journal Articles

Genome-Scale Crispr-Cas9 Knockout Studies Reveal Mutifactorial and Functionally Overlapping Mechanisms of Myeloma Cell Resistance to Proteasome Inhibition

Michal Sheffer, PhD, Yiguo Hu, PhD, Ophir Shalem, PhD, Neville Sanjana, PhD, Eugen Dhimolea, PhD, Subhashis Sarkar, PhD, Megan A. Bariteau, B.Sc., Blake T. Aftab, PhD, Richard W.J. Groen, PhD, Feng Zhang, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2014) 124 (21): 273.
https://doi.org/10.1182/blood.V124.21.273.273
Published: 2014