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Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD

Blood (2019) 134 (Supplement_1): 406.

https://doi.org/10.1182/blood-2019-123573

Published: 2019

Journal Articles

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Andrew E. Place, MD PhD, Traci M. Blonquist, MS, Elliot Stieglitz, MD, Todd M Cooper, DO, Lia Gore, MD, Richard Aplenc, MD PhD, Mignon L. Loh, MD, Melinda Pauly, MD, Rachel E. Rau, MD, Michael J. Burke, MD, Julia Etchin, PhD, A. Thomas Look, MD, Maria Luisa Sulis, MD, Lewis B. Silverman, MD

Blood (2018) 132 (Supplement 1): 1405.

https://doi.org/10.1182/blood-2018-99-116689

Published: 2018

Journal Articles

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Koshi Akahane, MD PhD, Zhaodong Li, PhD, Julia Etchin, PhD, Alla Berezovskaya, Evisa Gjini, PhD, Craig E Masse, PhD, Wenyan Miao, PhD, Jennifer Rocnik, PhD, Rosana Kapeller, MD PhD, Jeremy R Greenwood, PhD, Hong Tiv, Takaomi Sanda, MD PhD, David M Weinstock, MD, A. Thomas Look, MD

Blood (2016) 128 (22): 1596.

https://doi.org/10.1182/blood.V128.22.1596.1596

Published: 2016

Journal Articles

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Sunniyat Rahman, PhD DIC, MBiochem, Michael Magnussen, MSc, BSc, Theresa E. León, PhD MSc, BSc, Nadine Farah, FRCPath, MBBChir, MA, MRCP, Brian J. Abraham, PhD BSc, Zhaodong Li, PhD, Krisztina Z. Alapi, PhD MSc, BSc, Rachel J. Mitchell, MSc, Bsc, Tom Naughton, MSc, BSc, Adele K. Fielding, MB BS, PhD FRCP, FRCPath, Arnold Pizzey, Sophia Bustraan, BSc, Christopher Allen, BSc, Rosemary E. Gale, PhD BSc, David C. Linch, MD MRCP, MB BCh, BA, Richard A. Young, PhD BS, A. Thomas Look, MD, Marc R Mansour, MBChB, MRCP, PhD FRCPath

Blood (2016) 128 (22): 733.

https://doi.org/10.1182/blood.V128.22.733.733

Published: 2016

Journal Articles

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Julia Etchin, PhD, Alla Berezovskaya, Amy Saur Conway, Weihsu Claire Chen, PhD, Erkan Baloglu, PhD, Yosef Landesman, PhD, William Senapedis, PhD, Joel Ellis, PhD, Dilara McCauley, PhD, Richard M. Stone, MD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Michael Kauffman, Sharon Shacham, Jean C.Y. Wang, MDPhD, A. Thomas Look, MD

Blood (2015) 126 (23): 326.

https://doi.org/10.1182/blood.V126.23.326.326

Published: 2015

Journal Articles

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Adam Deveau, BSc, MSc, Alexander Michael Forrester, BSc, PhD, Andrew J Coombs, BScH, Gretchen S Wagner, BScH, Clemens Grabher, PhD, Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, Matthew Mingay, BSc, Martin Hirst, PhD, A. Thomas Look, MD, Jason N. Berman, MD

Blood (2014) 124 (21): 436.

https://doi.org/10.1182/blood.V124.21.436.436

Published: 2014

Journal Articles

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD PhD, Marc R Mansour, MDPhD, Alla Berezovskaya, B.S., Richard M. Stone, MD, Ilene Galinsky, RNP, Daniel J. DeAngelo, MDPhD, Dilara McCauley, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Jean C.Y. Wang, MDPhD, Andrew L Kung, MD PhD, A. Thomas Look, MD

Blood (2014) 124 (21): 995.

https://doi.org/10.1182/blood.V124.21.995.995

Published: 2014

Journal Articles

Targeting Oncogenic Interleukein-7 Receptor Signaling With N-Acetylcysteine In T-Cell Acute Lymphoblastic Leukemia

Marc R. Mansour, MD PhD FRCPath, Casie Reed, Amy Eisenberg, Jen-Chieh Tseng, PhD, Akinori Yoda, PhD, Scott J Rodig, MD, PhD, Daniel J. DeAngelo, MD, Ph.D, Stephen E. Sallan, MD, David M. Weinstock, MD, Shai Izraeli, MD, Andrew L Kung, MD, PhD, Alex Kentsis, MD, PhD, Thomas Look, MD

Blood (2013) 122 (21): 2535.

https://doi.org/10.1182/blood.V122.21.2535.2535

Published: 2013

Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD

Blood (2013) 122 (21): 3932.

https://doi.org/10.1182/blood.V122.21.3932.3932

Published: 2013

Journal Articles

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

Koshi Akahane, Takaomi Sanda, PhD, Marc R. Mansour, MD PhD FRCPath, Julia Etchin, PhD, Ng Cherry, David M. Weinstock, MD, Anthony Letai, MD, PhD, Daniel J. DeAngelo, MD, Ph.D, A. Thomas Look, MD

Blood (2013) 122 (21): 2528.

https://doi.org/10.1182/blood.V122.21.2528.2528

Published: 2013

Journal Articles

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

Nicole M Anderson, PhD, Hongling Peng, MD, Daniel Helman, BS, Itrat Harrold, PhD, Takaomi Sanda, PhD, Trevor Grant, MS, Nicholas Nagykery, BS, Yasmina Samaha, Meng Le, PhD, Adam Amsterdam, PhD, Donna Neuberg, ScD, Marc R. Mansour, MD PhD FRCPath, Travis Denton, PhD, John Kanki, PhD, Anurag Singh, PhD, A. Thomas Look, MD, Hui Feng, PhD

Blood (2013) 122 (21): 1273.

https://doi.org/10.1182/blood.V122.21.1273.1273

Published: 2013

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

Journal Articles

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

Julia Etchin, PhD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Andrew L. Kung, MD, PhD, Richard M. Stone, MD, Dilara McCauley, Michael Kauffman, MD, Ph.D., Sharon Shacham, PhD, Thomas Look, MD

Blood (2011) 118 (21): 2622.

https://doi.org/10.1182/blood.V118.21.2622.2622

Published: 2011

Journal Articles

NUP98-HOXA9 drives High-Risk Myeloid Disease in Zebrafish – An In Vivo platform to Study Interacting Genes and Perform Drug Discovery,

A. Michael Forrester, BSc(Hon), Andrew J Coombs, BSc(Hon), Eileen R McBride, MD, FRCP(C), Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, Clemens Grabher, PhD, Thomas Look, MD, Jason N Berman, MD

Blood (2011) 118 (21): 3622.

https://doi.org/10.1182/blood.V118.21.3622.3622

Published: 2011

Journal Articles

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Maria Virgilio, Elspeth Payne, MB, ChB, Ph.D, Anupama Narla, MD, Hong Sun, MD, Barry H. Paw, M.D., Ph.D., Thomas Look, MD, Benjamin L. Ebert, MD, D.Phil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2011) 118 (21): 970.

https://doi.org/10.1182/blood.V118.21.970.970

Published: 2011

Journal Articles

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Casie Reed, BS, Scott J. Rodig, MD, PhD, Eleni Tholouli, PhD, MRCPath, Vu Ngo, PhD, Jeffery Lorne Kutok, MD, PhD, Suzanne E. Dahlberg, PhD, Lisa A Moreau, PhD, George Vande Woude, PhD, James Christensen, MD, Richard Byers, PhD, MBChB, FRCPath, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD., Ph.D., Thomas Look, MD

Blood (2011) 118 (21): 1405.

https://doi.org/10.1182/blood.V118.21.1405.1405

Published: 2011

Journal Articles

MYBL2 Is a Candidate Tumor Suppressor Gene In MDS

Stefan Heinrichs, Lily Conover, Carlos E. Bueso-Ramos, Outi Kilpivaara, Ross Levine, MD, Kristen Stevenson, Donna Neuberg, ScD, Rafael Bejar, MD, PhD, Benjamin L. Ebert, MD, DPhil, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 1865.

https://doi.org/10.1182/blood.V116.21.1865.1865

Published: 2010

Journal Articles

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Maria Virgilio, Elspeth Payne, MBChB, Anupama Narla, MD, Hong Sun, MD, Barry Paw, M.D., Ph.D., A. Thomas Look, MD, Benjamin L. Ebert, MD, DPhil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2010) 116 (21): 195.

https://doi.org/10.1182/blood.V116.21.195.195

Published: 2010

Journal Articles

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

Lynnie A. Rudner, AB, Kim H. Brown, PhD, Kimberly P. Dobrinski, PhD, Diana F. Bradley, BS, Jonathan Downie, BS, Nathan D. Meeker, MD, Alexandra Smith, BA, Martha Iveth Garcia, Alejandro Gutierrez, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, A. Thomas Look, MD, James R. Downing, MD, Joshua D. Schiffman, MD, Charles Lee, PhD, Nikolaus Trede, MD, PhD, J. Kimble Frazer, MD, PhD

Blood (2010) 116 (21): 1192.

https://doi.org/10.1182/blood.V116.21.1192.1192

Published: 2010

Journal Articles

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Julia Etchin, PhD, Alexei Protopopov, PhD, Jianhua Zhang, PhD, Lynda Chin, MD, Lewis B. Silverman, MD, Stuart Winter, MD, Stephen Hunger, MD, Stephen E. Sallan, MD, Shan Zha, PhD, Frederick Alt, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 4177.

https://doi.org/10.1182/blood.V116.21.4177.4177

Published: 2010

NARROW

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Targeting Oncogenic Interleukein-7 Receptor Signaling With N-Acetylcysteine In T-Cell Acute Lymphoblastic Leukemia

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

NUP98-HOXA9 drives High-Risk Myeloid Disease in Zebrafish – An In Vivo platform to Study Interacting Genes and Perform Drug Discovery,

L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

MYBL2 Is a Candidate Tumor Suppressor Gene In MDS

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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