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Tomohiro Hirade, MD
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Journal Articles

Flt3/ITD Confers Resistance to FLT3 Inhibitor AC220 By up-Regulating Runx1

Tomohiro Hirade, MD, Mariko Abe, MD, Chie Onishi, MD, Seiji Yamaguchi, MD PhD, Seiji Fukuda, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2223.
https://doi.org/10.1182/blood.V124.21.2223.2223
Published: 2014
Journal Articles

Myeloid Cells Having NUP98-HOX Fusion Genes with Simultaneous FLT3 , NRAS , or WT1 Mutations Confer Growth Advantage, Inhibit Differeniation/Apoptosis, and Augment Self-Renewal

Takeshi Taketani, MD PhD, Miho Hattori, Mariko Abe, MD, Tomohiro Hirade, MD, Seiji Fukuda, MD PhD, Seiji Yamaguchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 5199.
https://doi.org/10.1182/blood.V124.21.5199.5199
Published: 2014
Journal Articles

Flt3/ITD Enhances Hematopoietic Cell Migration Towards Chemokine CCL2 Independent of Blocking the Negative Feedback Mechanism on Rho-Associated Kinase

Seiji Fukuda, MD PhD, Chie Onishi, MD, Tomohiro Hirade, MD, Mariko Abe, MD, Takeshi Taketani, MD PhD, Seiji Yamaguchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3597.
https://doi.org/10.1182/blood.V124.21.3597.3597
Published: 2014
Journal Articles

Flt3/ITD Blocks Myeloid Differentiation Of Hematopoietic Cells By Up-Regulating Runx1

Tomohiro Hirade, MD, Mariko Abe, MD, Chie Onishi, MD, Seiji Yamaguchi, MD, Seiji Fukuda, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3808.
https://doi.org/10.1182/blood.V122.21.3808.3808
Published: 2013
Journal Articles

The Internal-Tandem-Duplication of Flt3 Mutation Generates Growth Inhibitory Signals in Mouse Hematopoietic Progenitor Cells by Down-Regulating Pbx1 Expression Via P21 cdkn1a .

Seiji Fukuda, MD, PhD, Mariko Abe, MD, Tomohiro Hirade, MD, Chie Onishi, MD, Louis M. Pelus, PhD, Seiji Yamaguchi, MD
Journal: Blood
Blood (2012) 120 (21): 2340.
https://doi.org/10.1182/blood.V120.21.2340.2340
Published: 2012
Journal Articles

The Internal-Tandem-Duplication of Flt3 Mutations Augment Chemotaxis in Hematopoietic Cells by Blocking the Down-Regulation of Rho-Associated Kinase That Is Induced by SDF1/CXCR4 Signaling

Chie Onishi, MD, Satomi Mori, MD, Tomohiro Hirade, MD, Mariko Abe, MD, Seiji Yamaguchi, MD, Reuben Kapur, PhD, Seiji Fukuda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1319.
https://doi.org/10.1182/blood.V120.21.1319.1319
Published: 2012