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Journal Articles

Myeloid-Specific SHP-2 Ablation Induces Robust Anti-Tumor Immunity That Is Not Further Enhanced By PD-1 Blockade

Anthos Christofides, MD, Natalia M Tijaro-Ovalle, MD, Halil-Ibrahim Aksoylar, PhD, Rinku Pal, MS, Abdelrahman AA Mahmoud, Laura Strauss, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-138975

Published: 2020

Journal Articles

Development of HHV-6-Specific Immunity after Cord Blood Transplantation in Adults Depends on Reconstitution of Thymopoiesis and Regeneration of CD4 + T Cells

Blood (2019) 134 (Supplement_1): 3275.

https://doi.org/10.1182/blood-2019-129154

Published: 2019

Journal Articles

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

Yavuz-Furkan Yazicioglu, Halil-Ibrahim Aksoylar, PhD, Rinku Pal, MS, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 864.

https://doi.org/10.1182/blood-2018-99-119450

Published: 2018

Journal Articles

The Two SH2 Domains of SHP-2 Bridge Two PD-1 Molecules Resulting in SHP-2 Activation and PD-1-Mediated Inhibition

Nikolaos Patsoukis, PhD, Jonathan Duke-Cohan, PhD, Apoorvi Chaudhri, Eunyoung Park, PhD, Council Asia, Anders Berg, MD PhD, Gordon J Freeman, PhD, Michael Eck, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 862.

https://doi.org/10.1182/blood-2018-99-117486

Published: 2018

Journal Articles

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

Laura Strauss, PhD, Jessica D Weaver, PhD, Rinku Pal, MS, John Asara, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 14.

https://doi.org/10.1182/blood-2018-99-117438

Published: 2018

Journal Articles

Assessment of a Multi-Cytokine Profile By a Novel Biochip-Based Assay Reveals Unique Correlation Patterns with Immune Reconstitution after Cord Blood Transplantation in Adults

Theodoros Karantanos, MD, Haesook T Kim, PhD, Lequn Li, MD PhD, Corey Cutler, MD MPH, FRCPC, Joseph H. Antin, MD, Karen Ballen, MD, Jerome Ritz, MD, Ioannis Politikos, MD, Vassiliki A Boussiotis, MD PhD

Blood (2017) 130 (Supplement 1): 1980.

https://doi.org/10.1182/blood.V130.Suppl_1.1980.1980

Published: 2017

Journal Articles

PD-1 Mediates Lineage Fate Determination and Function of Myeloid Cells in Response to Tumor-Mediated "Emergency" Myelopoiesis

Laura Strauss, PhD, Jessica D Weaver, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2017) 130 (Supplement 1): 445.

https://doi.org/10.1182/blood.V130.Suppl_1.445.445

Published: 2017

Journal Articles

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Christoph Herbel, PhD, Nikolaos Patsoukis, PhD, Jessica D Weaver, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 552.

https://doi.org/10.1182/blood.V128.22.552.552

Published: 2016

Journal Articles

Interaction of Both SH2 Domains of SHP-2 with a PD-1 Homodimer Is Required for PD-1-Mediated Inhibition of T Cell Responses

Nikolaos Patsoukis, PhD, Asia Council, Anders Berg, MD PhD, Kankana Bardhan, PhD, Jessica D Weaver, PhD, Kathleen M. Mahoney, MD PhD, Gordon J. Freeman, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 859.

https://doi.org/10.1182/blood.V128.22.859.859

Published: 2016

Journal Articles

Rap1-GTP Augments TGF-b-Mediated Signaling in T Lymphocytes Via a Mechanism Dependent on the b Chain of LFA-1 Integrin

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Alexandra Plessa, Niko Tsopoulidis, Duygu Sari, Lequn Li, MD PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2015) 126 (23): 3422.

https://doi.org/10.1182/blood.V126.23.3422.3422

Published: 2015

Journal Articles

PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Duygu Sari, Theodore Anagnostou, Pranam Chatterjee, Gordon J. Freeman, PhD, Lequn Li, MD PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2015) 126 (23): 283.

https://doi.org/10.1182/blood.V126.23.283.283

Published: 2015

Journal Articles

RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Donna M Berry, Jane McGlade, Vassiliki A. Boussiotis, MD PhD

Blood (2014) 124 (21): 4138.

https://doi.org/10.1182/blood.V124.21.4138.4138

Published: 2014

Journal Articles

Phosphorylation of Tyrosine 340 in the Plekstrin Homology Domain of RIAM Is Required for Translocation of RIAM to the Plasma Membrane, Phosphorylation of RIAM-Associated PLC-g1 and LFA-1 Activation

Duygu Sari, Niko Tsopoulidis, John M. Asara, PhD, Nikolaos Patsoukis, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2014) 124 (21): 2743.

https://doi.org/10.1182/blood.V124.21.2743.2743

Published: 2014

Journal Articles

Prognostic Value of TREC, IL-7 and SCF Levels on Clinical Outcomes after Double Umbilical Cord Blood Transplantation in Adults

Ioannis Politikos, MD, Haesook T. Kim, PhD, Sarah Nikiforow, MD PhD, Lequn Li, MD PhD, Karen K. Ballen, MD, Joseph H. Antin, MD, Jerome Ritz, MD, Corey S Cutler, MD MPH, Vassiliki A. Boussiotis, MD PhD

Blood (2014) 124 (21): 2488.

https://doi.org/10.1182/blood.V124.21.2488.2488

Published: 2014

Journal Articles

Delayed Platelet Engraftment after Umbilical Cord Blood Transplant: Relationship to Circulating Levels of Thrombopoietin

Blood (2014) 124 (21): 3862.

https://doi.org/10.1182/blood.V124.21.3862.3862

Published: 2014

Journal Articles

Clinical Trial Evaluating DC/AML Fusion Cell Vaccination In AML Patients

Blood (2013) 122 (21): 3928.

https://doi.org/10.1182/blood.V122.21.3928.3928

Published: 2013

Journal Articles

Reconstitution Of EBV-Specific Immunity In Adult Recipients Of Double Cord Blood Transplantation Depends On SCF and IL-7 Levels and Maintenance Of a Diverse TCR Repertoire

Ioannis Politikos, MD, Haesook Kim, PhD, Sarah Nikiforow, MD, PhD, Anoma Nellore, MD, Lequn Li, MD, PhD, Sean McDonough, Robert J. Soiffer, MD, Joseph H. Antin, MD, Karen K. Ballen, MD, Corey S. Cutler, MD, MPH, FRCPC, Jerome Ritz, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 3302.

https://doi.org/10.1182/blood.V122.21.3302.3302

Published: 2013

Journal Articles

Inhibition Of Cdk2 Promotes The Generation Of Inducible CD8 + T Regulatory Cells By Modulating The Epigenetic Regulator EZH2

Lequn Li, MD, PhD, Nikolaos Patsoukis, PhD, Anoma Nellore, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 138.

https://doi.org/10.1182/blood.V122.21.138.138

Published: 2013

Journal Articles

Distinct Roles Of PD-1 Itsm and ITIM In Regulating Interactions With SHP-2, ZAP-70 and Lck, and PD-1-Mediated Inhibitory Function

Pranam Chatterjee, Nikolaos Patsoukis, PhD, Gordon J. Freeman, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 191.

https://doi.org/10.1182/blood.V122.21.191.191

Published: 2013

Journal Articles

PD-1 Induces Metabolic Reprogramming Of Activated T Cells From Glycolysis To Lipid Oxidation

Nikolaos Patsoukis, PhD, Pranam Chatterjee, Duygu Sari, Victoria Petkova, Lequn Li, MD, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 187.

https://doi.org/10.1182/blood.V122.21.187.187

Published: 2013

NARROW

Myeloid-Specific SHP-2 Ablation Induces Robust Anti-Tumor Immunity That Is Not Further Enhanced By PD-1 Blockade

Development of HHV-6-Specific Immunity after Cord Blood Transplantation in Adults Depends on Reconstitution of Thymopoiesis and Regeneration of CD4 + T Cells

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

The Two SH2 Domains of SHP-2 Bridge Two PD-1 Molecules Resulting in SHP-2 Activation and PD-1-Mediated Inhibition

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

Assessment of a Multi-Cytokine Profile By a Novel Biochip-Based Assay Reveals Unique Correlation Patterns with Immune Reconstitution after Cord Blood Transplantation in Adults

PD-1 Mediates Lineage Fate Determination and Function of Myeloid Cells in Response to Tumor-Mediated "Emergency" Myelopoiesis

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Interaction of Both SH2 Domains of SHP-2 with a PD-1 Homodimer Is Required for PD-1-Mediated Inhibition of T Cell Responses

Rap1-GTP Augments TGF-b-Mediated Signaling in T Lymphocytes Via a Mechanism Dependent on the b Chain of LFA-1 Integrin

PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck

RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1

Phosphorylation of Tyrosine 340 in the Plekstrin Homology Domain of RIAM Is Required for Translocation of RIAM to the Plasma Membrane, Phosphorylation of RIAM-Associated PLC-g1 and LFA-1 Activation

Prognostic Value of TREC, IL-7 and SCF Levels on Clinical Outcomes after Double Umbilical Cord Blood Transplantation in Adults

Delayed Platelet Engraftment after Umbilical Cord Blood Transplant: Relationship to Circulating Levels of Thrombopoietin

Clinical Trial Evaluating DC/AML Fusion Cell Vaccination In AML Patients

Reconstitution Of EBV-Specific Immunity In Adult Recipients Of Double Cord Blood Transplantation Depends On SCF and IL-7 Levels and Maintenance Of a Diverse TCR Repertoire

Inhibition Of Cdk2 Promotes The Generation Of Inducible CD8 + T Regulatory Cells By Modulating The Epigenetic Regulator EZH2

Distinct Roles Of PD-1 Itsm and ITIM In Regulating Interactions With SHP-2, ZAP-70 and Lck, and PD-1-Mediated Inhibitory Function

PD-1 Induces Metabolic Reprogramming Of Activated T Cells From Glycolysis To Lipid Oxidation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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