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William F. DeGrado, Ph.D.
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Journal Articles

Activating Individual αIIbβ3 Molecules Using An Anti-αIIb-Transmembrane Domain Peptide Causes αIIbβ3 Oligomerization and αIIbβ3-Mediated Outside-In Signaling

Hua Zhu, BS, David T. Moore, M.D, Ph.D, William F. DeGrado, Ph.D., Joel S. Bennett, MD
Journal: Blood
Blood (2013) 122 (21): 3506.
https://doi.org/10.1182/blood.V122.21.3506.3506
Published: 2013
Journal Articles

Analysis of β3 Binding to the c-Src SH3 Domain

Patrik Nygren, Ph.D., Lisa M. Span, David T. Moore, M.D, Ph.D, Hong Cheng, Ph.D., Heinrich Roder, PhD, William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2012) 120 (21): 383.
https://doi.org/10.1182/blood.V120.21.383.383
Published: 2012
Journal Articles

Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation

Craig N. Streu, Ph.D., Patrik Nygren, Ph.D., Paul C. Billings, Ph.D., David T. Moore, B.S., M.S., Kathleen S. Molnar, B.S.E., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2011) 118 (21): 1255.
https://doi.org/10.1182/blood.V118.21.1255.1255
Published: 2011
Journal Articles

Assessing the Biochemistry of Kindlin-3 In Human Platelets

Craig N. Streu, Ph.D., David Thomas Moore, B.S., M.S., Paul C. Billings, Ph.D., Patrik Nygren, Ph.D., Karen P. Fong, Ph.D., Douglas G. Metcalf, Ph.D., Yibing Wu, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, MD
Journal: Blood
Blood (2010) 116 (21): 2011.
https://doi.org/10.1182/blood.V116.21.2011.2011
Published: 2010
Journal Articles

Arylamides: Discovery of a Novel Class of Fully-Synthetic Small Molecule Heparin and LMWH Antagonists.

Richard W. Scott, Ph.D., Michael J. Costanzo, Ph.D., Katie B. Freeman, Ph.D., Robert W. Kavash, Ph.D., Trevor M. Young, William F. DeGrado, Ph.D., Walter Jeske, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 1096.
https://doi.org/10.1182/blood.V116.21.1096.1096
Published: 2010
Journal Articles

Optimized Fully-Synthetic Salicylamide Heparin Antagonists Have Greater Efficacy Versus LMWHs and Display Improved Hemodynamic Responses as Compared to Protamine

Richard W. Scott, Ph.D., Michael J. Costanzo, Ph.D., Katie B. Freeman, Ph.D., Robert W. Kavash, Ph.D., Trevor M. Young, William F. DeGrado, Ph.D., Walter Jeske, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 191.
https://doi.org/10.1182/blood.V116.21.191.191
Published: 2010
Journal Articles

Characterization of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer by NMR.

Douglas G. Metcalf, BS, Joseph M. Kielec, B.S., B.A., Kathleen G. Valentine, Ph.D., A. Joshua, Wand, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2007) 110 (11): 415.
https://doi.org/10.1182/blood.V110.11.415.415
Published: 2007
Journal Articles

Identification of Oligomerization Motifs in the β3 Transmembrane Domain.

Hua Zhu, BS, Douglas G. Metcalf, B.S., Wei Li, M.D., Roman Gorelik, B.S., Cinque Soto, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2007) 110 (11): 416.
https://doi.org/10.1182/blood.V110.11.416.416
Published: 2007
Journal Articles

The Design and Synthesis of Small Molecule Inhibitors of Collagen Binding to Integrin α2β1 as Antithrombotic Agents.

Meredith W. Miller, BS, Soni Basra, Ph.D., Paul C. Billings, Ph.D., Jamie Gewirtz, B.A., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2007) 110 (11): 306.
https://doi.org/10.1182/blood.V110.11.306.306
Published: 2007
Journal Articles

The Leech Product Saratin Is a Potent Inhibitor of Both VWF and Integrin α 2 β 1 Binding to Collagen.

Tara C. White, BS, David K. Robinson, Hang Yin, Ph.D., William F. DeGrado, Ph.D., Stephen R. Hanson, Ph.D., Owen J.T. McCarty, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3928.
https://doi.org/10.1182/blood.V108.11.3928.3928
Published: 2006
Journal Articles

Heteromeric and Homomeric Transmembrane Domain Associations Regulate αIIbβ3 Function.

Wei Li, M.D., Douglas Metcalf, B.S., Roman Gorelik, B.S., Renhao Li, Ph.D., Neal Mitra, B.S., Vikas Nanda, Ph.D., Peter B. Law, B.S., James D. Lear, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.
Journal: Blood
Blood (2004) 104 (11): 329.
https://doi.org/10.1182/blood.V104.11.329.329
Published: 2004