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Journal Articles

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

Lian Xu, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Sandra Kanan, NP, Jiaji G Chen, Neil I Lindeman, MD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 3024.

https://doi.org/10.1182/blood.V122.21.3024.3024

Published: 2013

Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4255.

https://doi.org/10.1182/blood.V122.21.4255.4255

Published: 2013

Journal Articles

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

Yang Cao, MD, Lian Xu, Xia Liu, MD, Yangsheng Zhou, MD, Guang Yang, MD, Christopher J Patterson, Steven Peter Treon, MD, MA, PhD, Zachary Hunter

Blood (2012) 120 (21): 2715.

https://doi.org/10.1182/blood.V120.21.2715.2715

Published: 2012

Journal Articles

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Yang Cao, MD, Christopher J Patterson, Yu-Tzu Tai, PhD, Kenneth C. Anderson, Zachary Hunter, Steven P. Treon, M.D., Ph.D.

Blood (2012) 120 (21): 897.

https://doi.org/10.1182/blood.V120.21.897.897

Published: 2012

Journal Articles

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

Lian Xu, Aliyah R. Sohani, MD, Luca Arcaini, MD, Zachary Hunter, Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Robert Manning, Christopher J Patterson, Leukothea Ioakimidis, Christina Tripsas, Geraldine S. Pinkus, MD, Nancy Lee Harris, MD, Scott J. Rodig, MD, PhD, Steven Treon, MD, PhD

Blood (2011) 118 (21): 261.

https://doi.org/10.1182/blood.V118.21.261.261

Published: 2011

Journal Articles

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Yang Cao, MD, Zachary Hunter, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Lian Xu, Christopher Patterson, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 3957.

https://doi.org/10.1182/blood.V118.21.3957.3957

Published: 2011

Journal Articles

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Guang Yang, PhD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 86.

https://doi.org/10.1182/blood.V118.21.86.86

Published: 2011

Journal Articles

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Zachary Hunter, Lian Xu, Yangsheng Zhou, MD, Guang Yang, PhD, Xia Liu, MD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 434.

https://doi.org/10.1182/blood.V118.21.434.434

Published: 2011

Journal Articles

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Steven P Treon, MD, PhD, Lian Xu, Yangsheng Zhou, MD, Xia Liu, MD, Guang Yang, PhD, Yang Cao, MD, Christina Hanzis, Patricia Sheehy, NP, Robert Manning, Christopher J Patterson, Jason M Laramie, PhD, Donald A Skifter, PhD, Stephen E Lincoln, PhD, Zachary Hunter

Blood (2011) 118 (21): 300.

https://doi.org/10.1182/blood.V118.21.300.300

Published: 2011

Journal Articles

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Guang Yang, PhD, Yangsheng Zhou, MD, Xia Liu, MD, Yang Cao, MD, Zachary Hunter, Steven P Treon, MD, PhD

Blood (2011) 118 (21): 597.

https://doi.org/10.1182/blood.V118.21.597.597

Published: 2011

Journal Articles

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

Lian Xu, Christopher Patterson, Jenny Sun, MD, Guang Yang, MD, Yangsheng Zhou, MD, Zachary Hunter, Bryan Ciccarelli, Robert Manning, Xia Liu, MD, Yang Cao, MD, Hsiuyi Tseng, Leukothea Ioakimidis, Christina Hanzis, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2991.

https://doi.org/10.1182/blood.V116.21.2991.2991

Published: 2010

Journal Articles

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

Guang Yang, MD, Lian Xu, Zachary Hunter, Xia Liu, MD, Yang Cao, MD, Jingrui Jiang, Hsiuyi Tseng, Yangsheng Zhou, MD, Leukothea Ioakimidis, Christina Hanzis, Patricia Sheehy, NP, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 2870.

https://doi.org/10.1182/blood.V116.21.2870.2870

Published: 2010

Journal Articles

Involvement of Ets Factor Spi-B and Id2 In Waldenström's Macroglobulinemia

Yangsheng Zhou, MD, Xia Liu, MD, Lian Xu, Zachary Hunter, Jenny Sun, MD, Guang Yang, MD, Bryan Ciccarelli, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 129.

https://doi.org/10.1182/blood.V116.21.129.129

Published: 2010

Journal Articles

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

Zachary Hunter, Yang Cao, MD, Megan Lewicki, Jenny Sun, MD, Hsiuyi Tseng, Christina Hanzis, Philip Brodsky, Robert Manning, Lian Xu, Guang Yang, MD, Yangsheng Zhou, MD, Xia Liu, MD, Jingrui Jiang, Christopher Patterson, Steven P. Treon, MD, PhD

Blood (2010) 116 (21): 1912.

https://doi.org/10.1182/blood.V116.21.1912.1912

Published: 2010

Journal Articles

IgA and IgG Hypogammaglobulinemia Does Not Predict for Recurrent Infection Risk and Persists Despite Therapeutic Response in Patients with Waldentrom's Macroglobulinemia.

Zachary Hunter, Robert Manning, Christina Hanzis, Bryan Ciccarelli, Thea Ioakimidis, MS, Christopher J Patterson, Megan Lewicki, Hsuiyi Tseng, Ping Gong, Xia Liu, MD, Yangsheng Zhou, MD, PhD, Guang Yang, PhD, Jenny Sun, MD, Lian Xu, Patricia Sheehy, NP, Massimo Morra, MD, Steven Treon, MD, PhD

Blood (2009) 114 (22): 1947.

https://doi.org/10.1182/blood.V114.22.1947.1947

Published: 2009

Journal Articles

Genome Wide Association Studies of Familial Waldenstrom's Macroglobulinemia (WM) Reveals a Loss of GSTM1 Is Common in Families with a History of B-Cell Disorders but Not in Those with a History Specific for WM.

Zachary Hunter, Christina Hanzis, Thea Ioakimidis, MS, Christopher J Patterson, Bryan Ciccarelli, Megan Lewicki, Robert Manning, Lian Xu, Xia Liu, Hsiuyi Tseng, Ping Gong, Jenny Sun, MD, Yangsheng Zhou, MD, PhD, Guang Yang, PhD, Patricia Sheehy, NP, Edward A. Fox, PhD, Steven Treon, MD, PhD

Blood (2009) 114 (22): 762.

https://doi.org/10.1182/blood.V114.22.762.762

Published: 2009

Journal Articles

Metalloproteinase Inhibitors Inhibit the Release of Soluble CD27 by Waldenström's Macroglobulinemia Cells.

Yangsheng Zhou, MD, PhD, Xia Liu, Ping Gong, Lian Xu, Bryan Ciccarelli, Guang Yang, PhD, Christopher J Patterson, Steven Treon, MD, PhD

Blood (2009) 114 (22): 3942.

https://doi.org/10.1182/blood.V114.22.3942.3942

Published: 2009

Journal Articles

Involvement of Fatty Acid Synthase in Azacytidine-Induced Cytotoxicity in Waldenstrom's Macroglobulinemia.

Lian Xu, Christopher J Patterson, Jenny Sun, MD, Guang Yang, PhD, Yangsheng Zhou, MD, PhD, Zachary Hunter, Evdoxia Hatjiharissi, MD, Bryan Ciccarelli, Ping Gong, Xia Liu, Hsiuyi Tseng, Thea Ioakimidis, MS, Robert Manning, Christina Hanzis, Yang Cao, Megan Lewicki, Steven Treon, MD, PhD

Blood (2009) 114 (22): 3731.

https://doi.org/10.1182/blood.V114.22.3731.3731

Published: 2009

Journal Articles

The Inhibitory Receptor FcgRIIB Is Overexpressed, and Its Ligation by Anti- FcgRIIB Antibodies Suppresses IgM Production and Induces Apoptosis in Waldenstrom's Macroglobulinemia.

Guang Yang, PhD, Ping Gong, Lian Xu, Zachary Hunter, Jenny Sun, MD, Bryan Ciccarelli, Yangsheng Zhou, MD, PhD, Xia Liu, Hsiuyi Tseng, Yang Cao, Robert Manning, Megan Lewicki, Christina Hanzis, Thea Ioakimidis, MS, Patricia Sheehy, NP, Christopher J Patterson, Steven Treon, MD, PhD

Blood (2009) 114 (22): 3736.

https://doi.org/10.1182/blood.V114.22.3736.3736

Published: 2009

Journal Articles

Vorinostat Induced Cellular Stress Disrupts the Balance Between p38 MAPK and Erk Pathways Leading to Apoptosis in WM Cells.

Jenny Sun, MD, Hsiuyi Tseng, Lian Xu, Zachary Hunter, Bryan Ciccarelli, Mariateresa Fulciniti, Guang Yang, PhD, Ping Gong, Yangsheng Zhou, MD, PhD, Xia Liu, Nikhil C. Munshi, Christopher J Patterson, Steven Treon, MD, PhD

Blood (2009) 114 (22): 3740.

https://doi.org/10.1182/blood.V114.22.3740.3740

Published: 2009

NARROW

Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström's Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom's Macroglobinemia.

MYD88 L265P Promotes Survival of Waldenstrom's Macroglobulinemia Cells by Activation of Bruton's Tyrosine Kinase

A Somatic Variant in MYD88 (L265P) Revealed by Whole Genome Sequencing Differentiates Lymphoplasmacytic Lymphoma From Marginal Zone Lymphomas

MicroRNA-21 and −155 Are Induced by a Widely Expressed Mutation in MyD88 (L265P) in Waldenstrom's Macroglobulinemia,

Aberrant Expression of Oct-2, Spi-B, and Id2/Id1 Is Associated with Repression of Plasma Cell Differentiation in Waldenström's Macroglobulinemia

Whole-Genome Sequencing Results From 30 Patients with Waldenstrom's Macroglobulinemia

Whole Genome Sequencing Reveals a Widely Expressed Mutation (MYD88 L265P) with Oncogenic Activity in Waldenstrom's Macroglobulinemia

Disruption of MYD88 Pathway Signaling Leads to Loss of Constitutive IRAK1, NF-κβ and JAK/STAT Signaling and Induces Apoptosis of Cells Expressing the MYD88 L265P Mutation in Waldenstrom's Macroglobulinemia

Involvement of Lipogenic Pathway In 5-Azacytidine-Induced Cytotoxicity In Waldenstrom's Macroglobulinemia

The Rituximab and IVIG Related IgM Flare In Waldenstrom's Macroglobulinemia Is Associated with Monocytic Activation of Fcgriia Signaling, and Triggering of IL-6 Release by the PI3K/AKT and MAPK Pathways

Involvement of Ets Factor Spi-B and Id2 In Waldenström's Macroglobulinemia

Aberrant Expression of Regulatory miRNAs and Transcripts for IRS-PI3K Growth and Survival Signaling In Waldenstrom's Macroglobulinemia

IgA and IgG Hypogammaglobulinemia Does Not Predict for Recurrent Infection Risk and Persists Despite Therapeutic Response in Patients with Waldentrom's Macroglobulinemia.

Genome Wide Association Studies of Familial Waldenstrom's Macroglobulinemia (WM) Reveals a Loss of GSTM1 Is Common in Families with a History of B-Cell Disorders but Not in Those with a History Specific for WM.

Metalloproteinase Inhibitors Inhibit the Release of Soluble CD27 by Waldenström's Macroglobulinemia Cells.

Involvement of Fatty Acid Synthase in Azacytidine-Induced Cytotoxicity in Waldenstrom's Macroglobulinemia.

The Inhibitory Receptor FcgRIIB Is Overexpressed, and Its Ligation by Anti- FcgRIIB Antibodies Suppresses IgM Production and Induces Apoptosis in Waldenstrom's Macroglobulinemia.

Vorinostat Induced Cellular Stress Disrupts the Balance Between p38 MAPK and Erk Pathways Leading to Apoptosis in WM Cells.

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American Society of Hematology

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American Society of Hematology

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