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Journal Articles

Targeting Myeloma Cell Metabolism Via Disruption of the Lnc-17-92 Transcriptional Program: Druggable New Vulnerability in Multiple Myeloma

Eugenio Morelli, MD, Mariateresa Fulciniti, PhD, Mehmet Kemal Samur, PhD, Caroline Ribeiro, PhD, Leon Wert-Lamas, PhD, Annamaria Gulla, MD, Anil Aktas Samur, PhD, Cinzia Federico, PhD, Francesca Scionti, PhD, Yao Yao, PhD, Nicola Amodio, PhD, Giada Bianchi, MD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD, Carl D. Novina, MD PhD, Massimo Loda, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 317.
https://doi.org/10.1182/blood-2019-130730
Published: 2019
Journal Articles

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Daniel Thomas, MD PhD, Yusuke Nakauchi, MD PhD, Manhong Wu, PhD, Ming Zheng, PhD, Subarna Sinha, PhD, David Dill, PhD, Gary Peltz, MD PhD, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 440.
https://doi.org/10.1182/blood-2018-99-115040
Published: 2018
Journal Articles

Functional Role of Linc-RNAs in Multiple Myeloma: Linc-MIR17HG Affects Fatty Acid Biosynthesis Via transcriptional Regulation of ACC1 with Potential Therapeutic Implications

Eugenio Morelli, MD, Mariateresa Fulciniti, PhD, Mehmet Kemal Samur, PhD, Francesca Scionti, Annamaria Gulla, MD, Nicola Amodio, PhD, Giada Bianchi, MD, Tommaso Perini, MD, Cinzia Federico, PhD, Michael A Lopez, Maria Teresa Di Martino, Pierosandro Tagliaferri, Pierfrancesco Tassone, MD, Kenneth Anderson, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1925.
https://doi.org/10.1182/blood-2018-99-119572
Published: 2018
Journal Articles

Phosphoproteomic Profiling Reveals Metabolic Factors Facilitating Leukemia-Stroma Crosstalk in Acute Myeloid Leukemia

Liliana H Mochmann, PhD, Denise Treue, PhD, Michael Bockmayr, MD, Eva Kristin Von Der Heide, PhD, Patricia Silva, MS, Konstandina Isaakidis, Caroline Busch, MS, Hifza Siddiq, Martin Neumann, Lars Fransecky, MD, Frederick Klauschen, MD, Claudia D. Baldus, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2695.
https://doi.org/10.1182/blood.V130.Suppl_1.2695.2695
Published: 2017
Journal Articles

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Steven M. Chan, MD PhD, Manhong Wu, Damoun Torabi, Gary Peltz, MD PhD, Yang Gao, David L Dill, PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1054.
https://doi.org/10.1182/blood.V128.22.1054.1054
Published: 2016
Journal Articles

Boolean Implication Mining for Synthetic Lethal Interactions in AML Identifies Acetyl-CoA Carboxylase As a Synthetic Lethal Partner of the IDH1 mutation

Subarna Sinha, PhD, Daniel Thomas, MD PhD, Steven M. Chan, MD PhD, Yang Gao, Rolf Jansen, PhD, Ravi Majeti, MD PhD, David L Dill, PhD
Journal: Blood
Blood (2015) 126 (23): 1404.
https://doi.org/10.1182/blood.V126.23.1404.1404
Published: 2015
Journal Articles

Metformin Exerts Anti-Leukemic Effects Via Direct Inhibition Of Oncogenic Kinase Activity In Leukemia Cells Derived From Myeloproliferative Neoplasms

Ichiro Kawashima, MD, Keita Kirito, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2853.
https://doi.org/10.1182/blood.V122.21.2853.2853
Published: 2013
Journal Articles

Altered Lipid and Mitochondrial Metabolism Are Viable Targets in Acute Leukemia,

Timothy Pardee, MD, PhD, Laura M DeFord-Watts, PhD, Erica Peronto, BS, Denise A Levitan, MD, David Duane Hurd, MD, Steven Kridel, PhD
Journal: Blood
Blood (2011) 118 (21): 3618.
https://doi.org/10.1182/blood.V118.21.3618.3618
Published: 2011