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Journal Articles

In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg Mice

Yuanbin Song, MD, Liang Shan, PhD, Rana Gbyli, MS, Wei Liu, PhD, Xiaoying Fu, MD, Xiaman Wang, MD PhD, Ashley Qin, Amisha Patel, MS, Yimeng Gao, PhD, Toma Tebaldi, PhD, Giulia Biancon, PhD, David Urbonas, Jonathan Alderman, PhD, Stephanie Halene, MD, Richard Flavell, PhD

Blood (2019) 134 (Supplement_1): 338.

https://doi.org/10.1182/blood-2019-130701

Published: 2019

Journal Articles

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

Yongsen Zhao, Dharaben Patel, MS, Jane A Thanassi, BS, Mingjun Huang, PhD, Steven D Podos, PhD

Blood (2019) 134 (Supplement_1): 5763.

https://doi.org/10.1182/blood-2019-132253

Published: 2019

Journal Articles

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Autoimmune Hemolytic Anemia (AIHA)

Federico Grossi, MD, Merrill Kingman Shum, MD, Morie A. Gertz, MD, Eloy Roman, MD, Pascal Deschatelets, PhD, Mohamed Hamdani, MS, Frank Stout, Cedric G Francois, MD PhD

Blood (2018) 132 (Supplement 1): 3623.

https://doi.org/10.1182/blood-2018-99-119468

Published: 2018

Journal Articles

Complement-Mediated Thrombotic Microangiopathy: A Murky Presentation of a Rare Disease Entity

Patrick Fleming, MD, Maggie Cheung, MD, David Sokol, MD

Blood (2018) 132 (Supplement 1): 5005.

https://doi.org/10.1182/blood-2018-99-119893

Published: 2018

Journal Articles

Patient with Myeloma Who Develops Thrombotic Microangiopathy without Hemolysis

Juliana Alvarez Argote, MD

Blood (2018) 132 (Supplement 1): 5661.

https://doi.org/10.1182/blood-2018-99-117095

Published: 2018

Journal Articles

In Vitro Combination Studies of ACH-4471 with Eculizumab to Assess a Potential "Switch" Treatment Approach for Paroxysmal Nocturnal Hemoglobinuria

Dharaben Patel, MS, Jane A Thanassi, BS, Guangwei Yang, PhD, Xuan Yuan, MD MSc, Robert A. Brodsky, MD, Mingjun Huang, PhD, Steven D Podos, PhD

Blood (2017) 130 (Supplement 1): 2198.

https://doi.org/10.1182/blood.V130.Suppl_1.2198.2198

Published: 2017

Journal Articles

C3 Modulates RBC Antigen to Negatively Regulate Antibody Response

Amanda Mener, Connie M. Arthur, PhD, Seema R. Patel, PhD, Sean R. Stowell, MD PhD

Blood (2016) 128 (22): 22.

https://doi.org/10.1182/blood.V128.22.22.22

Published: 2016

Journal Articles

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

Federico V Grossi, MDPhD, Pauline Bedwell, Pascal Deschatelets, PhD, Lil Edis, PhD, Cedric G Francois, MDPhD, Patrick J Johnson, PhD, Helen J Richardson, Lisa Tan, Carolina A Vega, Jason Lickliter, MBBS,PhD

Blood (2016) 128 (22): 1251.

https://doi.org/10.1182/blood.V128.22.1251.1251

Published: 2016

Journal Articles

Three Cases of Patients with Complement Regulatory Factor Genetic Mutations and Acquired Thrombotic Thrombocytopenic Purpura (TTP)

Shebli Atrash, MD, David Kent McKelvey, MD, Appalanaidu Sasapu, MD MS, Muthu Veeraputhiran, MD MPH, Soumya Pandey, MD, Michele H. Cottler-Fox, MD, Pooja Motwani, MD

Blood (2016) 128 (22): 1362.

https://doi.org/10.1182/blood.V128.22.1362.1362

Published: 2016

Journal Articles

A Novel Case of Direct Antiglobulin Test-Negative Intravascular Hemolysis in a Patient with Smoldering Myeloma

Selina Dobing, MD BSc, Nikolas Desilet, MD BSc, Irwindeep Sandhu, MD, Lauren Bolster, MD MD FRCPC

Blood (2015) 126 (23): 4539.

https://doi.org/10.1182/blood.V126.23.4539.4539

Published: 2015

Journal Articles

Novel Genetic Variants in Complement-Mediated Thrombotic Microangiopath

Blood (2015) 126 (23): 1050.

https://doi.org/10.1182/blood.V126.23.1050.1050

Published: 2015

Journal Articles

Large Granular Lymphocyte Infiltration in the Bone Marrow in Children and Young Adults May Suggest Primary Immune Deficiency

Mervi H Taskinen, MD PhD, Satu Mustjoki, MD PhD, Kirsi Jahnukainen, MD PhD, Luca Trotta, MSc, Timo Siitonen, MD PhD, Timo Hautala, MD PhD, Andrey Zavialov, PhD, Kaarina Heiskanen, MD PhD, Emma M Haapaniemi, MD PhD, Janna Saarela, MD PhD, Mikko Seppänen, MD PhD

Blood (2015) 126 (23): 1024.

https://doi.org/10.1182/blood.V126.23.1024.1024

Published: 2015

Journal Articles

Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance

Qi Cao, doctor, Xuan Zhao, Doctor, Sigal Gery, Doctor, Zhengshan Chen, PhDMD, Ruishu Deng, MD PhD, Haibo Sun, Doctor, De-chen Lin, Doctor, Zhiqiang Zhao, Doctor, Jonathan W Said, MD, Quan-zhen Li, Doctor, Markus Muschen, MDPhD, Ronald M. Evans, PhD, H. Phillip Koeffler, MD PhD

Blood (2015) 126 (23): 1029.

https://doi.org/10.1182/blood.V126.23.1029.1029

Published: 2015

Journal Articles

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

Elizabeth C. Schramm, Lubka T. Roumenina, Tania Rybkine, Sophie Chauvet, Paula Vieira-Martins, Christophe Hue, Tara Maga, Elisabetta Valoti, Valerie Wilson, Sakari Jokiranta, Richard J. H. Smith, Marina Noris, Tim Goodship, John P. Atkinson, Veronique Fremeaux-Bacchi

Blood (2015) 125 (15): 2359–2369.

https://doi.org/10.1182/blood-2014-10-609073

Published: 2015

Includes: Supplemental data

Journal Articles

Mutations in complement C3 from aHUS patients

Gregers R. Andersen

Blood (2015) 125 (15): 2316–2318.

https://doi.org/10.1182/blood-2015-02-625285

Published: 2015

Journal Articles

Complement Component 3 (C3) Is a Mediator of Epithelial-Mesenchymal Transition (EMT)

Min Soon Cho, PhD, Qianghua Hu, PhD, Rajesha Rupaimoole, M.S., Anil Sood, MD, Vahid Afshar-Kharghan, MD

Blood (2014) 124 (21): 1421.

https://doi.org/10.1182/blood.V124.21.1421.1421

Published: 2014

Journal Articles

Neutropenia during Hematopoietic Stem Cell Mobilization with G-CSF

Lezhong Yuan, MD, Hui Liu, Qiang Wang, Jing Sun, MD, Qifa Liu, MD, Hao Huang, MD, Yanyan Ye, Qianli Jiang, PhDMD

Blood (2014) 124 (21): 5835.

https://doi.org/10.1182/blood.V124.21.5835.5835

Published: 2014

Journal Articles

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Daniel Ricklin, Ph.D., Antonio M. Risitano, MD, PhD, Edimara S. Reis, Ph.D., Patrizia Ricci, Yijun Huang, Ph.D., Zhuoer Lin, Ph.D., Hui Chen, Ph.D., Caterina Pascariello, Maddalena Raia, Luigi Del Vecchio, MD, Fabrizio Pane, MD, Ranillo R. G. Resuello, D.V.M., Robert A. DeAngelis, Ph.D., John D. Lambris, Ph.D.

Blood (2013) 122 (21): 1239.

https://doi.org/10.1182/blood.V122.21.1239.1239

Published: 2013

Journal Articles

“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”

Praveen Kaudlay, MBBS, MRCP, Haiying Hua, MD, Guansheng He, MD, Darren J Newton, PhD, Abraham M Varghese, MB ChB, Talha Munir, MBBS, MRCP, FRCPath, Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Stephen John Richards, PhD, Peter Hillmen, MB ChB, PhD

Blood (2013) 122 (21): 2466.

https://doi.org/10.1182/blood.V122.21.2466.2466

Published: 2013

Journal Articles

Complement Component 3 (C3) Is Transcriptionally Regulated By TWIST1

Min Soon Cho, Ph.D, Rajesha Rupaimoole, M.S., Anil Sood, MD, Vahid Afshar-Kharghan, MD

Blood (2013) 122 (21): 1046.

https://doi.org/10.1182/blood.V122.21.1046.1046

Published: 2013

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In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg Mice

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Autoimmune Hemolytic Anemia (AIHA)

Complement-Mediated Thrombotic Microangiopathy: A Murky Presentation of a Rare Disease Entity

Patient with Myeloma Who Develops Thrombotic Microangiopathy without Hemolysis

In Vitro Combination Studies of ACH-4471 with Eculizumab to Assess a Potential "Switch" Treatment Approach for Paroxysmal Nocturnal Hemoglobinuria

C3 Modulates RBC Antigen to Negatively Regulate Antibody Response

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

Three Cases of Patients with Complement Regulatory Factor Genetic Mutations and Acquired Thrombotic Thrombocytopenic Purpura (TTP)

A Novel Case of Direct Antiglobulin Test-Negative Intravascular Hemolysis in a Patient with Smoldering Myeloma

Novel Genetic Variants in Complement-Mediated Thrombotic Microangiopath

Large Granular Lymphocyte Infiltration in the Bone Marrow in Children and Young Adults May Suggest Primary Immune Deficiency

Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

Mutations in complement C3 from aHUS patients

Complement Component 3 (C3) Is a Mediator of Epithelial-Mesenchymal Transition (EMT)

Neutropenia during Hematopoietic Stem Cell Mobilization with G-CSF

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”

Complement Component 3 (C3) Is Transcriptionally Regulated By TWIST1

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American Society of Hematology

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