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Journal Articles

A Highly Robust Model for Predicting Outcome of Multiple Myeloma Patients By Inferring Patient-Specific Transcription Factor Activity

Chuanpeng Dong, MS, Christina Y Yu, BSc, Travis S Johnson, MS, Jill L Reiter, PhD, Mohammad Issam Abu Zaid, MBBS, Rafat Abonour, MD, G. David Roodman, MD PhD, Kun Huang, PhD, Yunlong Liu, PhD

Blood (2019) 134 (Supplement_1): 1785.

https://doi.org/10.1182/blood-2019-131962

Published: 2019

Journal Articles

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Heidi M Schmidt, BSE, Eric Kelley, PhD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3529.

https://doi.org/10.1182/blood-2019-130274

Published: 2019

Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD

Blood (2019) 134 (Supplement_1): 3560.

https://doi.org/10.1182/blood-2019-125408

Published: 2019

Journal Articles

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Fernando Carazo, Edurne San Jose, Leire Garate, Estibaliz Miranda, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Bruno Paiva, PhD, Jesús San-Miguel, Xabier Agirre, PhD, Felipe Prósper, MD PhD, Angel Rubio

Blood (2019) 134 (Supplement_1): 1414.

https://doi.org/10.1182/blood-2019-126506

Published: 2019

Journal Articles

Mapping the Road of Gvhd and GVT: A Longitudinal Study of Immune-Transcriptome Signatures As Novel Approach to Solve Post-Allogeneic Hematopoietic Cell Transplantation Dilemmas

Merav Bar, MD, Alice Woo, Mohammed Toufiq, Sabri Boughorbel, Darawan Rinchai, Mohammed Elanbari, Valentina Mattei, Rebecca Mathew, Irene Cavattoni, MD, Sabine Forer, Marco Zecca, Patrizia Comoli, Giovanni Grillo, MD, Catherine Cole, Chiara Cugno, MD, Sara Tomei, PhD, Damien Chaussabel, Sara Deola

Blood (2019) 134 (Supplement_1): 4550.

https://doi.org/10.1182/blood-2019-122884

Published: 2019

Journal Articles

Enumerating Functional HSC Clones in the Zebrafish Using Gestalt

Emily M Teets, B.S., Charles Thomas Gregory, BS, Jami L Shaffer, B.S., James S. Blachly, MD, Bradley W Blaser, MD PhD

Blood (2019) 134 (Supplement_1): 3724.

https://doi.org/10.1182/blood-2019-131503

Published: 2019

Journal Articles

Application of Single Cell Technologies to the Study of Hematopoiesis

Bertie Gottgens, DPhil

Blood (2019) 134 (Supplement_1): SCI-19.

https://doi.org/10.1182/blood-2019-132314

Published: 2019

Journal Articles

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Tongjuan Li, MD PhD, Dan Li, Lei Zhao, MD, Jue Wang, MD PhD, Zhen Shang, MD PhD, Yicheng Zhang, MD PhD, Liang Huang, MD PhD, Jianfeng Zhou, PhD

Blood (2018) 132 (Supplement 1): 4051.

https://doi.org/10.1182/blood-2018-99-115793

Published: 2018

Journal Articles

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Michèle Kyncl, MSc, Lisa Bast, MSc, Lynette Henkel, Fabian Theis, PhD, Robert A.J. Oostendorp, PhD, Carsten Marr, PhD, Katharina S. Götze, MD

Blood (2018) 132 (Supplement 1): 4354.

https://doi.org/10.1182/blood-2018-99-115942

Published: 2018

Journal Articles

Computational Modeling and Microfluidics Reveal Characteristic Patterns of Regulation of Clot Structure and Mechanics By Tissue Factor Localization

Alexander Y. Mitrophanov, PhD, Vijay Govindarajan, PhD, Shu Zhu, PhD, Scott L. Diamond, PhD, Jaques Reifman, PhD

Blood (2018) 132 (Supplement 1): 1164.

https://doi.org/10.1182/blood-2018-99-111542

Published: 2018

Journal Articles

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

James T Yurkovich, PhD, Laurence Yang, PhD, Bernhard O Palsson, PhD

Blood (2018) 132 (Supplement 1): 4888.

https://doi.org/10.1182/blood-2018-99-114969

Published: 2018

Journal Articles

Split First Dose Administration of Daratumumab for the Treatment of Patients with Multiple Myeloma (MM): Clinical Pharmacology and Population Pharmacokinetic (PK) Analyses

Xu Steven Xu, Philippe Moreau, Saad Z. Usmani, MD, Sagar Lonial, MD, Andrzej Jakubowiak, MD PhD, Albert Oriol, MD, Amrita Krishnan, MD, Joan Bladé, MD PhD, Melody Luo, PhD, Yu-Nien Sun, PhD, Liping Zhang, William Deraedt, Ming Qi, MD PhD, Jon Ukropec, PhD, Pamela L Clemens, PhD

Blood (2018) 132 (Supplement 1): 1970.

https://doi.org/10.1182/blood-2018-99-113171

Published: 2018

Journal Articles

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Andrej Besse, M.Sc, Christopher R. Cogle, MD, Leylah M. Drusbosky, PhD, Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Neha G Gupta, M.Sc., Abha Kushwaha, M.Sc., Pallavi Kumari, M.Sc., Karthik Sundara Raju, M.Sc., Ganesh Naga, B.Tech, Sayani Basu, M.Tech, Christoph Driessen, MD, Lenka Besse, PhD

Blood (2018) 132 (Supplement 1): 3193.

https://doi.org/10.1182/blood-2018-99-116939

Published: 2018

Journal Articles

Computational Modelling of Multiple Myeloma Patient Genomic Signatures to Predict Treatment Outcome

Aneel Paulus, MD, Prachi Jani, MD, Salman Ahmed, MD, Sonikpreet Aulakh, MD, Alak Manna, PhD, Neeraj Kumar Singh, B.Tech, Mohammed Sauban, B.E, Zakir Husain, M.Tech, Ansu Kumar, M.Sc., Pallavi Kumari, M.Sc., Anuj Tyagi, M.Sc., Taimur Sher, MD, Rami Manochakian, MD, Vivek Roy, MD, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi

Blood (2018) 132 (Supplement 1): 1911.

https://doi.org/10.1182/blood-2018-99-119574

Published: 2018

Journal Articles

Predicting Mechanisms of Ibrutinib-Resistance in Chronic Lymphocytic Leukemia (CLL) Using Computational-Based Modeling for Personalized Therapy with Clinical Validation

Leylah M. Drusbosky, PhD, Aneel Paulus, MD, Anne Quillet Mary, PhD, Loic Ysebaert, MD PhD, Ansu Kumar, MS, Neeraj Kumar Singh, B.Tech, Yashaswini Ullal, BE, Priyanka Bhargav, BE, Humera Azam, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Asher A. Chanan-Khan, MD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 4278.

https://doi.org/10.1182/blood.V130.Suppl_1.4278.4278

Published: 2017

Journal Articles

A Genomic Signature Predicting Venetoclax Treatment Response in Acute Myeloid Leukemia (AML) Identified By Protein Network Mapping and Validated By Ex Vivo Ddrug Sensitivity Testing

Blood (2017) 130 (Supplement 1): 2707.

https://doi.org/10.1182/blood.V130.Suppl_1.2707.2707

Published: 2017

Journal Articles

Predictive Simulation Modeling of Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Patient Genomics Identifies Targeted Combination Treatment Options

Leylah M. Drusbosky, PhD, Ansu Kumar, MS, Shwetha K, BE, Priyanka Bhargav, BE, Ashish Choudhary, MS, Soumyashree L, BE, Shivgonda C. Birajdar, MCA, Kunal Ghosh Roy, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Manju Sengar, MD DM, Girish Chinnaswamy, MD MRCP, Bijal D. Shah, MD, Christopher R. Cogle, MD

Blood (2017) 130 (Supplement 1): 2708.

https://doi.org/10.1182/blood.V130.Suppl_1.2708.2708

Published: 2017

Journal Articles

Computer Modeling Using Historical Data Demonstrates a Significant Reduction in Expected Extravascular Fibrinous Lesions Due to Congenital Plasminogen Deficiency While Receiving Intravenous Plasminogen (PLG) Replacement

Joseph M Parker, MD, Danielle Craig, Marcia Gaido, Gary Albert, Arnaud Monseur, Amy D. Shapiro, MD, John Moran, MD

Blood (2017) 130 (Supplement 1): 2371.

https://doi.org/10.1182/blood.V130.Suppl_1.2371.2371

Published: 2017

Journal Articles

Multiple Myeloma Drivers of High Risk and Response to Stem Cell Transplantation Identified By Causal Machine Learning: Out-of-Cohort and Experimental Validation

Leon Furchtgott, PhD, Arnold Bolomsky, PhD, Fred Gruber, PhD, Mehmet Kemal Samur, PhD, Jonathan J. Keats, PhD, Jennifer Yesil, MS, Kathrin Stangelberger, MSc, Michel Attal, MD PhD, Philippe Moreau, MDPhD, Hervé Avet-Loiseau, MD PhD, Karl Runge, PhD, Diane Wuest, PhD, Kelly Rich, Iya Khalil, PhD, Boris Hayete, PhD, Heinz Ludwig, MD, Nikhil Munshi, MD, Daniel Auclair, PhD

Blood (2017) 130 (Supplement 1): 3029.

https://doi.org/10.1182/blood.V130.Suppl_1.3029.3029

Published: 2017

Journal Articles

Computational Integration to Model Tumor Dynamics in CLL Patients Treated with the Btk Inhibitor Ibrutinib (CompuTreatCLL): First Results of an Integrative Systems Biology Approach

Loic Ysebaert, MD PhD, Sarah Cadot, PhD, Salim Kanoun, MD, Soleakhena Ken, Christian Recher, MD PhD, François Malgouyres, Sebastien Gadat, Loic Dupre, PhD, Anne Quillet Mary, PhD

Blood (2017) 130 (Supplement 1): 2990.

https://doi.org/10.1182/blood.V130.Suppl_1.2990.2990

Published: 2017

NARROW

A Highly Robust Model for Predicting Outcome of Multiple Myeloma Patients By Inferring Patient-Specific Transcription Factor Activity

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Mapping the Road of Gvhd and GVT: A Longitudinal Study of Immune-Transcriptome Signatures As Novel Approach to Solve Post-Allogeneic Hematopoietic Cell Transplantation Dilemmas

Enumerating Functional HSC Clones in the Zebrafish Using Gestalt

Application of Single Cell Technologies to the Study of Hematopoiesis

SHP-1 As a Negative Regulator of FLT3 Associated Aberrant Signaling and a New Potential Target to FLT3-ITD Mutation

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Computational Modeling and Microfluidics Reveal Characteristic Patterns of Regulation of Clot Structure and Mechanics By Tissue Factor Localization

Toward a Proteome-Complete Computational Model of the Human Red Blood Cell

Split First Dose Administration of Daratumumab for the Treatment of Patients with Multiple Myeloma (MM): Clinical Pharmacology and Population Pharmacokinetic (PK) Analyses

Predicting Carfilzomib Resistance Mechanisms and Therapeutics Using Computational Modelling of Genomics and Proteomics

Computational Modelling of Multiple Myeloma Patient Genomic Signatures to Predict Treatment Outcome

Predicting Mechanisms of Ibrutinib-Resistance in Chronic Lymphocytic Leukemia (CLL) Using Computational-Based Modeling for Personalized Therapy with Clinical Validation

A Genomic Signature Predicting Venetoclax Treatment Response in Acute Myeloid Leukemia (AML) Identified By Protein Network Mapping and Validated By Ex Vivo Ddrug Sensitivity Testing

Predictive Simulation Modeling of Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Patient Genomics Identifies Targeted Combination Treatment Options

Computer Modeling Using Historical Data Demonstrates a Significant Reduction in Expected Extravascular Fibrinous Lesions Due to Congenital Plasminogen Deficiency While Receiving Intravenous Plasminogen (PLG) Replacement

Multiple Myeloma Drivers of High Risk and Response to Stem Cell Transplantation Identified By Causal Machine Learning: Out-of-Cohort and Experimental Validation

Computational Integration to Model Tumor Dynamics in CLL Patients Treated with the Btk Inhibitor Ibrutinib (CompuTreatCLL): First Results of an Integrative Systems Biology Approach

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American Society of Hematology

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ASH Publications

American Society of Hematology

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