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Journal Articles

Phase 1 First-in-Human Study of AUTO2, the First Chimeric Antigen Receptor (CAR) T Cell Targeting APRIL for Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Rakesh Popat, Sonja Zweegman, MD PhD, Jim Cavet, FRCPath, Kwee Yong, Lydia Lee, Jim Faulkner, Ekaterini Kotsopoulou, Muhammad Al-Hajj, Simon Thomas, PhD, Shaun P Cordoba, PhD, Martin Pule, MD, Virginie Cerec, PhD, Vijay G R Peddareddigari, Nushmia Z Khokhar, MD, Tobias F Menne, MD PhD FRCPath

Blood (2019) 134 (Supplement_1): 3112.

https://doi.org/10.1182/blood-2019-126689

Published: 2019

Journal Articles

Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia

Yunfeng Hao, Renchi Yang, MD, Zeping Zhou

Blood (2018) 132 (Supplement 1): 3763.

https://doi.org/10.1182/blood-2018-99-111743

Published: 2018

Journal Articles

Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Moua Yang, PhD, Andaleb Kholmukhamedov, MD, Marie L Schulte, PhD, Brian C Cooley, PhD, Na'il O Scoggins, Jeremy P. Wood, PhD, Scott J Cameron, MDPhD, Craig Morrell, DVM, PhD, Shawn M. Jobe, MD PhD, Roy L. Silverstein, MD

Blood (2018) 132 (Supplement 1): 867.

https://doi.org/10.1182/blood-2018-99-111204

Published: 2018

Journal Articles

Cyclosporine May Inhibit the Effect of Extra-Physiologic Oxygen Shock/Stress on Peripheral Blood Stem Cells

Amro Elshoury, MBBChir, Hans Minderman, PhD, Alexis Conway, PhD, Paul K. Wallace, MS, PhD, Charlie Mantel, Joseph Dennis Tario, PhD, Yeong Choi, Kieran O'Loughin, MS, Carlos Cedeno, PhD, Jenna Nichols, Kahteong Soh, MS, Philip L. McCarthy, MD, George Chen, MD

Blood (2018) 132 (Supplement 1): 3346.

https://doi.org/10.1182/blood-2018-99-119329

Published: 2018

Journal Articles

Delayed Wound Healing in Mice with Impaired Procoagulant Platelet Formation

Chad Skaer, BA, Andaleb Kholmukhamedov, MD, Shawn M. Jobe, MD PhD

Blood (2018) 132 (Supplement 1): 1127.

https://doi.org/10.1182/blood-2018-99-118602

Published: 2018

Journal Articles

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma

Lydia Lee, Benjamin Draper, Neil Chaplin, Brian Philip, Melody Chin, Daria Galas-Filipowicz, Shimobi Onuoha, Simon Thomas, Vania Baldan, Reyisa Bughda, Paul Maciocia, Eva Kokalaki, Margarida P. Neves, Dominic Patel, Manuel Rodriguez-Justo, James Francis, Kwee Yong, Martin Pule

Blood (2018) 131 (7): 746–758.

https://doi.org/10.1182/blood-2017-05-781351

Published: 2018

Includes: Supplemental data

Journal Articles

Platelet Cyclophilin D-Dependent Events Limit Venous Thrombotic Occlusion and Platelet Accretion

Chad Skaer, BA, Andaleb Kholmukhamedov, MD, Fang Liu, Shawn M. Jobe, MD PhD

Blood (2017) 130 (Supplement 1): 454.

https://doi.org/10.1182/blood.V130.Suppl_1.454.454

Published: 2017

Journal Articles

Cytoplasmic Phospholipase A2 Is Essential in GPVI Signaling Initiated Procoagulant Platelet Formation

Andaleb Kholmukhamedov, MD, Janecke Rae, Shawn M. Jobe, MD PhD

Blood (2017) 130 (Supplement 1): 1068.

https://doi.org/10.1182/blood.V130.Suppl_1.1068.1068

Published: 2017

Journal Articles

CD36 Promotes Platelet Phosphatidylserine Exposure through MAP Kinase ERK5

Moua Yang, Andaleb Kholmukhamedov, MD, Na'il O Scoggins, Brian C Cooley, PhD, Craig Morrell, DVM, PhD, Shawn M. Jobe, MD PhD, Roy L. Silverstein, MD

Blood (2017) 130 (Supplement 1): 2303.

https://doi.org/10.1182/blood.V130.Suppl_1.2303.2303

Published: 2017

Journal Articles

B- Cell Maturation Antigen Is Exclusively Expressed in a Wide Range of B-Cell and Plasma Cell Neoplasm and in a Potential Therapeutic Target for Bcma Directed Therapies

Pallavi Khattar, MD, Janine Pichardo, BS, Achim Jungbluth, MDPhD, Qi Gao, Eric L Smith, MDPhD, Mikhail Roshal, MDPhD, Ahmet Dogan, MD PhD

Blood (2017) 130 (Supplement 1): 2755.

https://doi.org/10.1182/blood.V130.Suppl_1.2755.2755

Published: 2017

Journal Articles

An APRIL Based Chimeric Antigen Receptor to Simultaneously Target BCMA and TACI in Multiple Myeloma (MM) Has Potent Activity in Vitro and in Vivo

Lydia Sarah Hui Lee, MBBS, MRCP, MRCPath, BSc, Benjamin Owen Draper, BSc, MSc, Neil Chaplin, BSc, MSc, Brian Philip, PhD, Melody Chin, BSc, MSc, Daria Galas-Filipowicz, BSc, MSc, Simon Thomas, PhD, Evangelia Kokalaki, BSc, MSc, James Francis, PhD, Kwee L Yong, Martin A Pule, MD PhD

Blood (2016) 128 (22): 379.

https://doi.org/10.1182/blood.V128.22.379.379

Published: 2016

Journal Articles

Calcium Independent Events Trigger VWF-Dependent Shear-Induced Procoagulant Platelet Formation

Andaleb Kholmukhamedov, MD, Ann An, Fang Liu, PhD, Rae Janecke, Shawn M Jobe, MD PhD

Blood (2016) 128 (22): 1354.

https://doi.org/10.1182/blood.V128.22.1354.1354

Published: 2016

Journal Articles

Necrotic platelets provide a procoagulant surface during thrombosis

Vu Minh Hua, Latasha Abeynaike, Elias Glaros, Heather Campbell, Leonardo Pasalic, Philip J. Hogg, Vivien M. Y. Chen

Blood (2015) 126 (26): 2852–2862.

https://doi.org/10.1182/blood-2015-08-663005

Published: 2015

Includes: Supplemental data

Journal Articles

Dipeptidyl Peptidase 4 (DPP4) Is Altered By, and Modulates Sensitivity to, Extra-Physiologic Oxygen Shock Stress (EPHOSS): Implications for Hematopoietic Stem Cell Transplantation

Heather A. O'Leary, PhD, Thomas McNamara, Hal E. Broxmeyer, PhD

Blood (2015) 126 (23): 2361.

https://doi.org/10.1182/blood.V126.23.2361.2361

Published: 2015

Journal Articles

Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation

Charlie Mantel, Heather A. O'Leary, PhD, Brahmananda Reddy Chitteti, PhD, Xinxin Huang, PhD, Scott Cooper, BS, Giao Hangoc, DVM, PhD, Nickolay Brustovetsky, PhD, Edward F. Srour, PhD, Man Ryul Lee, PhD, Steven Messina-Graham, Nadia Falah, MD, Reuben Kapur, PhD, Louis M. Pelus, PhD, Mircea Ivan, MD, PhD, Kye-Seong Kim, PhD, Hal E. Broxmeyer, PhD

Blood (2014) 124 (21): 2905.

https://doi.org/10.1182/blood.V124.21.2905.2905

Published: 2014

Journal Articles

Procoagulant Role Of Necrotic Platelets Demonstrated Using Novel Platelet Necrosis Marker

Minh Hua, MBBS, Leonardo Pasalic, MBBS, Robert Lindeman, MBBS, Philip Hogg, PhD, Vivien M Chen, MD, PhD

Blood (2013) 122 (21): 3512.

https://doi.org/10.1182/blood.V122.21.3512.3512

Published: 2013

Journal Articles

T Cells Engineered For Resistance To Mycophenolate Mofetil Demonstrate Enhanced Expansion and Improved Tumour Control In Immunosuppressed Hosts

James Edward Griffin, MD, Shoa-An Xue, Benjamin J Carpenter, Pedro Velica, PhD, Angelika Holler, Sara Ghorashian, MD, Emma Nicholson, MD, Martin Pule, MD, Ronjon Chakraverty, MD, PhD

Blood (2013) 122 (21): 4486.

https://doi.org/10.1182/blood.V122.21.4486.4486

Published: 2013

Journal Articles

Shear Stress Initiates Cyclophilin D-Dependent Phosphatidylserine Exposure and Integrin α IIb β 3 Cleavage in Platelets

Fang Liu, MD, PhD, Shawn M Jobe, MD, PhD

Blood (2012) 120 (21): 3301.

https://doi.org/10.1182/blood.V120.21.3301.3301

Published: 2012

Journal Articles

Mitochondrially-Mediated Platelet Integrin Alpha IIb beta 3 Inactivation Limits Platelet Recruitment and Thrombus Growth,

Fang Liu, MD, PhD, Graciela Gamez, David R Myers, PhD, Wilbur Lam, MD, PhD, Shawn M Jobe, MD, PhD

Blood (2011) 118 (21): 3251.

https://doi.org/10.1182/blood.V118.21.3251.3251

Published: 2011

Journal Articles

Regulation of Platelet Procoagulant Activity by Mitochondrial Calcium Influx

HyoJung Choo, PhD, Shawn M Jobe, MD, PhD

Blood (2011) 118 (21): 2193.

https://doi.org/10.1182/blood.V118.21.2193.2193

Published: 2011

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Phase 1 First-in-Human Study of AUTO2, the First Chimeric Antigen Receptor (CAR) T Cell Targeting APRIL for Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia

Platelet CD36 Promotes ERK5 and Caspase-Dependent Procoagulant Phosphatidylserine Externalization and In Vivo Fibrin Formation in Dyslipidemia

Cyclosporine May Inhibit the Effect of Extra-Physiologic Oxygen Shock/Stress on Peripheral Blood Stem Cells

Delayed Wound Healing in Mice with Impaired Procoagulant Platelet Formation

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma

Platelet Cyclophilin D-Dependent Events Limit Venous Thrombotic Occlusion and Platelet Accretion

Cytoplasmic Phospholipase A2 Is Essential in GPVI Signaling Initiated Procoagulant Platelet Formation

CD36 Promotes Platelet Phosphatidylserine Exposure through MAP Kinase ERK5

B- Cell Maturation Antigen Is Exclusively Expressed in a Wide Range of B-Cell and Plasma Cell Neoplasm and in a Potential Therapeutic Target for Bcma Directed Therapies

An APRIL Based Chimeric Antigen Receptor to Simultaneously Target BCMA and TACI in Multiple Myeloma (MM) Has Potent Activity in Vitro and in Vivo

Calcium Independent Events Trigger VWF-Dependent Shear-Induced Procoagulant Platelet Formation

Necrotic platelets provide a procoagulant surface during thrombosis

Dipeptidyl Peptidase 4 (DPP4) Is Altered By, and Modulates Sensitivity to, Extra-Physiologic Oxygen Shock Stress (EPHOSS): Implications for Hematopoietic Stem Cell Transplantation

Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation

Procoagulant Role Of Necrotic Platelets Demonstrated Using Novel Platelet Necrosis Marker

T Cells Engineered For Resistance To Mycophenolate Mofetil Demonstrate Enhanced Expansion and Improved Tumour Control In Immunosuppressed Hosts

Shear Stress Initiates Cyclophilin D-Dependent Phosphatidylserine Exposure and Integrin α IIb β 3 Cleavage in Platelets

Mitochondrially-Mediated Platelet Integrin Alpha IIb beta 3 Inactivation Limits Platelet Recruitment and Thrombus Growth,

Regulation of Platelet Procoagulant Activity by Mitochondrial Calcium Influx

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