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Journal Articles

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Anthony K. N. Chan, PhD, Christopher D. Delaney, Lu Yang, PhD, Wen-Han Chang, PhD, Kazuya Miyashita, PhD, Qiao Liu, MD, Sheela Pangeni Pokharel, MSc, Scott A. Armstrong, MD PhD, Chun-Wei David Chen, PhD

Blood (2019) 134 (Supplement_1): 530.

https://doi.org/10.1182/blood-2019-131467

Published: 2019

Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD

Blood (2019) 134 (Supplement_1): 111.

https://doi.org/10.1182/blood-2019-126505

Published: 2019

Journal Articles

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, Anne Lehman, Grace Jeschke, PhD, John D. Crispino, PhD MBA, Thierry Besson, PhD, Sarah K. Tasian, MD, Martin Carroll, MD

Blood (2019) 134 (Supplement_1): 2742.

https://doi.org/10.1182/blood-2019-123475

Published: 2019

Journal Articles

O-Glcnacylation Is Essential for Erythropoiesis

Matthew P Parker, BS, Halyna Fedosyuk, MS, Lesya V Novikova, PhD, Zhen Zhang, PhD, Chad Slawson, PhD, Kenneth R Peterson, PhD

Blood (2019) 134 (Supplement_1): 2218.

https://doi.org/10.1182/blood-2019-129468

Published: 2019

Journal Articles

Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies

Olli Dufva, Jay Klievink, Khalid Saeed, Matti Kankainen, PhD, Mette Ilander, PhD, Tiina Hannunen, Sonja Lagström, Pekka Ellonen, BSc, Dean Anthony Lee, MD PhD, Satu Mustjoki, MD PhD

Blood (2018) 132 (Supplement 1): 732.

https://doi.org/10.1182/blood-2018-99-117985

Published: 2018

Journal Articles

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Olga Dashevsky, PhD, Brian Glassner, PhD, Olivia Bare, John G Doench, PhD, Constantine S. Mitsiades, MD PhD

Blood (2018) 132 (Supplement 1): 1915.

https://doi.org/10.1182/blood-2018-99-114986

Published: 2018

Journal Articles

In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment

Ryosuke Shirasaki, MD, Csikos Tamas, PhD, Geoffrey Matthews, PhD, Ricardo De Matos Simoes, PhD, Subhashis Sarkar, PhD, Olga Dashevsky, PhD, Hu Yiguo, PhD, Jeffrey Sorrell, BA, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Megan Bariteau, Brian Glassner, PhD, Aedin Culhane, PhD, Richard WJ Groen, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 4414.

https://doi.org/10.1182/blood.V130.Suppl_1.4414.4414

Published: 2017

Journal Articles

Long-Term Interactions with Bone Marrow Stromal Cells Alter the Molecular Dependencies of Myeloma Cells: Insights from Genomewide CRISPR-Based Functional Genomic Screens

Sara Gandolfi, MD, Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Michal Sheffer, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 3028.

https://doi.org/10.1182/blood.V130.Suppl_1.3028.3028

Published: 2017

Journal Articles

RNAi and CRISPR/Cas9 Based In Vivo Models for Drug Discovery

Prem Premsrirut, MD PhD, Chia-Lin Wang, PhD, Yu-ting Yang, PhD, Christof Fellmann, PhD, Lukas Dow, PhD, Johannes Zuber, PhD, Scott Lowe, PhD, Marina Pesic, PhD, Katharina Wolter, PhD, Lars Zender, PhD

Blood (2017) 130 (Supplement 1): 5568.

https://doi.org/10.1182/blood.V130.Suppl_1.5568.5568

Published: 2017

Journal Articles

Functional Genomic Landscape of Epigenetic Dependencies in Myeloma

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Daphne Dupere Richer, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Richard WJ Groen, PhD, Franciska Vazquez, PhD, Joshua Dempster, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 1209.

https://doi.org/10.1182/blood.V130.Suppl_1.1209.1209

Published: 2017

Journal Articles

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

Ricardo De Matos Simoes, PhD, Eugen Dhimolea, PhD, Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Geoffrey Matthews, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 2501.

https://doi.org/10.1182/blood.V130.Suppl_1.2501.2501

Published: 2017

Journal Articles

O-Glcnacylation Modulates Erythropoiesis: O-Glcnac Transferase (OGT) Is an Essential Gene

Kenneth R Peterson, PhD, Halyna Fedosyuk, MS, Lesya V Novikova, PhD, Zhen Zhang, PhD, Matthew P Parker, BS, Chad Slawson, PhD

Blood (2017) 130 (Supplement 1): 3489.

https://doi.org/10.1182/blood.V130.Suppl_1.3489.3489

Published: 2017

Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Blood (2017) 130 (Supplement 1): 1212.

https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212

Published: 2017

Journal Articles

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

Geoffrey M. Matthews, PhD, Ricardo De Matos Simoes, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Paul J. Hengeveld, B.Sc., Megan A. Bariteau, BSc, Brian Glassner, PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Sara Gandolfi, MD, Pallavi Awate, MSc, Huihui Tang, PhD, Franciska Vazquez, PhD, Aedin Culhane, PhD, Constantine S Mitsiades, MD PhD

Blood (2016) 128 (22): 119.

https://doi.org/10.1182/blood.V128.22.119.119

Published: 2016

Journal Articles

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

Blood (2014) 124 (21): 125.

https://doi.org/10.1182/blood.V124.21.125.125

Published: 2014

Journal Articles

Transcriptional Regulation in Normal and Malignant Hematopoiesis

Koichi Akashi, MD, PhD.

Blood (2011) 118 (21): SCI-28.

https://doi.org/10.1182/blood.V118.21.SCI-28.SCI-28

Published: 2011

Journal Articles

Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells

Ying Liu, MD, Man Ryul Lee, PhD, Khalid Timani, PhD, Johnny J He, PhD, Hal E. Broxmeyer, PhD

Blood (2011) 118 (21): 2353.

https://doi.org/10.1182/blood.V118.21.2353.2353

Published: 2011

Journal Articles

A Chromatin Modifier SATB1 Promotes Lymphocyte Production From Primitive Hematopoietic Stem/Progenitor Cells

Yusuke Satoh, MD, PhD, Takafumi Yokota, MD, PhD, Hirokazu Tanaka, MD, PhD, Koichi Kokame, PhD, Toshiyuki Miyata, PhD, Itaru Matsumura, MD, PhD, Kenji Oritani, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2010) 116 (21): 836.

https://doi.org/10.1182/blood.V116.21.836.836

Published: 2010

Journal Articles

Canonical NF-κ B Pathway Is Required for Early Mesodermal Differentiation from the Murine Embryonic Stem Cells.

Hirokazu Tanaka, MD, PhD, Itaru Matsumura, M.D., Ph.D., Kazuki Nakao, Ph.D., Takumi Era, M.D., Ph.D., Yuzuru Kanakura, M.D., Ph.D.

Blood (2006) 108 (11): 1144.

https://doi.org/10.1182/blood.V108.11.1144.1144

Published: 2006

NARROW

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

O-Glcnacylation Is Essential for Erythropoiesis

Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

In Vivo Validation of Essential Genes for Myeloma Cells By CRISPR/Cas9 Studies in a Scaffold-Based System Engineered to Establish a "Humanized" Bone Marrow-like Microenvironment

Long-Term Interactions with Bone Marrow Stromal Cells Alter the Molecular Dependencies of Myeloma Cells: Insights from Genomewide CRISPR-Based Functional Genomic Screens

RNAi and CRISPR/Cas9 Based In Vivo Models for Drug Discovery

Functional Genomic Landscape of Epigenetic Dependencies in Myeloma

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

O-Glcnacylation Modulates Erythropoiesis: O-Glcnac Transferase (OGT) Is an Essential Gene

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

Transcriptional Regulation in Normal and Malignant Hematopoiesis

Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells

A Chromatin Modifier SATB1 Promotes Lymphocyte Production From Primitive Hematopoietic Stem/Progenitor Cells

Canonical NF-κ B Pathway Is Required for Early Mesodermal Differentiation from the Murine Embryonic Stem Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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