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Journal Articles

Elevated ANXA1 Expression Causes Glucocorticoid Resistance in Acute Lymphoblastic Leukemia Via Activating the Wnt/β-Catenin Signaling Pathway

Ping Liu, Dan Ma, MD, Jishi Wang, PhD

Blood (2019) 134 (Supplement_1): 5198.

https://doi.org/10.1182/blood-2019-130322

Published: 2019

Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Blood (2019) 134 (Supplement_1): 3758.

https://doi.org/10.1182/blood-2019-126910

Published: 2019

Journal Articles

Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia

Lauren K. Meyer, Cristina Delgado-Martin, PhD, Phillip P. Sharp, PhD, Dustin McMinn, PhD, Christopher J. Kirk, PhD, Jack Taunton, PhD, Michelle L. Hermiston, MD PhD

Blood (2019) 134 (Supplement_1): 805.

https://doi.org/10.1182/blood-2019-127537

Published: 2019

Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

Jianping Li, MD, Catalina Troche, PhD, Alok Swaroop, PhD, Marta Kulis, PhD, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Sharon Norton, MS, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD

Blood (2018) 132 (Supplement 1): 653.

https://doi.org/10.1182/blood-2018-99-116309

Published: 2018

Journal Articles

Genetic Heterogeneity and Evolution in Lymphoid Malignancies

Charles G. Mullighan, MBBS, MD

Blood (2018) 132 (Supplement 1): SCI-34.

https://doi.org/10.1182/blood-2018-99-109499

Published: 2018

Journal Articles

Akt2 Mediates Glucocorticoid Resistance in Acute Lymphoblastic Leukemia through FoxO3a/Bim Axis and Serves As a Direct Target for Resistance Reversal

Mixue Xie, Yanhui Xie, PhD, Apeng Yang, MD, Jiexian Ma, MD, Min Wu, Youxin Jin, PhD

Blood (2018) 132 (Supplement 1): 3955.

https://doi.org/10.1182/blood-2018-99-110496

Published: 2018

Journal Articles

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Laurens Van Der Meer, PhD, Rene Marke, MSc, Miriam Butler, MSc, Dorette van Ingen Schenau, MSc, Blanca Scheijen, PhD, Frank van Leeuwen, PhD

Blood (2018) 132 (Supplement 1): 4088.

https://doi.org/10.1182/blood-2018-99-112888

Published: 2018

Journal Articles

Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia

Xiao Haowen, MD PhD, Yingying Ding, Yang Gao, Limengmeng Wang, PhD, Huafang Wang, Xiaohong Yu, He Huang, MD PhD

Blood (2018) 132 (Supplement 1): 1328.

https://doi.org/10.1182/blood-2018-99-120089

Published: 2018

Journal Articles

Repression of the Orphan Nuclear Receptor Esrrb Results in Glucocorticoid Resistance in ALL

Kayleigh Gallagher, BS, Justine E. Roderick, PhD, Jun Yu, Julie Zhu, Michael R Green, PhD, Michelle Kelliher, PhD

Blood (2017) 130 (Supplement 1): 1259.

https://doi.org/10.1182/blood.V130.Suppl_1.1259.1259

Published: 2017

Journal Articles

Breaking IL7R Signaling-Induced Glucocorticoid Resistance By Small Molecule Inhibitors in T-Cell Acute Lymphoblastic Leukemia

Jordy Van Der Zwet, MD, Jules Meijerink, PhD, Jessica Buijs-Gladdines, Yunlei Li, PhD, Rob Pieters, MD PhD

Blood (2017) 130 (Supplement 1): 2534.

https://doi.org/10.1182/blood.V130.Suppl_1.2534.2534

Published: 2017

Journal Articles

Identifying Mechanisms of Glucocorticoid Resistance in Relapsed Pediatric T-ALL

Justine E. Roderick, PhD, Kayleigh M Gallagher, BS, Katherine M Tang, BS, Olivia Kugler-Umana, BS, Lihua J Zhu, PhD, Michael R Green, MD PhD, Michelle Kelliher, PhD

Blood (2016) 128 (22): 2769.

https://doi.org/10.1182/blood.V128.22.2769.2769

Published: 2016

Journal Articles

JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia

Cristina Delgado-Martin, PhD, Kristin Shimano, MD, Matthew S Zinter, MD, Justin T. Wahlstrom, MD, Geoffrey A. Smith, Jack Taunton, PhD, Stuart S. Winter, MD, Justine E. Roderick, PhD, Michelle Kelliher, PhD, Terzah M. Horton, MD PhD, Brent L. Wood, MD PhD, David T Teachey, MD, Michelle L. Hermiston, MD PhD

Blood (2016) 128 (22): 3963.

https://doi.org/10.1182/blood.V128.22.3963.3963

Published: 2016

Journal Articles

The Role and Mechanism Study of Lncrnas Involved in Glucocorticoid Resistance in Paediatric Acute Lymphoblastic Leukemia

Zhai Xiaowen, MD PhD, Cuiqing Fan, PhD, Hongsheng Wang, MD

Blood (2016) 128 (22): 5136.

https://doi.org/10.1182/blood.V128.22.5136.5136

Published: 2016

Journal Articles

Pharmacological Inhibition of Lck is Able to Revert Glucocorticoid Resistance in Pediatric T-ALL

Valentina Serafin, PhD, Giorgia Capuzzo, Gloria Milani, PhD, Silvia Bresolin, PhD, Marica Pinazza, PhD, Sonia Minuzzo, PhD, Stefano Indraccolo, MD, Roberta Bortolozzi, PhD, Giuseppe Basso, Benedetta Accordi, PhD

Blood (2016) 128 (22): 838.

https://doi.org/10.1182/blood.V128.22.838.838

Published: 2016

Journal Articles

Genetic Analysis of Distinct Phenotypic Subsets within MM1.S Multiple Myeloma Cell Line Reveals the Pre-Existence of MM.1R-like Glucocorticoid Resistance and a Sub-Clone with an Activating PI3-Kinase Delta Mutation That Is Preferentially Sensitive to the Selective PI3-Kinase Inhibitor, Idelalisib

James W Murray, MBBCh, Christopher Fegan, Chris Pepper, PhD

Blood (2016) 128 (22): 4449.

https://doi.org/10.1182/blood.V128.22.4449.4449

Published: 2016

Journal Articles

CRLF2 Rearrangement Status in Ph-like ALL Predicts Intrinsic Glucocorticoid Resistance In Vitro that is Reversible with Targeted MAPK and PI3K Pathway Inhibition

Lauren K Meyer, Cristina Delgado-Martin, PhD, Shannon L Maude, MD PhD, David T Teachey, MD, Michelle L. Hermiston, MD PhD

Blood (2016) 128 (22): 910.

https://doi.org/10.1182/blood.V128.22.910.910

Published: 2016

Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD

Blood (2015) 126 (23): 2619.

https://doi.org/10.1182/blood.V126.23.2619.2619

Published: 2015

Journal Articles

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells

Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, Hilde Schjerven, PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Andreas Hochhaus, MD, Giovanni Cazzaniga, PhD, Ari M Melnick, MD, Steven M. Kornblau, MD, Thomas G Graeber, PhD, Markus Muschen, MD PhD

Blood (2014) 124 (21): 262.

https://doi.org/10.1182/blood.V124.21.262.262

Published: 2014

Journal Articles

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Courtney L Jones, PhD, Christy M Gearheart, PhD, Susan Fosmire, Cristina Delgado-Martin, PhD, Faye Pais, MD, Jinhua Wang, PhD, Teena Bhatla, MD, Danielle S Bitterman, Simone R de Rijk, Wallace Bourgeois, Smita C. Dandekar, MD, Elizabeth A. Raetz, MD, Michelle L. Hermiston, MD PhD, Michael J Garabedian, PhD, Christopher C. Porter, MD, William L. Carroll, MD

Blood (2014) 124 (21): 789.

https://doi.org/10.1182/blood.V124.21.789.789

Published: 2014

Journal Articles

Genome-Wide shRNA Screen Implicates Mitogen Activated Protein Kinase (MAPK) Pathway In Glucocorticoid Resistance In Acute Lymphoblastic Leukemia

Jones L. Courtney, Christy M. Gearheart, Ph.D., Fosmire Susan, Wang Jinhua, Ph.D., Danielle S. Bitterman, Teena Bhatla, MD, Wallace Bourgeois, Christopher C. Porter, MD, William L. Carroll, MD

Blood (2013) 122 (21): 1296.

https://doi.org/10.1182/blood.V122.21.1296.1296

Published: 2013

NARROW

Elevated ANXA1 Expression Causes Glucocorticoid Resistance in Acute Lymphoblastic Leukemia Via Activating the Wnt/β-Catenin Signaling Pathway

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Protein Translocation Inhibitors Overcome Cytokine-Induced Glucocorticoid Resistance in T-Cell Acute Lymphoblastic Leukemia

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance of Acute Lymphoblastic Leukemia

Genetic Heterogeneity and Evolution in Lymphoid Malignancies

Akt2 Mediates Glucocorticoid Resistance in Acute Lymphoblastic Leukemia through FoxO3a/Bim Axis and Serves As a Direct Target for Resistance Reversal

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia

Repression of the Orphan Nuclear Receptor Esrrb Results in Glucocorticoid Resistance in ALL

Breaking IL7R Signaling-Induced Glucocorticoid Resistance By Small Molecule Inhibitors in T-Cell Acute Lymphoblastic Leukemia

Identifying Mechanisms of Glucocorticoid Resistance in Relapsed Pediatric T-ALL

JAK/STAT Pathway Inhibition Reverts IL7-Induced Glucocorticoid Resistance in a Subset of Human T-Cell Acute Lymphoblastic Leukemia

The Role and Mechanism Study of Lncrnas Involved in Glucocorticoid Resistance in Paediatric Acute Lymphoblastic Leukemia

Pharmacological Inhibition of Lck is Able to Revert Glucocorticoid Resistance in Pediatric T-ALL

Genetic Analysis of Distinct Phenotypic Subsets within MM1.S Multiple Myeloma Cell Line Reveals the Pre-Existence of MM.1R-like Glucocorticoid Resistance and a Sub-Clone with an Activating PI3-Kinase Delta Mutation That Is Preferentially Sensitive to the Selective PI3-Kinase Inhibitor, Idelalisib

CRLF2 Rearrangement Status in Ph-like ALL Predicts Intrinsic Glucocorticoid Resistance In Vitro that is Reversible with Targeted MAPK and PI3K Pathway Inhibition

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells

MAPK Signaling Cascades Mediate Distinct Glucocorticoid Resistance Mechanisms in Pediatric B-Precursor ALL

Genome-Wide shRNA Screen Implicates Mitogen Activated Protein Kinase (MAPK) Pathway In Glucocorticoid Resistance In Acute Lymphoblastic Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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