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Journal Articles

How I treat warm autoimmune hemolytic anemia

Wilma Barcellini, Bruno Fattizzo

Blood (2021) 137 (10): 1283–1294.

https://doi.org/10.1182/blood.2019003808

Published: 2021

Journal Articles

A complementary new drug for PNH

Robert A. Brodsky

Blood (2020) 135 (12): 884–885.

https://doi.org/10.1182/blood.2020004959

Published: 2020

Journal Articles

Glycosylation of Immunoglobulin Light Chains Is Highly Prevalent in Cold Agglutinin Disease

Surbhi Sidana, MD, David L Murray, MD PhD, Surendra Dasari, PhD, Ronald S. Go, MD, Maria Alice Willrich, PhD, Melissa Snyder, PhD, Mindy Kohlhagen, John A. Lust, MD PhD, Eli Muchtar, MD, Taxiarchis Kourelis, MD, Shaji K. Kumar, MD, Angela Dispenzieri, MD, Morie A. Gertz, MD

Blood (2019) 134 (Supplement_1): 3510.

https://doi.org/10.1182/blood-2019-121712

Published: 2019

Journal Articles

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Austin Kulasekararaj, MBBS MDMRCP FRCPath, Antonio M. Risitano, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Rosario Notaro, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA, Jong-Wook Lee, MD, Mingjun Huang, PhD, Michael Geffner, MD, Robert A. Brodsky, MD

Blood (2019) 134 (Supplement_1): 3514.

https://doi.org/10.1182/blood-2019-124748

Published: 2019

Journal Articles

Hematological Response to Eculizumab in Paroxysmal Nocturnal Hemoglobinuria: Application of a Novel Classification to Identify Unmet Clinical Needs and Future Clinical Goals

Pierre-Edouard Debureaux, MD, Fabiana Cacace, Bruno G.P. Silva, MD, Federica Barone, MD, Rodrigo T Calado, MD, Flore Sicre de Fontbrune, Juliette Soret-Dulphy, MD, Patrizia Ricci, Michela Sica, PhD, Rosario Notaro, MD, Phillip Scheinberg, MD, Austin Kulasekararaj, MDMBBS,MRCP,FRCPath, Antonio M. Risitano, MD PhD, Régis Peffault de Latour, MD PhD, Camilla Frieri, MD

Blood (2019) 134 (Supplement_1): 3517.

https://doi.org/10.1182/blood-2019-125917

Published: 2019

Journal Articles

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Antonio M. Risitano, MD PhD, Jong Wook Lee, MD PhD, Rosario Notaro, MD, Robert A. Brodsky, MD, Austin Kulasekararaj, MBBS MDMRCP FRCPath, Jaroslaw P. Maciejewski, MD PhD, Mingjun Huang, PhD, Michael Geffner, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 2226.

https://doi.org/10.1182/blood-2019-124837

Published: 2019

Journal Articles

Symptomatic Bilirubin Gallstones in Patients with PNH Treated with Eculizumab

David J. Araten, MD, H. Leon Pachter, Robert J Dring, Elliot Newman, Steven M Cohen

Blood (2019) 134 (Supplement_1): 4795.

https://doi.org/10.1182/blood-2019-124571

Published: 2019

Journal Articles

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

Laurent Kiger, Sandia Adypagavane, Laura Bencheikh, PhD, Nicolas Hebert, Stephane Moutereau, MD, Frédéric Galactéros, MD PhD, Michael Marden, PhD, Yves Beuzard, MD, France Pirenne, MD PhD, Pablo Bartolucci, MD PhD

Blood (2019) 134 (Supplement_1): 3381.

https://doi.org/10.1182/blood-2019-130600

Published: 2019

Journal Articles

Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia

Aleksandr Kulagin, Olesya Klimova, Tatiana Rudakova, Irina Golubovskaya, Maria Ivanova, Anna Smirnova, Alexandra Lapina, Tatiana Bykova, Elena Babenko, Marina Popova, Vladimir Dobronravov, Boris Afanasyev

Blood (2018) 132 (Supplement 1): 2589.

https://doi.org/10.1182/blood-2018-99-120139

Published: 2018

Journal Articles

Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria

Blood (2018) 132 (Supplement 1): 3642.

https://doi.org/10.1182/blood-2018-99-117290

Published: 2018

Journal Articles

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Autoimmune Hemolytic Anemia (AIHA)

Federico Grossi, MD, Merrill Kingman Shum, MD, Morie A. Gertz, MD, Eloy Roman, MD, Pascal Deschatelets, PhD, Mohamed Hamdani, MS, Frank Stout, Cedric G Francois, MD PhD

Blood (2018) 132 (Supplement 1): 3623.

https://doi.org/10.1182/blood-2018-99-119468

Published: 2018

Journal Articles

Macrophage Recycling of Red Blood Cells and Iron Following Transfusion

Eldad A. Hod, MD

Blood (2018) 132 (Supplement 1): SCI-3.

https://doi.org/10.1182/blood-2018-99-109520

Published: 2018

Journal Articles

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Raymond SM Wong, MRCP, FRCP, Humphrey W.H. Pullon, FRACP, FRCPA, Pascal Deschatelets, PhD, Cedric G Francois, MD PhD, Mohamed Hamdani, MS, Surapol Issaragrisil, MD, Patrick Johnson, PhD, Pimjai Niparuck, MD, Tontanai Numbenjapon, MD, Jameela Sathar, MB, MRCP, MRCPath, Lisa Tan, Eric Tse, MBBS, PhD FRCP, FRCPath, Federico Grossi, MD

Blood (2018) 132 (Supplement 1): 2314.

https://doi.org/10.1182/blood-2018-99-110827

Published: 2018

Journal Articles

Long Term Efficacy, Safety and PK/PD Profile of the Anti-C1s Antibody (BIVV009) in Primary Cold Agglutinin Disease Patients

Ulrich Jaeger, MD, Shirley D'Sa, MD FRCP, FRCPath, Christian Schoergenhofer, MD, Johann Bartko, MD, Christian Sillaber, MD, Petra Jilma-Stohlawetz, MD, Michael Fillitz, MD, Thomas Schenk, MD, Gary Patou, MD, Sandip Panicker, PhD, Graham C Parry, PhD, James C Gilbert, MD, Bernd Jilma, MD

Blood (2017) 130 (Supplement 1): 703.

https://doi.org/10.1182/blood.V130.Suppl_1.703.703

Published: 2017

Journal Articles

Use of Eculizumab in a Patient with Refractory Autoimmune Hemolytic Anemia with Heterozygous NFκB1 Mutation

Katharine Halligan, MD PhD, Lana Vasiljevic, Phillip Roehrs, MD, Andrew Mcginnitie, MD, Sung-Yun Pai, MD, Rachael F. Grace, MD, Maria Olivares Boucher, MD, Lauren Weintraub, MD

Blood (2017) 130 (Supplement 1): 4743.

https://doi.org/10.1182/blood.V130.Suppl_1.4743.4743

Published: 2017

Journal Articles

Extravascular Hemolysis Due to C3-Loading in Patients with PNH Treated with Eculizumab: Defining the Clinical Syndrome

Claire E McKinley, BSc, Stephen John Richards, PhD FRCPath, Talha Munir, Morag Griffin, Lindsay D Mitchell, MBChB, MRCP(UK), FRCPath, Louise Arnold, Kathryn Riley, Nicola Copeland, Darren J Newton, PhD, Anita Hill, MBChB (Hons), PhD, Peter Hillmen, MBChB, PhD

Blood (2017) 130 (Supplement 1): 3471.

https://doi.org/10.1182/blood.V130.Suppl_1.3471.3471

Published: 2017

Journal Articles

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

Federico V Grossi, MDPhD, Pauline Bedwell, Pascal Deschatelets, PhD, Lil Edis, PhD, Cedric G Francois, MDPhD, Patrick J Johnson, PhD, Helen J Richardson, Lisa Tan, Carolina A Vega, Jason Lickliter, MBBS,PhD

Blood (2016) 128 (22): 1251.

https://doi.org/10.1182/blood.V128.22.1251.1251

Published: 2016

Journal Articles

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

Fernanda F.C. Fabris, Flavia C. Leonardo, PhD, Rodolfo Cancado, MD, PhD, Rafaela Mendonça, B.Sc., Angelica A. Silveira, M.Sc., Kleber Yotsumoto Fertrin, MD, PhD, Sara Teresinha Olalla Saad, MD PhD, Fernando F. Costa, MD, PhD, Nicola Conran, PhD, Camila B. Almeida, PhD

Blood (2016) 128 (22): 1257.

https://doi.org/10.1182/blood.V128.22.1257.1257

Published: 2016

Journal Articles

The Effect of Splenectomy on Development of Cerebral Vasculopathy in Children with Sickle Cell Disease

Azada Ibrahimova, MD, Bruce Bernstein, Rida Abid, Nataly Apollonsky, MD

Blood (2016) 128 (22): 3647.

https://doi.org/10.1182/blood.V128.22.3647.3647

Published: 2016

Journal Articles

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Francesca Vinchi, PhD, Gregory M Vercellotti, MD, John D. Belcher, PhD, Eitan Fibach, PhD, Hala Zreid, MD, Rushdy Rasras, Hussam Ghoti, MD, Martina U. Muckenthaler, PhD, Eliezer A. Rachmilewitz, MD

Blood (2016) 128 (22): 2469.

https://doi.org/10.1182/blood.V128.22.2469.2469

Published: 2016

NARROW

How I treat warm autoimmune hemolytic anemia

A complementary new drug for PNH

Glycosylation of Immunoglobulin Light Chains Is Highly Prevalent in Cold Agglutinin Disease

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Hematological Response to Eculizumab in Paroxysmal Nocturnal Hemoglobinuria: Application of a Novel Classification to Identify Unmet Clinical Needs and Future Clinical Goals

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Symptomatic Bilirubin Gallstones in Patients with PNH Treated with Eculizumab

Interest of a New Method for Free Plasma Heme Related Species Dosages in Sickle Cell Disease and Beta Thalassemia

Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia

Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Autoimmune Hemolytic Anemia (AIHA)

Macrophage Recycling of Red Blood Cells and Iron Following Transfusion

Inhibition of C3 with APL-2 Results in Normalisation of Markers of Intravascular and Extravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Long Term Efficacy, Safety and PK/PD Profile of the Anti-C1s Antibody (BIVV009) in Primary Cold Agglutinin Disease Patients

Use of Eculizumab in a Patient with Refractory Autoimmune Hemolytic Anemia with Heterozygous NFκB1 Mutation

Extravascular Hemolysis Due to C3-Loading in Patients with PNH Treated with Eculizumab: Defining the Clinical Syndrome

APL-2, a Complement C3 Inhibitor for the Potential Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Phase I Data from Two Completed Studies in Healthy Volunteers

Modulation of Hemolytic and Hemoglobin/Heme Scavenging Profiles in Sickle Cell Anemia, Hereditary Spherocytosis and Paroxysmal Nocturnal Hemoglobinuria

The Effect of Splenectomy on Development of Cerebral Vasculopathy in Children with Sickle Cell Disease

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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