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Journal Articles

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Christine R. Keenan, Nadia Iannarella, Gaetano Naselli, Naiara G. Bediaga, Timothy M. Johanson, Leonard C. Harrison, Rhys S. Allan

Blood (2020) 135 (23): 2049–2058.

https://doi.org/10.1182/blood.2019002990

Published: 2020

Includes: Supplemental data

Journal Articles

Congenital Dyserythropoietic Anemia Type I Due to Biallelic CDAN1 mutations: Report from the Congenital Dyserythropoietic Anemia Registry (CDAR)

Omar Niss, MD, Robert B. Lorsbach, MD PhD, David K. Buchbinder, MD MSHS, Satheesh Chonat, MD, Morgan L. McLemore, MD, Timothy McCavit, MD, Jeffrey H Schwartz, MD, Jessica Meznarich, MD, Katie Seu, Wenying Zhang, MD PhD, Theodosia A. Kalfa, MD PhD

Blood (2019) 134 (Supplement_1): 3521.

https://doi.org/10.1182/blood-2019-128975

Published: 2019

Journal Articles

Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing

Zachary C. Murphy, PhD, Tyler A Couch, BS, Jacquelyn Lillis, MS, Michael Getman, MS, Kimberly Lezon-Geyda, PhD, Vincent P Schulz, PhD, Mohandas Narla, DSc, Patrick G. Gallagher, MD, Laurie A. Steiner, MD

Blood (2019) 134 (Supplement_1): 154.

https://doi.org/10.1182/blood-2019-129561

Published: 2019

Journal Articles

Codanin-1 Mutations Engineered in Human Erythroid Cells Allow Investigation of Mechanisms Underlying Congenital Dyserythropoietic Anemia

Zachary C. Murphy, PhD, Michael Getman, MS, Jacquelyn Lillis, Laurie A. Steiner, MD

Blood (2019) 134 (Supplement_1): 3739.

https://doi.org/10.1182/blood-2019-127415

Published: 2019

Journal Articles

The Histone Methyltransferase Setd8 Alters the Chromatin Landscape and Regulates the Expression of Key Transcription Factors during Erythroid Differentiation

Jacquelyn Lillis, Jeffrey Malik, PhD, Tyler A Couch, BS, Michael Getman, Laurie A. Steiner, MD

Blood (2018) 132 (Supplement 1): 2568.

https://doi.org/10.1182/blood-2018-99-110999

Published: 2018

Journal Articles

Crispri-Based Screening of Clustered Regulatory Elements Reveals Novel Leukemia Dependencies

Salima Benbarche, PhD, Cécile K Lopez, Thomas Mercher, PhD, Camille Lobry, PhD MSc

Blood (2018) 132 (Supplement 1): 654.

https://doi.org/10.1182/blood-2018-99-111865

Published: 2018

Journal Articles

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

Camila Prieto, BA, Diu Nguyen, PhD, Ly P Vu, PhD, Alexendar Perez, PhD, Saroj Gourkanti, BA, Alexandra Schurer, BS, Timothy Chou, BS, Arthur Chow, BA, James Taggart, BA, Trevor Stephen Barlowe, BA, Christina Leslie, PhD, Michael G. Kharas, PhD

Blood (2018) 132 (Supplement 1): 883.

https://doi.org/10.1182/blood-2018-99-112543

Published: 2018

Journal Articles

FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1

Peng Xu, PhD, Daniel C. Scott, PhD, Xing Tang, PhD, Yu Yao, MD, Yong-Dong Wang, PhD, Wenjian Bi, PhD, Lance E. Palmer, PhD, Ruopeng Feng, PhD, Arno F. Alpi, PhD, Chunliang Li, PhD, Yong Cheng, PhD, Brenda A. Schulman, PhD, Mitchell J. Weiss, MD PhD

Blood (2018) 132 (Supplement 1): 529.

https://doi.org/10.1182/blood-2018-99-117362

Published: 2018

Journal Articles

A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia

Samir H Barghout, BSPharm, MSc, Neil MacLean, G. Wei Xu, Geethu Thomas, PhDMSc,BSc, Zachary Blatman, Rose Hurren, BSc, Aaron D Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 1350.

https://doi.org/10.1182/blood-2018-99-110406

Published: 2018

Journal Articles

Active enhancer and chromatin accessibility landscapes chart the regulatory network of primary multiple myeloma

Yi Jin, Kenian Chen, Ayla De Paepe, Eva Hellqvist, Aleksandra D. Krstic, Lauren Metang, Charlotte Gustafsson, Richard E. Davis, Yair M. Levy, Rakesh Surapaneni, Ann Wallblom, Hareth Nahi, Robert Mansson, Yin C. Lin

Blood (2018) 131 (19): 2138–2150.

https://doi.org/10.1182/blood-2017-09-808063

Published: 2018

Includes: Supplemental data

Journal Articles

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

Jan C. Peeken, Jonas S. Jutzi, Julius Wehrle, Christoph Koellerer, Hans F. Staehle, Heiko Becker, Elias Schoenwandt, Thalia S. Seeger, Daniel H. Schanne, Monika Gothwal, Christopher J. Ott, Albert Gründer, Heike L. Pahl

Blood (2018) 131 (18): 2065–2073.

https://doi.org/10.1182/blood-2017-10-810622

Published: 2018

Includes: Supplemental data

Journal Articles

Chromosome 1q12 Instability Drives Both 1q21 Amplification and Arm-Length Deletions in Multiple Myeloma

Jeffery R. Sawyer, Erming Tian, PhD MBA, Brian A Walker, PhD, Charles M. Swanson, Janet L Lukacs, Gael M. Sammartino, Clyde Bailey, Sharmilan Thanendrarajan, MD, Carolina D. Schinke, MD, Maurizio Zangari, MD, Frits van Rhee, MD PhD, Faith E. Davies, MD, Gareth J. Morgan, MD PhD

Blood (2017) 130 (Supplement 1): 3060.

https://doi.org/10.1182/blood.V130.Suppl_1.3060.3060

Published: 2017

Journal Articles

Extracellular DEK Regulates Hematopoiesis through CXCR2-Mediated Intracellular Signaling That Does Not Require Its Translocation into the Nucleus or Binding to DNA

Maegan Capitano, PhD, Nirit Mor-Vaknin, PhD, Maureen Legendre, Scott Cooper, MS, Ferdinand Kappes, PhD, David Markovitz, MD, Hal E. Broxmeyer, PhD

Blood (2017) 130 (Supplement 1): 3770.

https://doi.org/10.1182/blood.V130.Suppl_1.3770.3770

Published: 2017

Journal Articles

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Makoto Yamagishi, PhD, Dai Fujikawa, PhD, Makoto Hori, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD PhD MPH, Atae Utsunomiya, MD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD

Blood (2017) 130 (Supplement 1): 1200.

https://doi.org/10.1182/blood.V130.Suppl_1.1200.1200

Published: 2017

Journal Articles

The Essential Cell Cycle Regulator Setd8 Drives Chromatin Condensation during Terminal Erythroid Maturation

Jeffrey Malik, PhD, Jacquelyn Lillis, MS, Michael Getman, MS, Laurie A Steiner, MD

Blood (2016) 128 (22): 1035.

https://doi.org/10.1182/blood.V128.22.1035.1035

Published: 2016

Journal Articles

DEK Regulates Hematopoietic Stem and Progenitor Cell Fate By Activating AKT and ERK Mediated Signaling through CXCR2/Heparan Sulfate Proteoglycans

Maegan L. Capitano, PhD, Nirit Mor-Vaknin, Maureen Legendre, Scott Cooper, MAS, David Markovitz, MD, Hal E. Broxmeyer, PhD

Blood (2016) 128 (22): 2645.

https://doi.org/10.1182/blood.V128.22.2645.2645

Published: 2016

Journal Articles

Lentiviral Vectors Incorporating Ubiquitous Chromatin Opening Element Driving Canine CD18 Expression

Everette J. R. Nelson, PhD, Laura M. Tuschong, B.S., Dennis D. Hickstein, MD

Blood (2016) 128 (22): 5890.

https://doi.org/10.1182/blood.V128.22.5890.5890

Published: 2016

Journal Articles

Recombinant DEK Enhances Ex Vivo expansion of Human Cord Blood and Mouse Bone Marrow Hematopoietic Stem Cells in a CXCR2- and Hspg-Dependent Manner

Maegan L. Capitano, PhD, Nirit Mor-Vaknin, Maureen Legendre, Scott Cooper, MAS, David Markovitz, MD, Hal E. Broxmeyer, PhD

Blood (2015) 126 (23): 779.

https://doi.org/10.1182/blood.V126.23.779.779

Published: 2015

Journal Articles

The Sea Urchin sns5 Chromatin Insulator Improves the Likelihood of Lentiviral Vectors in Erythroid Milieu By Organizing an Independent Chromatin Domain at the Integration Site

Elena Baiamonte, Rosalia Di Stefano, Melania Lo Iacono, Barbara Spina, Angela Vitrano, Rosario Di Maggio, Massimiliano Sacco, Giovanni Spinelli, Aurelio Maggio, Santina Acuto, Vincenzo Cavalieri

Blood (2015) 126 (23): 4414.

https://doi.org/10.1182/blood.V126.23.4414.4414

Published: 2015

Journal Articles

Inhibition of SUV39H Methyltransferase As a Potent Therapeutic Target in Multiple Myeloma

Julie Devin, Elena Viziteu, Laurie Herviou, Anja Seckinger, MD, Grandmougin Camille, Hartmut Goldschmidt, MD, Laure Vincent, MD, Philippe Pasero, PhD, Dirk Hose, MD, Bernard Klein, PhD, Jerome Moreaux, PhD

Blood (2015) 126 (23): 1771.

https://doi.org/10.1182/blood.V126.23.1771.1771

Published: 2015

NARROW

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging

Congenital Dyserythropoietic Anemia Type I Due to Biallelic CDAN1 mutations: Report from the Congenital Dyserythropoietic Anemia Registry (CDAR)

Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing

Codanin-1 Mutations Engineered in Human Erythroid Cells Allow Investigation of Mechanisms Underlying Congenital Dyserythropoietic Anemia

The Histone Methyltransferase Setd8 Alters the Chromatin Landscape and Regulates the Expression of Key Transcription Factors during Erythroid Differentiation

Crispri-Based Screening of Clustered Regulatory Elements Reveals Novel Leukemia Dependencies

RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α

FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1

A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia

Active enhancer and chromatin accessibility landscapes chart the regulatory network of primary multiple myeloma

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

Chromosome 1q12 Instability Drives Both 1q21 Amplification and Arm-Length Deletions in Multiple Myeloma

Extracellular DEK Regulates Hematopoiesis through CXCR2-Mediated Intracellular Signaling That Does Not Require Its Translocation into the Nucleus or Binding to DNA

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

The Essential Cell Cycle Regulator Setd8 Drives Chromatin Condensation during Terminal Erythroid Maturation

DEK Regulates Hematopoietic Stem and Progenitor Cell Fate By Activating AKT and ERK Mediated Signaling through CXCR2/Heparan Sulfate Proteoglycans

Lentiviral Vectors Incorporating Ubiquitous Chromatin Opening Element Driving Canine CD18 Expression

Recombinant DEK Enhances Ex Vivo expansion of Human Cord Blood and Mouse Bone Marrow Hematopoietic Stem Cells in a CXCR2- and Hspg-Dependent Manner

The Sea Urchin sns5 Chromatin Insulator Improves the Likelihood of Lentiviral Vectors in Erythroid Milieu By Organizing an Independent Chromatin Domain at the Integration Site

Inhibition of SUV39H Methyltransferase As a Potent Therapeutic Target in Multiple Myeloma

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American Society of Hematology

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American Society of Hematology

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