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Journal Articles

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao

Blood (2021) 137 (11): 1478–1490.

https://doi.org/10.1182/blood.2020005199

Published: 2021

Includes: Supplemental data

Journal Articles

Phase 1 Study of Bisthianostat, an Orally Efficacious Pan-HDAC Inhibitor: Part Results of Safety, Pharmacokinetics and Efficacy in Patients with Relapsed or Refractory Multiple Myeloma

Hong-Hui Huang, PhD MD, Jian Hou, PhD MD, Yang-Ming Zhang, PhD, Yu-Bo Zhou, PhD, Li Jia, PhD, Fa-Jun Nan, PhD

Blood (2019) 134 (Supplement_1): 5591.

https://doi.org/10.1182/blood-2019-129683

Published: 2019

Journal Articles

Low-Dose Triptolide Enhances Bromodomain Inhibitor JQ1-Induced Apoptosis of Acute Myeloid Leukemia Cells Via Down-Regulation of c-Myc Following RAS/MEK/ERK Inhibition

Bing Xu, Yuanfei Shi, Haijun Zhao, Yi Qiu, PhD

Blood (2019) 134 (Supplement_1): 5757.

https://doi.org/10.1182/blood-2019-123740

Published: 2019

Journal Articles

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

Ipsita Pal, PhD, Yu Ri Kim, MD, Sohani Das Sharma, PhD, Prabhjot S. Mundi, MD, Andre M. Grilo, PhD, Luke E Berchowitz, PhD, Mingzhao Zhu, PhD, Hull G. Kenneth, PhD, Daniel Romo, PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 4067.

https://doi.org/10.1182/blood-2019-131816

Published: 2019

Journal Articles

Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma

Xuan Zhang, BMBS, Chengfeng Bi, MD PhD, Ting Lu, MD PhD, Ting Yue, Weiwei Zhang, PhD, Xiaoyan Zhang, MD, Wang Cheng, MD, Tian Tian, MD, Matthew A. Lunning, DO, Julie M. Vose, MDMBA, Jerry Pelletier, PhD, John A Porco, Jr., PhD, Jianguo Tao, MD PhD, Kai Fu, MD PhD

Blood (2018) 132 (Supplement 1): 38.

https://doi.org/10.1182/blood-2018-99-117659

Published: 2018

Journal Articles

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 3941.

https://doi.org/10.1182/blood-2018-99-112376

Published: 2018

Journal Articles

Survey of Integrative Medicine in Myeloproliferative Neoplasms (The SIMM Study-2)

Krisstina L. Gowin, DO, Blake T. Langlais, Denise Millstine, MD, Heidi E. Kosiorek, MS, Jennifer Huberty, PhD, Ryan Eckert, MS, Ruben A. Mesa, MD FACP

Blood (2018) 132 (Supplement 1): 3047.

https://doi.org/10.1182/blood-2018-99-119493

Published: 2018

Journal Articles

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

Xin Xu, PhD, Wilhelm G Dirks, PhD, Hans G. Drexler, MD PhD, Zhenbo Hu, MD PhD

Blood (2018) 132 (Supplement 1): 4682.

https://doi.org/10.1182/blood-2018-99-112018

Published: 2018

Journal Articles

Silencing Oncogene Translation Using Pateamine a Analogues As a Novel Therapeutic Strategy for c-Myc Driven Lymphoma

Yu Ri Kim, MD, Ipsita Pal, PhD, Mark R Lipstein, PhD, Mingzhao Zhu, Hull Kenneth, Daniel Romo, Owen A. O'Connor, MD, PhD, Changchun Deng, MD PhD

Blood (2017) 130 (Supplement 1): 4111.

https://doi.org/10.1182/blood.V130.Suppl_1.4111.4111

Published: 2017

Journal Articles

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

Tara Peters, BA, Joseph Tillotson, PhD, Sarah C Wilmore, BSc, Alison Yeomans, PhD, Graham Packham, PhD, Eli Chapman, PhD, Jonathan H. Schatz, MD, Lingxiao Li, PhD

Blood (2017) 130 (Supplement 1): 4112.

https://doi.org/10.1182/blood.V130.Suppl_1.4112.4112

Published: 2017

Journal Articles

PCT3, a Combination of Active Steroidal Saponins from the Paris Forrestii (Takht.) H. Li, Displays Potent Activity Against Acute Myeloid Leukemia By Suppressing the PBX1/RNF6/AKT/mTOR Signaling Pathway

Qin Lu, MD, Yunjing Zheng, MD, Yuehu Wang, PhD, Jian Pan, PhD, Xinliang Mao, MD PhD, Shaoyan Hu, MD PhD

Blood (2017) 130 (Supplement 1): 2533.

https://doi.org/10.1182/blood.V130.Suppl_1.2533.2533

Published: 2017

Journal Articles

Narciclasine Display Preferential Pre-Clinical Activity Against KSHV-Associated Primary Effusion Lymphoma By Targeting MYC Via NF-κB

Ramakrishnan Gopalakrishnan, PhD, Hittu Matta, PhD, Sunju Choi, PhD, Preet M. Chaudhary, MD PhD

Blood (2017) 130 (Supplement 1): 2807.

https://doi.org/10.1182/blood.V130.Suppl_1.2807.2807

Published: 2017

Journal Articles

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

Andrew Lewis, Chun Shik Park, PhD, Ye Shen, PhD, Nam Kyung Lee, B.S., H. Daniel Lacorazza, PhD

Blood (2017) 130 (Supplement 1): 1329.

https://doi.org/10.1182/blood.V130.Suppl_1.1329.1329

Published: 2017

Journal Articles

XPO1 Target Occupancy Measurements Using Fluorescence Cross Correlation Spectroscopy Support the Selinexor Recommended Phase 2 Dose

Marsha L. Crochiere, PhD, Stefan Hannus, PhD, Kerrin Hansen, Frank Becker, PhD, Erkan Baloglu, PhD, Michael Kauffman, MD PhD, Yosef Landesman, PhD

Blood (2016) 128 (22): 1563.

https://doi.org/10.1182/blood.V128.22.1563.1563

Published: 2016

Journal Articles

Indirubins: A Potential Therapeutic Target in Multiple Myeloma

Tina Bagratuni, Nicolas Gaboriad-Kolar, Roubini Zakopoulou, Vassilios Myrianthopoulos, Efstathios Kastritis, MD, Evangelos Terpos, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Meletios A Dimopoulos

Blood (2016) 128 (22): 3259.

https://doi.org/10.1182/blood.V128.22.3259.3259

Published: 2016

Journal Articles

Inhibition of CML Stem Cells with an Alkaloid That Reduces β-Catenin

Shawnya J. Michaels, MS,MBA, Ngoc DeSouza, PhDCandidate, Yi Shan, MD, Shaoguang Li, MD PhD, Saira Bates, MBA

Blood (2016) 128 (22): 1882.

https://doi.org/10.1182/blood.V128.22.1882.1882

Published: 2016

Journal Articles

Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo

Mariko Sato, Kota Fujimori, Shotaro Kitabatake, Mikio Okayama, MD, Daiju Ichikawa, PhD, Yutaka Suto, PhD, Genji Iwasaki, PhD, Fumiyuki Kiuchi, PhD, Takashi Yamaguchi, Arimi Ueda, Shuji Aida, Hitomi Nakayama, MD, Maiko Matsushita, MD PhD, Yutaka Hattori, MD PhD

Blood (2016) 128 (22): 2100.

https://doi.org/10.1182/blood.V128.22.2100.2100

Published: 2016

Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Blood (2016) 128 (22): 966.

https://doi.org/10.1182/blood.V128.22.966.966

Published: 2016

Journal Articles

An Evaluation of the Cytotoxic Effect of the Natural Product Aaptamine Against t(4;11) Leukemias

Chandrima Sinha, PhD, John Bowling, PhD, Aman Seth, MS, Bensheng Ju, PhD, Bhaskar Kahali, PhD, Mark Hamann, PhD, Lea C. Cunningham, MD

Blood (2016) 128 (22): 1624.

https://doi.org/10.1182/blood.V128.22.1624.1624

Published: 2016

Journal Articles

Preliminary Characterization of Occipodins, Natural Product Anticoagulants from Hematophagous Marine Parasites, Isopod Elthusa vulgaris and Copepod Phrixocephalus Cincinnatus.

Alexander M. Urry, Alexandra N. Filkins, Shana K. Goffredi, PhD, Aram M Nersissian, William J Reeves

Blood (2016) 128 (22): 1443.

https://doi.org/10.1182/blood.V128.22.1443.1443

Published: 2016

NARROW

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Phase 1 Study of Bisthianostat, an Orally Efficacious Pan-HDAC Inhibitor: Part Results of Safety, Pharmacokinetics and Efficacy in Patients with Relapsed or Refractory Multiple Myeloma

Low-Dose Triptolide Enhances Bromodomain Inhibitor JQ1-Induced Apoptosis of Acute Myeloid Leukemia Cells Via Down-Regulation of c-Myc Following RAS/MEK/ERK Inhibition

Targeting eIF4A Using MZ-735 Potently Induces Cell Death in Lymphoma Cells and Rapidly Represses mRNA Translation at the Global Level and in C-MYC and Other Oncogenes

Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma

Small Molecular Modulators of Histone Demethylases Selectively Inhibits Growth of Hematopoietic Malignancies

Survey of Integrative Medicine in Myeloproliferative Neoplasms (The SIMM Study-2)

A Small Molecular Agonist of Histone Demethylase KDM3B Selectively Represses MLL -Rearranged Acute Leukemia

Silencing Oncogene Translation Using Pateamine a Analogues As a Novel Therapeutic Strategy for c-Myc Driven Lymphoma

The Marine Natural Compound Elatol Is a Novel Protein Translation Inhibitor with Potent Activity Against Aggressive Non-Hodgkin Lymphomas

PCT3, a Combination of Active Steroidal Saponins from the Paris Forrestii (Takht.) H. Li, Displays Potent Activity Against Acute Myeloid Leukemia By Suppressing the PBX1/RNF6/AKT/mTOR Signaling Pathway

Narciclasine Display Preferential Pre-Clinical Activity Against KSHV-Associated Primary Effusion Lymphoma By Targeting MYC Via NF-κB

Chemical Inhibition of the Macrophage Inhibitor Factor (MIF) Induces Cell Cycle Arrest and Apoptosis in Lymphoid and Myeloid Leukemia

XPO1 Target Occupancy Measurements Using Fluorescence Cross Correlation Spectroscopy Support the Selinexor Recommended Phase 2 Dose

Indirubins: A Potential Therapeutic Target in Multiple Myeloma

Inhibition of CML Stem Cells with an Alkaloid That Reduces β-Catenin

Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

An Evaluation of the Cytotoxic Effect of the Natural Product Aaptamine Against t(4;11) Leukemias

Preliminary Characterization of Occipodins, Natural Product Anticoagulants from Hematophagous Marine Parasites, Isopod Elthusa vulgaris and Copepod Phrixocephalus Cincinnatus.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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