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Journal Articles

Bone Marrow Ribonucleotide Reductase mRNA Levels and Methylation Status As a Prognostic Factor in Patients with Myelodysplastic Syndrome Treated with 5-Azacytidine

Christina-Nefeli Kontandreopoulou, BSc, Panagiotis T Diamantopoulos, MD PhD, Argiris Symeonidis, MD PhD, Ioannis Kotsianidis, Vassiliki Pappa, MD, Athanasios Galanopoulos, MD PhD, Andreas Giannopoulos, BSc, MSc, Katerina Zoi, PhD, Maria Dimou, MD PhD, Elena E. Solomou, MD, Panayiotis Panayiotidis, MD, Georgios Kyriakakis, Nefeli Giannakopoulou, Georgios Dryllis, Sevastianos Chatzidavid, Nora-Athina Viniou, MD PhD

Blood (2019) 134 (Supplement_1): 1721.

https://doi.org/10.1182/blood-2019-126426

Published: 2019

Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD

Blood (2018) 132 (Supplement 1): 5224.

https://doi.org/10.1182/blood-2018-99-113937

Published: 2018

Journal Articles

Setd2 Is Critical for Maintaining Hematopoietic Homeostasis

Yuanliang Zhang, Jiewen Sun, Zhu Chen, PhD, Sai-Juan Chen, PhD, Xiaojian Sun, Qiuhua Huang

Blood (2017) 130 (Supplement 1): 2414.

https://doi.org/10.1182/blood.V130.Suppl_1.2414.2414

Published: 2017

Journal Articles

Deferasirox Induces Apoptosis in Mantle Cell Lymphoma in a Mechanism Involving Cyclin-D1, p53 and the Ribonucleotide Reductase

Aladin Samara, BSc, MSc, Saar Shapira, MSc, Ido Lubin, PhD, Smadar Avigad, PhD, Pia Raanani, Galit Granot, PhD

Blood (2017) 130 (Supplement 1): 1481.

https://doi.org/10.1182/blood.V130.Suppl_1.1481.1481

Published: 2017

Journal Articles

Combination of Venetoclax and CUDC-907 Shows Superior Antileukemic Activity Against Acute Myeloid Leukemia Ex Vivo

Xinyu Li, Jun Ma, Yongwei Su, Jianyun Zhao, Holly Edwards, Yue Wang, Jay Yang, MD, Jeffrey W Taub, MD, Hai Lin, Yubin Ge, PhD

Blood (2016) 128 (22): 1571.

https://doi.org/10.1182/blood.V128.22.1571.1571

Published: 2016

Journal Articles

Targeting Ribonucleotide Reductase M1 and M2 in Multiple Myeloma

Morihiko Sagawa, MD PhD, Hiroto Ohguchi, MD PhD, Takeshi Harada, MD PhD, Mehmet K. Samur, PhD, Yu-Tzu Tai, PhD, Nikhil C Munshi, MD, Teru Hideshima, MD PhD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 360.

https://doi.org/10.1182/blood.V128.22.360.360

Published: 2016

Journal Articles

Synergistic Lethality with Gemcitabine and Arsenic Trioxide Against Human T Cell Lymphoma Jurkat Cells

Mingwan Zhang, MD, Xiaojun Xu, MD PhD, Yongbin Ye, MD PhD, Qifa Liu

Blood (2016) 128 (22): 5383.

https://doi.org/10.1182/blood.V128.22.5383.5383

Published: 2016

Journal Articles

Mechanisms of Resistance to 5-Azacytidine/Decitabine in MDS-AML and Pre-Clinical In Vivo Proof of Principle of Rational Solutions to Extend Response

Quteba Ebrahem, Reda Z. Mahfouz, MDPhD, Lisa Durkin, Mikkael A. Sekeres, MD MS, Anjali S. Advani, MD, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD, Betty K. Hamilton, MD, Aaron T. Gerds, MD MS, Ronald Sobecks, MD, Frederic J. Reu, MD, Eric D. Hsi, MD, Jaroslaw P. Maciejewski, MD PhD, Yogenthiran Saunthararajah, MD

Blood (2015) 126 (23): 678.

https://doi.org/10.1182/blood.V126.23.678.678

Published: 2015

Journal Articles

Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease

Xu Zhang, PhD, Wei Zhang, PhD, Binal Shah, PhD, Galina Miasnikova, MD, Adelina Sergueeva, MD, Tatiana Ammosova, PhD, Xiaomei Niu, Mehdi Nouraie, MD PhD, Sergei Nekhai, PhD, Roberto F. Machado, MD, Joe G.N. Garcia, Mark T. Gladwin, MD, Oswaldo L Castro, MD, Victor R. Gordeuk, MD

Blood (2015) 126 (23): 3380.

https://doi.org/10.1182/blood.V126.23.3380.3380

Published: 2015

Journal Articles

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

Leona Raskova Kafkova, Zuzana Somikova, Jana Kucerova, MSc, Lenka Calabkova, Pavla Luzna, Jan Stetka, Dana Simkova, Dalibor Dolezal, Vladimir Divoky, PhD

Blood (2015) 126 (23): 3351.

https://doi.org/10.1182/blood.V126.23.3351.3351

Published: 2015

Journal Articles

WT1 Protects Leukemic Cells from Cytotoxic Replicative Stress

Oliver H. Krämer, Prof. Dr., PhD

Blood (2014) 124 (21): 880.

https://doi.org/10.1182/blood.V124.21.880.880

Published: 2014

Journal Articles

Nelarabine Alone or in Combination in High Risk Childhood / Adolescent and Young Adults (AYA) T- Cell Acute Lymphoblastic Leukemia

Benoit Brethon, MD, Laetitia Morel, MD, Arnaud Petit, MD PhD, Etienne Lengliné, MD, Aurelie Cuinet, MD, Genevieve Vaudre, Thierry Leblanc, MD, Marie-Dominique Tabone, MD, Guy Leverger, MD, Nicolas Boissel, MD PhD, André Baruchel, MD

Blood (2014) 124 (21): 3723.

https://doi.org/10.1182/blood.V124.21.3723.3723

Published: 2014

Journal Articles

The Novel Phospholipid Gemcitabine Conjugate KPC34 Has Activity In Acute Leukemia

Timothy Pardee, MD, PhD, Peter Alexander, BA, Kristin Stadelman, MS, Greg Kucera, PhD

Blood (2013) 122 (21): 1425.

https://doi.org/10.1182/blood.V122.21.1425.1425

Published: 2013

Journal Articles

A Phase I Study Of The Histone Deacetylase Inhibitor Entinostat Plus Clofarabine For Philadelphia Chromosome Negative, Poor Risk (Newly Diagnosed Older Adults or Adults with Relapsed and Refractory Disease) Acute Lymphoblastic Leukemia Or Bilineage/Biphenotypic Leukemia

Hetty E Carraway, MD, MBA, Judith E. Karp, MD, Ivana Gojo, MD, Keith W. Pratz, MD, Nilanjan Ghosh, MD, PhD, Steven D. Gore, MD, Margaret M. Showel, MD, Mark Levis, MD, PhD, B. Douglas Smith, Jacqueline Greer, James G. Herman, MD, Lia Gore, MD, Min-Jung Lee, PhD, Sunmin Lee, PhD, Peter Ordentlich, PhD, Richard Piekarz, MD, PhD, Jane Trepel, PhD

Blood (2013) 122 (21): 1427.

https://doi.org/10.1182/blood.V122.21.1427.1427

Published: 2013

Journal Articles

Single Arm, Multi-Center, Phase II Study Of Clofarabine In Chinese Pediatric Patients With Refractory Or Relapsed Acute Lymphoblastic Leukemia

Leping Zhang, Xin Du, MD, Yan Li, MD, Zhen Cai, MD, PhD, Kang Yu, MD, Fenlai Tan, MD, PhD, Yi Fang, MD, Xiaojun Huang, MD, Jin Lu, MD

Blood (2013) 122 (21): 5016.

https://doi.org/10.1182/blood.V122.21.5016.5016

Published: 2013

Journal Articles

Defective Nucleotide Metabolism Contributes To p53 Activation In Diamond-Blackfan Anemia

Nadia Danilova, Ph.D, Bibikova Elena, Todd Covey, David Nathanson, Elizabeth Dimitrova, Lindgren Anne, Bertil Glader, M.D., Ph.D, Caius Radu, Kathleen Sakamoto, Shuo Lin

Blood (2013) 122 (21): 1225.

https://doi.org/10.1182/blood.V122.21.1225.1225

Published: 2013

Journal Articles

Efficacy and Relative Costs Of Re-Induction Chemotherapy With Clofarabine and Cytarabine For Adults With AML

K Leigh Casey, PharmD, Omar S. Aljitawi, MD, Siddhartha Ganguly, MD, Sunil Abhyankar, MD, Allan Fleming, MD, Heather Male, MD, Joseph P McGuirk, DO, Tara L. Lin, MD

Blood (2013) 122 (21): 5043.

https://doi.org/10.1182/blood.V122.21.5043.5043

Published: 2013

Journal Articles

The Novel Ribonucleotide Reductase Inhibitor Didox Is Active Against AML with Limited Toxicities

Guerry J Cook, MSc, David L. Caudell, DVM, PhD, Howard L Elford, PhD, Timothy Pardee, MD, PhD

Blood (2012) 120 (21): 1513.

https://doi.org/10.1182/blood.V120.21.1513.1513

Published: 2012

Journal Articles

The Use of Clofarabine and Cytarabine Combination (CLARA) As Salvage Therapy for Relapsed and/or Refractory Acute Myeloid Leukemia (AML)

Anskar Y.H. Leung, MD, Eric Tse, MBBS, PhD, Herman S.Y. Liu, M.D., Joycelyn Sim, M.D., Bonnie C.S. Kho, M.D., Sze-Fai Yip, M.D., Harold K.K. Lee, M.D., Yok Lam Kwong, MD

Blood (2012) 120 (21): 1518.

https://doi.org/10.1182/blood.V120.21.1518.1518

Published: 2012

Journal Articles

Establishment of Novel Leukemic Cell Lines Resistant to Clofarabine by Dual Mechanisms of Decreased Active Metabolite and Increased Antiapoptotic Factor

Hiroko Shigemi, MD, Takahiro Yamauchi, MD, PhD, Takanori Ueda, MD, PhD

Blood (2012) 120 (21): 1356.

https://doi.org/10.1182/blood.V120.21.1356.1356

Published: 2012

NARROW

Bone Marrow Ribonucleotide Reductase mRNA Levels and Methylation Status As a Prognostic Factor in Patients with Myelodysplastic Syndrome Treated with 5-Azacytidine

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Setd2 Is Critical for Maintaining Hematopoietic Homeostasis

Deferasirox Induces Apoptosis in Mantle Cell Lymphoma in a Mechanism Involving Cyclin-D1, p53 and the Ribonucleotide Reductase

Combination of Venetoclax and CUDC-907 Shows Superior Antileukemic Activity Against Acute Myeloid Leukemia Ex Vivo

Targeting Ribonucleotide Reductase M1 and M2 in Multiple Myeloma

Synergistic Lethality with Gemcitabine and Arsenic Trioxide Against Human T Cell Lymphoma Jurkat Cells

Mechanisms of Resistance to 5-Azacytidine/Decitabine in MDS-AML and Pre-Clinical In Vivo Proof of Principle of Rational Solutions to Extend Response

Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

WT1 Protects Leukemic Cells from Cytotoxic Replicative Stress

Nelarabine Alone or in Combination in High Risk Childhood / Adolescent and Young Adults (AYA) T- Cell Acute Lymphoblastic Leukemia

The Novel Phospholipid Gemcitabine Conjugate KPC34 Has Activity In Acute Leukemia

A Phase I Study Of The Histone Deacetylase Inhibitor Entinostat Plus Clofarabine For Philadelphia Chromosome Negative, Poor Risk (Newly Diagnosed Older Adults or Adults with Relapsed and Refractory Disease) Acute Lymphoblastic Leukemia Or Bilineage/Biphenotypic Leukemia

Single Arm, Multi-Center, Phase II Study Of Clofarabine In Chinese Pediatric Patients With Refractory Or Relapsed Acute Lymphoblastic Leukemia

Defective Nucleotide Metabolism Contributes To p53 Activation In Diamond-Blackfan Anemia

Efficacy and Relative Costs Of Re-Induction Chemotherapy With Clofarabine and Cytarabine For Adults With AML

The Novel Ribonucleotide Reductase Inhibitor Didox Is Active Against AML with Limited Toxicities

The Use of Clofarabine and Cytarabine Combination (CLARA) As Salvage Therapy for Relapsed and/or Refractory Acute Myeloid Leukemia (AML)

Establishment of Novel Leukemic Cell Lines Resistant to Clofarabine by Dual Mechanisms of Decreased Active Metabolite and Increased Antiapoptotic Factor

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American Society of Hematology

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ASH Publications

American Society of Hematology

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