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Journal Articles

Myeloma Heterogeneity within Its Complex Immune Ecosystem

Jana Jakubikova, PhD, Danka Cholujova, PhD, Gabor Beke, PhD, Zachary R Hunter, PhD, Teru Hideshima, MD PhD, Merav Leiba, MD, Krzysztof Jamroziak, MD PhD, Paul G. Richardson, MD, Eftathios Kastritis, David M. Dorfman, MD PhD, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 4354.

https://doi.org/10.1182/blood-2019-132193

Published: 2019

Journal Articles

Reduced SLIT2 Are Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in APL Cells

Isabel Weinhäuser, MSc, Diego A Pereira-Martins, MSc, Luíse A A Simões, BSc, César Alexander Ortiz Rojas, BSc, Thiago Mantello Bianco, MSc, Cleide Lucia Silva, MSc, Mariane Cristina Do Nascimento, BSc, Lorena Lobo Figueiredo-Pontes, MD PhD, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD

Blood (2019) 134 (Supplement_1): 5165.

https://doi.org/10.1182/blood-2019-131496

Published: 2019

Journal Articles

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Blood (2019) 134 (Supplement_1): 5166.

https://doi.org/10.1182/blood-2019-131595

Published: 2019

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

Hirohito Kubota, MD, Kana Furuichi, Tatsuya Masuda, Toshiya Tatsuta, Hidefumi Hiramatsu, MD PhD, Junko Takita, MD PhD, Sugiyama Hiroshi, PhD, Souichi Adachi, MD PhD, Yasuhiko Kamikubo, MD, PhD

Blood (2019) 134 (Supplement_1): 3359.

https://doi.org/10.1182/blood-2019-126428

Published: 2019

Journal Articles

High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment

Jana Jakubikova, PhD, Danka Cholujova, PhD, Gabor Beke, PhD, Zachary R Hunter, PhD, Teru Hideshima, MD PhD, Ludmila Flores, Merav Leiba, MD, Paul G. Richardson, MD, Eftathios Kastritis, David M. Dorfman, MD PhD, Steven P Treon, MD PhD FRCP, Kenneth C. Anderson, MD

Blood (2019) 134 (Supplement_1): 3975.

https://doi.org/10.1182/blood-2019-130011

Published: 2019

Journal Articles

Tumor Inflammation and Myeloid Derived Suppressor Cells Reduce the Efficacy of CD19 CAR T Cell Therapy in Lymphoma

Michael D. Jain, MD PhD, Hua Zhao, Reginald Atkins, Meghan A Menges, Crystal R Pope, Rawan Faramand, MD, Sae Bom Lee, Justin C. Boucher, PhD, Hiroshi Kotani, MD PhD, Christina A Bachmeier, PharmD, Julio Chavez, Bijal Shah, MD, Mohammad Hussaini, MD, Ricardo J Gonzalez, MD, John E Mullinax, MD PhD, Marco L. Davila, MD PhD, Frederick L. Locke, MD

Blood (2019) 134 (Supplement_1): 2885.

https://doi.org/10.1182/blood-2019-131041

Published: 2019

Journal Articles

Robust Hematopoietic Stem Cell Function and Minimal Myeloid Skewing with Aging in Un-Separated Murine Whole Bone Marrow: What Are We Losing with Hematopoietic Stem Cell Purification?

Mark S Dooner, Elaine Papa, Michael Del Tatto, Mandy Pereira, Sicheng Wen, MD PhD, Yan Cheng, PhD, Peter J. Quesenberry, MD, Laura R Goldberg, MD PhD

Blood (2019) 134 (Supplement_1): 3723.

https://doi.org/10.1182/blood-2019-124367

Published: 2019

Journal Articles

In Vivo Efficacy of Anti-CD20-Interferon-Gamma Fusion Protein Against Syngeneic B Cell Lymphoma Is Mediated By Natural Killer Cells

Alex Vasuthasawat, BS, MS, Reiko E Yamada, Kham R Trinh, Neiki Rokni, Sherie L Morrison, PhD, John M. Timmerman, MD

Blood (2019) 134 (Supplement_1): 1575.

https://doi.org/10.1182/blood-2019-131890

Published: 2019

Journal Articles

A Molecular Signature of Three tRNA-Derived RNA Fragments May Discriminate Smoldering from Symptomatic Multiple Myeloma Patients

Paraskevi Karousi, BSc, Aristea-Maria Papanota, MD, Pinelopi I Artemaki, BSc, Christine Liacos, MSc, Christos K. Kontos, PhD, Dimitris Patseas, BSc, Aikaterini-Anna Liosi, BSc, Nefeli Mavrianou-Koutsoukou, BSc, Maria-Anna Kalioraki, BSc, Despina Fotiou, BMBS, MA, Ioannis Ntanasis-Stathopoulos, MD, Magdalini Migkou, MD, Panagiotis Malandrakis, MD, Maria Gavriatopoulou, MD, Eftathios Kastritis, Evangelos Terpos, MD PhD, Andreas Scorilas, PhD, Meletios A. Dimopoulos, MD

Blood (2019) 134 (Supplement_1): 5528.

https://doi.org/10.1182/blood-2019-129082

Published: 2019

Journal Articles

IL-7 Activates a STAT5/PIM1 Axis to Promote T-Cell Acute Lymphoblastic Leukemia Proliferation and Viability in a Bcl-2-Independent Manner

Ribeiro Daniel, PhD, Alice Melão, Msc, Ruben van Boxtel, PhD, Cristina Santos, PhD, Ana Silva, PhD, Milene C Silva, PhD, Bruno António Cardoso, PhD, Paul J. Coffer, PhD Prof, Joao Barata, PhD

Blood (2018) 132 (Supplement 1): 914.

https://doi.org/10.1182/blood-2018-99-113778

Published: 2018

Journal Articles

Inhibitor of DNA Binding 2 (ID2) Plays a Key Tumor Suppressor Role in Promoting Oncogenic Transformation in Multiple Myeloma

Tommaso Perini, MD, Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, Matthew Lawlor, Christopher J. Ott, PhD, Na Li, MD, Yan Xu, MD, Kenneth Wen, BS, Nicola Amodio, PhD, Eugenio Morelli, MD, Kenneth Anderson, MD, Fabio Ciceri, MD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 60.

https://doi.org/10.1182/blood-2018-99-118401

Published: 2018

Journal Articles

Evaluation of Oncolytic Viral Therapy Combined with or without Artificial Immunoadjuvant Cell Therapy in Immunocompetent Mouse Tumor Models

Weng-Chit Ung, MSc, Muneyoshi Futami, MD PhD, Kota Sato, MDPhD, Arinobu Tojo, MD PhD

Blood (2018) 132 (Supplement 1): 5793.

https://doi.org/10.1182/blood-2018-99-112789

Published: 2018

Journal Articles

BCL-2 Inhibitor Venetoclax (ABT-199) and MEK Inhibitor GDC-0973 Synergise to Target AML Progenitors and Overcome Drug Resistance with the Use of PET Scanning in a Mouse Model of HR-MDS to Monitor Response to Treatment

Rose Ann Padua, PhD, Laure Sarda-Mantel, MD PhD, Mathieu Chiquet, BSc, Claire Kappel, BSc, Patricia Krief, PhD, Niclas Setterblad, PhD, Fortune Hontonnou, BSc, Benoit Hosten, PhD, Nicolas Vignal, BSc, Fabien Zassadowski, PhD, Bruno Cassinat, PharmD, PhD, Panhong Gou, BSc, Stephane Giraudier, MD PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD, Marika PLA, PhD, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Christine Chomienne, MD PhD

Blood (2018) 132 (Supplement 1): 5497.

https://doi.org/10.1182/blood-2018-99-114212

Published: 2018

Journal Articles

The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest

Mathias A. Schneeweiss, Gabriele Stefanzl, Daniela Berger, Gregor Eisenwort, Mohamad Jawhar, Greiner Georg, MD PhD, Gregor Hoermann, Wolfgang R. Sperr, Michel Arock, Andreas Reiter, MD, Peter Valent, Karoline V. Gleixner, MD

Blood (2018) 132 (Supplement 1): 1363.

https://doi.org/10.1182/blood-2018-99-116525

Published: 2018

Journal Articles

Phospholipase Cgamma Pathway-Dependent mTOR Signaling Controls IL-7-Mediated Early B Cell Development

Mei Yu, PhD, Chen Yuhong, PhD, Hu Zeng, PhD, Yongwei Zheng, PhD, Guoping Fu, PhD, Wen Zhu, Ulrich Broeckel, MD, Praful Aggarwal, Amy Turner, Geoffrey A.M. Neale, PhD, Nan Zhu, PhD, Hongbo Chi, PhD, Renren Wen, PhD, Demin Wang, PhD

Blood (2017) 130 (Supplement 1): 620.

https://doi.org/10.1182/blood.V130.Suppl_1.620.620

Published: 2017

Journal Articles

Hematopoietic Stem Cell Potential within the Primary Sorted Lineage Positive Population: What Are We Losing with Hematopoietic Stem Cell Purification?

Laura R Goldberg, MD PhD, Mark S Dooner, Elaine Papa, Michael Del Tatto, Isabel Barnet, Mandy Pereira, Sicheng Wen, MD PhD, Yan Cheng, Peter J. Quesenberry, MD

Blood (2017) 130 (Supplement 1): 1145.

https://doi.org/10.1182/blood.V130.Suppl_1.1145.1145

Published: 2017

Journal Articles

Recurrent Genetic Variants of Long Non-Coding RNAs (lncRNAs) Independently Associate with Clinical Outcome of Younger Adults with Cytogenetically Normal Acute Myeloid Leukemia

Dimitrios Papaioannou, MD, Hatice Gulcin Ozer, PhD, Deedra Nicolet, MS, Krzysztof Mrózek, MD PhD, Volinia Stefano, PhD, Andrew J. Carroll, III, PhD, Jessica Kohlschmidt, PhD, William Blum, MD, Bayard L. Powell, MD, Eunice S. Wang, MD, Geoffrey L. Uy, MD, Jonathan E. Kolitz, MD, Ann-Kathrin Eisfeld, MD, Richard M. Stone, MD, John C. Byrd, MD, Ramiro Garzon, MD, Clara D. Bloomfield, MD

Blood (2017) 130 (Supplement 1): 1401.

https://doi.org/10.1182/blood.V130.Suppl_1.1401.1401

Published: 2017

Journal Articles

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Stine Nygaard Nielsen, PhD MD, Kathrine Grell, PhD, Jacob Nersting, PhD, Jonas Abrahamsson, MD PhD, Bendik Lund, MD PhD, Jukka A. Kanerva, MD, Ólafur G Jónsson, MD, Goda Vaitkeviciene, MD, Kaie Pruunsild, MD, Malin Lindqvist Appell, Lisa Hjalgrim, PhD, Kjeld Schmiegelow, MD DMSc

Blood (2017) 130 (Supplement 1): 1279.

https://doi.org/10.1182/blood.V130.Suppl_1.1279.1279

Published: 2017

Journal Articles

Efficacy of Early Post-Transplant Vaccination Using a Prime and Boost Strategy Is Independent of a Prior History of GvHD: Results from BMT CTN 0201

Edmund K. Waller, MD, Brent R. Logan, PhD, Mingwei Fei, MS, Alan Howard, PhD, John R. Wingard, MD, Claudio Anasetti, MD, Cynthia R. Giver, PhD

Blood (2017) 130 (Supplement 1): 1972.

https://doi.org/10.1182/blood.V130.Suppl_1.1972.1972

Published: 2017

NARROW

Myeloma Heterogeneity within Its Complex Immune Ecosystem

Reduced SLIT2 Are Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in APL Cells

Arsenic Trioxide Abrogate MN1 Mediated RA-Resistance in Acute Promyelocytic Leukemia

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Therapeutic Targeting of RUNX-NFATC2 Axis for Acute Promyelocytic Leukemia and T Cell Immunity

High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment

Tumor Inflammation and Myeloid Derived Suppressor Cells Reduce the Efficacy of CD19 CAR T Cell Therapy in Lymphoma

Robust Hematopoietic Stem Cell Function and Minimal Myeloid Skewing with Aging in Un-Separated Murine Whole Bone Marrow: What Are We Losing with Hematopoietic Stem Cell Purification?

In Vivo Efficacy of Anti-CD20-Interferon-Gamma Fusion Protein Against Syngeneic B Cell Lymphoma Is Mediated By Natural Killer Cells

A Molecular Signature of Three tRNA-Derived RNA Fragments May Discriminate Smoldering from Symptomatic Multiple Myeloma Patients

IL-7 Activates a STAT5/PIM1 Axis to Promote T-Cell Acute Lymphoblastic Leukemia Proliferation and Viability in a Bcl-2-Independent Manner

Inhibitor of DNA Binding 2 (ID2) Plays a Key Tumor Suppressor Role in Promoting Oncogenic Transformation in Multiple Myeloma

Evaluation of Oncolytic Viral Therapy Combined with or without Artificial Immunoadjuvant Cell Therapy in Immunocompetent Mouse Tumor Models

BCL-2 Inhibitor Venetoclax (ABT-199) and MEK Inhibitor GDC-0973 Synergise to Target AML Progenitors and Overcome Drug Resistance with the Use of PET Scanning in a Mouse Model of HR-MDS to Monitor Response to Treatment

The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest

Phospholipase Cgamma Pathway-Dependent mTOR Signaling Controls IL-7-Mediated Early B Cell Development

Hematopoietic Stem Cell Potential within the Primary Sorted Lineage Positive Population: What Are We Losing with Hematopoietic Stem Cell Purification?

Recurrent Genetic Variants of Long Non-Coding RNAs (lncRNAs) Independently Associate with Clinical Outcome of Younger Adults with Cytogenetically Normal Acute Myeloid Leukemia

No Association between Relapse Risk and Thiopurine Methyltransferase Activity By Either Geno- or Phenotype in the NOPHO ALL-2008 Protocol

Efficacy of Early Post-Transplant Vaccination Using a Prime and Boost Strategy Is Independent of a Prior History of GvHD: Results from BMT CTN 0201

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American Society of Hematology

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