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Journal Articles

Megakaryocyte-Driven Myelofibrosis Leads to Progressive Osteosclerosis in G6b-B Knockout Mice

Mariya Stavnichuk, BSc, Zoltan Nagy, Yotis A. Senis, Svetlana V. Komarova

Blood (2019) 134 (Supplement_1): 4199.

https://doi.org/10.1182/blood-2019-124186

Published: 2019

Journal Articles

Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-β Signaling Pathway

Ehsan Malek, MD, Sunjin Hwang, MD, Marcos de Lima, MD, Paolo Caimi, MD, Molly M Gallogly, MD PhD, Leland Metheny, III, MD, Folashade Otegbeye, MBBChir,MPH, Benjamin K. Tomlinson, MD, Kirsten M Boughan, DO, Brenda Cooper, MD, James Driscoll, MD PhD, John Letterio, MD

Blood (2019) 134 (Supplement_1): 3232.

https://doi.org/10.1182/blood-2019-126728

Published: 2019

Journal Articles

Mutation of Murine Rpl5 reveals a New Model for Diamond Blackfan Anemia Characterized By Defective Erythropoiesis

Philippe Lemay, PhD, Morgan A Jones, MD PhD BS, MS, Fatma Mohamed, Marie-Claude Guyot, Alexander Ludlow, Qing Li, MD, James Douglas Engel, PhD, Renny Franceschi, PhD, Thomas L. Rothstein, MD PhD, Vesa Kaartinen, PhD, Zoha Kibar, PhD, Sharon A Singh, MD

Blood (2019) 134 (Supplement_1): 2495.

https://doi.org/10.1182/blood-2019-131526

Published: 2019

Journal Articles

Exosomes Play a Key Role in Multiple Myeloma Bone Disease and Tumor Development

Sylvia Faict, MD, Josephine Muller, PhD, Kim De Veirman, PhD, Ken Maes, Elke De Bruyne, PhD, Rik Schots, Jo Caers, MD PhD, Karin Vanderkerken, PhD, Eline Menu, PhD

Blood (2018) 132 (Supplement 1): 4484.

https://doi.org/10.1182/blood-2018-99-112428

Published: 2018

Journal Articles

Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model

Fani Ziouti, Maximilian Rummler, Andreas Brandl, PhD, Andreas Beilhack, MD, Maureen Lynch, PhD, Bettina Willie, PhD, Franziska Jundt, MD

Blood (2018) 132 (Supplement 1): 3164.

https://doi.org/10.1182/blood-2018-99-116796

Published: 2018

Journal Articles

Preclinical Studies and a Phase I Trial of the TGF-β Receptor Inhibitor, Vactosertib (TEW-7197), in Combination with Pomalidomide in Patients with Multiple Myeloma Refractory to Bortezomib or Lenalidomide

Ehsan Malek, MD, Byung-Gyu Kim, PhD DVM, Jason Valent, MD, James Driscoll, MD PhD, Paolo Caimi, MD, Seong-Jin Kim, PhD, Marcos de Lima, MD, John Letterio, MD

Blood (2018) 132 (Supplement 1): 1962.

https://doi.org/10.1182/blood-2018-99-112449

Published: 2018

Journal Articles

Vactosertib, a TGF-ß Receptor I Kinase/ALK5 Inhibitor, Diminishes Tumor Progression and Bone Disease in a Mouse Model of Multiple Myeloma and Overcomes Resistance to Proteasome Inhibitors

Byung-Gyu Kim, PhD DVM, Sung Hee Choi, PhD, George Luo, Olga Sergeeva, PhD, Zhenghong Lee, PhD, James Driscoll, MD PhD, Marcos de Lima, MD, Rose Beck, MD PhD, Seong-Jin Kim, PhD, John Letterio, MD, Ehsan Malek, MD

Blood (2018) 132 (Supplement 1): 1918.

https://doi.org/10.1182/blood-2018-99-117852

Published: 2018

Journal Articles

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Janik Engelmann, Isabel Ben Batalla, PhD, Hanna Taipaleenmäki, PhD, Kristoffer Riecken, PhD, Victoria Gensch, Sarina Paesler, Nikolaus Berenbrok, Maria Elena Vargas, Jonas Waizenegger, MD, Boris Fehse, PhD, Klaus Pantel, MD, PhD, Ihab S Darwish, PhD, Somasekhar Bhamidipati, PhD, Esteban Masuda, PhD, Carsten Bokemeyer, MD, PhD, Eric Hesse, MD, PhD, Sonja Loges, MD, PhD

Blood (2018) 132 (Supplement 1): 1922.

https://doi.org/10.1182/blood-2018-99-118273

Published: 2018

Journal Articles

Erythropoietin Eliminates Increased Bone Marrow Adiposity and Alters Bone Features in Obese Mice

Sukanya Suresh, PhD, Josue Caban Alvarez, MD, Constance Tom Noguchi, PhD

Blood (2017) 130 (Supplement 1): 3778.

https://doi.org/10.1182/blood.V130.Suppl_1.3778.3778

Published: 2017

Journal Articles

Correlative Lightsheet and Electron Microscopy Applied to a Zebrafish Model of Fetal Bone Marrow: Resolving the Ultrastructure of a Single Hematopoietic Stem Cell in the Niche

Sobhika Agarwala, PhD, Keun-Young Kim, PhD, Eric A Bushong, PhD, Mark H Ellisman, PhD, Jonathan E Henninger, Leonard I. Zon, MD, Owen J Tamplin, PhD

Blood (2017) 130 (Supplement 1): 137.

https://doi.org/10.1182/blood.V130.Suppl_1.137.137

Published: 2017

Journal Articles

The Novel Subtype-Selective Histone Deacetylase (HDAC) Inhibitor, Chidamide, Exerts Dual Anti-Myeloma and Bone Protective Effect in Vitro and In Vivo

Jingsong He, MD, Qingxiao Chen, MS, Yang Yang, MD, Yi Li, MD, Li Yang, MD, He Huang, MD PhD, Qing Yi, MD PhD, Zhen Cai, MD PhD

Blood (2017) 130 (Supplement 1): 5392.

https://doi.org/10.1182/blood.V130.Suppl_1.5392.5392

Published: 2017

Journal Articles

Targeted Remodeling of the Tumor Microenvironment Via Mechanical Stimulation Defines a Novel Therapeutic Strategy in Myeloma Bone Disease

Fani Ziouti, Maximilian Rummler, Anne Seliger, Andreas Brandl, PhD, Andreas Beilhack, MD, Bjarne Bogen, MD PhD, Maureen Lynch, PhD, Franz Jakob, MD, Regina Ebert, PhD, Bettina Willie, PhD, Franziska Jundt, MD

Blood (2017) 130 (Supplement 1): 1778.

https://doi.org/10.1182/blood.V130.Suppl_1.1778.1778

Published: 2017

Journal Articles

Bone-Targeted Pharmacological Inhibition of Notch Signaling As a Novel Approach to Inhibit Myeloma Growth and Bone Destruction

Jesus Delgado-Calle, PhD, Gerald Wu, Jessica Nelson, Emily G Atkinson, Kevin McAndrews, Lifeng Xiao, Frank H Ebetino, Robert K Boeckman, Jr., David David Roodman, MD PhD, Teresita Bellido

Blood (2017) 130 (Supplement 1): 4419.

https://doi.org/10.1182/blood.V130.Suppl_1.4419.4419

Published: 2017

Journal Articles

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Josephine Muller, Arnold Bolomsky, PhD, Kathrin Schonfelder, Frederic Baron, Yves Beguin, MD PhD, Heinz Ludwig, MD, Jo Caers, MD, Roy Heusschen, PhD

Blood (2017) 130 (Supplement 1): 4416.

https://doi.org/10.1182/blood.V130.Suppl_1.4416.4416

Published: 2017

Journal Articles

Role of Sclerostin in Multiple Myeloma Progression

Cristina Panaroni, PhD, Keertik Fulzele, PhD, Ka Tat Siu, PhD, Peter Wang, BS, Noopur Raje, MD

Blood (2017) 130 (Supplement 1): 4341.

https://doi.org/10.1182/blood.V130.Suppl_1.4341.4341

Published: 2017

Journal Articles

The Mechanisms of PIM Kinase Inhibitor, SGI-1776 Free Base, in Treating Myeloma-Associated Bone Disease

Qingxiao Chen, MS, Jingsong He, MD, Huiyao Gu, Xi Huang, MD, Jing Chen, MD, Zhang En Fan, Xing Guo, MD, Haimeng Yan, He Huang, MD, Zhen Cai, MD PhD

Blood (2017) 130 (Supplement 1): 3079.

https://doi.org/10.1182/blood.V130.Suppl_1.3079.3079

Published: 2017

Journal Articles

Hematopoietic Capacity in the Fatty Marrow of X. Laevis under the Low-Temperature Condition

Yuta Tanizaki, DSc, Takaki Aiso, BSc, Yoko Mochizuki, MSc, Takashi Kato, DSc

Blood (2016) 128 (22): 5050.

https://doi.org/10.1182/blood.V128.22.5050.5050

Published: 2016

Journal Articles

Recombinant Erythropoietin and Darbepoetin Alpha Exert a Similar Dose-Dependent Osteopenic Effect Which May Advocate for "Start Low, Go Slow" Dosing Strategy in Clinical Practice

Kolomansky Albert, MD, Sahar Hiram-Bab, PhD, Naamit Deshet-Unger, MSc, Nathalie Ben-Califa, PhD, Dafna Gilboa, MSc, Tamar Liron, PhD, Howard S Oster, MD PhD, Moshe Mittelman, MD, Yankel Gabet, DMD, PhD, Drorit Neumann, PhD

Blood (2016) 128 (22): 2445.

https://doi.org/10.1182/blood.V128.22.2445.2445

Published: 2016

Journal Articles

RANK-RANKL Mediated Bone Destruction in B-Cell Acute Lymphoblastic Leukemia

Sujeetha A. Rajakumar, MSc, Eniko Papp, PhD, Ildiko Grandal, MSc, Daniele Merico, PhD, Careesa C. Liu, MSc, Bedilu Allo, PhD, Lucia Zhang, Marc Grynpas, PhD, Mark D. Minden, MD PhD, Johann K. Hitzler, MD, Cynthia J. Guidos, PhD, Jayne S. Danska, PhD

Blood (2016) 128 (22): 908.

https://doi.org/10.1182/blood.V128.22.908.908

Published: 2016

Journal Articles

The Effect of Prophylactic Recombinant Factor IX and Glycopegylated Factor IX to Normalize Articular Wound Healing Following Hemarthrosis Examined in Hemophilia B Mice

Junjiang Sun, MD, Eric Livingston, Tom Knudsen, DVM, PhD, Dougald M. Monroe, III, PhD, Mirella Ezban, PhD, Ted Bateman, PhD, Paul E. Monahan, MD

Blood (2015) 126 (23): 549.

https://doi.org/10.1182/blood.V126.23.549.549

Published: 2015

NARROW

Megakaryocyte-Driven Myelofibrosis Leads to Progressive Osteosclerosis in G6b-B Knockout Mice

Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-β Signaling Pathway

Mutation of Murine Rpl5 reveals a New Model for Diamond Blackfan Anemia Characterized By Defective Erythropoiesis

Exosomes Play a Key Role in Multiple Myeloma Bone Disease and Tumor Development

Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model

Preclinical Studies and a Phase I Trial of the TGF-β Receptor Inhibitor, Vactosertib (TEW-7197), in Combination with Pomalidomide in Patients with Multiple Myeloma Refractory to Bortezomib or Lenalidomide

Vactosertib, a TGF-ß Receptor I Kinase/ALK5 Inhibitor, Diminishes Tumor Progression and Bone Disease in a Mouse Model of Multiple Myeloma and Overcomes Resistance to Proteasome Inhibitors

Blockade of Mer By the Small Molecule Inhibitor R992 Inhibits Multiple Myeloma and Its Associated Bone Disease By Restoring the Perturbed Bone Homeostasis

Erythropoietin Eliminates Increased Bone Marrow Adiposity and Alters Bone Features in Obese Mice

Correlative Lightsheet and Electron Microscopy Applied to a Zebrafish Model of Fetal Bone Marrow: Resolving the Ultrastructure of a Single Hematopoietic Stem Cell in the Niche

The Novel Subtype-Selective Histone Deacetylase (HDAC) Inhibitor, Chidamide, Exerts Dual Anti-Myeloma and Bone Protective Effect in Vitro and In Vivo

Targeted Remodeling of the Tumor Microenvironment Via Mechanical Stimulation Defines a Novel Therapeutic Strategy in Myeloma Bone Disease

Bone-Targeted Pharmacological Inhibition of Notch Signaling As a Novel Approach to Inhibit Myeloma Growth and Bone Destruction

Maternal Embryonic Leucine Zipper Kinase Inhibitor OTSSP167 Inhibits Osteoclast Activity and Restores Osteoblast Activity in a Murine Model of Multiple Myeloma Bone Disease

Role of Sclerostin in Multiple Myeloma Progression

The Mechanisms of PIM Kinase Inhibitor, SGI-1776 Free Base, in Treating Myeloma-Associated Bone Disease

Hematopoietic Capacity in the Fatty Marrow of X. Laevis under the Low-Temperature Condition

Recombinant Erythropoietin and Darbepoetin Alpha Exert a Similar Dose-Dependent Osteopenic Effect Which May Advocate for "Start Low, Go Slow" Dosing Strategy in Clinical Practice

RANK-RANKL Mediated Bone Destruction in B-Cell Acute Lymphoblastic Leukemia

The Effect of Prophylactic Recombinant Factor IX and Glycopegylated Factor IX to Normalize Articular Wound Healing Following Hemarthrosis Examined in Hemophilia B Mice

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American Society of Hematology

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American Society of Hematology

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