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Issue Archive

Volume 3, Issue 23
December 10 2019
Issue Cover

Table of Contents

CLINICAL GUIDELINES

American Society of Hematology 2019 guidelines for immune thrombocytopenia
Cindy Neunert,Deirdra R. Terrell,Donald M. Arnold,George Buchanan,Douglas B. Cines,Nichola Cooper,Adam Cuker,Jenny M. Despotovic,James N. George,Rachael F. Grace,Thomas Kühne,David J. Kuter,Wendy Lim,Keith R. McCrae,Barbara Pruitt,Hayley Shimanek,Sara K. Vesely
View Articletitled, American Society of Hematology 2019 guidelines for immune thrombocytopenia
Supplemental data
American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease
Robert I. Liem,Sophie Lanzkron,Thomas D. Coates,Laura DeCastro,Ankit A. Desai,Kenneth I. Ataga,Robyn T. Cohen,Johnson Haynes, Jr,Ifeyinwa Osunkwo,Jeffrey D. Lebensburger,James P. Lash,Theodore Wun,Madeleine Verhovsek,Elodie Ontala,Rae Blaylark,Fares Alahdab,Abdulrahman Katabi,Reem A. Mustafa
View Articletitled, American Society of Hematology 2019 guidelines for sickle cell disease: cardiopulmonary and kidney disease
Supplemental data
American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients
David R. Anderson,Gian Paolo Morgano,Carole Bennett,Francesco Dentali,Charles W. Francis,David A. Garcia,Susan R. Kahn,Maryam Rahman,Anita Rajasekhar,Frederick B. Rogers,Maureen A. Smythe,Kari A. O. Tikkinen,Adolph J. Yates,Tejan Baldeh,Sara Balduzzi,Jan L. Brożek,Itziar Etxeandia- Ikobaltzeta,Herman Johal,Ignacio Neumann,Wojtek Wiercioch,Juan José Yepes-Nuñez,Holger J. Schünemann,Philipp Dahm
View Articletitled, American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients
Supplemental data

EXCEPTIONAL CASE REPORT

Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib
Clinical Trials & Observations
Scott R. Goldsmith,Sana Saif Ur Rehman,Cara L. Shirai,Kiran Vij,John F. DiPersio
View Articletitled, Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib

STIMULUS REPORTS

Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma
David A. Alagpulinsa,Subodh Kumar,Srikanth Talluri,Purushothama Nanjappa,Leutz Buon,Chandraditya Chakraborty,Mehmet K. Samur,Raphael Szalat,Masood A. Shammas,Nikhil C. Munshi
View Articletitled, Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma
Stroke and myocardial infarction in hereditary thrombotic thrombocytopenic purpura: similarities to sickle cell anemia
Azra Borogovac,James N. George
View Articletitled, Stroke and myocardial infarction in hereditary thrombotic thrombocytopenic purpura: similarities to sickle cell anemia
Supplemental data
Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice
Kuang He,Zhenke Wu,Hideaki Fujiwara,Steven Whitesall,Cynthia K. Zajac,Sung Won Choi,Pavan Reddy,Muneesh Tewari
View Articletitled, Computational analysis of continuous body temperature provides early discrimination of graft-versus-host disease in mice
Supplemental data
Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor
Margaret Nieborowska-Skorska,Elisabeth M. Paietta,Ross L. Levine,Hugo F. Fernandez,Martin S. Tallman,Mark R. Litzow,Tomasz Skorski
View Articletitled, Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor
Supplemental data

REVIEW ARTICLES

2019 sickle cell disease guidelines by the American Society of Hematology: methodology, challenges, and innovations
M. Hassan Murad,Robert I. Liem,Eddy S. Lang,Elie A. Akl,Joerg J. Meerpohl,Michael R. DeBaun,John F. Tisdale,Amanda M. Brandow,Sophie M. Lanzkron,Stella T. Chou,Starr Webb,Reem A. Mustafa
View Articletitled, 2019 sickle cell disease guidelines by the American Society of Hematology: methodology, challenges, and innovations
End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain
Ann T. Farrell,Julie Panepinto,C. Patrick Carroll,Deepika S. Darbari,Ankit A. Desai,Allison A. King,Robert J. Adams,Tabitha D. Barber,Amanda M. Brandow,Michael R. DeBaun,Manus J. Donahue,Kalpna Gupta,Jane S. Hankins,Michelle Kameka,Fenella J. Kirkham,Harvey Luksenburg,Shirley Miller,Patricia Ann Oneal,David C. Rees,Rosanna Setse,Vivien A. Sheehan,John Strouse,Cheryl L. Stucky,Ellen M. Werner,John C. Wood,William T. Zempsky
View Articletitled, End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain
Supplemental data
End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings
Ann T. Farrell,Julie Panepinto,Ankit A. Desai,Adetola A. Kassim,Jeffrey Lebensburger,Mark C. Walters,Daniel E. Bauer,Rae M. Blaylark,Donna M. DiMichele,Mark T. Gladwin,Nancy S. Green,Kathryn Hassell,Gregory J. Kato,Elizabeth S. Klings,Donald B. Kohn,Lakshmanan Krishnamurti,Jane Little,Julie Makani,Punam Malik,Patrick T. McGann,Caterina Minniti,Claudia R. Morris,Isaac Odame,Patricia Ann Oneal,Rosanna Setse,Poornima Sharma,Shalini Shenoy
View Articletitled, End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings
Supplemental data

SYSTEMATIC REVIEW

Patients with FLT3-mutant AML needed to enroll on FLT3-targeted therapeutic clinical trials
Clinical Trials & Observations
Taylor Bucy,John M. Zoscak, III,Motomi Mori,Uma Borate
View Articletitled, Patients with FLT3-mutant AML needed to enroll on FLT3-targeted therapeutic clinical trials
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Vedolizumab for prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
Yi-Bin Chen,Nirav N. Shah,Anne S. Renteria,Corey Cutler,Johan Jansson,Mona Akbari,Chunlin Chen,Syed Quadri,Andrejus Parfionovas,Steven M. Devine
View Articletitled, Vedolizumab for prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias
Clinical Trials & Observations
Ashwin Sridharan,Carolina D. Schinke,George Georgiev,Mariana Da Silva Ferreira,Victor Thiruthuvanathan,Ian MacArthur,Tushar D. Bhagat,Gaurav S. Choudhary,Srinivas Aluri,Jiahao Chen,Kith Pradhan,Yu Xia,Maya Panjikaran,Gregory Sims,Chirag K. Bhagat,Ryan Bender,Lauryn Keeler,Armin Graber,Christoph Heuck,Frederick A. Fletcher,Daisy Alapat,Niels Weinhold,Sarah K. Johnson,Amittha Wickrema,Bart Barlogie,Gareth J. Morgan,Aditi Shastri,Ulrich Steidl,Britta Will,Amit Verma
View Articletitled, Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias
Supplemental data

LYMPHOID NEOPLASIA

Molecular features of a large cohort of primary central nervous system lymphoma using tissue microarray
Clinical Trials & Observations
Diego Villa,King L. Tan,Christian Steidl,Susana Ben-Neriah,Muntadhar Al Moosawi,Tamara N. Shenkier,Joseph M. Connors,Laurie H. Sehn,Kerry J. Savage,David W. Scott,Randy D. Gascoyne,Graham W. Slack
View Articletitled, Molecular features of a large cohort of primary central nervous system lymphoma using tissue microarray
Supplemental data
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Kirsty Wienand,Bjoern Chapuy,Chip Stewart,Andrew J. Dunford,David Wu,Jaegil Kim,Atanas Kamburov,Timothy R. Wood,Fathima Zumla Cader,Matthew D. Ducar,Aaron R. Thorner,Anwesha Nag,Alexander T. Heubeck,Michael J. Buonopane,Robert A. Redd,Kamil Bojarczuk,Lee N. Lawton,Philippe Armand,Scott J. Rodig,Jonathan R. Fromm,Gad Getz,Margaret A. Shipp
View Articletitled, Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Supplemental data
Impact of last lenalidomide dose, duration, and IMiD-free interval in patients with myeloma treated with pomalidomide/dexamethasone
Clinical Trials & Observations
Efstathios Kastritis,Maria Roussou,Maria Gavriatopoulou,Nikolaos Kanellias,Magdalini Migkou,Evangelos Eleutherakis-Papaiakovou,Dimitrios C. Ziogas,Despina Fotiou,Ioannis Ntanasis-Stathopoulos,Ioanna Dialoupi,Stavroula Giannouli,Panagiotis Tsirigotis,Sossana Delimpasi,Despina Mparmparousi,Mairylin Spyropoulou-Vlachou,Aikaterini Xirokosta,Evangelos Terpos,Meletios A. Dimopoulos
View Articletitled, Impact of last lenalidomide dose, duration, and IMiD-free interval in patients with myeloma treated with pomalidomide/dexamethasone

MYELOID NEOPLASIA

Invasive fungal infections in acute myeloid leukemia treated with venetoclax and hypomethylating agents
Clinical Trials & Observations
Ibrahim Aldoss,Sanjeet Dadwal,Jianying Zhang,Bernard Tegtmeier,Matthew Mei,Shukaib Arslan,Monzr M. Al Malki,Amandeep Salhotra,Haris Ali,Ahmed Aribi,Karamjeet Sandhu,Samer Khaled,David Snyder,Ryotaro Nakamura,Anthony S. Stein,Stephen J. Forman,Guido Marcucci,Vinod Pullarkat
View Articletitled, Invasive fungal infections in acute myeloid leukemia treated with venetoclax and hypomethylating agents

THROMBOSIS AND HEMOSTASIS

Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT?
Luise Goldmann,Rundan Duan,Thorsten Kragh,Georg Wittmann,Christian Weber,Reinhard Lorenz,Philipp von Hundelshausen,Michael Spannagl,Wolfgang Siess
View Articletitled, Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT?
Supplemental data

TRANSPLANTATION

The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease
Clinical Trials & Observations
Hrishikesh K. Srinagesh,Umut Özbek,Urvi Kapoor,Francis Ayuk,Mina Aziz,Kaitlyn Ben-David,Hannah K. Choe,Zachariah DeFilipp,Aaron Etra,Stephan A. Grupp,Matthew J. Hartwell,Elizabeth O. Hexner,William J. Hogan,Alexander B. Karol,Stelios Kasikis,Carrie L. Kitko,Steven Kowalyk,Jung-Yi Lin,Hannah Major-Monfried,Stephan Mielke,Pietro Merli,George Morales,Rainer Ordemann,Michael A. Pulsipher,Muna Qayed,Pavan Reddy,Ran Reshef,Wolf Rösler,Karamjeet S. Sandhu,Tal Schechter,Jay Shah,Keith Sigel,Daniela Weber,Matthias Wölfl,Kitsada Wudhikarn,Rachel Young,John E. Levine,James L. M. Ferrara
View Articletitled, The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease
Supplemental data
PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade
Shuntaro Ikegawa,Yusuke Meguri,Takumi Kondo,Hiroyuki Sugiura,Yasuhisa Sando,Makoto Nakamura,Miki Iwamoto,Yoshinobu Maeda,Ken-ichi Matsuoka
View Articletitled, PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade
Supplemental data
A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation
Li Li,Han Chen,David Marin,Yuanxin Xi,Qi Miao,Jiangxing Lv,Pinaki Prosad Banerjee,Hila Shaim,May Daher,Rafet Basar,Nobuhiko Imahashi,Juan Jimenez,Bingqian Hu,Rohtesh S. Mehta,Lucila Nassif Kerbauy,Mecit Kaplan,Mayela Mendt,Gonca Ozcan,Elif Gokdemir,Mayra Hernandez Sanabria,Ye Li,Ken Chen,Jing Wang,Luis Muniz-Feliciano,Wei-Li Zhao,Richard E. Champlin,Elizabeth J. Shpall,Katayoun Rezvani
View Articletitled, A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation
Supplemental data

VASCULAR BIOLOGY

Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice
Katherine C. Wood,Brittany G. Durgin,Heidi M. Schmidt,Scott A. Hahn,Jeffrey J. Baust,Tim Bachman,Dario A. Vitturi,Samit Ghosh,Solomon F. Ofori-Acquah,Ana L. Mora,Mark T. Gladwin,Adam C. Straub
View Articletitled, Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice
Supplemental data

RESPONSE

Leukocytosis and thrombosis in polycythemia vera: can clinical trials settle the debate?
Clinical Trials & Observations
Tiziano Barbui,Alessandra Carobbio,Alberto Ferrari
View Articletitled, Leukocytosis and thrombosis in polycythemia vera: can clinical trials settle the debate?
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