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John Mascarenhas
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Journal Articles

Pacritinib is a potent ACVR1 inhibitor with significant anemia benefit in patients with myelofibrosis

Clinical Trials & Observations
Stephen T. Oh, Ruben A. Mesa, Claire N. Harrison, Prithviraj Bose, Aaron T. Gerds, Vikas Gupta, Bart L. Scott, Jean-Jacques Kiladjian, Alessandro Lucchesi, Tim Kong, Sarah A. Buckley, Shanthakumar Tyavanagimatt, Bryan G. Harder, Karisse Roman-Torres, Jennifer Smith, Adam R. Craig, John Mascarenhas, Srdan Verstovsek
Journal: Blood Advances
Blood Adv (2023) 7 (19): 5835–5842.
https://doi.org/10.1182/bloodadvances.2023010151
Published: 2023
Includes: Supplemental data
Journal Articles

Matching-adjusted indirect comparison of the pelabresib-ruxolitinib combination vs JAKi monotherapy in myelofibrosis

Clinical Trials & Observations
Vikas Gupta, John Mascarenhas, Marina Kremyanskaya, Raajit K. Rampal, Moshe Talpaz, Jean-Jacques Kiladjian, Alessandro M. Vannucchi, Srdan Verstovsek, Gozde Colak, Debarshi Dey, Claire Harrison
Journal: Blood Advances
Blood Adv (2023) 7 (18): 5421–5432.
https://doi.org/10.1182/bloodadvances.2023010628
Published: 2023
Includes: Supplemental data
Journal Articles

CNL and aCML are prognostically distinct: a large National Cancer Database analysis

Douglas Tremblay, Dahniel Sastow, John Mascarenhas
Journal: Blood Advances
Blood Adv (2023) 7 (16): 4400–4402.
https://doi.org/10.1182/bloodadvances.2023010722
Published: 2023
Journal Articles

The odyssey of pacritinib in myelofibrosis

Sangeetha Venugopal, John Mascarenhas
Journal: Blood Advances
Blood Adv (2022) 6 (16): 4905–4913.
https://doi.org/10.1182/bloodadvances.2022007524
Published: 2022
Journal Articles

Single-cell analysis reveals selection of TP53 -mutated clones after MDM2 inhibition

Nabih Maslah, Emmanuelle Verger, Stéphane Giraudier, Mathias Chea, Ronald Hoffman, John Mascarenhas, Bruno Cassinat, Jean-Jacques Kiladjian
Journal: Blood Advances
Blood Adv (2022) 6 (9): 2813–2823.
https://doi.org/10.1182/bloodadvances.2021005867
Published: 2022
Includes: Supplemental data
Journal Articles

The MDM2 antagonist idasanutlin in patients with polycythemia vera: results from a single-arm phase 2 study

Clinical Trials & Observations
John Mascarenhas, Francesco Passamonti, Kate Burbury, Tarec Christoffer El-Galaly, Aaron Gerds, Vikas Gupta, Brian Higgins, Kathrin Wonde, Candice Jamois, Bruno Kovic, Ling-Yuh Huw, Sudhakar Katakam, Margherita Maffioli, Ruben Mesa, Jeanne Palmer, Marta Bellini, David M. Ross, Alessandro M. Vannucchi, Abdulraheem Yacoub
Journal: Blood Advances
Blood Adv (2022) 6 (4): 1162–1174.
https://doi.org/10.1182/bloodadvances.2021006043
Published: 2022
Includes: Supplemental data
Journal Articles

PD-1 inhibition in advanced myeloproliferative neoplasms

Gabriela Hobbs, Cansu Cimen Bozkus, Erin Moshier, Mikaela Dougherty, Michal Bar-Natan, Lonette Sandy, Kathryn Johnson, Julia Elise Foster, Tina Som, Molly Macrae, Hetal Marble, Mohamed Salama, Siraj M. El Jamal, Nicole Zubizarreta, Martha Wadleigh, Richard Stone, Nina Bhardwaj, Camelia Iancu-Rubin, John Mascarenhas
Journal: Blood Advances
Blood Adv (2021) 5 (23): 5086–5097.
https://doi.org/10.1182/bloodadvances.2021005491
Published: 2021
Includes: Supplemental data
Journal Articles

Pacritinib demonstrates spleen volume reduction in patients with myelofibrosis independent of JAK2V617F allele burden

Clinical Trials & Observations
Douglas Tremblay, Ruben Mesa, Bart Scott, Sarah Buckley, Karisse Roman-Torres, Srdan Verstovsek, John Mascarenhas
Journal: Blood Advances
Blood Adv (2020) 4 (23): 5929–5935.
https://doi.org/10.1182/bloodadvances.2020002970
Published: 2020
Includes: Supplemental data
Journal Articles

Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Clinical Trials & Observations
Bridget K. Marcellino, Noushin Farnoud, Bruno Cassinat, Min Lu, Emanuelle Verger, Erin McGovern, Minal Patel, Juan Medina-Martinez, Max Fine Levine, Juanes E. Arango Ossa, Yangyu Zhou, Heidi Kosiorek, Meenakshi Mehrotra, Jane Houldsworth, Amylou Dueck, Michael Rossi, John Mascarenhas, Jean-Jacques Kiladjian, Raajit K. Rampal, Ronald Hoffman
Journal: Blood Advances
Blood Adv (2020) 4 (22): 5735–5744.
https://doi.org/10.1182/bloodadvances.2020002379
Published: 2020
Includes: Supplemental data
Journal Articles

Clinical developments in epigenetic-directed therapies in acute myeloid leukemia

Darren Pan, Raajit Rampal, John Mascarenhas
Journal: Blood Advances
Blood Adv (2020) 4 (5): 970–982.
https://doi.org/10.1182/bloodadvances.2019001245
Published: 2020
Journal Articles

The efficacy and safety of direct oral anticoagulants in noncirrhotic portal vein thrombosis

Clinical Trials & Observations
Leonard Naymagon, Douglas Tremblay, Nicole Zubizarreta, Erin Moshier, Kevin Troy, Thomas Schiano, John Mascarenhas
Journal: Blood Advances
Blood Adv (2020) 4 (4): 655–666.
https://doi.org/10.1182/bloodadvances.2019001310
Published: 2020
Journal Articles

Response to meta-analysis of leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera

Lukas Ronner, John Mascarenhas, Erin L. Moshier
Journal: Blood Advances
Blood Adv (2019) 3 (20): 3010–3012.
https://doi.org/10.1182/bloodadvances.2019000822
Published: 2019
Journal Articles

Myoclonic jerks complicating treatment of acute promyelocytic leukemia: case report and literature review

Clinical Trials & Observations
John Y. Rhee, Douglas Tremblay, Amy M. Chan, Martin S. Tallman, John Mascarenhas
Journal: Blood Advances
Blood Adv (2019) 3 (12): 1854–1857.
https://doi.org/10.1182/bloodadvances.2019000249
Published: 2019
Journal Articles

Advanced forms of MPNs are accompanied by chromosomal abnormalities that lead to dysregulation of TP53

Clinical Trials & Observations
Bridget K. Marcellino, Ronald Hoffman, Joseph Tripodi, Min Lu, Heidi Kosiorek, John Mascarenhas, Raajit K. Rampal, Amylou Dueck, Vesna Najfeld
Journal: Blood Advances
Blood Adv (2018) 2 (24): 3581–3589.
https://doi.org/10.1182/bloodadvances.2018024018
Published: 2018