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Kate Downes
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Journal Articles

The role of genetic sequencing in the diagnostic workup for chronic immune thrombocytopenia

Nehal Joshi, Hana Lango-Allen, Kate Downes, Ilenia Simeoni, Camelia Vladescu, Deena Paul, Alice Hart, Christine Ademokun, Nichola Cooper
Journal: Blood Advances
Blood Adv (2025) 9 (7): 1497–1507.
https://doi.org/10.1182/bloodadvances.2024014639
Published: 2025
Includes: Supplemental data
Journal Articles

The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding

Matthew C. Sims, Magdalena Gierula, Jonathan C. Stephens, Alex Tokolyi, Luca Stefanucci, Elodie Persyn, Luanluan Sun, Janine H. Collins, Emma E. Davenport, Emanuele Di Angelantonio, Kate Downes, Michael Inouye, Dirk S. Paul, Will Thomas, Alexander Tolios, Willem H. Ouwehand, Nicholas S. Gleadall, James T. B. Crawley, Adam S. Butterworth, Mattia Frontini, Josefin Ahnström
Journal: Blood Advances
Blood Adv (2024) 9 (1): 132–142.
https://doi.org/10.1182/bloodadvances.2024014020
Published: 2024
Includes: Supplemental data
Journal Articles

G protein–coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1

Kate Downes, Xuefei Zhao, Nicholas S. Gleadall, Harriet McKinney, Carly Kempster, Joana Batista, Patrick L. Thomas, Matthew Cooper, James V. Michael, Roman Kreuzhuber, Katherine Wedderburn, Kathryn Waller, Bianca Varney, Hippolyte Verdier, Neline Kriek, Sofie E. Ashford, Kathleen E. Stirrups, Joanne L. Dunster, Steven E. McKenzie, Willem H. Ouwehand, Jonathan M. Gibbins, Jing Yang, William J. Astle, Peisong Ma
Journal: Blood Advances
Blood Adv (2022) 6 (7): 2319–2330.
https://doi.org/10.1182/bloodadvances.2021005453
Published: 2022
Includes: Supplemental data
Journal Articles

Multiparameter phenotyping of platelet reactivity for stratification of human cohorts

Joanne L. Dunster, Alexander P. Bye, Neline Kriek, Tanya Sage, Joanne L. Mitchell, Carly Kempster, Joana Batista, Harriet McKinney, Patrick Thomas, Chris I. Jones, Kate Downes, Amanda J. Unsworth, Jonathan M. Gibbins
Journal: Blood Advances
Blood Adv (2021) 5 (20): 4017–4030.
https://doi.org/10.1182/bloodadvances.2020003261
Published: 2021
Includes: Supplemental data
Journal Articles

Neutrophil specific granule and NETosis defects in gray platelet syndrome

Cathelijn E. M. Aarts, Kate Downes, Arie J. Hoogendijk, Evelien G. G. Sprenkeler, Roel P. Gazendam, Rémi Favier, Marie Favier, Anton T. J. Tool, John L. van Hamme, Myrto A. Kostadima, Kate Waller, Barbara Zieger, Maaike G. J. M. van Bergen, Saskia M. C. Langemeijer, Bert A. van der Reijden, Hans Janssen, Timo K. van den Berg, Robin van Bruggen, Alexander B. Meijer, Willem H. Ouwehand, Taco W. Kuijpers
Journal: Blood Advances
Blood Adv (2021) 5 (2): 549–564.
https://doi.org/10.1182/bloodadvances.2020002442
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Elevated levels of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency

Clinical Trials & Observations
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Judit Rejtö, Willem H. Ouwehand, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Journal: Blood Advances
Blood Adv (2021) 5 (2): 391–398.
https://doi.org/10.1182/bloodadvances.2020003464
Published: 2021
Includes: Supplemental data
Journal Articles

Monoallelic loss-of-function THPO variants cause heritable thrombocytopenia

Naomi Cornish, M. Riyaad Aungraheeta, Lucy FitzGibbon, Kate Burley, Dominic Alibhai, Janine Collins, Daniel Greene, Kate Downes, NIHR BioResource, Sarah K. Westbury, Ernest Turro, Andrew D. Mumford
Journal: Blood Advances
Blood Adv (2020) 4 (5): 920–924.
https://doi.org/10.1182/bloodadvances.2019001293
Published: 2020
Includes: Supplemental data
Journal Articles

Phenotype description and response to thrombopoietin receptor agonist in DIAPH1 -related disorder

Clinical Trials & Observations
Sarah K. Westbury, Kate Downes, Claire Burney, Maria L. Lozano, Samya G. Obaji, Cheng Hock Toh, Teresa Sevivas, Neil V. Morgan, Wendy N. Erber, Carly Kempster, Samantha F. Moore, Chantal Thys, Sofia Papadia, Willem H. Ouwehand, NIHR BioResource–Rare Diseases, Michael A. Laffan, Keith Gomez, Kathleen Freson, Jose Rivera, Andrew D. Mumford
Journal: Blood Advances
Blood Adv (2018) 2 (18): 2341–2346.
https://doi.org/10.1182/bloodadvances.2018020370
Published: 2018
Includes: Supplemental data