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Journal Articles

Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MM

Marietta S. Truger, Johannes Duell, Xiang Zhou, Larissa Heimeshoff, Anna Ruckdeschel, Mara John, Angela Riedel, Sebastian Hüper, Jessica Peter, Wencke Walter, Larissa Haertle, Manja Meggendorfer, Max S. Topp, Andreas Rosenwald, Matteo Claudio Da Via, Niccolo Bolli, Niels Weinhold, Hermann Einsele, Claudia Haferlach, K. Martin Kortüm, Leo Rasche
Journal: Blood Advances
Blood Adv (2021) 5 (19): 3794–3798.
https://doi.org/10.1182/bloodadvances.2021004418
Published: 2021
Includes: Supplemental data
Journal Articles

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

Howard S. Oster, Simon Crouch, Alexandra Smith, Ge Yu, Bander Abu Shrkihe, Shoham Baruch, Albert Kolomansky, Jonathan Ben-Ezra, Shachar Naor, Pierre Fenaux, Argiris Symeonidis, Reinhard Stauder, Jaroslav Cermak, Guillermo Sanz, Eva Hellström-Lindberg, Luca Malcovati, Saskia Langemeijer, Ulrich Germing, Mette Skov Holm, Krzysztof Madry, Agnes Guerci-Bresler, Dominic Culligan, Laurence Sanhes, Juliet Mills, Ioannis Kotsianidis, Corine van Marrewijk, David Bowen, Theo de Witte, Moshe Mittelman
Journal: Blood Advances
Blood Adv (2021) 5 (16): 3066–3075.
https://doi.org/10.1182/bloodadvances.2020004055
Published: 2021
Journal Articles

Genomic and clinical characterization of early T-cell precursor lymphoblastic lymphoma

Clinical Trials & Observations
Xinjie Xu, Christian N. Paxton, Robert J. Hayashi, Kimberly P. Dunsmore, Stuart S. Winter, Stephen P. Hunger, Naomi J. Winick, William L. Carroll, Mignon L. Loh, Meenakshi Devidas, Thomas G. Gross, Catherine M. Bollard, Sherrie L. Perkins, Rodney R. Miles
Journal: Blood Advances
Blood Adv (2021) 5 (14): 2890–2900.
https://doi.org/10.1182/bloodadvances.2021004334
Published: 2021
Includes: Supplemental data
Journal Articles

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma

Stephan R. Bohl, Laura K. Schmalbrock, Imke Bauhuf, Tatjana Meyer, Anna Dolnik, Martin Szyska, Tamara J. Blätte, Sarah Knödler, Linda Röhner, Denise Miller, Miriam Kull, Christian Langer, Hartmut Döhner, Anthony Letai, Frederik Damm, Dirk Heckl, Lars Bullinger, Jan Krönke
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2391–2402.
https://doi.org/10.1182/bloodadvances.2020003541
Published: 2021
Includes: Supplemental data
Journal Articles

G9a/GLP targeting in MM promotes autophagy-associated apoptosis and boosts proteasome inhibitor–mediated cell death

Eva De Smedt, Julie Devin, Catharina Muylaert, Nicolas Robert, Guilhem Requirand, Philip Vlummens, Laure Vincent, Guillaume Cartron, Ken Maes, Jerome Moreaux, Elke De Bruyne
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2325–2338.
https://doi.org/10.1182/bloodadvances.2020003217
Published: 2021
Includes: Supplemental data
Journal Articles

LSD1 defines erythroleukemia metabolism by controlling the lineage-specific transcription factors GATA1 and C/EBPα

Kensaku Kohrogi, Shinjiro Hino, Akihisa Sakamoto, Kotaro Anan, Ryuta Takase, Hirotaka Araki, Yuko Hino, Kazutaka Araki, Tetsuya Sato, Kimitoshi Nakamura, Mitsuyoshi Nakao
Journal: Blood Advances
Blood Adv (2021) 5 (9): 2305–2318.
https://doi.org/10.1182/bloodadvances.2020003521
Published: 2021
Includes: Supplemental data
Journal Articles

Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ≥80 years

Clinical Trials & Observations
Isabelle A. van Zeventer, Jonas B. Salzbrunn, Aniek O. de Graaf, Bert A. van der Reijden, H. Marike Boezen, Judith M. Vonk, Pim van der Harst, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls
Journal: Blood Advances
Blood Adv (2021) 5 (8): 2115–2122.
https://doi.org/10.1182/bloodadvances.2020004062
Published: 2021
Includes: Supplemental data
Journal Articles

Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia

Pablo Iglesias, Ann-Christin Puller, Marcos Seoane, Michael Spohn, Sabine Raasch, Marianne Klokow, Jürgen Müller, Lia Burkhardt, Daniela Indenbirken, Martin A. Horstmann
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1209–1223.
https://doi.org/10.1182/bloodadvances.2020001844
Published: 2021
Includes: Supplemental data
Journal Articles

Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial

Clinical Trials & Observations
Catia Simoes, Bruno Paiva, David Martínez-Cuadrón, Juan-Miguel Bergua, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose-Luis Lopez, Maria-Belen Vidriales, Jorge Labrador, Jose-Francisco Falantes, María-José Sayas, Rosa Ayala, Joaquin Martinez-Lopez, Sara Villar, Maria-Jose Calasanz, Felipe Prosper, Jesús F. San-Miguel, Miguel Ángel Sanz, Pau Montesinos
Journal: Blood Advances
Blood Adv (2021) 5 (3): 760–770.
https://doi.org/10.1182/bloodadvances.2020003195
Published: 2021
Includes: Supplemental data
Journal Articles

Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features

Clinical Trials & Observations
Xiaolong Alan Zhou, Jingyi Yang, Kimberly G. Ringbloom, Maria Estela Martinez-Escala, Kristen E. Stevenson, Alexander T. Wenzel, Damiano Fantini, Haley K. Martin, Andrea P. Moy, Elizabeth A. Morgan, Shannon Harkins, Christian N. Paxton, Bo Hong, Erica F. Andersen, Joan Guitart, David M. Weinstock, Lorenzo Cerroni, Jaehyuk Choi, Abner Louissaint, Jr
Journal: Blood Advances
Blood Adv (2021) 5 (3): 649–661.
https://doi.org/10.1182/bloodadvances.2020002469
Published: 2021
Includes: Supplemental data
Journal Articles

Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice

Sanjay Rathod, Manda Ramsey, Fred D. Finkelman, Christian A. Fernandez
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4406–4416.
https://doi.org/10.1182/bloodadvances.2020002478
Published: 2020
Includes: Supplemental data
Journal Articles

A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data

Ti-Cheng Chang, Kelly M. Haupfear, Jing Yu, Evadnie Rampersaud, Vivien A. Sheehan, Jonathan M. Flanagan, Jane S. Hankins, Mitchell J. Weiss, Gang Wu, Sunitha Vege, Connie M. Westhoff, Stella T. Chou, Yan Zheng
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4347–4357.
https://doi.org/10.1182/bloodadvances.2020002148
Published: 2020
Includes: Supplemental data
Journal Articles

Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation

Clinical Trials & Observations
Paul J. Martin, David M. Levine, Barry E. Storer, Sarah C. Nelson, Xinyuan Dong, John A. Hansen
Journal: Blood Advances
Blood Adv (2020) 4 (14): 3224–3233.
https://doi.org/10.1182/bloodadvances.2020001927
Published: 2020
Includes: Supplemental data
Journal Articles

Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma

Christopher K. Rushton, Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, Nicole Thomas, Laura K. Hilton, Neil Michaud, Scott Daigle, Jordan Davidson, Kevin Bushell, Stephen Yu, Ryan N. Rys, Michael Jain, Lois Shepherd, Marco A. Marra, John Kuruvilla, Michael Crump, Koren Mann, Sarit Assouline, Joseph M. Connors, Christian Steidl, Mark S. Cragg, David W. Scott, Nathalie A. Johnson, Ryan D. Morin
Journal: Blood Advances
Blood Adv (2020) 4 (13): 2886–2898.
https://doi.org/10.1182/bloodadvances.2020001696
Published: 2020
Includes: Supplemental data
Journal Articles

Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance

Alyssa I. Clay-Gilmour, Michelle A. T. Hildebrandt, Elizabeth E. Brown, Jonathan N. Hofmann, John J. Spinelli, Graham G. Giles, Wendy Cozen, Parveen Bhatti, Xifeng Wu, Rosalie G. Waller, Alem A. Belachew, Dennis P. Robinson, Aaron D. Norman, Jason P. Sinnwell, Sonja I. Berndt, S. Vincent Rajkumar, Shaji K. Kumar, Stephen J. Chanock, Mitchell J. Machiela, Roger L. Milne, Susan L. Slager, Nicola J. Camp, Elad Ziv, Celine M. Vachon
Journal: Blood Advances
Blood Adv (2020) 4 (12): 2789–2797.
https://doi.org/10.1182/bloodadvances.2020001435
Published: 2020
Includes: Supplemental data
Journal Articles

Frequency and spectrum of disease-causing variants in 1892 patients with suspected genetic HLH disorders

Clinical Trials & Observations
Vanessa Gadoury-Levesque, Lei Dong, Rui Su, Jianjun Chen, Kejian Zhang, Kimberly A. Risma, Rebecca A. Marsh, Miao Sun
Journal: Blood Advances
Blood Adv (2020) 4 (12): 2578–2594.
https://doi.org/10.1182/bloodadvances.2020001605
Published: 2020
Includes: Supplemental data
Journal Articles

Search for multiple myeloma risk factors using Mendelian randomization

Molly Went, Alex J. Cornish, Philip J. Law, Ben Kinnersley, Mark van Duin, Niels Weinhold, Asta Försti, Markus Hansson, Pieter Sonneveld, Hartmut Goldschmidt, Gareth J. Morgan, Kari Hemminki, Björn Nilsson, Martin Kaiser, Richard S. Houlston
Journal: Blood Advances
Blood Adv (2020) 4 (10): 2172–2179.
https://doi.org/10.1182/bloodadvances.2020001502
Published: 2020
Includes: Supplemental data
Journal Articles

Clinical developments in epigenetic-directed therapies in acute myeloid leukemia

Darren Pan, Raajit Rampal, John Mascarenhas
Journal: Blood Advances
Blood Adv (2020) 4 (5): 970–982.
https://doi.org/10.1182/bloodadvances.2019001245
Published: 2020
Journal Articles

Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia

Clinical Trials & Observations
Shady Adnan Awad, Matti Kankainen, Teija Ojala, Perttu Koskenvesa, Samuli Eldfors, Bishwa Ghimire, Ashwini Kumar, Soili Kytölä, Mahmoud M. Kamel, Caroline A. Heckman, Kimmo Porkka, Satu Mustjoki
Journal: Blood Advances
Blood Adv (2020) 4 (3): 546–559.
https://doi.org/10.1182/bloodadvances.2019000943
Published: 2020
Includes: Supplemental data
Journal Articles

Early peripheral clearance of leukemia-associated immunophenotypes in AML: centralized analysis of a randomized trial

Clinical Trials & Observations
Giacomo Gianfaldoni, Francesco Mannelli, Tamara Intermesoli, Sara Bencini, Damiano Giupponi, Giorgio Farina, Ilaria Cutini, Maria Ida Bonetti, Arianna Masciulli, Ernesta Audisio, Dario Ferrero, Chiara Pavoni, Anna Maria Scattolin, Alberto Bosi, Alessandro Rambaldi, Renato Bassan
Journal: Blood Advances
Blood Adv (2020) 4 (2): 301–311.
https://doi.org/10.1182/bloodadvances.2019000406
Published: 2020
Includes: Supplemental data