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Journal Articles

Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma

Ingrid Spaan, Laura M. Timmerman, Thomas Kimman, Anne Slomp, Marta Cuenca, Niels van Nieuwenhuijzen, Laura M. Moesbergen, Monique C. Minnema, Reinier A. Raymakers, Victor Peperzak
Journal: Blood Advances
Blood Adv (2021) 5 (12): 2593–2607.
https://doi.org/10.1182/bloodadvances.2020003624
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma

Neeraj Jain, Satishkumar Singh, Georgios Laliotis, Amber Hart, Elizabeth Muhowski, Kristyna Kupcova, Tereza Chrbolkova, Tamer Khashab, Sayan Mullick Chowdhury, Anuvrat Sircar, Fazal Shirazi, Ram Kumar Singh, Lapo Alinari, Jiangjiang Zhu, Ondrej Havranek, Philip Tsichlis, Jennifer Woyach, Robert Baiocchi, Felipe Samaniego, Lalit Sehgal
Journal: Blood Advances
Blood Adv (2020) 4 (18): 4382–4392.
https://doi.org/10.1182/bloodadvances.2020001685
Published: 2020
Includes: Supplemental data
Journal Articles

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

Timon A. Bloedjes, Guus de Wilde, Chiel Maas, Eric Eldering, Richard J. Bende, Carel J. M. van Noesel, Steven T. Pals, Marcel Spaargaren, Jeroen E. J. Guikema
Journal: Blood Advances
Blood Adv (2020) 4 (17): 4151–4164.
https://doi.org/10.1182/bloodadvances.2019001393
Published: 2020
Includes: Supplemental data
Journal Articles

Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif

Clinical Trials & Observations Global Advances
Peixun Zhou, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, Casey Broadbent, Lewis Chaytor, Amber Whitehead, Amy Hall, Hettie O’Connor, Susan Van Noorden, Irvin Lampert, Simon Bailey, Elizabeth Molyneux, Chris M. Bacon, Simon Bomken, Vikki Rand
Journal: Blood Advances
Blood Adv (2019) 3 (14): 2118–2127.
https://doi.org/10.1182/bloodadvances.2018029546
Published: 2019
Includes: Supplemental data
Journal Articles

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα

Caroline Kardeby, Knut Fälker, Elizabeth J. Haining, Maarten Criel, Madelene Lindkvist, Ruben Barroso, Peter Påhlsson, Liza U. Ljungberg, Mattias Tengdelius, G. Ed Rainger, Stephanie Watson, Johannes A. Eble, Marc F. Hoylaerts, Jonas Emsley, Peter Konradsson, Steve P. Watson, Yi Sun, Magnus Grenegård
Journal: Blood Advances
Blood Adv (2019) 3 (3): 275–287.
https://doi.org/10.1182/bloodadvances.2018024950
Published: 2019
Includes: Supplemental data
Journal Articles

CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML

Claire M. Lucas, Laura J. Scott, Natasha Carmell, Alison K. Holcroft, Robert K. Hills, Alan K. Burnett, Richard E. Clark
Journal: Blood Advances
Blood Adv (2018) 2 (9): 964–968.
https://doi.org/10.1182/bloodadvances.2017013615
Published: 2018
Includes: Supplemental data
Journal Articles

Regulation of the maturation of human monocytes into immunosuppressive macrophages

Defne Bayik, Debra Tross, Lydia A. Haile, Daniela Verthelyi, Dennis M. Klinman
Journal: Blood Advances
Blood Adv (2017) 1 (26): 2510–2519.
https://doi.org/10.1182/bloodadvances.2017011221
Published: 2017
Includes: Supplemental data
Journal Articles

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT

Akil A. Merchant, Aparna Jorapur, Amy McManus, Ren Liu, Valery Krasnoperov, Parvesh Chaudhry, Mohan Singh, Lisa Harton, Mary Agajanian, Miriam Kim, Timothy J. Triche, Jr, Brian J. Druker, Jeffrey W. Tyner, Parkash S. Gill
Journal: Blood Advances
Blood Adv (2017) 1 (20): 1635–1644.
https://doi.org/10.1182/bloodadvances.2017005694
Published: 2017
Includes: Supplemental data
Journal Articles

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function

Eliana Ribechini, James A. Hutchinson, Sabine Hergovits, Marion Heuer, Jörg Lucas, Ulrike Schleicher, Ana-Laura Jordán Garrote, Sarah J. Potter, Paloma Riquelme, Heike Brackmann, Nora Müller, Hartmann Raifer, Ingolf Berberich, Magdalena Huber, Andreas Beilhack, Michael Lohoff, Christian Bogdan, Matthias Eyrich, Heike M. Hermanns, Edward K. Geissler, Manfred B. Lutz
Journal: Blood Advances
Blood Adv (2017) 1 (14): 947–960.
https://doi.org/10.1182/bloodadvances.2017006858
Published: 2017
Includes: Supplemental data