Awareness of thalassemia in medical students. Thalassemia affects 200 million people worldwide. In Southeast Asia, it is a major public health problem. In India, 10 000 cases are born per year. Thalassemia has until recently, received little attention and is not widely understood by health professionals. There is lack of proper awareness of Thalassemia. Thus. This study was done in 203 medical students at Delhi to assess their awareness about Thalassemia. A preformed proforma was used for this purpose. All the students present on a day in a particular batch were included. MS EXCEL and SPSS were used for analysis. P-value was calculated to assess the statistic significance.

Concepts like hematological, genetic & non-infective were well known as opposed to symptoms like fatigue, muscular weakness, abnormal bleeding, jaundice, protruding abdomen, fits, dark urine, bone pain, abnormal facial bones, and susceptibility to infections. Diagnostic and treatment modalities like electromyography, vitamins, antibiotics, cryoprecipitates, spleenectomy, bone marrow transplant and umbilical cord were also much less known. Awareness of preventive interventions like genetic counseling, consanguity, fetal blood sampling was less.

Thus, a continuous education model for medical staff is required. Although programs for increasing community awareness are underway in many countries; interventions to raise thalassemia awareness in medical professionals are also required.

General & Symptoms

2nd sem n=394th sem n=476th sem n=598th sem n=58’p’ value(X2)
aware of thalassemia 38(97.4%) 47(100%) 59(100%) 58(100%) 0.238 
not infectious disease 38(97.4%) 46(97.8%) 57(96.6) 57(98.3) 0.861 
disorder of blood 37(94.9) 47(100%) 57(96.6) 58(100%) 0.267 
genetic 37(94.9) 46(97.8%) 54(91.5) 57(98.3) 0.378 
fatigue 28(71.8) 45(95.7) 51(86.4) 51(86.4) 0.009 
muscular weakness 16(41) 21(44.7) 23(38.9) 24(40.6) 0.01 
abnormal bleeding 21(53.8) 11(23.4) 24(40.7) 28(47.5) 
jaundice 13(33.3) 42(89.4) 38(64.4) 40(67.8) 
protruding abdomen 2(5.1) 13(27.6) 21(35.6) 25(42.4) 
fits 7(17.9) 5(10.6) 7(11.9) 12(20.3) 
dark urine 7(17.9) 33(70.2) 25(42.4)  
bone pain 10(25.6) 35(74.5) 42(71.2) 40(68.9) 
abnormal facial bones 5(12.8) 37(78.7) 50(84.7) 44(75.9) 
susceptibility to infections 14(35.9) 27(57.4) 42(71.2) 41(70.7) 
2nd sem n=394th sem n=476th sem n=598th sem n=58’p’ value(X2)
aware of thalassemia 38(97.4%) 47(100%) 59(100%) 58(100%) 0.238 
not infectious disease 38(97.4%) 46(97.8%) 57(96.6) 57(98.3) 0.861 
disorder of blood 37(94.9) 47(100%) 57(96.6) 58(100%) 0.267 
genetic 37(94.9) 46(97.8%) 54(91.5) 57(98.3) 0.378 
fatigue 28(71.8) 45(95.7) 51(86.4) 51(86.4) 0.009 
muscular weakness 16(41) 21(44.7) 23(38.9) 24(40.6) 0.01 
abnormal bleeding 21(53.8) 11(23.4) 24(40.7) 28(47.5) 
jaundice 13(33.3) 42(89.4) 38(64.4) 40(67.8) 
protruding abdomen 2(5.1) 13(27.6) 21(35.6) 25(42.4) 
fits 7(17.9) 5(10.6) 7(11.9) 12(20.3) 
dark urine 7(17.9) 33(70.2) 25(42.4)  
bone pain 10(25.6) 35(74.5) 42(71.2) 40(68.9) 
abnormal facial bones 5(12.8) 37(78.7) 50(84.7) 44(75.9) 
susceptibility to infections 14(35.9) 27(57.4) 42(71.2) 41(70.7) 

Investigations, Treatment & Prevention

2nd sem n=394th sem n=476th sem n=598th sem n=58’p’ value(X2)
CBC & ferretin 22(56.4) 21(44.7) 26(44) 32(55.1) 
radiography 6(12.7) 11(18.6) 25(42.4) 
Hb electrophoresis 12(30.7) 34(72.3) 40(67.8) 35(60.3) 
vitamins 12(25.5) 18(30.5) 21(36.2) 
antibotic 1(2.5) 18(38.3) 21(35.6) 26(44.8) 
transfusion 30(76.9) 35(74.5) 43(72.9) 39(67.2) 0.121 
cryoprecipitate 13(33.3) 20(42.5) 23(38.9) 25(42.4) 0.001 
spleenectomy 1(2.5) 27(57.4) 20(33.9) 32(55.1) 
BM transplant 22(56.4) 34(72.3) 35(59.3) 32(55.1) 0.005 
umbilical cord 3(7.6) 22(46.8) 22(37.3) 28(48.3) 
penatal diagnosis 23(59) 27(57.4) 37(62.7) 41(70.7) 0.5 
genetic counselling 12(30.8) 29(61.7) 43(72.9) 38(65.5) 
gene therapy 19(48.7) 18(38.3) 29(49.1) 38(65.5) 0.044 
consanguity 4(10.2) 15(31.9) 17(28.8) 33(55.9) 
fetal blood 5(12.8) 17(36.1) 22(37.3) 30(50.8) 0.002 
2nd sem n=394th sem n=476th sem n=598th sem n=58’p’ value(X2)
CBC & ferretin 22(56.4) 21(44.7) 26(44) 32(55.1) 
radiography 6(12.7) 11(18.6) 25(42.4) 
Hb electrophoresis 12(30.7) 34(72.3) 40(67.8) 35(60.3) 
vitamins 12(25.5) 18(30.5) 21(36.2) 
antibotic 1(2.5) 18(38.3) 21(35.6) 26(44.8) 
transfusion 30(76.9) 35(74.5) 43(72.9) 39(67.2) 0.121 
cryoprecipitate 13(33.3) 20(42.5) 23(38.9) 25(42.4) 0.001 
spleenectomy 1(2.5) 27(57.4) 20(33.9) 32(55.1) 
BM transplant 22(56.4) 34(72.3) 35(59.3) 32(55.1) 0.005 
umbilical cord 3(7.6) 22(46.8) 22(37.3) 28(48.3) 
penatal diagnosis 23(59) 27(57.4) 37(62.7) 41(70.7) 0.5 
genetic counselling 12(30.8) 29(61.7) 43(72.9) 38(65.5) 
gene therapy 19(48.7) 18(38.3) 29(49.1) 38(65.5) 0.044 
consanguity 4(10.2) 15(31.9) 17(28.8) 33(55.9) 
fetal blood 5(12.8) 17(36.1) 22(37.3) 30(50.8) 0.002 

Disclosure: No relevant conflicts of interest to declare.

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