Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113(22):5628-5634.

doi:10.1182/blood-2015-09-670943

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ERRATA| November 5, 2015

Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113(22):5628-5634.

Blood (2015) 126 (19): 2256.

https://doi.org/10.1182/blood-2015-09-670943

On page 5630 in the 28 May 2009 issue, there are errors in Table 1. Under the row heading “No. of donors, no. (%),” the row for 1 donor reads “033 (100)” under the “KIR-L mismatched, n = 33” column and “069 (100)” in the “KIR-L matched, n = 69” column. Both entries should read “0.” Also, the row for 2 donors is blank in the same columns. The entries should read “33 (100)” in the “KIR-L mismatched, n = 33 column” and “69 (100)” in the “KIR-L matched, n = 69” column. The corrected table is shown below.

2015

Table 1

Patients, conditioning regimen, and graft characteristics

Factor	MA conditioning			RI conditioning			MA vs RI, P
Factor	KIR-L mismatched, n = 41	KIR-L matched, n = 114	P	KIR-L mismatched, n = 33	KIR-L matched, n = 69	P	MA vs RI, P
Median age at transplantation, y (range)	15 (0.6-53)	15.9 (1.0-59)	.84	48 (22-69)	52 (6-68)	.10	< .01
Median weight, kg (range)	75.8 (57.2-130.3)	69.8 (33.4-148.6)	.30	86.9 (55.9-125.7)	78.5 (22.1-121.8)	.31	< .01
Male, no. (%)	27 (66)	66 (58)	.37	22 (67)	45 (65)	.89	.36
Recipient CMV positive, no. (%) Diagnosis, no. (%)	14 (34)	73 (64)	< .01	14 (42)	44 (64)	.04	.91
AML	18 (44)	42 (37)		8 (24)	20 (29)
ALL	13 (32)	42 (37)		1 (3)	8 (11)
CML	3 (7)	11 (9)	.86	2 (6)	3 (4)	.47	< .01
MDS	2 (5)	3 (3)		2 (6)	8 (12)
NHL/Hodgkin	4 (10)	8 (7)		17 (52)	24 (35)
Other	1 (2)	8 (7)		3 (9)	6 (9)
Year of transplantation, no. (%)	1 (2)	8 (7)		3 (9)	6 (9)
1998-2000	9 (22)	23 (20)	.12	0	0	.89	< .01
2001-2006	54 (78)	91 (80)		33 (100)	69 (100)
High-risk disease,* no. (%)	13 (32)	32 (28)	.66	21 (64)	30 (43)	.06	< .01
ATG with conditioning, no. (%)	17 (41)	43 (38)	.67	8 (24)	22 (32)	.43	.13
GVHD prophylaxis, no. (%)	17 (41)	43 (38)	.67	8 (24)	22 (32)	.43	.13
CSA/MPD	16 (39)	44 (39)	.99	0	0	na	< .01
CSA/MMF±MPD	25 (61)	70 (61)		36 (100)	69 (100)
HLA matching,† no. (%)	25 (61)	70 (61)		36 (100)	69 (100)
4/6	25 (61)	59 (52)		28 (85)	45 (65)
5/6	14 (34)	42 (37)	.42	5 (15)	18 (26)	.08	.68
6/6	2 (5)	13 (11)		0	6 (9)
No. of donors, no. (%)			.28			na	na
1	27 (66)	64 (56)		0	0
2	14 (34)	50 (44)		33 (100)	69 (100)
Conditioning, no. (%)	14 (34)	50 (44)		33 (100)	69 (100)
Bu containing	1 (2)	8 (7)		1 (3)	1 (1)	.54	< .01
Cy/Flu/TBI	24 (59)	70 (61)	.75	32 (97)	68 (99)
Cy/TBI	16 (39)	36 (32)
Median infused TNC, ×10⁷ (range)	3.4 (1.0-10.3)	3.8 (1.2-10.8)	.51	3.3 (2.0-6.8)	3.6 (1.5-5.9)	.26	.72
Median infused CD34⁺, ×10⁵ (range)	4.6 (0.9-21.6)	4.0 (0.6-34.8)	.49	4.0 (1.1-16.6)	4.6 (1.1-13.7)	.84	.40
Median infused CD3⁺, ×10⁷ (range)	1.2 (0.1-2.6)	1.3 (0.2-3.2)	.32	1.1 (0.1-2.7)	1.4 (0.2-3.1)	.07	.62
Median follow-up among survivors, y (range)	2.2 (1.0-6.8)	2.1 (0.9-7.8)	.99	2.0 (1.0-3.5)	1.8 (0.9-5.3)	.94	.02

Factor	MA conditioning			RI conditioning			MA vs RI, P
Factor	KIR-L mismatched, n = 41	KIR-L matched, n = 114	P	KIR-L mismatched, n = 33	KIR-L matched, n = 69	P	MA vs RI, P
Median age at transplantation, y (range)	15 (0.6-53)	15.9 (1.0-59)	.84	48 (22-69)	52 (6-68)	.10	< .01
Median weight, kg (range)	75.8 (57.2-130.3)	69.8 (33.4-148.6)	.30	86.9 (55.9-125.7)	78.5 (22.1-121.8)	.31	< .01
Male, no. (%)	27 (66)	66 (58)	.37	22 (67)	45 (65)	.89	.36
Recipient CMV positive, no. (%) Diagnosis, no. (%)	14 (34)	73 (64)	< .01	14 (42)	44 (64)	.04	.91
AML	18 (44)	42 (37)		8 (24)	20 (29)
ALL	13 (32)	42 (37)		1 (3)	8 (11)
CML	3 (7)	11 (9)	.86	2 (6)	3 (4)	.47	< .01
MDS	2 (5)	3 (3)		2 (6)	8 (12)
NHL/Hodgkin	4 (10)	8 (7)		17 (52)	24 (35)
Other	1 (2)	8 (7)		3 (9)	6 (9)
Year of transplantation, no. (%)	1 (2)	8 (7)		3 (9)	6 (9)
1998-2000	9 (22)	23 (20)	.12	0	0	.89	< .01
2001-2006	54 (78)	91 (80)		33 (100)	69 (100)
High-risk disease,* no. (%)	13 (32)	32 (28)	.66	21 (64)	30 (43)	.06	< .01
ATG with conditioning, no. (%)	17 (41)	43 (38)	.67	8 (24)	22 (32)	.43	.13
GVHD prophylaxis, no. (%)	17 (41)	43 (38)	.67	8 (24)	22 (32)	.43	.13
CSA/MPD	16 (39)	44 (39)	.99	0	0	na	< .01
CSA/MMF±MPD	25 (61)	70 (61)		36 (100)	69 (100)
HLA matching,† no. (%)	25 (61)	70 (61)		36 (100)	69 (100)
4/6	25 (61)	59 (52)		28 (85)	45 (65)
5/6	14 (34)	42 (37)	.42	5 (15)	18 (26)	.08	.68
6/6	2 (5)	13 (11)		0	6 (9)
No. of donors, no. (%)			.28			na	na
1	27 (66)	64 (56)		0	0
2	14 (34)	50 (44)		33 (100)	69 (100)
Conditioning, no. (%)	14 (34)	50 (44)		33 (100)	69 (100)
Bu containing	1 (2)	8 (7)		1 (3)	1 (1)	.54	< .01
Cy/Flu/TBI	24 (59)	70 (61)	.75	32 (97)	68 (99)
Cy/TBI	16 (39)	36 (32)
Median infused TNC, ×10⁷ (range)	3.4 (1.0-10.3)	3.8 (1.2-10.8)	.51	3.3 (2.0-6.8)	3.6 (1.5-5.9)	.26	.72
Median infused CD34⁺, ×10⁵ (range)	4.6 (0.9-21.6)	4.0 (0.6-34.8)	.49	4.0 (1.1-16.6)	4.6 (1.1-13.7)	.84	.40
Median infused CD3⁺, ×10⁷ (range)	1.2 (0.1-2.6)	1.3 (0.2-3.2)	.32	1.1 (0.1-2.7)	1.4 (0.2-3.1)	.07	.62
Median follow-up among survivors, y (range)	2.2 (1.0-6.8)	2.1 (0.9-7.8)	.99	2.0 (1.0-3.5)	1.8 (0.9-5.3)	.94	.02

P values less than .05 are shown in bold for easy identification.

ALL indicates acute lymphoblastic leukemia; CML, chronic myelogenous leukemia; MDS, myelodysplastic syndrome; and NHL, non-Hodgkin lymphoma.

Disease was defined as standard risk if patients underwent transplantation with AML and ALL in first or second complete remission, CML in first chronic phase, and chemotherapy-sensitive lymphoma in partial or complete remission. Other patients were considered to have high-risk disease.

†

For recipients of 2 UCB units the HLA matching reflects the worst matched of the 2 units.

Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113(22):5628-5634.

Contents

Data & Figures

Supplemental data

References

Cited By

Email alerts

ASH Publications

American Society of Hematology

Brunstein CG, Wagner JE, Weisdorf DJ, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113(22):5628-5634.

Contents

Data & Figures

Supplemental data

References

Related

Related

Cited By

Email alerts

ASH Publications

American Society of Hematology

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