A method is described for producing large numbers of bone marrow lymphocytes in Lewis rats. The bone marrow of posthypoxic polycythemic rats contained larger numbers of lymphocytes than was found in mice and guinea pigs subjected to similar procedures. Autoradiographical studies on the rebound bone marrow, produced evidence that the majority of the lymphocytes were produced in situ, and that they were rapidly turning over. One hundred per cent labeling was achieved after thrice daily intraperitoneal injections of 3/4 µc, tritiated thymidine for 4 days.

This content is only available as a PDF.
© 1969 by American Society of Hematology, Inc.
1969
Sign in via your Institution