Virus-reactive T cells expanded in aplastic anemia eliminate hematopoietic progenitor cells by molecular mimicry

2.

Tometten

M

,

Kirschner

M

,

Meyer

R

, et al.

Identification of adult patients with classical and/or cryptic dyskeratosis congenita (DKC) by telomere lenght screening using age-modified criteria

.

Hemasphere

.

2023

;

7

(

5

):

e874

.

3.

Vieri

M

,

Brummendorf

TH

,

Beier

F

.

Treatment of telomeropathies

.

Best Pract Res Clin Haematol

.

2021

;

34

(

2

):

101282

.

4.

Rosenfeld

S

,

Follmann

D

,

Nunez

O

,

Young

NS

.

Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome

.

JAMA

.

2003

;

289

(

9

):

1130

-

1135

.

5.

Risitano

AM

.

(Auto-)immune signature in aplastic anemia

.

Haematologica

.

2018

;

103

(

5

):

747

-

749

.

6.

Zheng

M

,

Liu

C

,

Fu

R

, et al.

Abnormal immunomodulatory ability on memory T cells in humans with severe aplastic anemia

.

Int J Clin Exp Pathol

.

2015

;

8

(

4

):

3659

-

3669

.

7.

Zhu

C

,

Lian

Y

,

Wang

C

, et al.

Single-cell transcriptomics dissects hematopoietic cell destruction and T-cell engagement in aplastic anemia

.

Blood

.

2021

;

138

(

1

):

23

-

33

.

8.

Peffault de Latour

R

,

Kulasekararaj

A

,

Iacobelli

S

, et al.

Eltrombopag added to immunosuppression in severe aplastic anemia

.

N Engl J Med

.

2022

;

386

(

1

):

11

-

23

.

9.

Hosokawa

K

,

Muranski

P

,

Feng

X

, et al.

Memory stem T cells in autoimmune disease: high frequency of circulating CD8+ memory stem cells in acquired aplastic anemia

.

J Immunol

.

2016

;

196

(

4

):

1568

-

1578

.

10.

Solomou

EE

,

Keyvanfar

K

,

Young

NS

.

T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia

.

Blood

.

2006

;

107

(

10

):

3983

-

3991

.

11.

Giudice

V

,

Feng

X

,

Lin

Z

, et al.

Deep sequencing and flow cytometric characterization of expanded effector memory CD8(+)CD57(+) T cells frequently reveals T-cell receptor Vbeta oligoclonality and CDR3 homology in acquired aplastic anemia

.

Haematologica

.

2018

;

103

(

5

):

759

-

769

.

12.

Zaimoku

Y

,

Patel

BA

,

Adams

SD

, et al.

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

.

Blood

.

2021

;

138

(

26

):

2799

-

2809

.

13.

Deng

XZ

,

Du

M

,

Peng

J

, et al.

Associations between the HLA-A/B/DRB1 polymorphisms and aplastic anemia: evidence from 17 case-control studies

.

Hematology

.

2018

;

23

(

3

):

154

-

162

.

14.

Pagliuca

S

,

Gurnari

C

,

Awada

H

, et al.

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

.

Blood

.

2021

;

138

(

26

):

2781

-

2798

.

15.

Chang

HD

,

Radbruch

A

.

Maintenance of quiescent immune memory in the bone marrow

.

Eur J Immunol

.

2021

;

51

(

7

):

1592

-

1601

.

16.

Hislop

AD

,

Annels

NE

,

Gudgeon

NH

,

Leese

AM

,

Rickinson

AB

.

Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection

.

J Exp Med

.

2002

;

195

(

7

):

893

-

905

.

17.

Hislop

AD

,

Taylor

GS

,

Sauce

D

,

Rickinson

AB

.

Cellular responses to viral infection in humans: lessons from Epstein-Barr virus

.

Annu Rev Immunol

.

2007

;

25

:

587

-

617

.

18.

Lanz

TV

,

Brewer

RC

,

Ho

PP

, et al.

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

.

Nature

.

2022

;

603

(

7900

):

321

-

327

.

19.

Schneider-Hohendorf

T

,

Gerdes

LA

,

Pignolet

B

, et al.

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis

.

J Exp Med

.

2022

;

219

(

11

):

e20220650

.

20.

Siewert

K

,

Malotka

J

,

Kawakami

N

,

Wekerle

H

,

Hohlfeld

R

,

Dornmair

K

.

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides

.

Nat Med

.

2012

;

18

(

5

):

824

-

828

.

21.

Welters

C

,

Lammoglia Cobo

MF

,

Stein

CA

, et al.

Immune phenotypes and target antigens of clonally expanded bone marrow T cells in treatment-naive multiple myeloma

.

Cancer Immunol Res

.

2022

;

10

(

11

):

1407

-

1419

.

22.

Ballhausen

A

,

Ben Hamza

A

,

Welters

C

, et al.

Immune phenotypes and checkpoint molecule expression of clonally expanded lymph node-infiltrating T cells in classical Hodgkin lymphoma

.

Cancer Immunol Immunother

.

2023

;

72

(

2

):

515

-

521

.

23.

Penter

L

,

Dietze

K

,

Bullinger

L

,

Westermann

J

,

Rahn

HP

,

Hansmann

L

.

FACS single cell index sorting is highly reliable and determines immune phenotypes of clonally expanded T cells

.

Eur J Immunol

.

2018

;

48

(

7

):

1248

-

1250

.

24.

Penter

L

,

Dietze

K

,

Ritter

J

, et al.

Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer

.

Oncoimmunology

.

2019

;

8

(

6

):

e1586409

.

25.

Han

A

,

Glanville

J

,

Hansmann

L

,

Davis

MM

.

Linking T-cell receptor sequence to functional phenotype at the single-cell level

.

Nat Biotechnol

.

2014

;

32

(

7

):

684

-

692

.

26.

Engels

B

,

Cam

H

,

Schuler

T

, et al.

Retroviral vectors for high-level transgene expression in T lymphocytes

.

Hum Gene Ther

.

2003

;

14

(

12

):

1155

-

1168

.

27.

Lammoglia Cobo

MF

,

Welters

C

,

Rosenberger

L

, et al.

Rapid single-cell identification of Epstein-Barr virus-specific T-cell receptors for cellular therapy

.

Cytotherapy

.

2022

;

24

(

8

):

818

-

826

.

https://doi.org/10.3324/haematol.2023.283812

28.

Welters

C

,

Welters

ML

,

Stadler

S

, et al.

HLA-C∗04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

.

Haematologica

.

Published online 28 September 2023

.

29.

Bruggemann

M

,

Kotrova

M

,

Knecht

H

, et al.

Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

.

Leukemia

.

2019

;

33

(

9

):

2241

-

2253

.

30.

Bystry

V

,

Reigl

T

,

Krejci

A

, et al.

ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data

.

Bioinformatics

.

2017

;

33

(

3

):

435

-

437

.

31.

Giudicelli

V

,

Brochet

X

,

Lefranc

MP

.

IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences

.

Cold Spring Harb Protoc

.

2011

;

2011

(

6

):

695

-

715

.

32.

R Core Team

.

R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing

. Accessed in 2021.. https://www.R-project.org.

33.

Henson

SM

,

Riddell

NE

,

Akbar

AN

.

Properties of end-stage human T cells defined by CD45RA re-expression

.

Curr Opin Immunol

.

2012

;

24

(

4

):

476

-

481

.

34.

Moosmann

A

,

Khan

N

,

Cobbold

M

, et al.

B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells

.

Blood

.

2002

;

100

(

5

):

1755

-

1764

.

35.

Hansmann

L

,

Han

A

,

Penter

L

,

Liedtke

M

,

Davis

MM

.

Clonal expansion and interrelatedness of distinct B-lineage compartments in multiple myeloma bone marrow

.

Cancer Immunol Res

.

2017

;

5

(

9

):

744

-

754

.

36.

Graham

N

,

Eisenhauer

P

,

Diehl

SA

, et al.

Rapid induction and maintenance of virus-specific CD8(+) T(EMRA) and CD4(+) T(EM) cells following protective vaccination against dengue virus challenge in humans

.

Front Immunol

.

2020

;

11

:

479

.

37.

Salumets

A

,

Tserel

L

,

Rumm

AP

, et al.

Epigenetic quantification of immunosenescent CD8(+) TEMRA cells in human blood

.

Aging Cell

.

2022

;

21

(

5

):

e13607

.

38.

Glanville

J

,

Huang

H

,

Nau

A

, et al.

Identifying specificity groups in the T cell receptor repertoire

.

Nature

.

2017

;

547

(

7661

):

94

-

98

.

39.

Huang

H

,

Wang

C

,

Rubelt

F

,

Scriba

TJ

,

Davis

MM

.

Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening

.

Nat Biotechnol

.

2020

;

38

(

10

):

1194

-

1202

.

40.

Scheinberg

P

,

Fischer

SH

,

Li

L

, et al.

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia

.

Blood

.

2007

;

109

(

8

):

3219

-

3224

.

41.

Bozhilov

YK

,

Hsu

I

,

Brown

EJ

,

Wilkinson

AC

.

In vitro human haematopoietic stem cell expansion and differentiation

.

Cells

.

2023

;

12

(

6

):

896

.

42.

Sauvageau

G

,

Iscove

NN

,

Humphries

RK

.

In vitro and in vivo expansion of hematopoietic stem cells

.

Oncogene

.

2004

;

23

(

43

):

7223

-

7232

.

43.

Boitano

AE

,

Wang

J

,

Romeo

R

, et al.

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

.

Science

.

2010

;

329

(

5997

):

1345

-

1348

.

44.

Fares

I

,

Chagraoui

J

,

Gareau

Y

, et al.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

.

Science

.

2014

;

345

(

6203

):

1509

-

1512

.

45.

Singh

J

,

Chen

ELY

,

Xing

Y

,

Stefanski

HE

,

Blazar

BR

,

Zuniga-Pflucker

JC

.

Generation and function of progenitor T cells from StemRegenin-1-expanded CD34+ human hematopoietic progenitor cells

.

Blood Adv

.

2019

;

3

(

20

):

2934

-

2948

.

46.

Walenda

T

,

Bokermann

G

,

Ventura Ferreira

MS

, et al.

Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells

.

Exp Hematol

.

2011

;

39

(

6

):

617

-

628

.

47.

Risitano

AM

,

Maciejewski

JP

,

Green

S

,

Plasilova

M

,

Zeng

W

,

Young

NS

.

In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing

.

Lancet

.

2004

;

364

(

9431

):

355

-

364

.

48.

Olson

TS

,

Frost

BF

,

Duke

JL

, et al.

Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities

.

JCI Insight

.

2022

;

7

(

22

):

e163040

.

49.

Uhlen

M

,

Fagerberg

L

,

Hallstrom

BM

, et al.

Proteomics. Tissue-based map of the human proteome

.

Science

.

2015

;

347

(

6220

):

1260419

.

50.

Grishaber

JE

,

McClain

KL

,

Mahoney

DH

,

Fernbach

DJ

.

Successful outcome of severe aplastic anemia following Epstein-Barr virus infection

.

Am J Hematol

.

1988

;

28

(

4

):

273

-

275

.

51.

Inoue

H

,

Shinohara

K

,

Nomiyama

J

,

Oeda

E

.

Fatal aplastic anemia caused by Epstein-Barr virus infection after autologous bone marrow transplantation for non-Hodgkin malignant lymphoma

.

Intern Med

.

1994

;

33

(

5

):

303

-

307

.

52.

Zhang

WJ

,

Wu

LQ

,

Wang

J

,

Lin

SY

,

Wang

B

.

Epstein-Barr-virus-associated hepatitis with aplastic anemia: a case report

.

World J Clin Cases

.

2022

;

10

(

23

):

8242

-

8248

.

53.

Baranski

B

,

Armstrong

G

,

Truman

JT

,

Quinnan

GV

,

Straus

SE

,

Young

NS

.

Epstein-Barr virus in the bone marrow of patients with aplastic anemia

.

Ann Intern Med

.

1988

;

109

(

9

):

695

-

704

.

54.

Shadduck

RK

,

Winkelstein

A

,

Zeigler

Z

, et al.

Aplastic anemia following infectious mononucleosis: possible immune etiology

.

Exp Hematol

.

1979

;

7

(

5

):

264

-

271

.

55.

Simmons

P

,

Kaushansky

K

,

Torok-Storb

B

.

Mechanisms of cytomegalovirus-mediated myelosuppression: perturbation of stromal cell function versus direct infection of myeloid cells

.

Proc Natl Acad Sci U S A

.

1990

;

87

(

4

):

1386

-

1390

.

56.

Sakurai

M

,

Kogure

Y

,

Mizuno

K

,

Matsuki

E

,

Kataoka

K

.

Long-term reduction in the incidence of aplastic anemia and immune thrombocytopenia during the COVID-19 pandemic

.

Haematologica

.

2023

;

108

(

9

):

2546

-

2550

.