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Journal Articles

Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression

Lilian Varricchio, Gohar Mosoyan, Sebastian Elghaity-Beckley, Md. Babu Mia, Shivani Handa, Christian Salib, John Mascarenhas, Ronald Hoffman

Blood (2025) 146 (13): 1612–1624.

https://doi.org/10.1182/blood.2024027363

Published: 2025

Includes: Supplemental data

Journal Articles

Clonal tracing of blood stem cells across mouse and human lifespans

Alejo E Rodriguez-Fraticelli

Blood blood.2024028195.

https://doi.org/10.1182/blood.2024028195

Published: 2025

Journal Articles

VEXAS anemia is a mosaic erythroblastopenia

Blood blood.2025029081.

https://doi.org/10.1182/blood.2025029081

Published: 2025

Includes: Supplemental data

Journal Articles

Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEX

Vincent Jachiet, Olivier Kosmider, Maxime Beydon, Jérôme Hadjadj, Lin-Pierre Zhao, Vincent Grobost, Valentin Lacombe, Guillaume Le Guenno, Yann Nguyen, Jean-Benoît Arlet, Jérémie Dion, Maël Heiblig, Alice Garnier, Maxime Samson, Achille Aouba, Sylvain Thépot, Sophie Dimicoli-Salazar, Fabien Dutasta, Benoît Faucher, Estibaliz Lazaro, Véronique Morel, Antoine Néel, Roderau Outh, Holy Bezanahary, Julien Rossignol, Anne-Sophie Alary, Audrey Bidet, Pauline Blateau, Anne Bouvier, Guilaine Boursier, Matthieu Decamp, Benjamin Lebecque, Yannick Le Bris, Pierre Sujobert, Alice Marceau-Renaut, Cédric Pastoret, David Rizzo, Nathalie Boiret-Dupré, Lara Boucher, Stéphanie Dulucq, Franck Genevieve, Cassandra Jadeau, Pierre Lemaire, Romain Vazquez, Jean-Baptiste Rieu, Olivier Fain, Sophie Georgin-Lavialle, Lucie Rigolot, Lise Larcher, Pierre Hirsch, Benjamin Terrier, Pierre Fenaux, Arsène Mékinian, Thibault Comont

Blood (2025) 146 (12): 1450–1461.

https://doi.org/10.1182/blood.2024028133

Published: 2025

Includes: Supplemental data

Journal Articles

Loss of BAP1 defines a unique subtype of TP53 -mutated de novo AML and confers sensitivity to BCL-xL inhibitors

Jaclyn Andricovich, Coen Johannes Lap, Alexandros Tzatsos

Blood (2025) 146 (12): 1493–1510.

https://doi.org/10.1182/blood.2024026417

Published: 2025

Includes: Supplemental data

Journal Articles

Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis

Pengfei Xu, Xiuli Zhang, Donghe Li, Bo Jiao, Jiawei Nie, Yi Huang, Zhizhou Xia, Jiaoyang Li, Yuqing Dan, Xu Huang, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Shiyu Ji, Yong Cang, Ruibao Ren, Ping Liu

Blood (2025) 146 (12): 1462–1475.

https://doi.org/10.1182/blood.2024027335

Published: 2025

Includes: Supplemental data

Journal Articles

A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment

Grace A Meaker, Matthew Nicholls, Catherine Chahrour, Ian Hsu, Alastair Smith, Yavor Bozhilov, Maurice Ga Hay Leung, Hugo Vassort, Mr, Leonid Olender, Oliver Beaven, Xinran Huang, Elizabeth J Brown, Marlies Vanden Bempt, Hwei Minn Khoo, Joydeep Bhadury, Thomas A Milne, Adam C. Wilkinson

Blood blood.2025029115.

https://doi.org/10.1182/blood.2025029115

Published: 2025

Includes: Supplemental data

Journal Articles

Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone

Tsuyoshi Isojima, Blessing Crimeen-Irwin, Narelle E. McGregor, Ryan C. Chai, Ingrid J. Poulton, Emma C. Walker, Mriga Dutt, Benjamin L. Parker, Natalie A. Sims

Blood (2025) 146 (11): 1331–1345.

https://doi.org/10.1182/blood.2025028310

Published: 2025

Includes: Supplemental data

Journal Articles

CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell-intrinsic inflammatory pathways

Tanner C Martinez, Matthew R. M. Jotte, Saira Khan, Angela Stoddart, Hunter Z. Blaylock, Ankit Malik, Megan E. McNerney

Blood blood.2024026815.

https://doi.org/10.1182/blood.2024026815

Published: 2025

Includes: Supplemental data

Journal Articles

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

Sen Zhang, Charles E. Ayemoba, Anna M. Di Staulo, Kenneth Joves, Chandani M. Patel, Eva Hin Wa Leung, Maura Lima Pereira Bueno, Xiaoping Du, Mortimer Poncz, Sang-Ging Ong, Claus Nerlov, Maria Maryanovich, Constantinos Chronis, Sandra Pinho

Blood blood.2024027432.

https://doi.org/10.1182/blood.2024027432

Published: 2025

Includes: Supplemental data

Journal Articles

An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesis

Justin Loke, Peter G. Kim, Thuy T. P. Nguyen, Meaghan Boileau, Marie McConkey, Aidan Miller, Wesley Shin, Christopher B. Hergott, Maria Ericsson, Anja Nordstrom, Paula Montero Llopis, Scott A. Armstrong, Joseph D. Mancias, Benjamin L. Ebert

Blood (2025) 146 (10): 1174–1186.

https://doi.org/10.1182/blood.2024028033

Published: 2025

Includes: Supplemental data

Journal Articles

Clinical and molecular features of immunodeficiency in patients with telomere biology disorders

Luiz Fernando Bazzo Catto, Nidhi Aggarwal, Ruba Shalhoub, Xiaoyang Ma, Ivana Darden, Tania Machado, Yue Zhang, Neelam R. Redekar, Natthakan Thongon, Simona Colla, Geraldine Aubert, Cynthia E. Dunbar, Colin O. Wu, Neal S. Young, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Emma M. Groarke

Blood (2025) 146 (10): 1187–1193.

https://doi.org/10.1182/blood.2024026735

Published: 2025

Includes: Supplemental data

Journal Articles

Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women

Blood (2025) 146 (9): 1078–1087.

https://doi.org/10.1182/blood.2025028417

Published: 2025

Includes: Supplemental data

Journal Articles

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation

Madeline Y. Mayday, Giulia Biancon, Manyi Wei, Christian Ramirez, Irene Moratti, Andreas P. Pintado-Urbanc, Jether Amos Espinosa, Mi Chen, Lin Wang, Matthew D. Simon, Yaara Ofir-Rosenfeld, Oliver Rausch, Toma Tebaldi, Stephanie Halene, Diane S. Krause

Blood (2025) 146 (9): 1096–1109.

https://doi.org/10.1182/blood.2024027712

Published: 2025

Includes: Supplemental data

Journal Articles

Platelet Heterogeneity: Variety Makes Immune and Vascular Function Better

Michael Malloy, Kathleen E McGrath, Craig N Morrell

Blood blood.2025028955.

https://doi.org/10.1182/blood.2025028955

Published: 2025

Journal Articles

Imaging mass cytometry reveals the order of events in the pathogenesis of immune-mediated aplastic anemia

Emma S. Pool, Sietse J. Luk, Marieke E. Ijsselsteijn, Vincent van Unen, Noel F. C. C. de Miranda, J. H. Frederik Falkenburg, Frits Koning, Mirjam H. M. Heemskerk, Jennifer M.-L. Tjon

Blood (2025) 146 (8): 951–963.

https://doi.org/10.1182/blood.2025028723

Published: 2025

Includes: Supplemental data

Journal Articles

T-ICAHT: grading and prognostic impact of thrombocytopenia after CAR T-cell therapy

Blood (2025) 146 (7): 834–846.

https://doi.org/10.1182/blood.2025028833

Published: 2025

Includes: Supplemental data

Journal Articles

PERK signaling maintains hematopoietic stem cell pool integrity under endoplasmic reticulum stress by promoting proliferation

Manxi Zheng, Qinlu Peng, Erin M. Kropp, Zhejuan Shen, Suxuan Liu, Zhengyou Yin, Sho Matono, Takao Iwawaki, Xiang Wang, Ken Inoki, Yang Mei, Qing Li, Lu Liu

Blood (2025) 146 (7): 806–818.

https://doi.org/10.1182/blood.2024027846

Published: 2025

Includes: Supplemental data

Journal Articles

Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction

Fangwu Wang, Laura Gonzalez, Qiuyu Lian, Colin A. Hammond, Yasmine Y. M. Lau, Benjamin D. Simons, Martin Hirst, Connie J. Eaves

Blood (2025) 146 (6): 693–706.

https://doi.org/10.1182/blood.2024026936

Published: 2025

Includes: Supplemental data

Journal Articles

Defective neutrophil clearance in JAK2 V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

Eman Khatib-Massalha, Christian A. Di Buduo, Agathe L. Chédeville, Ya-Hsuan Ho, Yexuan Zhu, Elodie Grockowiak, Yuki Date, Lam T. Khuat, Zijian Fang, José Quesada-Salas, Eva Carrillo Félez, Matteo Migliavacca, Isabel Montero, José A. Pérez-Simón, Alessandra Balduini, Simón Méndez-Ferrer

Blood (2025) 146 (6): 717–731.

https://doi.org/10.1182/blood.2024027455

Published: 2025

Includes: Supplemental data

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Thrombocytopenia in myelofibrosis is characterized by inflammatory megakaryocytes with reduced G6B expression

Clonal tracing of blood stem cells across mouse and human lifespans

VEXAS anemia is a mosaic erythroblastopenia

Efficacy and safety of azacitidine for VEXAS syndrome: a large-scale retrospective study from FRENVEX

Loss of BAP1 defines a unique subtype of TP53 -mutated de novo AML and confers sensitivity to BCL-xL inhibitors

Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis

A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment

Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone

CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell-intrinsic inflammatory pathways

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4- mediated ferritinophagy as a dependence in Tet2 -deficient hematopoiesis

Clinical and molecular features of immunodeficiency in patients with telomere biology disorders

Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation

Platelet Heterogeneity: Variety Makes Immune and Vascular Function Better

Imaging mass cytometry reveals the order of events in the pathogenesis of immune-mediated aplastic anemia

T-ICAHT: grading and prognostic impact of thrombocytopenia after CAR T-cell therapy

PERK signaling maintains hematopoietic stem cell pool integrity under endoplasmic reticulum stress by promoting proliferation

Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction

Defective neutrophil clearance in JAK2 V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

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