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Megan E. McNerney
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Journal Articles

CUX1 Levels Control Hematopoietic Stem Cell Fate and Plasticity

Free
Tanner C. Martinez, Matthew R. M. Jotte, Megan E. McNerney
Journal: Blood
Blood (2023) 142 (Supplement 1): 399.
https://doi.org/10.1182/blood-2023-179523
Published: 2023
Journal Articles

Combined Deficiency of Chromosome 7 Myeloid Tumor Suppressors Enhances Chemotherapy Resistance

Free
Matthew R. M. Jotte, Tanner C. Martinez, Angela Stoddart, Molly K. Imgruet, Henna S. Nam, Bonnie Hu, Saira Khan, Ningfei An, Megan E. McNerney
Journal: Blood
Blood (2023) 142 (Supplement 1): 5689.
https://doi.org/10.1182/blood-2023-189308
Published: 2023
Journal Articles

NAMPT Haploinsufficiency Is a Therapeutic Vulnerability in High-Risk Myeloid Malignancies

Free
Madhavi D. Senagolage, Saira Khan, Sarah Skuli, Martin Carroll, Megan E. McNerney
Journal: Blood
Blood (2023) 142 (Supplement 1): 5753.
https://doi.org/10.1182/blood-2023-191061
Published: 2023
Journal Articles

Chromosome 7 Myeloid Tumor Suppressor Genes Cooperate in Chemotherapy Resistance

Free
Matthew R.M. Jotte, Henna S. Nam, Bonnie Hu, Tanner C. Martinez, Saira Khan, Ningfei An, Angela Stoddart, Megan E. McNerney
Journal: Blood
Blood (2022) 140 (Supplement 1): 8720.
https://doi.org/10.1182/blood-2022-169602
Published: 2022
Journal Articles

CUX1 Deficiency Potentiates RAS Signaling to Drive Malignancy

Free
Ningfei An, Molly K Imgruet, Saira Khan, Lia Jueng, Sandeep Gurbuxani, Megan E. McNerney
Journal: Blood
Blood (2021) 138 (Supplement 1): 1159.
https://doi.org/10.1182/blood-2021-148694
Published: 2021
Journal Articles

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Free
Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Hu, Saira Khan, Jeffrey Kurkewich, Tanner C. Martinez, Donald Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron, Megan E. McNerney
Journal: Blood
Blood (2021) 138 (9): 790–805.
https://doi.org/10.1182/blood.2020009195
Published: 2021
Includes: Supplemental data
Journal Articles

Deficiency of CUX1, Encoded on 7q, Blocks the Normal HSC DNA Damage Response and Drives Highly Penetrant Therapy-Related Myeloid Neoplasms in Mice

Free
Molly K Imgruet, BS, Ningfei An, PhD, Saira Khan, MS, Julian K Lutze, BS, Bonnie Hu, Stephen J. Kron, MD PhD, Sandeep Gurbuxani, MBBS, PhD, Megan E. McNerney, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 641.
https://doi.org/10.1182/blood-2019-130717
Published: 2019
Journal Articles

Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS

Free
Ningfei An, Saira Khan, Molly K. Imgruet, Sandeep K. Gurbuxani, Stephanie N. Konecki, Michael R. Burgess, Megan E. McNerney
Journal: Blood
Blood (2018) 131 (24): 2682–2697.
https://doi.org/10.1182/blood-2017-10-810028
Published: 2018
Includes: Supplemental data
Journal Articles

Deficiency of Cux1 , Encoded on Human Chromosome 7q, Causes Aberrant Hematopoietic Stem Cell Function and Spontaneous Myeloproliferative Disease in Mice

Free
Ningfei An, PhD, Saira Khan, Molly Imgruet, Sandeep Gurbuxani, MBBS, PhD, Michael R. Burgess, MD PhD, Megan E. McNerney, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 789.
https://doi.org/10.1182/blood.V130.Suppl_1.789.789
Published: 2017
Journal Articles

Enhancer-Promoter Looping Deciphers Dosage of the Haploinsufficient Transcription Factor, CUX1

Free
Robert K Arthur, PhD, Ningfei An, PhD, Saira Kahn, Megan E. McNerney, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2700.
https://doi.org/10.1182/blood.V128.22.2700.2700
Published: 2016
Journal Articles

Retroviral Insertional Mutagenesis In Egr1 +/- mice, Haploinsufficient For a Human Del(5q) Myeloid Leukemia Gene, Develop Myeloid Neoplasms With Proviral Insertions In Genes Syntenic To Human 5q

Free
Angela Stoddart, PhD, Anthony Fernald, Rachel Joy Bergerson, PhD, Jianghong Wang, M.D., Megan E. McNerney, MD, PhD, Theodore Karrison, Ph.D., John Anastasi, MD, Elizabeth Bartom, Ph.D., Aaron G. Sarver, Ph.D., Zhijian Qian, PhD, Linda Wolff, PhD, David A. Largaespada, PhD, Michelle M. le Beau, PhD
Journal: Blood
Blood (2013) 122 (21): 1275.
https://doi.org/10.1182/blood.V122.21.1275.1275
Published: 2013
Journal Articles

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

Free
Megan E. McNerney, Christopher D. Brown, Xiaoyue Wang, Elizabeth T. Bartom, Subhradip Karmakar, Chaitanya Bandlamudi, Shan Yu, Jinkyung Ko, Barry P. Sandall, Thomas Stricker, John Anastasi, Robert L. Grossman, John M. Cunningham, Michelle M. Le Beau, Kevin P. White
Journal: Blood
Blood (2013) 121 (6): 975–983.
https://doi.org/10.1182/blood-2012-04-426965
Published: 2013
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing Analysis of 23 Therapy-Related Acute Myeloid Leukemia Transcriptomes

Free
Megan E. McNerney, MD, PhD, Christopher D. Brown, PhD, Kevin P. White, PhD
Journal: Blood
Blood (2010) 116 (21): 850.
https://doi.org/10.1182/blood.V116.21.850.850
Published: 2010
Journal Articles

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions

Free
Kyung-Mi Lee, John P. Forman, Megan E. McNerney, Susan Stepp, Sumalatha Kuppireddi, Dustin Guzior, Yvette E. Latchman, Mohamed H. Sayegh, Hideo Yagita, Chul-Kyu Park, Seog Bae Oh, Christoph Wülfing, John Schatzle, Porunelloor A. Mathew, Arlene H. Sharpe, Vinay Kumar
Journal: Blood
Blood (2006) 107 (8): 3181–3188.
https://doi.org/10.1182/blood-2005-01-0185
Published: 2006
Journal Articles

2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice

Free
Brief Report
Megan E. McNerney, Dustin Guzior, Vinay Kumar
Journal: Blood
Blood (2005) 106 (4): 1337–1340.
https://doi.org/10.1182/blood-2005-01-0357
Published: 2005