Hematopoietic stem cells (HSCs) are instrumental for organismal survival because they are responsible for lifelong production of mature blood lineages in homeostasis and response to external stress. To fulfill their function, HSCs rely on reciprocal interactions with specialized tissue microenvironments, termed HSC niches. From embryonic development to advanced aging, HSCs transition through several hematopoietic organs in which they are supported by distinct extrinsic cues. Here, we describe recent discoveries on how HSC niches collectively adapt to ensure robust hematopoietic function during biological aging and after exposure to acute stress. We also discuss the latest strategies leveraging niche-derived signals to revert aging-associated phenotypes and enhance hematopoietic recovery after myeloablation.
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July 4, 2024
Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress
Johanna Hofmann,
Johanna Hofmann
1Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany
2Department 15, Biosciences, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
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Konstantinos D. Kokkaliaris
Konstantinos D. Kokkaliaris
1Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany
3German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Quantitative Spatial Cancer Biology Laboratory, and German Cancer Research Center (DKFZ), Heidelberg, Germany
4Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt am Main, Germany
5University Cancer Center, Frankfurt am Main, Germany
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Blood (2024) 144 (1): 21–34.
Article history
Submitted:
January 18, 2024
Accepted:
March 28, 2024
First Edition:
April 5, 2024
Citation
Johanna Hofmann, Konstantinos D. Kokkaliaris; Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress. Blood 2024; 144 (1): 21–34. doi: https://doi.org/10.1182/blood.2023023788
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July 4 2024
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