Brief Report: Commentary on Hemosiderin

In conclusion we should like to emphasize that the classical hemosiderin of the histologist is not a single or unique substance.⁸ The constitution of this material is quite variable. Removal of hemosiderin granules from cells for chemical analysis demands careful control based on morphologic criteria and is, in any case, not a substitute, but a concomitant of examination in situ in cells. One should bear in mind that in its natural state hemosiderin occurs in living tissues, not as a test tube isolate, or as a thin section.