Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

Debureaux, Pierre-Edouard; Poulain, Stéphanie; Harel, Stephanie; Passet, Marie; Templé, Marie; Friedrich, Chloe; Forgeard, Nathalie; Elessa, Dikelele; Plas, William; Chat, Laureen; Lazarian, Gregory; Willems, Lise; Royer, Bruno; Talbot, Alexis; Vaugeois, Tristan; Theves, Floriane; Terré, Alexandre; Brignier, Anne C.; Malphettes, Marion; Krzisch, Daphné; Frenzel, Laurent; Davi, Frédéric; Bravetti, Clotilde; Nguyen-Khac, Florence; Dupuis, Jehan; Cuccuini, Wendy; Bouscary, Didier; Hermine, Olivier; Roos-Weil, Damien; Kosmider, Olivier; Clappier, Emmanuelle; Espéli, Marion; Balabanian, Karl; Arnulf, Bertrand

doi:10.1182/blood.2024025738

Inflammation in Waldenström Macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and BTK inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in iWM patients (61% versus 23% in non-inflammatory WM), suggesting a contribution of environmental cells to iWM.

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2024

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Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

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Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort

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